메뉴 건너뛰기




Volumn 129, Issue 1, 2011, Pages 66-73

Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: Relationship with stearoyl-CoA desaturase activity

Author keywords

Desaturation index; Erythrocytes; Glucose; Insulin; Liver; Oleic acid; Postprandial; Rat; Stearoyl CoA desaturase 1; Triglycerides

Indexed keywords

ACYL COENZYME A DESATURASE; GLUCOSE; HALOPERIDOL; INSULIN; OLANZAPINE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PALIPERIDONE; POLYUNSATURATED FATTY ACID; QUETIAPINE; RISPERIDONE; TRIACYLGLYCEROL;

EID: 79956088603     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2011.03.016     Document Type: Article
Times cited : (25)

References (58)
  • 1
    • 0036289385 scopus 로고    scopus 로고
    • Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs
    • Andersson C., Hamer R.M., Lawler C.P., Mailman R.B., Lieberman J.A. Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs. Neuropsychopharmacology 2002, 27:143-151.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 143-151
    • Andersson, C.1    Hamer, R.M.2    Lawler, C.P.3    Mailman, R.B.4    Lieberman, J.A.5
  • 3
    • 34447520136 scopus 로고    scopus 로고
    • Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    • Bansal S., Buring J.E., Rifai N., Mora S., Sacks F.M., Ridker P.M. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 2007, 298:309-316.
    • (2007) JAMA , vol.298 , pp. 309-316
    • Bansal, S.1    Buring, J.E.2    Rifai, N.3    Mora, S.4    Sacks, F.M.5    Ridker, P.M.6
  • 4
    • 27644536615 scopus 로고    scopus 로고
    • Actions of antipsychotic drugs on pancreatic beta-cell function: contrasting effects of clozapine and haloperidol
    • Best L., Yates A.P., Reynolds G.P. Actions of antipsychotic drugs on pancreatic beta-cell function: contrasting effects of clozapine and haloperidol. J. Psychopharmacol. 2005, 19:597-601.
    • (2005) J. Psychopharmacol. , vol.19 , pp. 597-601
    • Best, L.1    Yates, A.P.2    Reynolds, G.P.3
  • 5
    • 17644407316 scopus 로고    scopus 로고
    • Quetiapine (Seroquel) shows a pattern of behavioral effects similar to the atypical antipsychotics clozapine and olanzapine: studies with tremulous jaw movements in rats
    • Betz A., Ishiwari K., Wisniecki A., Huyn N., Salamone J.D. Quetiapine (Seroquel) shows a pattern of behavioral effects similar to the atypical antipsychotics clozapine and olanzapine: studies with tremulous jaw movements in rats. Psychopharmacol. Berl. 2005, 179:383-392.
    • (2005) Psychopharmacol. Berl. , vol.179 , pp. 383-392
    • Betz, A.1    Ishiwari, K.2    Wisniecki, A.3    Huyn, N.4    Salamone, J.D.5
  • 6
    • 33745626493 scopus 로고    scopus 로고
    • Effect of omega-3 fatty acids on the lipid profile of patients taking clozapine
    • Caniato R.N., Alvarenga M.E., Garcia-Alcaraz M.A. Effect of omega-3 fatty acids on the lipid profile of patients taking clozapine. Aust. N Z J. Psychiatry 2006, 40:691-697.
    • (2006) Aust. N Z J. Psychiatry , vol.40 , pp. 691-697
    • Caniato, R.N.1    Alvarenga, M.E.2    Garcia-Alcaraz, M.A.3
  • 7
    • 34447575781 scopus 로고    scopus 로고
    • Effects of olanzapine in male rats: enhanced adiposity in the absence of hyperphagia, weight gain or metabolic abnormalities
    • Cooper G.D., Pickavance L.C., Wilding J.P., Harrold J.A., Halford J.C., Goudie A.J. Effects of olanzapine in male rats: enhanced adiposity in the absence of hyperphagia, weight gain or metabolic abnormalities. J. Psychopharmacol. 2007, 21:405-413.
