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Volumn 147, Issue 5, 2011, Pages 590-596

Epidermodysplasia verruciformis in human immunodeficiency virus-infected patients: A marker of human papillomavirus-related disorders not affected by antiretroviral therapy

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIRETROVIRUS AGENT; FLUOROURACIL; IMIQUIMOD; RETINOIC ACID; UREA;

EID: 79956095902     PISSN: 0003987X     EISSN: 15383652     Source Type: Journal    
DOI: 10.1001/archdermatol.2010.399     Document Type: Article
Times cited : (41)

References (50)
  • 1
    • 33749430257 scopus 로고    scopus 로고
    • Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses
    • DOI 10.1016/j.smim.2006.07.008, PII S1044532306001023, Human Genetics of Infectious Desiases: Immunological Implications
    • Orth G. Genetics of epidermodysplasia verruciformis: insights into host defense against papillomaviruses. Semin Immunol. 2006;18(6):362-374. (Pubitemid 44511885)
    • (2006) Seminars in Immunology , vol.18 , Issue.6 , pp. 362-374
    • Orth, G.1
  • 2
    • 18744369886 scopus 로고    scopus 로고
    • Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis
    • DOI 10.1038/ng1044
    • Ramoz N, Rueda LA, Bouadjar B, Montoya LS, Orth G, Favre M. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat Genet. 2002;32(4):579-581. (Pubitemid 35435168)
    • (2002) Nature Genetics , vol.32 , Issue.4 , pp. 579-581
    • Ramoz, N.1    Rueda, L.-A.2    Bouadjar, B.3    Montoya, L.-S.4    Orth, G.5    Favre, M.6
  • 3
    • 38749086503 scopus 로고    scopus 로고
    • Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses
    • DOI 10.1084/jem.20071311
    • Lazarczyk M, Pons C, Mendoza JA, Cassonnet P, Jacob Y, Favre M. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. J Exp Med. 2008;205(1):35-42. (Pubitemid 351185713)
    • (2008) Journal of Experimental Medicine , vol.205 , Issue.1 , pp. 35-42
    • Lazarczyk, M.1    Pons, C.2    Mendoza, J.-A.3    Cassonnet, P.4    Jacob, Y.5    Favre, M.6
  • 4
    • 0017869260 scopus 로고
    • Epidermodysplasia verruciformis. An autosomal recessive disease characterized by viral warts and skin cancer: A model for viral oncogenesis
    • Lutzner MA. Epidermodysplasia verruciformis. An autosomal recessive disease characterized by viral warts and skin cancer: a model for viral oncogenesis. Bull Cancer. 1978;65(2):169-182.
    • (1978) Bull Cancer , vol.65 , Issue.2 , pp. 169-182
    • Lutzner, M.A.1
  • 5
    • 0034692433 scopus 로고    scopus 로고
    • Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome
    • Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst. 2000;92(18):1500-1510.
    • (2000) J Natl Cancer Inst , vol.92 , Issue.18 , pp. 1500-1510
    • Frisch, M.1    Biggar, R.J.2    Goedert, J.J.3
  • 7
    • 0031040163 scopus 로고    scopus 로고
    • Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy
    • Arends MJ, Benton EC, McLaren KM, Stark LA, Hunter JA, Bird CC. Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy. Br J Cancer. 1997;75(5):722-728. (Pubitemid 27091088)
    • (1997) British Journal of Cancer , vol.75 , Issue.5 , pp. 722-728
    • Arends, M.J.1    Benton, E.C.2    McLaren, K.M.3    Stark, L.A.4    Hunter, J.A.A.5    Bird, C.C.6
  • 8
    • 48049085259 scopus 로고    scopus 로고
    • Human papilloma virus infection and cervical intraepithelial neoplasia in transplanted patients
    • Paternoster DM, Cester M, Resente C, et al. Human papilloma virus infection and cervical intraepithelial neoplasia in transplanted patients. Transplant Proc. 2008;4(6):1877-1880.
