Prospective, randomized trial comparing 5-FU/LV with or without oxaliplatin as adjuvant treatment following curative resection of gastric adenocarcinoma

European Journal of Surgical Oncology

Volumn 37, Issue 6, 2011, Pages 466-472

  Zhang, X L ^a   Shi, H J ^b   Cui, S Z ^a   Tang, Y Q ^a   Ba, M C ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Advanced gastric adenocarcinoma; Chemotherapy; Overall survival; Oxaliplatin; Recurrence free survival

Indexed keywords

FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANEMIA; ARTICLE; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DISEASE FREE SURVIVAL; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; DRUG WITHDRAWAL; FEBRILE NEUTROPENIA; FEMALE; GASTRECTOMY; GASTROINTESTINAL SYMPTOM; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; NEUROTOXICITY; NEUTROPENIA; OVERALL SURVIVAL; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSORY NEUROPATHY; STOMACH ADENOCARCINOMA;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; GASTRECTOMY; HUMANS; KAPLAN-MEIER ESTIMATE; LEUCOVORIN; MALE; MIDDLE AGED; ORGANOPLATINUM COMPOUNDS; PATIENT SELECTION; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STOMACH NEOPLASMS; TREATMENT OUTCOME;

EID: 79956048184     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2011.01.027     Document Type: Article

References (33)

