Cancer physics: Diagnostics based on damped cellular elastoelectrical vibrations in microtubules

European Biophysics Journal

Volumn 40, Issue 6, 2011, Pages 747-759

  Pokorný, Jiří ^a   Vedruccio, Clarbruno ^b   Cifra, Michal ^a   Kučera, Ondřej ^a,c  

^a INSTITUTE OF PHOTONICS AND ELECTRONICS   (Czech Republic)

^b Italian Navy ^*  (Italy)

^c CZECH TECHNICAL UNIVERSITY IN PRAGUE   (Czech Republic)

Author keywords

Biological electromagnetic field; Bioscanner TRIMprob ; Cancer diagnostics; Nonlinear resonance interaction (NLRI); Physical processes in cancer; Water ordering in cells

Indexed keywords

WATER;

ARTICLE; BIOPHYSICS; CASE CONTROL STUDY; CHEMISTRY; ELASTICITY; ELECTRICITY; ELECTROMAGNETIC FIELD; HUMAN; INSTRUMENTATION; METABOLISM; METHODOLOGY; MICROTUBULE; MICROWAVE RADIATION; NEOPLASM; PATHOLOGY; RADIATION EXPOSURE; VIBRATION;

BIOPHYSICS; CASE-CONTROL STUDIES; ELASTICITY; ELECTRICITY; ELECTROMAGNETIC FIELDS; HUMANS; MICROTUBULES; MICROWAVES; NEOPLASMS; VIBRATION; WATER;

EID: 79956077561     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-011-0688-1     Document Type: Article

References (103)

1. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2008) Molecular biology of the cell, 5th edn. Garland Science, New York
2. Amos LA (1979) Structure of microtubules. In: Roberts K, Hyams JS (eds) Microtubules. Academic Press, London, pp 1-64
3. AP Batyanov 1984 Distant optical interaction of the mitochondria through quartz Bull Exp Biol Med 97 740 742
4. Batyanov AP (1995) Correlation between mitochondria metabolism and the physical characteristics of incubation cells. In: Belousov L, Popp F-A (eds) Biophotonics. Non-equilibrium and coherent systems in biology, biophysics and biotechnology. Bioinform Services, Moscow, pp 439-446
5. M Beil A Micoulet G von Wichert S Paschke P Walther MB Omary PP Van Veldhoven U Gern E Wolff-Hieber J Eggermann J Waltenberger G Adler J Spatz T Seufferlein 2003 Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells Nature Cell Biol 5 803 811 12942086 10.1038/ncb1037 1:CAS:528:DC%2BD3sXmvVWltbY%3D (Pubitemid 37087168)
6. C Bellorofonte C Vedruccio P Tombolini M Ruoppolo A Tubaro 2005 Non-invasive detection of prostate cancer by electromagnetic interaction Eur Urol 47 29 37 15582246 10.1016/j.eururo.2004.09.012 discussion 37 (Pubitemid 39575715)
7. Bibbo M (1997) Comprehensive cytopathology. WB Saunders, Philadelphia
8. S Bonnet S Archer J Allalunis-Turner A Haromy B Ch R Thompson C Lee G Lopaschuk L Puttagunta G Harry K Hashimoto C Porter M Andrade B Thebaud E Michelakis 2007 A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth Cancer Cell 11 37 51 17222789 10.1016/j.ccr.2006.10.020 1:CAS:528:DC%2BD2sXhtFClsLg%3D (Pubitemid 46054520)
9. F Booth 1951 The dielectric constant of water and the saturation effect J Chem Phys 19 391 10.1063/1.1748233 1:CAS:528:DyaG3MXlsVGqsw%3D%3D
10. M Brandon P Baldi DC Wallace 2006 Mitochondrial mutations in cancer Oncogene 25 4647 4662 16892079 10.1038/sj.onc.1209607 1:CAS:528: DC%2BD28Xnsl2hsLY%3D (Pubitemid 44187615)
11. Brenan KE, Campbell SL, Campbell SLV, Petzold LR (1996) Numerical solution of initial-value problems in differential-algebraic equations. Society for Industrial Mathematics, Philadelphia
12. E Cadenas A Boveris B Chance 1980 Low-level chemiluminescence of bovine heart submitochondrial particles Biochem J 186 659 667 6249259 1:CAS:528:DyaL3cXkt1Srtbo%3D
13. JS Carew P Huang 2002 Mitochondrial defects in cancer Mol Cancer 1 9 20 12513701 10.1186/1476-4598-1-9 (Pubitemid 38751447)
14. B Chai J Zheng Q Zhao G Pollack 2008 Spectroscopic studies of solutes in aqueous solution J Phys Chem A 112 2242 2247 18298105 10.1021/jp710105n 1:CAS:528:DC%2BD1cXitlCnsr8%3D
15. B Chai H Yoo G Pollack 2009 Effect of radiant energy on near-surface water J Phys Chem B 113 13953 13958 19827846 10.1021/jp908163w 1:CAS:528:DC%2BD1MXhtF2lur3F
16. M Cifra J Pokorny D Havelka O Kucera 2010 Electric field generated by axial longitudinal vibration modes of microtubule BioSystems 100 122 131 20178826 10.1016/j.biosystems.2010.02.007 1:STN:280:DC%2BC3c3mvVKjtA%3D%3D
17. JM Cuezva M Krajewska M López de Heredia S Krajewski G Santamaria H Kim JM Zapata H Marusawa M Chamorro J Reed 2002 The bioenergetic signature of cancer: a marker of tumor progression Cancer Res 62 6674 6681 12438266 1:CAS:528:DC%2BD38XovFOksLo%3D (Pubitemid 35364137)
18. L Da Pozzo V Scattoni B Mazzoccoli P Rigatti F Manferrari G Martorana F Pietropaolo E Belgrano D Prezioso T Lotti D Villari G Nicita 2007 Tissue-resonance interaction method for the noninvasive diagnosis of prostate cancer: analysis of a multicentre clinical evaluation BJU Int 100 1055 1059 17711511 (Pubitemid 47537662)
19. R Damadian 1971 Tumor detection by nuclear magnetic resonance Science 171 1151 1153 5544870 10.1126/science.171.3976.1151 1:STN:280:DyaE3M7hsFyitg%3D%3D
