High Prevalence of Anal Squamous Intraepithelial Lesions in HIV-Positive Men Despite the Use of Highly Active Antiretroviral Therapy

Sexually Transmitted Diseases

Volumn 31, Issue 2, 2004, Pages 96-99

  Piketty, Christophe ^a,c   Darragh, Teresa M ^b   Heard, Isabelle ^a   Da Costa, Maria ^b   Bruneval, Patrick ^c   Kazatchkine, Michel D ^a   Palefsky, Joel M ^b  

^a SORBONNE UNIVERSITÉ   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; PROTEINASE INHIBITOR; VIRUS RNA;

ADULT; ANUS CANCER; ARTICLE; CLINICAL ARTICLE; CYTOLOGY; FLOW CYTOMETRY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HISTOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKOCYTE COUNT; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; SQUAMOUS CELL CARCINOMA; VIRUS DETECTION; VIRUS INFECTION; WART VIRUS;

ADULT; ANAL CANAL; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; ANUS NEOPLASMS; CD4 LYMPHOCYTE COUNT; DNA, VIRAL; FRANCE; HIV INFECTIONS; HIV-1; HOMOSEXUALITY, MALE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS, SQUAMOUS CELL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; PREVALENCE; RNA, VIRAL; TUMOR VIRUS INFECTIONS;

EID: 0942290569     PISSN: 01485717     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.OLQ.0000109515.75864.2B     Document Type: Article

References (17)

1. Melbye M, Sprogel P. Aetiological parallel between anal cancer and cervical cancer. Lancet 1991; 338:657-659.
2. Palefsky JM, Holly EA, Gonzales J, Berline J, Ahn DK, Greenspan JS. Detection of human papillomavirus DNA in anal intraepithelial neoplasia and anal cancer. Cancer Res 1991; 51:1014-1019.
3. Critchlow CW, Hawes SE, Kuypers JM, et al. Effect of HIV infection on the natural history of anal human papillomavirus infection. AIDS 1998; 12:1177-1184.
4. Kiviat NB, Critchlow CW, Holmes KK, et al. Association of anal dysplasia and human papillomavirus with immunosuppression and HIV infection among homosexual men. AIDS 1993; 7:43-49.
5. Palefsky JM, Holly EA, Ralston ML, Jay N, Berry JM, Darragh TM. High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men. AIDS 1998; 12:495-503.
6. Goedert JJ, Cote TR, Virgo P, et al. Spectrum of AIDS-associated malignant disorders. Lancet 1998; 351:1833-1839.
7. Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst 2000; 92:1500-1510.
8. Piketty C, Darragh TM, Da Costa M, et al. High prevalence of anal HPV infection and anal cancer precursors among HIV-infected individuals in the absence of anal intercourse. Ann Intern Med 2003; 183:453-459.
9. Piketty C, Weiss L, Thomas F, Mohamed AS, Belec L, Kazatchkine MD. Long-term clinical outcome of human immunodeficiency virus-infected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen. J Infect Dis 2001; 183:1328-1335.
10. Palefsky JM, Holly EA, Ralston ML, Jay N. Prevalence and risk factors for human papillomavirus infection of the anal canal in human immunodeficiency virus (HIV)-positive and HIV-negative homosexual men. J Infect Dis 1998; 177:361-367.
11. Palefsky JM. Human papillomavirus infection and anogenital neoplasia in human immunodeficiency virus-positive men and women. J Natl Cancer Inst Monogr 1998; 23:15-20.
12. Palefsky JM, Holly EA, Ralston ML, et al. Effect of highly active antiretroviral therapy on the natural history of anal squamous intra-epithelial lesions and anal human papillomavirus infection. J Acquir Immun Defic Syndr 2001; 28:422-428.
13. Minkoff H, Ahdieh L, Massad LS, et al. The effect of highly active antiretroviral therapy on cervical cytologic changes associated with oncogenic HPV among HIV-infected women. AIDS 2001; 15:2157-2164.
14. Heard I, Tassie JM, Kazatchkine MD, Orth G. Highly active antiretroviral therapy enhances regression of cervical intraepithelial neoplasia in HIV-seropositive women. AIDS 2002; 16:1799-1802.
15. Lillo FB, Ferrari D, Veglia F, et al. Human papillomavirus infection and associated cervical disease in human immunodeficiency virus-infected women: effect of highly active antiretroviral therapy. J Infect Dis 2001; 184:547-551.
16. Heard I, Schmitz V, Costagliola D, Orth G, Kazatchkine MD. Early regression of cervical lesions in HIV-seropositive women receiving highly active antiretroviral therapy. AIDS 1998; 12:1459-1464.
17. Chin-Hong P, Palefsky JM. The natural history and clinical management of anal HPV disease in HIV-positive men and women. Clin Infect Dis 2002; 35:1127-1134.