Penrose-Hameroff orchestrated objective-reduction proposal for human consciousness is not biologically feasible

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

Volumn 80, Issue 2, 2009, Pages

  McKemmish, Laura K ^a   Reimers, Jeffrey R ^a   McKenzie, Ross H ^b   Mark, Alan E ^b   Hush, Noel S ^c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXICITY; QUANTUM COMPUTERS;

COMPUTATIONAL ELEMENTS; CONFORMATIONAL STATE; CONVENTIONAL MODELS; HUMAN CONSCIOUSNESS; MICROTUBULE ASSEMBLY; PROCESSING UNITS; QUANTUM COMPUTING; RECENT PROGRESS;

PHYSIOLOGICAL MODELS;

EID: 77949988128     PISSN: 15393755     EISSN: 15502376     Source Type: Journal    
DOI: 10.1103/PhysRevE.80.021912     Document Type: Article

References (66)

1. R. Penrose, The Emperor's New Mind (Oxford Univ. Press, Oxford, 1989).
2. R. Penrose, Shadows of the Mind (Oxford University Press, New York, 1994).
3. R. Penrose and S. R. Hameroff, J. Conscious. Stud. 2, 99 (1995).
4. S. Hameroff and R. Penrose, Math. Comput. Simul. 40, 453 (1996). 10.1016/0378-4754(96)80476-9
5. S. Hameroff, Phil. Trans. R. Soc. London, Ser. A 356, 1869 (1998). 10.1098/rsta.1998.0254
6. S. Hagan, S. R. Hameroff, and J. A. Tuszynski, Phys. Rev. E 65, 061901 (2002). 10.1103/PhysRevE.65.061901
7. S. R. Hameroff, Cogn. Sci. 31, 1035 (2007).
8. S. R. Hameroff, in Towards a Science of Consciousness II: The Second Tucson Discussions and Debates, edited by, S. R. Hameroff, A. Kaszniak, and, A. C. Scott, (MIT Press, Cambridge, MA, 1998), p. 197.
9. P. C. W. Davies, Biosystems 78, 69 (2004). 10.1016/j.biosystems.2004.07.001
10. D. Abbott, Fluct. Noise Lett. 8, C5 (2008). 10.1142/S0219477508004301
11. D. Abbott, Proc. SPIE 6802, 680201 (2007).
12. C. Conde and A. Cáceres, Nat. Rev. Neurosci. 10, 319 (2009). 10.1038/nrn2631
13. M. J. Robey and E. W. Schlag, J. Chem. Phys. 67, 2775 (1977). 10.1063/1.435193
14. J. R. Reimers and N. S. Hush, J. Am. Chem. Soc. 126, 4132 (2004). 10.1021/ja036883m
15. A. P. Hines, C. M. Dawson, R. H. McKenzie, and G. J. Milburn, Phys. Rev. A 70, 022303 (2004). 10.1103/PhysRevA.70.022303
16. M. P. A. Branderhorst, Science 320, 638 (2008). 10.1126/science.1154576
17. C. Creutz and H. Taube, J. Am. Chem. Soc. 91, 3988 (1969). 10.1021/ja01042a072
18. P. J. Reid, C. Silva, P. F. Barbara, L. Karki, and J. T. Hupp, J. Phys. Chem. 99, 2609 (1995). 10.1021/j100009a019
19. J. R. Reimers, B. B. Wallace, and N. S. Hush, Phil. Trans. R. Soc. London, Ser. A 366, 15 (2008). 10.1098/rsta.2007.2136
20. H. Lee, Y.-C. Cheng, and G. R. Fleming, Science 316, 1462 (2007). 10.1126/science.1142188
21. R. A. Marcus and N. Sutin, Biochim. Biophys. Acta 811, 265 (1985).
22. N. S. Hush, J. Electroanal. Chem. 460, 5 (1999). 10.1016/S0022-0728(98)00371-4
23. A. Litt, C. Eliasmith, F. W. Kroon, S. Weinstein, and P. Thagard, Cogn. Sci. 30, 593 (2006). 10.1207/s15516709cog0000-59
24. J. Gilmore and R. H. McKenzie, J. Phys. Chem. A 112, 2162 (2008). 10.1021/jp710243t
25. M. Tegmark, Phys. Rev. E 61, 4194 (2000). 10.1103/PhysRevE.61.4194
26. L. P. Rosa and J. Faber, Phys. Rev. E 70, 031902 (2004). 10.1103/PhysRevE.70.031902
27. T. Hiramatsu, T. Matsui, and K. Sakakibara, Int. J. Mod. Phys. C 19, 291 (2008). 10.1142/S0129183108012194
28. A. Des Georges, Nat. Struct. Mol. Biol. 15, 1102 (2008). 10.1038/nsmb.1482
29. K. W. Farrell, M. A. Jordan, H. P. Miller, and L. Wilson, J. Cell Biol. 104, 1035 (1987). 10.1083/jcb.104.4.1035
30. R. J. Stewart, K. W. Farrell, and L. Wilson, Biochemistry 29, 6489 (1990). 10.1021/bi00479a022