20. C De Cicco L Mariani C Vedruccio C Ricci M Balma N Rotmensz ME Ferrari E Autino G Trifirò V Sacchini G Viale G Paganelli 2006 Clinical application of spectral electromagnetic interaction in breast cancer: diagnostic results of a pilot study Tumori 92 207 212 16869237 (Pubitemid 44090297)
21. E Del Giudice A Tedeschi 2009 Water and autocatalysis in living matter Electromagn Biol Med 28 46 52 19337894 10.1080/15368370802708728
22. E Del Giudice V Elia A Tedeschi 2009 The role of water in the living organisms Neural Netw World 19 355 360
23. JR Dormand PJ Prince 1980 A family of embedded Runge-Kutta formulae J Comput Appl Math 6 19 26 10.1016/0771-050X(80)90013-3
24. W Duncan-Hewitt M Thompson 1992 Four-layer theory for the acoustic shear wave sensor in liquids incorporating interfacial slip and liquid structure Anal Chem 64 94 105 10.1021/ac00025a017 1:CAS:528:DyaK38XhsVSntQ%3D%3D
25. F Ferrante A Kipling M Thompson 1994 Molecular slip at the solid-liquid interface of an acoustic-wave sensor J Appl Phys 76 3448 3462 10.1063/1.357475 1:CAS:528:DyaK2MXpvVemtw%3D%3D
26. KR Foster JW Baisch 2000 Viscous damping of vibrations in microtubules J Biol Phys 26 255 260 10.1023/A:1010306216654 (Pubitemid 32506033)
27. KR Foster HC Lukaski 1997 Whole-body impedance-what does it measure? Am J Clin Nutr 64 388S 396S
28. H Fröhlich 1968 Bose condensation of strongly excited longitudinal electric modes Phys Lett A 26 402 403 10.1016/0375-9601(68)90242-9
29. H Fröhlich 1968 Long-range coherence and energy storage in biological systems Int J Quant Chem II 641 649 10.1002/qua.560020505
30. Fröhlich H (1969) Quantum mechanical concepts in biology. In: Marois M (ed) Theoretical physics and biology. North Holland, Amsterdam, pp 13-22
31. H Fröhlich 1973 Collective behaviour of non-linearly coupled oscillating fields (with applications to biological systems) J Collect Phenom 1 101 109
32. H Fröhlich 1978 Coherent electric vibrations in biological systems and cancer problem IEEE Trans MTT 26 613 617 10.1109/TMTT.1978.1129446 (Pubitemid 8404017)
33. Fröhlich H (1980) The biological effects of microwaves and related questions. In: Marton L, Marton C (eds) Advances in electronics and electron physics, vol 53. Academic Press, New York, pp 85-152 (Pubitemid 11478866)
34. EC Fuchs J Woisetschlager K Gatterer E Maier R Pecnik G Holler H Eisenkolbl 2007 The floating water bridge J Phys D Appl Phys 40 6112 6114 10.1088/0022-3727/40/19/052 1:CAS:528:DC%2BD2sXht1Wksb%2FE (Pubitemid 47469858)
35. EC Fuchs K Gatterer G Holler J Woisetschlager 2008 Dynamics of the floating water bridge J Phys D Appl Phys 41 185502-1 185502-5 10.1088/0022-3727/41/18/185502
36. EC Fuchs B Bitschnau J Woisetschlager E Maier B Beuneu J Teixeira 2009 Neutron scattering of a floating heavy water bridge J Phys D Appl Phys 42 065502-1 065502-4 10.1088/0022-3727/42/6/065502
37. T Fukuma 2010 Water distribution at solid/liquid interfaces visualized by frequency modulation atomic force microscopy Sci Technol Adv Mater 11 033003 10.1088/1468-6996/11/3/033003
38. G Gervino E Autino E Kolomoets G Leucci M Balma 2007 Diagnosis of bladder cancer at 465 MHz Electromagn Biol Med 26 119 134 17613039 10.1080/ 15368370701380850 1:STN:280:DC%2BD2szpsFGitQ%3D%3D (Pubitemid 47147928)
39. L Giuliani E D'Emilia A Lisi S Grimaldi A Foletti E Del Giudice 2009 The floating water bridge under strong electric potential Neural Netw World 19 393 398
40. O Gokce O Sanli A Salmaslioglu A Tunaci C Ozsoy F Ozcan 2009 Tissue resonance interaction method (TRIMprob) has the potential to be used alongside the recognized tests in the screening protocols for prostate cancer Int J Urol 16 580 583 19456986 10.1111/j.1442-2042.2009.02306.x
41. S Hameroff S Lindsay T Bruchmann A Scott 1986 Acoustic modes of microtubules Biophys J 49 2 Pt 2 58a