1. D.H. Roukos, P. Paraschou, and M. Lorenz Distal gastric cancer and extensive surgery: a new evaluation method based on the study of the status of residual lymph nodes after limited surgery Ann Surg Oncol 7 2000 719 726
2. C.H. Kohne, J.A. Wils, and H.J. Wilke Developments in the treatment of gastric cancer in Europe Oncology (Williston Park) 14 2000 22 25
3. C. Kollmannsberger, D. Quietzsch, and C. Haag A phase II study of paclitaxel, weekly, 24-hour continous infusion 5-fluorouracil, folinic acid and cisplatin in patients with advanced gastric cancer Br J Cancer 83 2000 458 462 (Pubitemid 30487857)
4. K.H. Lee, M.S. Hyun, and H.K. Kim Randomized, multicenter, phase III trial of heptaplatin 1-hour infusion and 5-fluorouracil combination chemotherapy comparing with cisplatin and 5-fluorouracil combination chemotherapy in patients with advanced gastric cancer Cancer Res Treat 41 2009 12 18
5. R.C. Coombes, C.E. Chilvers, and D. Amadori Randomised trial of epirubicin versus fluorouracil in advanced gastric cancer. An International Collaborative Cancer Group (ICCG) study Ann Oncol 5 1994 33 36 (Pubitemid 24049851)
6. T. Conroy, F. Viret, and E. Francois Phase I trial of oxaliplatin with fluorouracil, folinic acid and concurrent radiotherapy for oesophageal cancer Br J Cancer 99 2008 1395 1401
7. P.W. Johnson, P.I. Thompson, and M.T. Seymour A less toxic regimen of 5-fluorouracil and high-dose folinic acid for advanced gastrointestinal adenocarcinomas Br J Cancer 64 1991 603 605
8. F. Lordick, and D. Jager Current status and future of chemotherapy and biochemotherapy in gastroesophageal cancers Gastrointest Cancer Res 2 2008 187 197
9. Y. Chao, K.H. Yeh, and C.J. Chang Phase II study of weekly oxaliplatin and 24-h infusion of high-dose 5-fluorouracil and folinic acid in the treatment of advanced gastric cancer Br J Cancer 91 2004 453 458 (Pubitemid 39106839)
10. A. Abdullah, F. Huq, and A. Chowdhury Studies on the synthesis, characterization, binding with DNA and activities of two cis- planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine BMC Chem Biol 6 2006 3
11. A.C. Pieck, A. Drescher, and K.G. Wiesmann Oxaliplatin-DNA adduct formation in white blood cells of cancer patients Br J Cancer 98 2008 1959 1965 (Pubitemid 351821558)
12. M. Tampellini, A. Saini, and I. Alabiso The role of haemoglobin level in predicting the response to first-line chemotherapy in advanced colorectal cancer patients Br J Cancer 95 2006 13 20 (Pubitemid 43980548)
13. A. de Gramont, A. Figer, and M. Seymour Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer J Clin Oncol 18 2000 2938 2947 (Pubitemid 30644117)
14. J.W. Huh, Y.A. Park, and K.Y. Lee Heterogeneity of adenosine triphosphate-based chemotherapy response assay in colorectal cancer-secondary publication Yonsei Med J 50 2009 697 703
15. S.M. Jamieson, J. Subramaniam, and J.J. Liu Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue Mol Pain 5 2009 66
16. S.E. Al-Batran, A. Atmaca, and S. Hegewisch-Becker Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer J Clin Oncol 22 2004 658 663 (Pubitemid 41102130)
17. C. Louvet, T. Andre, and J.M. Tigaud Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients J Clin Oncol 20 2002 4543 4548 (Pubitemid 35407422)
18. F. De Vita, M. Orditura, and E. Matano A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients Br J Cancer 92 2005 1644 1649 (Pubitemid 40762627)
19. F. Lordick, S. Lorenzen, and J. Stollfuss Phase II study of weekly oxaliplatin plus infusional fluorouracil and folinic acid (FUFOX regimen) as first-line treatment in metastatic gastric cancer Br J Cancer 93 2005 190 194 (Pubitemid 41135888)
20. A. Zaniboni, and F. Meriggi The emerging role of oxaliplatin in the treatment of gastric cancer J Chemother 17 2005 656 662 (Pubitemid 43097754)
21. D.Y. Kim, J.H. Kim, and S.H. Lee Phase II study of oxaliplatin, 5-fluorouracil and leucovorin in previously platinum-treated patients with advanced gastric cancer Ann Oncol 14 2003 383 387 (Pubitemid 36367414)
22. S.E. Al-Batran, A. Kerber, and A. Atmaca Mitomycin C, 5-fluorouracil, leucovorin, and oxaliplatin as a salvage therapy for patients with cisplatin-resistant advanced gastric cancer: a phase I dose escalation trial Onkologie 30 2007 29 34 (Pubitemid 46175617)
23. O. Nehls, H. Oettle, and J.T. Hartmann Capecitabine plus oxaliplatin as first-line treatment in patients with advanced biliary system adenocarcinoma: a prospective multicentre phase II trial Br J Cancer 98 2008 309 315 (Pubitemid 351161262)
24. T. Andre, M.A. Bensmaine, and C. Louvet Multicenter phase II study of bimonthly high-dose leucovorin, fluorouracil infusion, and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen J Clin Oncol 17 1999 3560 3568 (Pubitemid 29517928)
25. M. Moehler, U. Haas, and J. Siebler Weekly treatment with irinotecan, folinic acid and infusional 5-fluorouracil (ILF) in patients with advanced gastric cancer Anticancer Drugs 14 2003 645 650 (Pubitemid 37303932)
26. M. Nardi, D. Azzarello, and R. Maisano FOLFOX-4 regimen as fist-line chemotherapy in elderly patients with advanced gastric cancer: a safety study J Chemother 19 2007 85 89
27. R.M. Goldberg, I. Tabah-Fisch, and H. Bleiberg Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer J Clin Oncol 24 2006 4085 4091 (Pubitemid 46622283)
28. D. Cunningham, N. Starling, and S. Rao Capecitabine and oxaliplatin for advanced esophagogastric cancer N Engl J Med 358 2008 36 46
29. S. Giacchetti, B. Perpoint, and R. Zidani Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer J Clin Oncol 18 2000 136 147 (Pubitemid 30036347)
30. G. Rosati, and D. Bilancia Role of chemotherapy and novel biological agents in the treatment of elderly patients with colorectal cancer World J Gastroenterol 14 2008 1812 1822 (Pubitemid 351523809)
31. J.Y. Douillard, P.M. Hoff, and J.R. Skillings Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer J Clin Oncol 20 2002 3605 3616 (Pubitemid 34983220)
32. P. Comella, R. Casaretti, and C. Sandomenico Role of oxaliplatin in the treatment of colorectal cancer Ther Clin Risk Manag 5 2009 229 238
33. C.J. Punt, H.J. Keizer, and J. Douma Trimetrexate as biochemical modulator of 5-fluorouracil/leucovorin in advanced colorectal cancer: final results of a randomised European study Ann Oncol 13 2002 81 86 (Pubitemid 34436729)