Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Andersen, Sigve ^a,b   Donnem, Tom ^a,b   Al Shibli, Khalid ^a,c   Al Saad, Samer ^a,b   Stenvold, Helge ^a,b   Busund, Lill Tove ^a,b   Bremnes, Roy M ^a,b  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c NORDLAND HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 2; ANGIOPOIETIN 4; ANGIOPOIETIN RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN A; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; STROMA CELL; SURVIVAL RATE; TISSUE MICROARRAY; TUMOR CELL; LUNG TUMOR; MIDDLE AGED; MORTALITY; PROGNOSIS;

AGED; ANGIOPOIETIN-2; ANGIOPOIETINS; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; RECEPTOR, TIE-2; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79956068289     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019773     Document Type: Article

References (34)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2009) Cancer statistics, 2009. CA Cancer J Clin 59: 225-249.
2. Mantovani A, (2009) Cancer: Inflaming metastasis. Nature 457: 36-37.
3. Hanahan D, Weinberg RA, (2000) The hallmarks of cancer. Cell 100: 57-70.
4. Saharinen P, Bry M, Alitalo K, (2010) How do angiopoietins Tie in with vascular endothelial growth factors? Curr Opin Hematol 17: 198-205.
5. Fukuhara S, Sako K, Noda K, Zhang J, Minami M, et al. (2010) Angiopoietin-1/Tie2 receptor signaling in vascular quiescence and angiogenesis. Histol Histopathol 25: 387-396.
6. Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E, (1999) Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103: 159-165.
7. Puri MC, Rossant J, Alitalo K, Bernstein A, Partanen J, (1995) The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J 14: 5884-5891.
8. Huang J, Bae JO, Tsai JP, Kadenhe-Chiweshe A, Papa J, et al. (2009) Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int J Oncol 34: 79-87.
9. Augustin HG, Koh GY, Thurston G, Alitalo K, (2009) Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 10: 165-177.
10. Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, et al. (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376: 70-74.
11. Lee HJ, Cho CH, Hwang SJ, Choi HH, Kim KT, et al. (2004) Biological characterization of angiopoietin-3 and angiopoietin-4. FASEB J 18: 1200-1208.
12. Olsen MW, Ley CD, Junker N, Hansen AJ, Lund EL, et al. (2006) Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure. Neoplasia 8: 364-372.
13. Wong MP, Chan SY, Fu KH, Leung SY, Cheung N, et al. (2000) The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas. Lung Cancer 29: 11-22.
14. Saharinen P, Eklund L, Miettinen J, Wirkkala R, Anisimov A, et al. (2008) Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol 10: 527-537.
15. Holopainen T, Huang H, Chen C, Kim KE, Zhang L, et al. (2009) Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Res 69: 4656-4664.
16. Donnem T, Al-Saad S, Al-Shibli K, Delghandi MP, Persson M, et al. (2007) Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer. Clin Cancer Res 13: 6649-6657.
17. Brunckhorst MK, Wang H, Lu R, Yu Q, (2010) Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis. Cancer Res 70: 7283-7293.
18. Tanaka F, Ishikawa S, Yanagihara K, Miyahara R, Kawano Y, et al. (2002) Expression of angiopoietins and its clinical significance in non-small cell lung cancer. Cancer Res 62: 7124-7129.
19. Reinmuth N, Piegelbrock E, Raedel M, Fehrmann N, Hintelmann H, et al. (2007) Prognostic significance of vessel architecture and vascular stability in non-small cell lung cancer. Lung Cancer 55: 53-60.
20. Chung YC, Hou YC, Chang CN, Hseu TH, (2006) Expression and prognostic significance of angiopoietin in colorectal carcinoma. J Surg Oncol 94: 631-638.
21. Takanami I, (2004) Overexpression of Ang-2 mRNA in non-small cell lung cancer: association with angiogenesis and poor prognosis. Oncol Rep 12: 849-853.
22. Chien CY, Su CY, Chuang HC, Fang FM, Huang HY, et al. (2008) Angiopoietin-1 and-2 expression in recurrent squamous cell carcinoma of the oral cavity. J Surg Oncol 97: 273-277.
23. Szarvas T, Jager T, Totsch M, vom DF, Kempkensteffen C, et al. (2008) Angiogenic switch of angiopietins-Tie2 system and its prognostic value in bladder cancer. Clin Cancer Res 14: 8253-8262.
24. Sie M, Wagemakers M, Molema G, Mooij JJ, de Bont ES, et al. (2009) The angiopoietin 1/angiopoietin 2 balance as a prognostic marker in primary glioblastoma multiforme. J Neurosurg 110: 147-155.
25. Welsh TJ, Green RH, Richardson D, Waller DA, O'Byrne KJ, et al. (2005) Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol 23: 8959-8967 JCO.2005.01.4910 [pii];10.1200/JCO.2005.01.4910 [doi].
26. Wakabayashi O, Yamazaki K, Oizumi S, Hommura F, Kinoshita I, et al. (2003) CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers. Cancer Sci 94: 1003-1009.
27. Al-Shibli KI, Donnem T, Al-Saad S, Persson M, Bremnes RM, et al. (2008) Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer. Clin Cancer Res 14: 5220-5227.
28. Huang H, Bhat A, Woodnutt G, Lappe R, (2010) Targeting the ANGPT-TIE2 pathway in malignancy. Nat Rev Cancer 10: 575-585.
29. Goldstraw P, (2009) The 7th Edition of TNM in Lung Cancer: what now? J Thorac Oncol 4: 671-673.
30. World Health Organization (1999) Histological Typing of Lung and Pleural Tumours Geneva, Switzerland Springer-Verlag.
31. Nakayama T, Yoshizaki A, Kawahara N, Ohtsuru A, Wen CY, et al. (2004) Expression of Tie-1 and 2 receptors, and angiopoietin-1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors. Histopathology 44: 232-239.
32. Nakayama T, Inaba M, Naito S, Mihara Y, Miura S, et al. (2007) Expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma. World J Gastroenterol 13: 4473-4479.
33. Al-Saad S, Al-Shibli K, Donnem T, Persson M, Bremnes RM, et al. (2008) The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer. Br J Cancer 99: 1476-1483.
34. Soltermann A, Tischler V, Arbogast S, Braun J, Probst-Hensch N, et al. (2008) Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer. Clin Cancer Res 14: 7430-7437.