Structure-activity relationship of cyclic thiacarbocyanine tau aggregation inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3273-3276

  Schafer, Kelsey N ^a   Murale, Dhiraj P ^b   Kim, Kibong ^b   Cisek, Katryna ^a   Kuret, Jeff ^a   Churchill, David G ^b  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Aggregation; Alzheimer's disease; Cyanine dye; Neurofibrillary tangle; Tau protein

Indexed keywords

CARBOCYANINE; N,N' ALKYLENE BIS THIACARBOCYANINE; TAU PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; INHIBITION KINETICS; PROTEIN AGGREGATION; PROTEIN FOLDING; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

CARBOCYANINES; CYCLIZATION; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP; TAU PROTEINS;

EID: 79956061251     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.039     Document Type: Article

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