31. D. Sept, H. J. Limbach, H. Bolterauer, and J. A. Tuszynski, J. Theor. Biol. 197, 77 (1999). 10.1006/jtbi.1998.0861
32. R. Melki, M. F. Carlier, and D. Pantaloni, Biochemistry 29, 8921 (1990). 10.1021/bi00490a007
33. E. Nogales, Annu. Rev. Biochem. 69, 277 (2000). 10.1146/annurev.biochem.69.1.277
34. E. M. Mandelkow, E. Mandelkow, and R. A. Milligan, J. Cell Biol. 114, 977 (1991). 10.1083/jcb.114.5.977
35. P. Carvalho, J. S. Tirnauer, and D. Pellman, Trends Cell Biol. 13, 229 (2003). 10.1016/S0962-8924(03)00074-6
36. L. A. Amos, Org. Biomol. Chem. 2, 2153 (2004). 10.1039/b403634d
37. J. Howard and A. A. Hyman, Nature (London) 422, 753 (2003). 10.1038/nature01600
38. A. A. Hyman, D. Chretien, I. Arnal, and R. H. Wade, J. Cell Biol. 128, 117 (1995). 10.1083/jcb.128.1.117
39. P. T. Tran, R. A. Walker, and E. D. Salmon, J. Cell Biol. 138, 105 (1997). 10.1083/jcb.138.1.105
40. J. A. Tuszynski, J. A. Brown, and D. Sept, J. Biol. Phys. 29, 401 (2003). 10.1023/A:1027318920964
41. R. Heald and E. Nogales, J. Cell Sci. 115, 3 (2002).
42. A. Desai and T. J. Mitchison, Annu. Rev. Cell Dev. Biol. 13, 83 (1997). 10.1146/annurev.cellbio.13.1.83
43. L. Guillaud, J. Cell Biol. 142, 167 (1998). 10.1083/jcb.142.1.167
44. S. Okabe and N. Hirokawa, Nature (London) 343, 479 (1990). 10.1038/343479a0
45. J. A. Tuszynski, J. A. Brown, and P. Hawrylak, Phil. Trans. R. Soc. London, Ser. A 356, 1897 (1998). 10.1098/rsta.1998.0255
46. H. Fröhlich, Int. J. Quantum Chem. 2, 641 (1968). 10.1002/qua.560020505
47. H. Fröhlich, Phys. Lett. A 26, 402 (1968). 10.1016/0375-9601(68)90242-9
48. H. Fröhlich, Nature (London) 228, 1093 (1970). 10.1038/2281093a0
49. J. R. Reimers, L. K. McKemmish, R. H. McKenzie, A. E. Mark, and N. S. Hush, Proc. Natl. Acad. Sci. U.S.A. 106, 4219 (2009). 10.1073/pnas.0806273106
50. J. Pokorný, J. Hašek, F. Jelínek, J. Šaroch, and B. Palán, Electro- Magnetobiol. 20, 371 (2001).
51. J. Pokorný, Electromagn. Biol. Med. 22, 15 (2003). 10.1081/JBC-120020349
52. J. Pokorný, Bioelectrochemistry 63, 321 (2004). 10.1016/j.bioelechem.2003.09.028
53. J. Pokorný, Bioelectrochem. Bioenerg. 48, 267 (1999). 10.1016/S0302-4598(99)00016-1
54. E. Nogales, S. G. Wolf, and K. H. Downing, Nature (London) 391, 199 (1998). 10.1038/34465
55. S. R. Hameroff and R. C. Watt, J. Theor. Biol. 98, 549 (1982). 10.1016/0022-5193(82)90137-0
56. R. Melki, S. Fievez, and M. F. Carlier, Biochemistry 35, 12038 (1996). 10.1021/bi961325o
57. J. M. Hush, P. Wadsworth, D. A. Callaham, and P. K. Hepler, J. Cell Sci. 107, 775 (1994).
58. M. Dogterom and B. Yurke, Science 278, 856 (1997). 10.1126/science.278.5339.856
59. M. V. Mesquita, A. R. Vasconcellos, and R. Luzzi, Int. J. Quantum Chem. 60, 689 (1996). 10.1002/(SICI)1097-461X(1996)60:2<689::AID-QUA7>3.0.CO;2-T
60. P. Stenius, W. Zhao, and A. Imamoglu Phys. Status Solidi A 164, 365 (1997). 10.1002/1521-396X(199711)164:1<365::AID-PSSA365>3.0.CO;2-L
61. L. V. Butov, Phys. Rev. Lett. 86, 5608 (2001). 10.1103/PhysRevLett.86.5608
62. A. V. Kuznetsov and C. J. Stanton, Phys. Rev. Lett. 73, 3243 (1994). 10.1103/PhysRevLett.73.3243
63. M. L. Groot, Proc. Natl. Acad. Sci. U.S.A. 99, 1323 (2002). 10.1073/pnas.251662698
64. M. Först, Phys. Status Solidi B 244, 2971 (2007). 10.1002/pssb.200675615
65. G. I. Groma, Proc. Natl. Acad. Sci. U.S.A. 105, 6888 (2008). 10.1073/pnas.0706336105
66. H. A. Gebbie and P. F. Miller, Int. J. Infrared Millim. Waves 18, 951 (1997). 10.1007/BF02678092