    • (2008) Transplant Proc , vol.4 , Issue.6 , pp. 1877-1880
    • Paternoster, D.M.1    Cester, M.2    Resente, C.3
  • 10
    • 0032859819 scopus 로고    scopus 로고
    • A broad range of human papillomavirus types detected with a general PCR method suitable for analysis of cutaneous tumours and normal skin
    • Forslund O, Antonsson A, Nordin P, Stenquist B, Hansson BG. A broad range of human papillomavirus types detected with a general PCR method suitable for analysis of cutaneous tumours and normal skin. J Gen Virol. 1999;80(pt 9):2437-2443. (Pubitemid 29408373)
    • (1999) Journal of General Virology , vol.80 , Issue.9 , pp. 2437-2443
    • Forslund, O.1    Antonsson, A.2    Nordin, P.3    Stenquist, B.4    Hansson, B.G.5
  • 11
    • 0025043187 scopus 로고
    • Widespread flat warts associated with human papillomavirus type 5: A cutaneous manifestation of human immunodeficiency virus infection
    • Prose NS, von Knebel-Doeberitz C, Miller S, Milburn PB, Heilman E. Widespread flat warts associated with human papillomavirus type 5: a cutaneous manifestation of human immunodeficiency virus infection. J Am Acad Dermatol. 1990;23(5, pt 2):978-981. (Pubitemid 20364348)
    • (1990) Journal of the American Academy of Dermatology , vol.23 , Issue.5 II SUPPL. , pp. 978-981
    • Prose, N.S.1    Von Knebel-Doeberitz, C.2    Miller, S.3    Milburn, P.B.4    Heilman, E.5
  • 12
    • 0026069315 scopus 로고
    • Epidermodysplasia verruciformis-associated papillomavirus infection complicating human immunodeficiency virus disease
    • Berger TG, Sawchuk WS, Leonardi C, Langenberg A, Tappero J, Leboit PE. Epidermodysplasia verruciformis-associated papillomavirus infection complicating human immunodeficiency virus disease. Br J Dermatol. 1991;124(1):79-83.
    • (1991) Br J Dermatol , vol.124 , Issue.1 , pp. 79-83
    • Berger, T.G.1    Sawchuk, W.S.2    Leonardi, C.3    Langenberg, A.4    Tappero, J.5    Leboit, P.E.6
  • 14
    • 0035788785 scopus 로고    scopus 로고
    • Remission of epidermodysplasia verruciformis-like skin eruption after highly active antiretroviral therapy in a human immunodeficiency virus-positive patient [3]
    • DOI 10.1046/j.1365-2133.2001.04426.x
    • Haas N, Fuchs PG, Hermes B, Henz BM. Remission of epidermodysplasia verru-ciformis-like skin eruption after highly active antiretroviral therapy in a human immunodeficiency virus-positive patient. Br J Dermatol. 2001;145(4):669-670. (Pubitemid 36138936)
    • (2001) British Journal of Dermatology , vol.145 , Issue.4 , pp. 669-670
    • Haas, N.1    Fuchs, P.G.2    Hermes, B.3    Henz, B.M.4
  • 15
    • 0036220616 scopus 로고    scopus 로고
    • Groin eruption in an HIV-positive man: Epidermodysplasia verruciformis (EDV)
    • Trauner MA, Ruben BS, Hatcher SL, Lawry MA. Groin eruption in an HIV-positive man: epidermodysplasia verruciformis (EDV). Arch Dermatol. 2002;138(4):527-532.
