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Volumn 5, Issue 1, 2009, Pages 229-238

Role of oxaliplatin in the treatment of colorectal cancer

Author keywords

Adjuvant treatment; Advanced disease; Bevacizumab; Cetuximab; Colorectal cancer; Fluorouracil; Leucovorin; Oxaliplatin

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; UFT;

EID: 77949450168     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/tcrm.s3583     Document Type: Review
Times cited : (70)

References (59)
  • 1
    • 0014691619 scopus 로고
    • Platinum compounds: A new class of potent antitumour agents
    • Rosenberg B, VanCamp L, Trosko JE, Mansour VH. Platinum compounds: a new class of potent antitumour agents. Nature. 1969;26(222):385-386.
    • (1969) Nature , vol.26 , Issue.222 , pp. 385-386
    • Rosenberg, B.1    VanCamp, L.2    Trosko, J.E.3    Mansour, V.H.4
  • 3
    • 0004700371 scopus 로고    scopus 로고
    • Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: A phase II multicentric study
    • Diaz-Rubio E, Sastre J, Zaniboni A, et al. Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: A phase II multicentric study. Ann Oncol. 1998;9(1):105-118.
    • (1998) Ann Oncol , vol.9 , Issue.1 , pp. 105-118
    • Diaz-Rubio, E.1    Sastre, J.2    Zaniboni, A.3
  • 4
    • 0012797224 scopus 로고    scopus 로고
    • Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines
    • Machover D, Diaz-Rubio E, de Gramont A, et al. Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines. Ann Oncol. 1996;7(1):95-98.
    • (1996) Ann Oncol , vol.7 , Issue.1 , pp. 95-98
    • Machover, D.1    Diaz-Rubio, E.2    de Gramont, A.3
  • 5
    • 0027310715 scopus 로고
    • Oxaliplatin activity against metastatic colorectal cancer. A phase II study of 5-day continuous venous infusion at circadian rhythm modulated rate
    • Lévi F, Perpoint B, GarufiC, et al. Oxaliplatin activity against metastatic colorectal cancer. A phase II study of 5-day continuous venous infusion at circadian rhythm modulated rate. Eur J Cancer. 1993;29(9):1280-1284.
    • (1993) Eur J Cancer , vol.29 , Issue.9 , pp. 1280-1284
    • Lévi, F.1    Perpoint, B.2    GarufiC3
  • 6
    • 0030888321 scopus 로고    scopus 로고
    • Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer
    • De Gramont A, Vignoud J, Tournigand C, et al. Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer. Eur J Cancer. 1997;33(2):214-219.
    • (1997) Eur J Cancer , vol.33 , Issue.2 , pp. 214-219
    • De Gramont, A.1    Vignoud, J.2    Tournigand, C.3
  • 7
    • 0031774842 scopus 로고    scopus 로고
    • Bimonthly high dose leucovorin, 5-fluorouracil infusion and oxaliplatin (FOLFOX3) for metastatic colorectal cancer resistant to the same leucovorin and 5-fluorouracil regimen
    • André T, Louvet C, Raymond E, Tournigand C, de Gramont A. Bimonthly high dose leucovorin, 5-fluorouracil infusion and oxaliplatin (FOLFOX3) for metastatic colorectal cancer resistant to the same leucovorin and 5-fluorouracil regimen. Ann Oncol. 1998;9(11): 1251-1253.
    • (1998) Ann Oncol , vol.9 , Issue.11 , pp. 1251-1253
    • André, T.1    Louvet, C.2    Raymond, E.3    Tournigand, C.4    de Gramont, A.5
  • 8
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer
    • De Gramont A, Figer A, Seymour M, et al. Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer. J Clin Oncol. 2000;18(16):2938-2847.
    • (2000) J Clin Oncol , vol.18 , Issue.16 , pp. 2938-2847
    • De Gramont, A.1    Figer, A.2    Seymour, M.3
  • 9
    • 60649088752 scopus 로고    scopus 로고
    • Two different first-line 5-fluorouracil regimens with or without oxaliplatin in patients with metastatic colorectal cancer
    • Epub Oct 14. doi:10.1093/annonc/ mdn638
    • Cunningham D, Sirohi B, Pluzanska A, et al. Two different first-line 5-fluorouracil regimens with or without oxaliplatin in patients with metastatic colorectal cancer. Ann Oncol. Epub 2008 Oct 14. doi:10.1093/annonc/ mdn638.