42. G Hayward M Thompson 1998 A transverse shear model of a piezoelectric chemical sensor J Appl Phys 83 2194 2201 10.1063/1.366956 1:CAS:528: DyaK1cXps1Grsw%3D%3D (Pubitemid 128580890)
43. S Hayward A Kitao F Hirata 1993 Effect of solvent on collective motions in globular protein J Mol Biol 234 4 1207 1217 7505336 10.1006/jmbi.1993.1671 1:CAS:528:DyaK2cXpvFOktA%3D%3D (Pubitemid 24027248)
44. È Hideg 1993 On the spontaneous ultraweak light emission of plants J Photochem Photobiol B Biol 18 239 244 10.1016/1011-1344(93)80070-P (Pubitemid 23151459)
45. È Hideg M Kobayashi H Inaba 1991 Spontaneous ultraweak light emission from respiring spinach leaf mitochondria Biochem Biophys Acta 1098 27 31 10.1016/0005-2728(91)90005-9 1:CAS:528:DyaK38XlsFKnug%3D%3D (Pubitemid 121006935)
46. Howard J (2001) Mechanics of motor proteins and the cytoskeleton. Sinauer, Suderland
47. A Jandová J Pokorný J Kobilková M Janoušek J Mašata S Trojan M Nedbalová A Dohnalová A Beková V Slavík A Čoček J Sanitrák 2009 Cell-mediated immunity in cervical cancer evolution Electromagn Biol Med 28 1 14 19337890 10.1080/15368370802708868
48. A Jandová J Pokorný J Kobilková S Trojan M Nedbalová A Dohnalová A Čoček J Mašata R Holaj E Tvrzická P Zvolský M Dvořáková M Cifra 2009 Mitochondrial dysfunction Neural Netw World 19 379 391
49. K Kimura S Ido N Oyabu K Kobayashi Y Hirata T Imai H Yamada 2010 Visualizing water molecule distribution by atomic force microscopy J Chem Phys 132 194705 20499982 10.1063/1.3408289
50. M Kobayashi M Takeda T Sato Y Yamazaki K Kaneko K-I Ito H Kato H Inaba 1999 In vivo imaging of spontaneous ultraweak photon emission from a rat's brain correlated with cerebral energy metabolism and oxidative stress Neurosci Res 34 103 113 10498336 10.1016/S0168-0102(99)00040-1 1:CAS:528:DyaK1MXksV2qtbY%3D (Pubitemid 29378298)
51. Kobilková J, Pokorný J, Jandová A, Mašata J (2010) Changes of morphologic and surface properties of cancer cells observed by cytology and histology depend on mitochondrial dysfunction. Acta Cytol 54(3 Supp):477
52. O Kučera M Cifra J Pokorný 2010 Technical aspects of measurement of cellular electromagnetic field Eur Biophys J 39 10 1465 20306029 10.1007/s00249-010-0597-8
53. G Ling 2006 A new theoretical foundation for the polarized-oriented multilayer theory of cell water and for inanimate systems demonstrating long-range dynamic structuring of water molecules Physiol Chem Phys Med NMR 35 91 130 (Pubitemid 39504691)
54. T-M Liu H-P Chen S-CH Yeh CH-Y Wu CH-H Wang T-N Luo Y-J Chen S-I Liu CH-K Sun 2009 Effects of hydration levels on the bandwith of microwave resonant absorption induced by confined acoustic vibrations Appl Phys Lett 95 173702 10.1063/1.3254251
55. E López-Beltrán M Maté S Cerdán 1996 Dynamics and environment of mitochondrial water as detected by 1H NMR J Biol Chem 271 18 10648 8631870 10.1074/jbc.271.18.10648 (Pubitemid 26145799)
56. LK McKemmish JR Reimers RH McKenzie AE Mark NS Hush 2009 Penrose-Hameroff orchestrated objective-reduction proposal for human consciousness is not biologically feasible Phys Rev E 80 021912-1 021912-6 10.1103/PhysRevE.80.021912
57. V Mitrofanov Y Romanovsky A Netrebko 2006 On the damping of the fluctuations of atomic groups in water environment Fluct Noise Lett 6 2 L133 L145 10.1142/S0219477506003227 (Pubitemid 43700317)
58. PL Pedersen 2007 Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen J Bioenerg Biomembr 39 211 222 17879147 10.1007/s10863-007-9094-x 1:CAS:528:DC%2BD2sXhtF2iu7zP (Pubitemid 47619382)
59. Pizzi R, Strini G, Fiorentini S, Pappalardo V, Pregnolato M (2011) Artificial neural networks. Nova Science, New York
60. J Pokorný 2001 Endogenous electromagnetic forces in living cells: implications for transfer of reaction components Electro- Magnetobiol 20 59 73