    • (2002) Arch Dermatol , vol.138 , Issue.4 , pp. 527-532
    • Trauner, M.A.1    Ruben, B.S.2    Hatcher, S.L.3    Lawry, M.A.4
  • 17
    • 27544492205 scopus 로고    scopus 로고
    • Epidermodysplasia verruciformis in two half brothers with HIV infection
    • DOI 10.1007/s10227-005-0022-6
    • Hu W, Nuovo G, Willen M, Somach S. Epidermodysplasia verruciformis in two half brothers with HIV infection. J Cutan Med Surg. 2004;8(5):357-360. (Pubitemid 41542425)
    • (2004) Journal of Cutaneous Medicine and Surgery , vol.8 , Issue.5 , pp. 357-360
    • Hu, W.1    Nuovo, G.2    Willen, M.3    Somach, S.4
  • 18
    • 2442639091 scopus 로고    scopus 로고
    • Epidermodysplasia verruciformis-like eruption associated with HIV infection [1]
    • DOI 10.1111/j.1365-2230.2004.01503.x
    • Davison SC, Francis N, McLean K, Bunker CB. Epidermodysplasia verruciformis-like eruption associated with HIV infection. Clin Exp Dermatol. 2004;29(3):311-312. (Pubitemid 38658479)
    • (2004) Clinical and Experimental Dermatology , vol.29 , Issue.3 , pp. 311-312
    • Davison, S.C.1    Francis, N.2    McLean, K.3    Bunker, C.B.4
  • 20
    • 34548531900 scopus 로고    scopus 로고
    • Epidermodysplasia verruciformis-like disorder in a teenager with HIV and HCV infections [11]
    • DOI 10.1111/j.1525-1470.2007.00487.x
    • Bonamigo R, Maldonado G, Londero RM, Cartell A. Epidermodysplasia verruciformis- like disorder in a teenager with HIV and HCV infections. Pediatr Dermatol. 2007;24(4):456-457. (Pubitemid 47382854)
    • (2007) Pediatric Dermatology , vol.24 , Issue.4 , pp. 456-457
    • Bonamigo, R.1    Maldonado, G.2    Londero, R.M.3    Cartell, A.4
  • 21
    • 34248377370 scopus 로고    scopus 로고
    • Epidermodysplasia verruciformis occurring in a patient with human immunodeficiency virus: A case report
    • Hultgren TL, Srinivasan SK, DiMaio DJ. Epidermodysplasia verruciformis occurring in a patient with human immunodeficiency virus: a case report. Cutis. 2007;79(4):307-311.
    • (2007) Cutis , vol.79 , Issue.4 , pp. 307-311
    • Hultgren, T.L.1    Srinivasan, S.K.2    DiMaio, D.J.3
  • 24
    • 58449121047 scopus 로고    scopus 로고
    • Treatment of epidermodysplasia verruciformis in human immunodeficiency virus-positive patients
    • Rallis E, Paparizos V, Kyriakis K, Katsambas A. Treatment of epidermodysplasia verruciformis in human immunodeficiency virus-positive patients. J Eur Acad Dermatol Venereol. 2009;23(2):195-196.
    • (2009) J Eur Acad Dermatol Venereol , vol.23 , Issue.2 , pp. 195-196
    • Rallis, E.1    Paparizos, V.2    Kyriakis, K.3    Katsambas, A.4
  • 25
    • 59149091970 scopus 로고    scopus 로고
    • Epidermodysplasia verruciform-like lesions in an HIV patient
    • Berk DR, Bruckner AL, Lu D. Epidermodysplasia verruciform-like lesions in an HIV patient. Dermatol Online J. 2009;15(1):1.
    • (2009) Dermatol Online J , vol.15 , Issue.1 , pp. 1
    • Berk, D.R.1    Bruckner, A.L.2    Lu, D.3
  • 26
    • 59049090031 scopus 로고    scopus 로고
    • Epidermodysplasia verruciformis in a HIV-positive patient homozygous for the c917A - >T polymorphism in the TMC8/EVER2 gene
    • Hohenstein E, Rady PL, Hergersberg M, et al. Epidermodysplasia verruciformis in a HIV-positive patient homozygous for the c917A - >T polymorphism in the TMC8/EVER2 gene. Dermatology. 2009;218(2):114-118.