    • (2007) J. Psychopharmacol. , vol.21 , pp. 405-413
    • Cooper, G.D.1    Pickavance, L.C.2    Wilding, J.P.3    Harrold, J.A.4    Halford, J.C.5    Goudie, A.J.6
  • 8
    • 74949133571 scopus 로고    scopus 로고
    • The polyunsaturated fatty acid composition of hepatic and plasma lipids differ by both sex and dietary fat intake in rats
    • Childs C.E., Romeu-Nadal M., Burdge G.C., Calder P.C. The polyunsaturated fatty acid composition of hepatic and plasma lipids differ by both sex and dietary fat intake in rats. J. Nutr. 2010, 140:245-250.
    • (2010) J. Nutr. , vol.140 , pp. 245-250
    • Childs, C.E.1    Romeu-Nadal, M.2    Burdge, G.C.3    Calder, P.C.4
  • 9
    • 0037992856 scopus 로고    scopus 로고
    • Relation of triglyceride levels, fasting and nonfasting, to fatal and nonfatal coronary heart disease
    • Multiple Risk Factor Intervention Trial Research Group
    • Eberly L.E., Stamler J., Neaton J.D., Multiple Risk Factor Intervention Trial Research Group Relation of triglyceride levels, fasting and nonfasting, to fatal and nonfatal coronary heart disease. Arch. Intern. Med. 2003, 163:1077-1083.
    • (2003) Arch. Intern. Med. , vol.163 , pp. 1077-1083
    • Eberly, L.E.1    Stamler, J.2    Neaton, J.D.3
  • 11
    • 59049098636 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
    • Flowers M.T., Ntambi J.M. Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity. Biochim. Biophys. Acta 2009, 1791:85-91.
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 85-91
    • Flowers, M.T.1    Ntambi, J.M.2
  • 13
    • 34548288088 scopus 로고    scopus 로고
    • Effect on lipid profiles of switching from olanzapine to another second-generation antipsychotic agent in veterans with schizophrenia
    • Garman P.M., Ried L.D., Bengtson M.A., Hsu C., McConkey J.R. Effect on lipid profiles of switching from olanzapine to another second-generation antipsychotic agent in veterans with schizophrenia. J. Am. Pharm. Assoc. 2007, 47:373-378.
    • (2007) J. Am. Pharm. Assoc. , vol.47 , pp. 373-378
    • Garman, P.M.1    Ried, L.D.2    Bengtson, M.A.3    Hsu, C.4    McConkey, J.R.5
  • 14
    • 73449142133 scopus 로고    scopus 로고
    • Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat
    • Hassanali Z., Ametaj B.N., Field C.J., Proctor S.D., Vine D.F. Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat. Diab. Obes. Metab. 2010, 12:139-147.
    • (2010) Diab. Obes. Metab. , vol.12 , pp. 139-147
    • Hassanali, Z.1    Ametaj, B.N.2    Field, C.J.3    Proctor, S.D.4    Vine, D.F.5
  • 15
    • 35648948443 scopus 로고    scopus 로고
    • Weight gain with atypical antipsychotics: evidence and insights
    • Henderson D.C. Weight gain with atypical antipsychotics: evidence and insights. J. Clin. Psychiatry 2007, 68:18-26.
    • (2007) J. Clin. Psychiatry , vol.68 , pp. 18-26
    • Henderson, D.C.1
  • 18
    • 0028267164 scopus 로고
    • Transcriptional control of the stearoyl-CoA desaturase-1 gene by polyunsaturated fatty acids
    • Landschulz K.T., Jump D.B., MacDougald O.A., Lane M.D. Transcriptional control of the stearoyl-CoA desaturase-1 gene by polyunsaturated fatty acids. Biochem. Biophys. Res. Commun. 1994, 200:763-768.