61. J Pokorný 2003 Viscous effects on polar vibrations in microtubules Electromagn Biol Med 22 15 29 10.1081/JBC-120020349 (Pubitemid 36755364)
62. J Pokorný 2004 Excitation of vibration in microtubules in living cells Bioelectrochem 63 321 326 10.1016/j.bioelechem.2003.09.028 (Pubitemid 38534243)
63. Pokorný J (2006) The role of Fröhlich's coherent excitations in cancer transformation of cells. In: Hyland GJ, Rowlands P (eds) Herbert Fröhlich, FRS: a physicist ahead of his time. The University of Liverpool, Liverpool, pp 177-207
64. J Pokorný 2009 Biophysical cancer transformation pathway Electromagn Biol Med 28 105 123 19811394 10.1080/15368370802711615
65. J Pokorný 2009 Fröhlich's coherent vibrations in healthy and cancer cells Neural Netw World 19 369 378
66. Pokorný J, Wu T-M (1998) Biophysical aspects of coherence and biological order. Springer, Heidelberg
67. J Pokorný F Jelínek V Trkal I Lamprecht R Hölzel 1997 Vibrations in microtubules J Biol Phys 23 171 179 10.1023/A:1005092601078 (Pubitemid 127506781)
68. J Pokorný J Hašek F Jelínek J Šaroch B Palán 2001 Electromagnetic activity of yeast cells in the M phase Electro-Magnetobiol 20 371 396
69. J Pokorný J Hašek F Jelínek 2005 Electromagnetic field in microtubules: effects on transfer of mass particles and electrons J Biol Phys 31 501 514 10.1007/s10867-005-1286-1 (Pubitemid 41758702)
70. J Pokorný J Hašek F Jelínek 2005 Endogenous electric field and organization of living matter Electromagn Biol Med 24 185 197 10.1080/15368370500379566 (Pubitemid 43062408)
71. J Pokorný J Hašek J Vaniš F Jelínek 2008 Biophysical aspects of cancer-electromagnetic mechanism Indian J Exper Biol 46 310 321
72. Pollack G, Cameron I, Wheatley D (2006) Water and the cell. Springer, Dordrecht
73. G Pollack X Figueroa Q Zhao 2009 Molecules, water, and radiant energy: new clues for the origin of life Int J Molec Sci 10 1419 1429 10.3390/ijms10041419 1:CAS:528:DC%2BD1MXltFaisL4%3D
74. Preparata G (1995) QED coherence in matter. World Scientific, New Jersey
75. XS Qian JQ Zhang CQ Ru 2007 Wave propagation in orthotropic microtubules J Appl Phys 101 084702-1 084702-7
76. JR Reimers LK McKemmish RH McKenzie AE Mark NS Hush 2009 Weak, strong, and coherent regimes of Fröhlich condensation and their applications to terahertz medicine and quantum consciousness Proc Natl Acad Sci USA 106 4219 4224 19251667 10.1073/pnas.0806273106 1:CAS:528:DC%2BD1MXjslChuro%3D
77. Y Romanovsky A Netrebko A Chikishev 2003 Are the subglobular oscillations of protein molecules in water overdamped? Laser Phys 13 6 827 838 1:CAS:528:DC%2BD3sXlslCjt7w%3D
78. R Sacco N Innaro F Pata AM Lucisano C Talarico S Aversa 2007 Preoperative diagnosis of incidental carcinoma in multinodular goitre by means of electromagnetic interactions Chir Ital 59 247 251 17500182
79. R Sacco G Sammarco R De Vinci G Vescio A Scarpelli AM Lucisano F Pata E Mascia V Martines 2007 Relief of gastric cancer with an electromagnetic interaction system (TRIMprob) in outpatients Chir Ital 59 823 828 18360987
80. M Satarić JA Tuszyński RB Žakula 1993 Kinklike excitation as an energy transfer mechanism in microtubules Phys Rev E48 1993 2001
81. YM Sirenko MA Stroscio KW Kim 1996 Elastic vibrations of microtubules in a fluid Phys Rev E 53 1003 1010 10.1103/PhysRevE.53.1003 1:CAS:528: DyaK28Xnsl2nsw%3D%3D (Pubitemid 126558826)
82. H Stebbings C Hunt 1982 The nature of the clear zone around microtubules Cell Tissue Res 227 609 617 6185230 10.1007/BF00204791 1:STN:280: DyaL3s7gtlSmsQ%3D%3D (Pubitemid 13174831)
83. S Suresh 2007 Biomechanics and biophysics of cancer cells Acta Mater 55 3989 4014 10.1016/j.actamat.2007.04.022 1:CAS:528:DC%2BD2sXmt1Khtb8%3D (Pubitemid 46880462)