    • (2008) Ann Oncol
    • Cunningham, D.1    Sirohi, B.2    Pluzanska, A.3
  • 10
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004;22(1):23-30.
    • (2004) J Clin Oncol , vol.22 , Issue.1 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3
  • 11
    • 33746805967 scopus 로고    scopus 로고
    • Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: A North American Intergroup Trial
    • Goldberg RM, Sargent DJ, Morton RF, et al. Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: A North American Intergroup Trial. J Clin Oncol. 2006;24(21):3347-3353.
    • (2006) J Clin Oncol , vol.24 , Issue.21 , pp. 3347-3353
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3
  • 12
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR Study
    • Tournigand C, André T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR Study. J Clin Oncol. 2004;22(2):229-237.
    • (2004) J Clin Oncol , vol.22 , Issue.2 , pp. 229-237
    • Tournigand, C.1    André, T.2    Achille, E.3
  • 13
    • 24644457747 scopus 로고    scopus 로고
    • Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: A multicenter Study of the Gruppo Oncologico Dell'Italia Meridionale
    • Colucci G, Gebbia V, Paoletti G, et al. Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: A multicenter Study of the Gruppo Oncologico Dell'Italia Meridionale. J Clin Oncol. 2005;23(22):4866-4875.
    • (2005) J Clin Oncol , vol.23 , Issue.22 , pp. 4866-4875
    • Colucci, G.1    Gebbia, V.2    Paoletti, G.3
  • 14
    • 21344459245 scopus 로고    scopus 로고
    • Oxaliplatin plus high dose folinic acid and 5-fluoruracil i.v. bolus (OXAFAFU) versus irinotecan plus high dose folinic acid and 5-fluoruracil i.v. bolus (IRIFAFU) in patients with metastatic colorectal carcinoma: A Southern Italy Cooperative Oncology Group phase III trial
    • Comella P, Massidda B, Filippelli G, et al. Oxaliplatin plus high dose folinic acid and 5-fluoruracil i.v. bolus (OXAFAFU) versus irinotecan plus high dose folinic acid and 5-fluoruracil i.v. bolus (IRIFAFU) in patients with metastatic colorectal carcinoma: A Southern Italy Cooperative Oncology Group phase III trial. Ann Oncol. 2005;16(6):878-886.
    • (2005) Ann Oncol , vol.16 , Issue.6 , pp. 878-886
    • Comella, P.1    Massidda, B.2    Filippelli, G.3
  • 15
    • 21344448162 scopus 로고    scopus 로고
    • Irinotecan or oxaliplatin combined with leucovorin and 5-fluorouracil as first-line treatment in advanced colorectal cancer: A multicenter, randomized, phase II study
    • Kalofonos HP, Aravantinos G, Kosmidis P, et al. Irinotecan or oxaliplatin combined with leucovorin and 5-fluorouracil as first-line treatment in advanced colorectal cancer: a multicenter, randomized, phase II study. Ann Oncol. 2005;16(6):869-877.
    • (2005) Ann Oncol , vol.16 , Issue.6 , pp. 869-877
    • Kalofonos, H.P.1    Aravantinos, G.2    Kosmidis, P.3
  • 16
    • 0037531121 scopus 로고    scopus 로고
    • Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a phase III trial
    • Rothenberg ML, Oza AM, Bigelow RH, et al. Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a phase III trial. J Clin Oncol. 2003;21(11):2059- 2069.
    • (2003) J Clin Oncol , vol.21 , Issue.11 , pp. 2059-2069
    • Rothenberg, M.L.1    Oza, A.M.2    Bigelow, R.H.3
  • 17
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients metastatic colorectal cancer: Results of a randomized phase III study
    • Hoff PM, Ansari R, Batist G, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol. 2001;19(8):2282-2292.
    • (2001) J Clin Oncol , vol.19 , Issue.8 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3
  • 18
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study
    • Van Cutsem E, Twelves C, Cassidy J, et al. Oral capecitabine compared with fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol. 2001;19(21):4097-4106.