    • (2009) Dermatology , vol.218 , Issue.2 , pp. 114-118
    • Hohenstein, E.1    Rady, P.L.2    Hergersberg, M.3
  • 28
    • 55449099333 scopus 로고    scopus 로고
    • Extensive development of flat warts as a cutaneous manifestation of immune reconstitution syndrome
    • Iarikov D, Duke W, Skiest D. Extensive development of flat warts as a cutaneous manifestation of immune reconstitution syndrome. AIDS Read. 2008;18(10):524-527.
    • (2008) AIDS Read , vol.18 , Issue.10 , pp. 524-527
    • Iarikov, D.1    Duke, W.2    Skiest, D.3
  • 29
    • 34547122205 scopus 로고    scopus 로고
    • A case of efflorescence of cutaneous warts as a manifestation of immune reconstitution inflammatory syndrome in an HIV-infected patient [10]
    • DOI 10.1086/519504
    • Kerob D, Dupuy A, Vignon-Pennamen MD, Bournerias I, Dohin E, Lebbe C. A case of efflorescence of cutaneous warts as a manifestation of immune reconstitution inflammatory syndrome in an HIV-infected patient. Clin Infect Dis. 2007;45(3):405-406. (Pubitemid 47101049)
    • (2007) Clinical Infectious Diseases , vol.45 , Issue.3 , pp. 405-406
    • Kerob, D.1    Dupuy, A.2    Vignon-Pennamen, M.-D.3    Bournerias, I.4    Dohin, E.5    Lebbe, C.6
  • 30
    • 0018953956 scopus 로고
    • A potentially oncogenic human papillomavirus (HPV-5) found in two renal allograft recipients
    • Lutzner M, Croissant O, Ducasse MF, Kreis H, Crosnier J, Orth G. A potentially oncogenic human papillomavirus (HPV-5) found in two renal allograft recipients. J Invest Dermatol. 1980;75(4):353-356. (Pubitemid 10024621)
    • (1980) Journal of Investigative Dermatology , vol.75 , Issue.4 , pp. 353-356
    • Lutzner, M.1    Croissant, O.2    Ducasse, M.-F.3
  • 31
    • 0022998167 scopus 로고
    • Human papillomavirus infections in a group of renal transplant recipients
    • DOI 10.1111/j.1365-2133.1986.tb06649.x
    • Rüdlinger R, Smith IW, Bunney MH, Hunter JA. Human papillomavirus infections in a group of renal transplant recipients. Br J Dermatol. 1986;115(6):681-692. (Pubitemid 17181893)
    • (1986) British Journal of Dermatology , vol.115 , Issue.6 , pp. 681-692
    • Rudlinger, R.1    Smith, I.W.2    Bunney, M.H.3    Hunter, J.A.A.4
  • 32
    • 0036734789 scopus 로고    scopus 로고
    • The histologic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients
    • DOI 10.1034/j.1600-0560.2002.290806.x
    • Morrison C, Eliezri Y, Magro C, Nuovo GJ. The histologic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients. J Cutan Pathol. 2002;29(8):480-489. (Pubitemid 35034459)
    • (2002) Journal of Cutaneous Pathology , vol.29 , Issue.8 , pp. 480-489
    • Morrison, C.1    Eliezri, Y.2    Magro, C.3    Nuovo, G.J.4
  • 33
    • 45449126315 scopus 로고
    • Epidermodysplasia verruciformis in a patient with Hodgkin's disease: Characterization of a new papillomavirus type and interferon treatment
    • Gross G, Ellinger K, Roussaki A, Fuchs PG, Peter HH, Pfister H. Epidermodysplasia verruciformis in a patient with Hodgkin's disease: characterization of a new papillomavirus type and interferon treatment. J Invest Dermatol. 1988;91(1):43-48.