    • (1994) Biochem. Biophys. Res. Commun. , vol.200 , pp. 763-768
    • Landschulz, K.T.1    Jump, D.B.2    MacDougald, O.A.3    Lane, M.D.4
  • 19
    • 57149133676 scopus 로고    scopus 로고
    • Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction
    • Langsted A., Freiberg J.J., Nordestgaard B.G. Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction. Circulation 2008, 118:2047-2056.
    • (2008) Circulation , vol.118 , pp. 2047-2056
    • Langsted, A.1    Freiberg, J.J.2    Nordestgaard, B.G.3
  • 21
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 23
    • 34548772365 scopus 로고    scopus 로고
    • Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response
    • Mangravite L.M., Dawson K., Davis R.R., Gregg J.P., Krauss R.M. Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response. Am. J. Clin. Nutr. 2007, 86:759-767.
    • (2007) Am. J. Clin. Nutr. , vol.86 , pp. 759-767
    • Mangravite, L.M.1    Dawson, K.2    Davis, R.R.3    Gregg, J.P.4    Krauss, R.M.5
  • 25
    • 39049128900 scopus 로고    scopus 로고
    • Omega-3 fatty acid deficiency augments the development of behavioral sensitization in adult mice: prevention by chronic lithium treatment
    • McNamara R.K., Sullivan J., Richtand N.M. Omega-3 fatty acid deficiency augments the development of behavioral sensitization in adult mice: prevention by chronic lithium treatment. J. Psychiatr. Res. 2008, 42:458-468.
    • (2008) J. Psychiatr. Res. , vol.42 , pp. 458-468
    • McNamara, R.K.1    Sullivan, J.2    Richtand, N.M.3
  • 26
    • 58249088139 scopus 로고    scopus 로고
    • Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis
    • McNamara R.K., Able J.A., Jandacek R., Rider T., Tso P. Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. Schizophr. Res. 2009, 107:150-157.
    • (2009) Schizophr. Res. , vol.107 , pp. 150-157
    • McNamara, R.K.1    Able, J.A.2    Jandacek, R.3    Rider, T.4    Tso, P.5
  • 27
    • 62549095874 scopus 로고    scopus 로고
    • Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition
    • McNamara R.K., Able J.A., Liu Y., Jandacek R., Rider T., Tso P. Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition. Psychoneuroendocrinology 2009, 34:532-539.
    • (2009) Psychoneuroendocrinology , vol.34 , pp. 532-539
    • McNamara, R.K.1    Able, J.A.2    Liu, Y.3    Jandacek, R.4    Rider, T.5    Tso, P.6
  • 28
    • 79956143583 scopus 로고    scopus 로고
    • Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: relationship with liver delta6-desaturase expression
    • [Epub ahead of print]
    • McNamara R.K., Rider T., Jandacek R., Tso P., Cole-Strauss A., Lipton J.W. Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: relationship with liver delta6-desaturase expression. Schizophr. Res. 2011, [Epub ahead of print].
    • (2011) Schizophr. Res.
    • McNamara, R.K.1    Rider, T.2    Jandacek, R.3    Tso, P.4    Cole-Strauss, A.5    Lipton, J.W.6
  • 30
    • 3142769794 scopus 로고    scopus 로고
    • The effects of antipsychotic therapy on serum lipids: a comprehensive review
    • Meyer J.M., Koro C.E. The effects of antipsychotic therapy on serum lipids: a comprehensive review. Schizophr. Res. 2004, 70:1-17.
    • (2004) Schizophr. Res. , vol.70 , pp. 1-17
    • Meyer, J.M.1    Koro, C.E.2
  • 31
    • 0035684803 scopus 로고    scopus 로고
    • Effects of atypical antipsychotics on weight and serum lipid levels
    • Meyer J.M. Effects of atypical antipsychotics on weight and serum lipid levels. J. Clin. Psychiatry 2001, 62:27-34.