    • (2001) J Clin Oncol , vol.19 , Issue.21 , pp. 4097-4106
    • Van Cutsem, E.1    Twelves, C.2    Cassidy, J.3
  • 19
    • 0036176033 scopus 로고    scopus 로고
    • Capecitabine as first-line treatment in colorectal cancer: Pooled data from two large, phase III trials. Capecitabine Colorectal Cancer Group
    • Twelves C. Capecitabine as first-line treatment in colorectal cancer: pooled data from two large, phase III trials. Capecitabine Colorectal Cancer Group. Eur J Cancer. 2002;38(Suppl 2):15-20.
    • (2002) Eur J Cancer , vol.38 , Issue.SUPPL. 2 , pp. 15-20
    • Twelves, C.1
  • 20
    • 2942638081 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer
    • Cassidy J, Tabernero J, Twelves CJ, et al. XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol. 2004;22(11):2084-2089.
    • (2004) J Clin Oncol , vol.22 , Issue.11 , pp. 2084-2089
    • Cassidy, J.1    Tabernero, J.2    Twelves, C.J.3
  • 21
    • 33645731984 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer
    • Feliu J, Salud A, Escudero P, et al: XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer. Br J Cancer. 2006;94(7):969-975.
    • (2006) Br J Cancer , vol.94 , Issue.7 , pp. 969-975
    • Feliu, J.1    Salud, A.2    Escudero, P.3
  • 22
    • 22244477362 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal cancer. Final results of the Southern Italy Cooperative Oncology Group (SICOG) trial 0108
    • Comella P, Natale D, Farris A, et al. Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal cancer. Final results of the Southern Italy Cooperative Oncology Group (SICOG) trial 0108. Cancer. 2005;104(2):282-289.
    • (2005) Cancer , vol.104 , Issue.2 , pp. 282-289
    • Comella, P.1    Natale, D.2    Farris, A.3
  • 23
    • 34948857445 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin: A randomized comparison in metastatic colorectal cancer - A final report of the AIO Colorectal Study Group
    • Porschen R, Arkenau H-T, Kubicka S, et al. Capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin: A randomized comparison in metastatic colorectal cancer - A final report of the AIO Colorectal Study Group. J Clin Oncol. 2007;25(27):4217-4223.
    • (2007) J Clin Oncol , vol.25 , Issue.27 , pp. 4217-4223
    • Porschen, R.1    Arkenau, H.-T.2    Kubicka, S.3
  • 24
    • 34948892881 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin versus continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: Final report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial
    • Díaz-Rubio E, Tabernero J, Gómez-Espa a J, et al. Phase III study of capecitabine plus oxaliplatin versus continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: Final report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial. J Clin Oncol. 2007;25(27):4224-4230.
    • (2007) J Clin Oncol , vol.25 , Issue.27 , pp. 4224-4230
    • Díaz-Rubio, E.1    Tabernero, J.2    Gómez-Espa a, J.3
  • 25
    • 65849108886 scopus 로고    scopus 로고
    • Randomised trial comparing biweekly oxaliplatin plus oral capecitabine versus oxaliplatin plus i.v. bolus fluorouracil/leucovorin in metastatic colorectal cancer patients. Results of the Southern Italy Cooperative oncology Group study 0401
    • Comella P, Massidda B, Filippelli G, et al. Randomised trial comparing biweekly oxaliplatin plus oral capecitabine versus oxaliplatin plus i.v. bolus fluorouracil/leucovorin in metastatic colorectal cancer patients. Results of the Southern Italy Cooperative oncology Group study 0401. J Cancer Res Clin Oncol. 2009;135(2):217-226.
    • (2009) J Cancer Res Clin Oncol , vol.135 , Issue.2 , pp. 217-226
    • Comella, P.1    Massidda, B.2    Filippelli, G.3
  • 26
    • 42949150908 scopus 로고    scopus 로고
    • Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer
    • Cassidy J, Clarke S, Díaz-Rubio E, et al. Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol. 2008;26(12):2006-2012.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 2006-2012
    • Cassidy, J.1    Clarke, S.2    Díaz-Rubio, E.3
  • 27
    • 58049194302 scopus 로고    scopus 로고
    • Efficacy of oxaliplatin plus capecitabine or infusional fluorouracil/leucovorin in patients with metastatic colorectal cancer: A pooled analysis of randomized trials
    • Arkenau H-T, Arnold D, Cassidy J, et al. Efficacy of oxaliplatin plus capecitabine or infusional fluorouracil/leucovorin in patients with metastatic colorectal cancer: A pooled analysis of randomized trials. J Clin Oncol. 2008;26(36):5910-5917.