    • (1988) J Invest Dermatol , vol.91 , Issue.1 , pp. 43-48
    • Gross, G.1    Ellinger, K.2    Roussaki, A.3    Fuchs, P.G.4    Peter, H.H.5    Pfister, H.6
  • 34
    • 70350335341 scopus 로고    scopus 로고
    • Epidermodysplasia-verruciformis-like eruption associated with gamma-papillomavirus infection in a patient with adult T-cell leukemia
    • Kawai K, Egawa N, Kiyono T, Kanekura T. Epidermodysplasia-verruciformis- like eruption associated with gamma-papillomavirus infection in a patient with adult T-cell leukemia. Dermatology. 2009;219(3):274-278.
    • (2009) Dermatology , vol.219 , Issue.3 , pp. 274-278
    • Kawai, K.1    Egawa, N.2    Kiyono, T.3    Kanekura, T.4
  • 36
    • 0022638278 scopus 로고
    • Epidermodysplasia verruciformis (L-L, 1922) in a patient with systemic lupus erythematosus
    • Tanigaki T, Kanda R, Sato K. Epidermodysplasia verruciformis (L-L, 1922) in a patient with systemic lupus erythematosus. Arch Dermatol Res. 1986;278(3):247-248.
    • (1986) Arch Dermatol Res , vol.278 , Issue.3 , pp. 247-248
    • Tanigaki, T.1    Kanda, R.2    Sato, K.3
  • 37
    • 0037563394 scopus 로고    scopus 로고
    • Epidermodysplasia verruciformis-like lesions in a patient with systemic lupus erythematosus [5]
    • DOI 10.1080/00015550310007300
    • García-Río I, Garcia-F-Villalta MJ, Daudén E, Fraga J, García-Díez A. Epidermodysplasia verruciformis-like lesions in a patient with systemic lupus erythematosus. Acta Derm Venereol. 2003;83(3):229-230. (Pubitemid 36629834)
    • (2003) Acta Dermato-Venereologica , vol.83 , Issue.3 , pp. 229-230
    • Garcia-Rio, I.1    Garcia-F-Villalta, M.-J.2    Dauden, E.3    Fraga, J.4    Garcia-Diez, A.5
  • 38
    • 0142025179 scopus 로고    scopus 로고
    • Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia
    • DOI 10.1046/j.1365-2133.2003.05543.x
    • Tobin E, Rohwedder A, Holland SM, Philips B, Carlson JA. Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia. Br J Dermatol. 2003;149(3):627-633. (Pubitemid 37281599)
    • (2003) British Journal of Dermatology , vol.149 , Issue.3 , pp. 627-633
    • Tobin, E.1    Rohwedder, A.2    Holland, S.M.3    Philips, B.4    Carlson, J.A.5
  • 40
    • 0942290569 scopus 로고    scopus 로고
    • High Prevalence of Anal Squamous Intraepithelial Lesions in HIV-Positive Men Despite the Use of Highly Active Antiretroviral Therapy
    • DOI 10.1097/01.OLQ.0000109515.75864.2B
    • Piketty C, Darragh TM, Heard I, et al. High prevalence of anal squamous intraepithelial lesions in HIV-positive men despite the use of highly active antiretroviral therapy. Sex Transm Dis. 2004;31(2):96-99. (Pubitemid 38141642)
    • (2004) Sexually Transmitted Diseases , vol.31 , Issue.2 , pp. 96-99
    • Piketty, C.1    Darragh, T.M.2    Heard, I.3    Da, C.M.4    Bruneval, P.5    Kazatchkine, M.D.6    Palefsky, J.M.7
  • 41
    • 0022896897 scopus 로고
    • Human papillomavirus type 38 isolated from patients with epidermodysplasia verruciformis
    • Yutsudo M, Kanda R, Tanigaki T, Kitano Y, Hakura A. Human papillomavirus type 38 isolated from patients with epidermodysplasia verruciformis. Intervirology. 1986;26(1-2):104-108. (Pubitemid 17039215)
    • (1986) Intervirology , vol.26 , Issue.1-2 , pp. 104-108
    • Yutsudo, M.1    Kanda, R.2    Tanigaki, T.3
  • 43
    • 0028559782 scopus 로고
    • Immunological events in regressing genital warts
    • Coleman N, Birley HD, Renton AM, et al. Immunological events in regressing genital warts. Am J Clin Pathol. 1994;102(6):768-774.
