Biosynthesis and regulation of grisemycin, a new member of the linaridin family of ribosomally synthesized peptides produced by Streptomyces griseus IFO 13350

Journal of Bacteriology

Volumn 193, Issue 10, 2011, Pages 2510-2516

  Claesen, Jan ^a,b   Bibb, Mervyn J ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b San Francisco   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CYPEMYCIN; GRISEMYCIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; CONTROLLED STUDY; GENE CLUSTER; GENE DELETION; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN MODIFICATION; PROTEIN SYNTHESIS; STREPTOMYCES COELICOLOR; STREPTOMYCES GRISEUS; WILD TYPE;

STREPTOMYCES COELICOLOR; STREPTOMYCES GRISEUS;

EID: 79956067794     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00171-11     Document Type: Article

References (27)

1. Bibb, M. J. 2005. Regulation of secondary metabolism in streptomycetes. Curr. Opin. Microbiol. 8:208-215.
2. Bonelli, R. R., T. Schneider, H. G. Sahl, and I. Wiedemann. 2006. Insights into in vivo activities of lantibiotics from gallidermin and epidermin modeof-action studies. Antimicrob. Agents Chemother. 50:1449-1457.
3. Claesen, J., and M. Bibb. 2010. Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of post-translationally modified peptides. Proc. Natl. Acad. Sci. U. S. A. 107:16297-16302.
4. Flett, F., V. Mersinias, and C. P. Smith. 1997. High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes. FEMS Microbiol. Lett. 155:223-229.
5. Gomez-Escribano, J. P., and M. J. Bibb. 2011. Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters. Microb. Biotechnol. 4:207-215. doi:10.1111/j.1751-7915.2010.00219.x.
6. Gust, B., et al. 2004. Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces. Adv. Appl. Microbiol. 54:107-128.
7. Hara, H., Y. Ohnishi, and S. Horinouchi. 2009. DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus. Microbiology 155:2197-2210.
8. Kato, J. Y., I. Miyahisa, M. Mashiko, Y. Ohnishi, and S. Horinouchi. 2004. A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus. J. Bacteriol. 186:2206-2211.
9. Kelly, W. L., L. Pan, and C. Li. 2009. Thiostrepton biosynthesis: prototype for a new family of bacteriocins. J. Am. Chem. Soc. 131:4327-4334.
10. Kieser, T., M. J. Bibb, M. J. Buttner, K. F. Chater, and D. A. Hopwood. 2000. Practical Streptomyces genetics. The John Innes Foundation, Norfolk, United Kingdom.
11. Komiyama, K., et al. 1993. A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics. J. Antibiot. (Tokyo) 46:1666-1671.
12. Kupke, T., et al. 2000. Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis. J. Biol. Chem. 275:31838-31846.
13. Lee, S. W., et al. 2008. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc. Natl. Acad. Sci. U. S. A. 105:5879-5884.
14. Leskiw, B. K., E. J. Lawlor, J. M. Fernandez-Abalos, and K. F. Chater. 1991. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. Proc. Natl. Acad. Sci. U. S. A. 88:2461-2465.
15. Liao, R., et al. 2009. Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chem. Biol. 16:141-147.
16. MacNeil, D. J., et al. 1992. Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. Gene 111: 61-68.
17. Morris, R. P., et al. 2009. Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu. J. Am. Chem. Soc. 131:5946-5955.
18. Ohnishi, Y., et al. 2008. Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350. J. Bacteriol. 190:4050-4060.
19. Ohnishi, Y., H. Yamazaki, J. Y. Kato, A. Tomono, and S. Horinouchi. 2005. AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus. Biosci. Biotechnol. Biochem. 69:431-439.
20. Ohnishi, Y., S. Kameyama, H. Onaka, and S. Horinouchi. 1999. The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol. Microbiol. 34:102-111.
21. Oman, T. J., and W. A. van der Donk. 2010. Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat. Chem. Biol. 6:9-18.
22. Pag, U., and H. G. Sahl. 2002. Multiple activities in lantibiotics-models for the design of novel antibiotics? Curr. Pharm. Des. 8:815-833.
23. Sambrook, J., E. F. Fritch, and T. Maniatis. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
24. Schmidt, E. W., et al. 2005. Patellamide A and C biosynthesis by a microcinlike pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc. Natl. Acad. Sci. U. S. A. 102:7315-7320.
25. Takano, E., et al. 2003. A rare leucine codon in adpA is implicated in the morphological defect of bldA mutants of Streptomyces coelicolor. Mol. Microbiol. 50:475-486.
26. Wieland-Brown, L. C., M. G. Acker, J. Clardy, C. T. Walsh, and M. A. Fischbach. 2009. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc. Natl. Acad. Sci. U. S. A. 106:2549-2553.
27. Yamazaki, H., A. Tomono, Y. Ohnishi, and S. Horinouchi. 2004. DNAbinding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus. Mol. Microbiol. 53:555-572.