    • (2008) J Clin Oncol , vol.26 , Issue.36 , pp. 5910-5917
    • Arkenau, H.-T.1    Arnold, D.2    Cassidy, J.3
  • 28
    • 53049092394 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: A randomized phase III noninferiority study
    • Rothenberg ML, Cox JV, Butts C, et al. Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: a randomized phase III noninferiority study. Ann Oncol. 2008;19(10):1720-1726.
    • (2008) Ann Oncol , vol.19 , Issue.10 , pp. 1720-1726
    • Rothenberg, M.L.1    Cox, J.V.2    Butts, C.3
  • 29
    • 0029972388 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of oral uracil, ftorafur, and leucovorin in patients with advanced cancer
    • Meropol NJ, Rustum YM, Petrelli NJ, et al. A phase I and pharmacokinetic study of oral uracil, ftorafur, and leucovorin in patients with advanced cancer. Cancer Chemother Pharmacol. 1996;37(6):581-586.
    • (1996) Cancer Chemother Pharmacol , vol.37 , Issue.6 , pp. 581-586
    • Meropol, N.J.1    Rustum, Y.M.2    Petrelli, N.J.3
  • 30
    • 0030639034 scopus 로고    scopus 로고
    • UFT modulated with leucovorin in advanced colorectal cancer: Oncopaz experience
    • González-Barón M, Feliu J, Garcia Girón C, et al. UFT modulated with leucovorin in advanced colorectal cancer: Oncopaz experience. Oncology. 1997;54(Suppl 1):24-29.
    • (1997) Oncology , vol.54 , Issue.SUPPL. 1 , pp. 24-29
    • González-Barón, M.1    Feliu, J.2    Garcia Girón, C.3
  • 31
    • 0028820944 scopus 로고
    • A fixed-ratio combination of uracil and ftorafur (UFT) with low dose leucovorin
    • Saltz LB, Leichman CG, Young CW, et al. A fixed-ratio combination of uracil and ftorafur (UFT) with low dose leucovorin. Cancer. 1995;75(3):782-785.
    • (1995) Cancer , vol.75 , Issue.3 , pp. 782-785
    • Saltz, L.B.1    Leichman, C.G.2    Young, C.W.3
  • 32
    • 0028099423 scopus 로고
    • Phase II study of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal cancer
    • Pazdur R, Lassere Y, Rhodes V, et al. Phase II study of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal cancer. J Clin Oncol. 1994;12(11):2296-2300.
    • (1994) J Clin Oncol , vol.12 , Issue.11 , pp. 2296-2300
    • Pazdur, R.1    Lassere, Y.2    Rhodes, V.3
  • 33
    • 0036727089 scopus 로고    scopus 로고
    • Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Carmichael J , Popiela T , Radstone D, et al. Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2002;20(17):3617-3627.
    • (2002) J Clin Oncol , vol.20 , Issue.17 , pp. 3617-3627
    • Carmichael, J.1    Popiela, T.2    Radstone, D.3
  • 34
    • 0036731818 scopus 로고    scopus 로고
    • Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Douillard J-Y, Hoff PM, Skillings JR, et al. Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2002;20(17):3605-3616.
    • (2002) J Clin Oncol , vol.20 , Issue.17 , pp. 3605-3616
    • Douillard, J.-Y.1    Hoff, P.M.2    Skillings, J.R.3
  • 35
    • 30644475407 scopus 로고    scopus 로고
    • A phase II study of oral uracil/ftorafur (UFTs) plus leucovorin combined with oxaliplatin (TEGAFOX) as first-line treatment in patients with metastatic colorectal cancer
    • Bennouna J, Perrier H, Paillot B, et al. A phase II study of oral uracil/ftorafur (UFTs) plus leucovorin combined with oxaliplatin (TEGAFOX) as first-line treatment in patients with metastatic colorectal cancer. Br J Cancer. 2006;94(1):69-73.