    • (2001) J. Clin. Psychiatry , vol.62 , pp. 27-34
    • Meyer, J.M.1
  • 32
    • 0027218797 scopus 로고
    • Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug
    • Migler B.M., Warawa E.J., Malick J.B. Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug. Psychopharmacol. Berl. 1993, 112:299-307.
    • (1993) Psychopharmacol. Berl. , vol.112 , pp. 299-307
    • Migler, B.M.1    Warawa, E.J.2    Malick, J.B.3
  • 33
    • 33744992710 scopus 로고    scopus 로고
    • Long term treatment with olanzapine mixed with the food in male rats induces body fat deposition with no increase in body weight and no thermogenic alteration
    • Minet-Ringuet J., Even P.C., Goubern M., Tomé D., de Beaurepaire R. Long term treatment with olanzapine mixed with the food in male rats induces body fat deposition with no increase in body weight and no thermogenic alteration. Appetite 2006, 46:254-262.
    • (2006) Appetite , vol.46 , pp. 254-262
    • Minet-Ringuet, J.1    Even, P.C.2    Goubern, M.3    Tomé, D.4    de Beaurepaire, R.5
  • 34
    • 0034730532 scopus 로고    scopus 로고
    • The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    • Miyazaki M., Kim Y.C., Gray-Keller M.P., Attie A.D., Ntambi J.M. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J. Biol. Chem. 2000, 275:30132-30138.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30132-30138
    • Miyazaki, M.1    Kim, Y.C.2    Gray-Keller, M.P.3    Attie, A.D.4    Ntambi, J.M.5
  • 35
    • 0034958783 scopus 로고    scopus 로고
    • A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
    • Miyazaki M., Kim Y.C., Ntambi J.M. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J. Lipid Res. 2001, 42:1018-1024.
    • (2001) J. Lipid Res. , vol.42 , pp. 1018-1024
    • Miyazaki, M.1    Kim, Y.C.2    Ntambi, J.M.3
  • 36
    • 79956160797 scopus 로고    scopus 로고
    • Opposing effects of omega-3 and omega-6 long chain polyunsaturated Fatty acids on the expression of lipogenic genes in omental and retroperitoneal adipose depots in the rat
    • [Epub ahead of print]
    • Muhlhausler B.S., Cook-Johnson R., James M., Miljkovic D., Duthoit E., Gibson R. Opposing effects of omega-3 and omega-6 long chain polyunsaturated Fatty acids on the expression of lipogenic genes in omental and retroperitoneal adipose depots in the rat. J Nutr Metab. 2010, [Epub ahead of print].
    • (2010) J Nutr Metab.
    • Muhlhausler, B.S.1    Cook-Johnson, R.2    James, M.3    Miljkovic, D.4    Duthoit, E.5    Gibson, R.6
  • 37
    • 33748475637 scopus 로고    scopus 로고
    • Differential effects of n-3 polyunsaturated fatty acids on metabolic control and vascular reactivity in the type 2 diabetic ob/ob mouse
    • Mustad V.A., Demichele S., Huang Y.S., Mika A., Lubbers N., Berthiaume N., Polakowski J., Zinker B. Differential effects of n-3 polyunsaturated fatty acids on metabolic control and vascular reactivity in the type 2 diabetic ob/ob mouse. Metabolism 2006, 55:1365-1374.
    • (2006) Metabolism , vol.55 , pp. 1365-1374
    • Mustad, V.A.1    Demichele, S.2    Huang, Y.S.3    Mika, A.4    Lubbers, N.5    Berthiaume, N.6    Polakowski, J.7    Zinker, B.8
  • 38
    • 34248562315 scopus 로고    scopus 로고
    • Antipsychotic medications: metabolic and cardiovascular risk
    • Newcomer J.W. Antipsychotic medications: metabolic and cardiovascular risk. J. Clin. Psychiatry 2007, 68:8-13.