84. S Suresh J Spatz JP Mills A Micoulet M Dao CT Lim M Beil T Seufferlein 2005 Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria Acta Biomater 1 15 30 16701777 10.1016/j.actbio.2004.09.001 1:STN:280:DC%2BD283ntFehuw%3D%3D (Pubitemid 43348807)
85. M Takeda Y Tanno M Kobayashi M Usa N Ohuchi S Satomi H Inaba 1998 A novel method of assessing carcinoma cell proliferation by biophoton emission Cancer Lett 127 155 160 9619872 10.1016/S0304-3835(98)00064-0 1:CAS:528: DyaK1cXitlSksrY%3D (Pubitemid 28230799)
86. R Tilbury T Quickenden 1992 Luminescence from the yeast Candida utilis and comparisons across three genera J Biolum Chemilum 7 4 245 253 10.1002/bio.1170070404 1:CAS:528:DyaK3sXpsl2nuw%3D%3D
87. K Trombitás P Baatsen J Schreuder GH Pollack 1993 Contraction-induced movements of water in single fibres of frog skeletal muscle J Mus Res Cell Mot 14 6 573 584 10.1007/BF00141554 (Pubitemid 24028590)
88. A Tubaro C De Nunzio A Trucchi A Stoppacciaro L Miano 2008 The electromagnetic detection of prostatic cancer: evaluation of diagnostic accuracy Urology 72 340 344 18336888 10.1016/j.urology.2007.11.058
89. JA Tuszyński S Hameroff M Satarić B Trpisová MLA Nip 1995 Ferroelectric behavior in microtubule dipole lattices: implications for conformation processing, signaling and assembly/disassembly J Theor Biol 174 371 380 10.1006/jtbi.1995.0105
90. JA Tuszyński T Luchko S Portet JM Dixon 2005 Anisotropic elastic properties of microtubules Eur J Phys E Soft Cond Matter 17 1 29 35 10.1140/epje/i2004-10102-5 (Pubitemid 40626334)
91. KM Tyner R Kopelman MA Philbert 2007 "Nanosized voltmeter" enables cellular-wide electric field mapping Biophys J 93 1163 1174 17513359 10.1529/biophysj.106.092452 1:CAS:528:DC%2BD2sXosFCjtbg%3D (Pubitemid 47330896)
92. Van Wijk R, Schamhart DHJ (1988) Regulatory aspects of low intensity photon emission. Experientia 44:586-593
93. LL Van Zandt 1986 Resonant microwave absorption by dissolved DNA Phys Rev Lett 57 16 2085 2087 10033628 10.1103/PhysRevLett.57.2085
94. LL Van Zandt 1987 Why structured water causes sharp absorption by DNA at microwave frequencies J Biomol Struct Dyn 4 4 569 3271456
95. A Vannelli E Leo L Battaglia E Poiasina 2009 Diagnosis of rectal cancer by electromagnetic interactions: preliminary results Dis Colon Rectum 52 162 166 19273973 10.1007/DCR.0b013e31819722f6
96. Vedruccio C, Meessen A (2004) EM cancer detection by means of non linear resonance interaction. In: Proceedings PIERS progress in electromagnetics research symposium, Pisa, March 28-31, pp 909-912
97. CY Wang CQ Ru A Mioduchowski 2006 Vibration of microtubules as orthotropic elastic shells Physica E 35 48 56 10.1016/j.physe.2006.05.008 1:CAS:528:DC%2BD2sXnt1aksLc%3D (Pubitemid 44437004)
98. O Warburg 1956 On the origin of cancer cells Science 123 309 314 13298683 10.1126/science.123.3191.309 1:STN:280:DyaG28%2FltV2ktQ%3D%3D
99. O Warburg K Posener E Negelein 1924 Über den Stoffwechsel der Carcinomzelle Biochem Z 152 309 344 1:CAS:528:DyaB2MXhvVanuw%3D%3D
100. A Xie A van der Meer R Austin 2001 Excited-state lifetimes of far-infrared collective modes in proteins Phys Rev Lett 88 1 18102-1 18102-4 10.1103/PhysRevLett.88.018102
101. J Zheng G Pollack 2003 Long-range forces extending from polymer-gel surfaces Phys Rev E 68 031408-1 031408-7
102. J Zheng W Chin E Khijniak E Khijniak Jr GH Pollack 2006 Surfaces and interfacial water: evidence that hydrophilic surfaces have long-range impact Adv Colloid Interface Sci 127 19 27 16952332 10.1016/j.cis.2006.07.002 1:CAS:528:DC%2BD28Xht12jurjM (Pubitemid 44854784)
103. S Zimmerman AM Zimmerman GD Fullerton RF Luduena IL Cameron 1985 Water ordering during the cell cycle: nuclear magnetic resonance studies of the sea-urchin egg J Cell Sci 79 247 257 3833865 1:STN:280:DyaL287ps1egsQ%3D%3D