    • (2006) Br J Cancer , vol.94 , Issue.1 , pp. 69-73
    • Bennouna, J.1    Perrier, H.2    Paillot, B.3
  • 36
    • 10844241474 scopus 로고    scopus 로고
    • Phase II study of UFT and oxaliplatin in first-line treatment of advanced colorectal cancer
    • Feliu J, Vicent JM, García-Girón C, et al. Phase II study of UFT and oxaliplatin in first-line treatment of advanced colorectal cancer. Br J Cancer. 2004;91(10):1758-1762.
    • (2004) Br J Cancer , vol.91 , Issue.10 , pp. 1758-1762
    • Feliu, J.1    Vicent, J.M.2    García-Girón, C.3
  • 37
    • 33846821578 scopus 로고    scopus 로고
    • Uracil/ftorafur/leucovorin combined with irinotecan (TEGAFIRI) or oxaliplatin (TEGAFOX) as first-line treatment for metastatic colorectal cancer patients: Results of randomised phase II study
    • Bajetta E, Di Bartolomeo M, Buzzoni R, et al. Uracil/ftorafur/leucovorin combined with irinotecan (TEGAFIRI) or oxaliplatin (TEGAFOX) as first-line treatment for metastatic colorectal cancer patients: results of randomised phase II study. Br J Cancer. 2007;96(3):439-444.
    • (2007) Br J Cancer , vol.96 , Issue.3 , pp. 439-444
    • Bajetta, E.1    Di Bartolomeo, M.2    Buzzoni, R.3
  • 38
    • 0036787717 scopus 로고    scopus 로고
    • Biweekly chemotherapy with oxaliplatin, irinotecan, infusional fluorouracil, and leucovorin: A pilot study in patients with metastatic colorectal cancer
    • Falcone A, Masi G, Allegrini G, et al. Biweekly chemotherapy with oxaliplatin, irinotecan, infusional fluorouracil, and leucovorin: a pilot study in patients with metastatic colorectal cancer. J Clin Oncol. 2002;20(19):4006-4014.
    • (2002) J Clin Oncol , vol.20 , Issue.19 , pp. 4006-4014
    • Falcone, A.1    Masi, G.2    Allegrini, G.3
  • 39
    • 34249000361 scopus 로고    scopus 로고
    • Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: The Gruppo Oncologico Nord Ovest
    • Falcone A, Ricci S, Brunetti, et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol. 2007;25(13):1670-1676.
    • (2007) J Clin Oncol , vol.25 , Issue.13 , pp. 1670-1676
    • Falcone, A.1    Ricci, S.2    Brunetti3
  • 40
    • 33645309877 scopus 로고    scopus 로고
    • FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): A multicentre randomised phase III trial from the Hellenic Oncology Research Group (HORG)
    • Souglakos J, Androulakis N, Syrigos K, et al. FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): a multicentre randomised phase III trial from the Hellenic Oncology Research Group (HORG). Br J Cancer. 2006;94(6):798-805.
    • (2006) Br J Cancer , vol.94 , Issue.6 , pp. 798-805
    • Souglakos, J.1    Androulakis, N.2    Syrigos, K.3
  • 41
    • 38449107093 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin and irinotecan regimen every other week: A phase I/II study in first-line treatment of metastatic colorectal cancer
    • Bajetta E, Celio L, Ferrario E, et al. Capecitabine plus oxaliplatin and irinotecan regimen every other week: a phase I/II study in first-line treatment of metastatic colorectal cancer. Ann Oncol. 2007;18(11):1810-1816.
    • (2007) Ann Oncol , vol.18 , Issue.11 , pp. 1810-1816
    • Bajetta, E.1    Celio, L.2    Ferrario, E.3
  • 42
    • 61449180226 scopus 로고    scopus 로고
    • A dose finding and pharmacokinetic study of capecitabine in combination with oxaliplatin and irinotecan in metastatic colorectal cancer
    • Oct 7 [Epub ahead of print, DOI 10.1007/s00280-008-0840-5
    • Fornaro L, Masi G, Bursi S, et al. A dose finding and pharmacokinetic study of capecitabine in combination with oxaliplatin and irinotecan in metastatic colorectal cancer. Cancer Chemother Pharmacol. 2008 Oct 7 [Epub ahead of print]. DOI 10.1007/s00280-008-0840-5.