    • (2007) J. Clin. Psychiatry , vol.68 , pp. 8-13
    • Newcomer, J.W.1
  • 41
    • 0032871502 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
    • Ntambi J.M. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J. Lipid Res. 1999, 40:1549-1558.
    • (1999) J. Lipid Res. , vol.40 , pp. 1549-1558
    • Ntambi, J.M.1
  • 44
    • 67650088283 scopus 로고    scopus 로고
    • Biochemical and physiological function of stearoyl-CoA desaturase
    • Paton C.M., Ntambi J.M. Biochemical and physiological function of stearoyl-CoA desaturase. Am. J. Physiol. Endocrinol. Metab. 2009, 297:28-37.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , pp. 28-37
    • Paton, C.M.1    Ntambi, J.M.2
  • 45
    • 0036140127 scopus 로고    scopus 로고
    • A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms
    • E-E Multicentre Study Group
    • Peet M., Horrobin D.F., E-E Multicentre Study Group A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms. J. Psychiatr. Res. 2002, 36:7-18.
    • (2002) J. Psychiatr. Res. , vol.36 , pp. 7-18
    • Peet, M.1    Horrobin, D.F.2
  • 47
    • 60249089094 scopus 로고    scopus 로고
    • Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis in schizophrenia
    • Polymeropoulos M.H., Licamele L., Volpi S., Mack K., Mitkus S.N., Carstea E.D., Getoor L., Thompson A., Lavedan C. Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis in schizophrenia. Schizophr. Res. 2009, 108:134-142.
    • (2009) Schizophr. Res. , vol.108 , pp. 134-142
    • Polymeropoulos, M.H.1    Licamele, L.2    Volpi, S.3    Mack, K.4    Mitkus, S.N.5    Carstea, E.D.6    Getoor, L.7    Thompson, A.8    Lavedan, C.9
  • 48
    • 33748328048 scopus 로고    scopus 로고
    • SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects?
    • Raeder M.B., Fernø J., Vik-Mo A.O., Steen V.M. SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects?. Mol. Cell. Biochem. 2006, 289:167-173.
    • (2006) Mol. Cell. Biochem. , vol.289 , pp. 167-173
    • Raeder, M.B.1    Fernø, J.2    Vik-Mo, A.O.3    Steen, V.M.4
  • 49
    • 0141813781 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
    • Rahman S.M., Dobrzyn A., Dobrzyn P., Lee S.H., Miyazaki M., Ntambi J.M. Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc. Natl Acad. Sci. U.S.A. 2003, 100:11110-11115.
    • (2003) Proc. Natl Acad. Sci. U.S.A. , vol.100 , pp. 11110-11115
    • Rahman, S.M.1    Dobrzyn, A.2    Dobrzyn, P.3    Lee, S.H.4    Miyazaki, M.5    Ntambi, J.M.6
  • 50
    • 33750904424 scopus 로고    scopus 로고
    • The atypical antipsychotic clozapine impairs insulin secretion by inhibiting glucose metabolism and distal steps in rat pancreatic islets
    • Sasaki N., Iwase M., Uchizono Y., Nakamura U., Imoto H., Abe S., Iida M. The atypical antipsychotic clozapine impairs insulin secretion by inhibiting glucose metabolism and distal steps in rat pancreatic islets. Diabetologia 2006, 49:2930-2938.
    • (2006) Diabetologia , vol.49 , pp. 2930-2938
    • Sasaki, N.1    Iwase, M.2    Uchizono, Y.3    Nakamura, U.4    Imoto, H.5    Abe, S.6    Iida, M.7
  • 51
    • 0029860445 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes
    • Sessler A.M., Kaur N., Palta J.P., Ntambi J.M. Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes. J. Biol. Chem. 1996, 271:29854-29858.