    • (1994) Am J Clin Pathol , vol.102 , Issue.6 , pp. 768-774
    • Coleman, N.1    Birley, H.D.2    Renton, A.M.3
  • 44
    • 0029910846 scopus 로고    scopus 로고
    • Phenotypical characterization of lymphocytes infiltrating regressing papillomas
    • Knowles G, O'Neil BW, Campo MS. Phenotypical characterization of lymphocytes infiltrating regressing papillomas. J Virol. 1996;70(12):8451-8458. (Pubitemid 26378422)
    • (1996) Journal of Virology , vol.70 , Issue.12 , pp. 8451-8458
    • Knowles, G.1    O'Neil, B.W.2    Campo, M.S.3
  • 45
    • 77949330985 scopus 로고    scopus 로고
    • Incidence and risk factors of HIV-related non-Hodgkin's lymphoma in the era of combination antiretroviral therapy: A European multicohort study
    • Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study Group
    • Bohlius J, Schmidlin K, Costagliola D, et al; Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study Group. Incidence and risk factors of HIV-related non-Hodgkin's lymphoma in the era of combination antiretroviral therapy: a European multicohort study. Antivir Ther. 2009;14(8):1065-1074.
    • (2009) Antivir Ther , vol.14 , Issue.8 , pp. 1065-1074
    • Bohlius, J.1    Schmidlin, K.2    Costagliola, D.3
  • 46
    • 0034876535 scopus 로고    scopus 로고
    • Cutaneous warts in HIV-positive patients undergoing highly active antiretroviral therapy [1]
    • Rodrigues LK, Baker T, Maurer T. Cutaneous warts in HIV-positive patients undergoing highly active antiretroviral therapy. Arch Dermatol. 2001;137(8):1103-1104. (Pubitemid 32756474)
    • (2001) Archives of Dermatology , vol.137 , Issue.8 , pp. 1103-1104
    • Rodrigues, L.K.E.1    Maurer, T.2
  • 47
    • 77952691932 scopus 로고    scopus 로고
    • Human Immunodeficiency virus and human papilloma virus - Why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful
    • van der Burg SH, Palefsky JM. Human Immunodeficiency virus and human papilloma virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful. J Transl Med. 2009;7:108.
    • (2009) J Transl Med , vol.7 , pp. 108
    • Van Der Burg, S.H.1    Palefsky, J.M.2
  • 48
    • 0021821063 scopus 로고
    • X-linked inheritance of epidermodysplasia verruciformis: Genetic and virologic studies of a kindred
    • DOI 10.1001/archderm.121.7.864
    • Androphy EJ, Dvoretzky I, Lowy DR. X-linked inheritance of epidermodysplasia verruciformis: genetic and virologic studies of a kindred. Arch Dermatol. 1985;121(7):864-868. (Pubitemid 15070196)
    • (1985) Archives of Dermatology , vol.121 , Issue.7 , pp. 864-868
    • Androphy, E.J.1    Dvoretzky, I.2    Lowy, D.R.3
  • 49
    • 34247105788 scopus 로고    scopus 로고
    • A distinct variant of Epidermodysplasia verruciformis in a Turkish family lacking EVER1 and EVER2 mutations
    • DOI 10.1016/j.jdermsci.2007.01.002, PII S0923181107000254
    • Akgül B, Köse O, Safali M, et al. A distinct variant of epidermodysplasia verruciformis in a Turkish family lacking EVER1 and EVER2 mutations. J Dermatol Sci. 2007;46(3):214-216. (Pubitemid 46601835)
    • (2007) Journal of Dermatological Science , vol.46 , Issue.3 , pp. 214-216
    • Akgul, B.1    Kose, O.2    Safali, M.3    Purdie, K.4    Cerio, R.5    Proby, C.6    Storey, A.7


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