    • (2008) Cancer Chemother Pharmacol
    • Fornaro, L.1    Masi, G.2    Bursi, S.3
  • 43
    • 36749067866 scopus 로고    scopus 로고
    • Phase II Trial of Cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer
    • Tabernero J, Van Cutsem E, Diaz-Rubio E, et al. Phase II Trial of Cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2007;25(33):5225-5232.
    • (2007) J Clin Oncol , vol.25 , Issue.33 , pp. 5225-5232
    • Tabernero, J.1    Van Cutsem, E.2    Diaz-Rubio, E.3
  • 44
    • 33847261015 scopus 로고    scopus 로고
    • Phase II trial of capecitabine and oxaliplatin (CAPOX) plus cetuximab in patients with metastatic colorectal cancer who progressed after oxaliplatin-based chemotherapy
    • Souglakos J, Kalykaki A, Vamvakas L, et al. Phase II trial of capecitabine and oxaliplatin (CAPOX) plus cetuximab in patients with metastatic colorectal cancer who progressed after oxaliplatin-based chemotherapy. Ann Oncol. 2007;18(2):305-310.
    • (2007) Ann Oncol , vol.18 , Issue.2 , pp. 305-310
    • Souglakos, J.1    Kalykaki, A.2    Vamvakas, L.3
  • 45
    • 77949457915 scopus 로고    scopus 로고
    • Borner M, Mingrone W, Koeberle D, et al. The impact of cetuximab on the capecitabine plus oxaliplatin (XELOX) combination in first-line treatment of metastatic colorectal cancer (MCC): A randomized phase II trial of the Swiss Group for Clinical Cancer Research (SAKK). J Clin Oncol. 2006; ASCO Annual Meeting Proceedings, Part I, 24(18S):3551.
    • Borner M, Mingrone W, Koeberle D, et al. The impact of cetuximab on the capecitabine plus oxaliplatin (XELOX) combination in first-line treatment of metastatic colorectal cancer (MCC): A randomized phase II trial of the Swiss Group for Clinical Cancer Research (SAKK). J Clin Oncol. 2006; ASCO Annual Meeting Proceedings, Part I, 24(18S):3551.
  • 46
    • 77949452950 scopus 로고    scopus 로고
    • Bokemeyer C, Bondarenko I, Makhson A, et al. Cetuximab plus 5FU/FA/oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized phase II study. J Clin Oncol. 2007; ASCO Annual Meeting Proceedings, Part I, 25(18S):4035.
    • Bokemeyer C, Bondarenko I, Makhson A, et al. Cetuximab plus 5FU/FA/oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized phase II study. J Clin Oncol. 2007; ASCO Annual Meeting Proceedings, Part I, 25(18S):4035.
  • 47
    • 77949474287 scopus 로고    scopus 로고
    • Bokemeyer, Bondarenko I, Hartmann JT, et al. KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: The OPUS experience. J Clin Oncol. 2008; ASCO Annual Meeting Proceeding, Part I, 26(15S):4000.
    • Bokemeyer, Bondarenko I, Hartmann JT, et al. KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: The OPUS experience. J Clin Oncol. 2008; ASCO Annual Meeting Proceeding, Part I, 26(15S):4000.
  • 48
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Díaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study. J Clin Oncol. 2008;26(12):2013-2019.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Díaz-Rubio, E.3
  • 49
    • 49049105525 scopus 로고    scopus 로고
    • Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE Study
    • Hochster HS, Hart LL, Ramanathan RK, et al. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study. J Clin Oncol. 2008;26(21):3523-3529.
    • (2008) J Clin Oncol , vol.26 , Issue.21 , pp. 3523-3529
    • Hochster, H.S.1    Hart, L.L.2    Ramanathan, R.K.3
  • 50
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX-4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX-4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007;25(12):1539-1544.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 51
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • André T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350(23):2343-2351.