    • (1996) J. Biol. Chem. , vol.271 , pp. 29854-29858
    • Sessler, A.M.1    Kaur, N.2    Palta, J.P.3    Ntambi, J.M.4
  • 52
    • 72849106609 scopus 로고    scopus 로고
    • Effects of olanzapine and risperidone on glucose metabolism and insulin sensitivity in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized 5-month study
    • Smith R.C., Lindenmayer J.P., Davis J.M., Kelly E., Viviano T.F., Cornwell J., Hu Q., Khan A., Vaidhyanathaswamy S. Effects of olanzapine and risperidone on glucose metabolism and insulin sensitivity in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized 5-month study. J. Clin. Psychiatry 2009, 70:1501-1513.
    • (2009) J. Clin. Psychiatry , vol.70 , pp. 1501-1513
    • Smith, R.C.1    Lindenmayer, J.P.2    Davis, J.M.3    Kelly, E.4    Viviano, T.F.5    Cornwell, J.6    Hu, Q.7    Khan, A.8    Vaidhyanathaswamy, S.9
  • 53
    • 77954141786 scopus 로고    scopus 로고
    • Effects of olanzapine and risperidone on lipid metabolism in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized five month study
    • Smith R.C., Lindenmayer J.P., Hu Q., Kelly E., Viviano T.F., Cornwell J., Vaidhyanathaswamy S., Marcovina S., Davis J.M. Effects of olanzapine and risperidone on lipid metabolism in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized five month study. Schizophr. Res. 2010, 120:204-209.
    • (2010) Schizophr. Res. , vol.120 , pp. 204-209
    • Smith, R.C.1    Lindenmayer, J.P.2    Hu, Q.3    Kelly, E.4    Viviano, T.F.5    Cornwell, J.6    Vaidhyanathaswamy, S.7    Marcovina, S.8    Davis, J.M.9
  • 54
    • 0035991065 scopus 로고    scopus 로고
    • Long-term effects of olanzapine, risperidone, and quetiapine on serotonin 1A, 2A and 2C receptors in rat forebrain regions
    • Tarazi F.I., Zhang K., Baldessarini R.J. Long-term effects of olanzapine, risperidone, and quetiapine on serotonin 1A, 2A and 2C receptors in rat forebrain regions. Psychopharmacol. Berl. 2002, 161:263-270.
    • (2002) Psychopharmacol. Berl. , vol.161 , pp. 263-270
    • Tarazi, F.I.1    Zhang, K.2    Baldessarini, R.J.3
  • 55
    • 27744453285 scopus 로고    scopus 로고
    • Chronic exposure to typical or atypical antipsychotics in rodents: temporal effects on central alpha7 nicotinic acetylcholine receptors
    • Terry A.V., Gearhart D.A., Mahadik S.P., Warsi S., Davis L.W., Waller J.L. Chronic exposure to typical or atypical antipsychotics in rodents: temporal effects on central alpha7 nicotinic acetylcholine receptors. Neuroscience 2005, 136:519-529.
    • (2005) Neuroscience , vol.136 , pp. 519-529
    • Terry, A.V.1    Gearhart, D.A.2    Mahadik, S.P.3    Warsi, S.4    Davis, L.W.5    Waller, J.L.6
  • 56
    • 72049095318 scopus 로고    scopus 로고
    • Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl) amide and its plasma triglyceride-lowering effects in Zucker fatty rats
    • Uto Y., Ogata T., Kiyotsuka Y., Ueno Y., Miyazawa Y., Kurata H., Deguchi T., Watanabe N., Konishi M., Okuyama R., Kurikawa N., Takagi T., Wakimoto S., Ohsumi J. Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl) amide and its plasma triglyceride-lowering effects in Zucker fatty rats. Bioorg. Med. Chem. Lett. 2010, 20:341-345.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 341-345
    • Uto, Y.1    Ogata, T.2    Kiyotsuka, Y.3    Ueno, Y.4    Miyazawa, Y.5    Kurata, H.6    Deguchi, T.7    Watanabe, N.8    Konishi, M.9    Okuyama, R.10    Kurikawa, N.11    Takagi, T.12    Wakimoto, S.13    Ohsumi, J.14


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.