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2343-2351
    • André, T.1    Boni, C.2    Mounedji-Boudiaf, L.3
  • 52
    • 77949446100 scopus 로고    scopus 로고
    • De Gramont A, Boni C, Navarro M, et al. Oxaliplatin/5FU/LV in adjuvant colon cancer: Updated efficacy results of the MOSAIC trial, including survival, with a median follow-up of six years. J Clin Oncol. 2007; ASCO Annual Meeting Proceeding, Part I, 25(15S):4007.
    • De Gramont A, Boni C, Navarro M, et al. Oxaliplatin/5FU/LV in adjuvant colon cancer: Updated efficacy results of the MOSAIC trial, including survival, with a median follow-up of six years. J Clin Oncol. 2007; ASCO Annual Meeting Proceeding, Part I, 25(15S):4007.
  • 53
    • 34250210799 scopus 로고    scopus 로고
    • Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07
    • Kuebler JP, Wieand HS, O'Connell MJ, et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07. J Clin Oncol. 2007;25(16):2198-2204.
    • (2007) J Clin Oncol , vol.25 , Issue.16 , pp. 2198-2204
    • Kuebler, J.P.1    Wieand, H.S.2    O'Connell, M.J.3
  • 54
    • 77949464073 scopus 로고    scopus 로고
    • Schmoll HJ, Tabernero J, Nowacki M, et al. Final safety findings from a randomized phase III trial of capecitabine + oxaliplatin (XELOX) vs. bolus 5-FU/LV as adjuvant therapy for patients (pts) with stage III colon cancer. J Clin Oncol. 2006; ASCO Annual Meeting Proceedings, Part I, 24(18S):3569.
    • Schmoll HJ, Tabernero J, Nowacki M, et al. Final safety findings from a randomized phase III trial of capecitabine + oxaliplatin (XELOX) vs. bolus 5-FU/LV as adjuvant therapy for patients (pts) with stage III colon cancer. J Clin Oncol. 2006; ASCO Annual Meeting Proceedings, Part I, 24(18S):3569.
  • 55
    • 77949458349 scopus 로고    scopus 로고
    • Allegra CJ, Yothers G, O'Connell MJ, Sharif S, Wolmark N. Initial safety report of NSABP C-08, a randomized phase III study of modified 5-fluorouracil (5-FU)/leucovorin (LCV) and oxaliplatin (OX) (mFOLFOX6) with or without bevacizumab (bev) in the adjuvant treatment of patients with stage II/III colon cancer. J Clin Oncol. 2008; ASCO Annual Meeting Proceeding, Part I, 26(15S):4006.
    • Allegra CJ, Yothers G, O'Connell MJ, Sharif S, Wolmark N. Initial safety report of NSABP C-08, a randomized phase III study of modified 5-fluorouracil (5-FU)/leucovorin (LCV) and oxaliplatin (OX) (mFOLFOX6) with or without bevacizumab (bev) in the adjuvant treatment of patients with stage II/III colon cancer. J Clin Oncol. 2008; ASCO Annual Meeting Proceeding, Part I, 26(15S):4006.
  • 56
    • 3042523914 scopus 로고    scopus 로고
    • Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: A retrospective study of 161 patients receiving oxaliplatin combined with 5-Fluorouracil and leucovorin for advanced colorectal cancer
    • Gamelin L Boisdron-Celle M, Delva R. Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: a retrospective study of 161 patients receiving oxaliplatin combined with 5-Fluorouracil and leucovorin for advanced colorectal cancer. Clin Cancer Res. 2004;15;10:4055-4061.
    • (2004) Clin Cancer Res , vol.15 , Issue.10 , pp. 4055-4061
    • Gamelin, L.1    Boisdron-Celle, M.2    Delva, R.3
  • 57
    • 77949428016 scopus 로고    scopus 로고
    • Nickevich DA, Grothey A, Sloan JA, et al. Effect of intravenous calcium and magnesium (IV CaMg) on oxaliplatin-induced sensory neurotoxicity (sNT) in adjuvant colon cancer: Results of the phase III placebo-controlled, double blind NCCTG trial N04c7. J Clin Oncol. 2008; ASCO Annual Meeting Proceeding, Part I, 26(15S):4009.
    • Nickevich DA, Grothey A, Sloan JA, et al. Effect of intravenous calcium and magnesium (IV CaMg) on oxaliplatin-induced sensory neurotoxicity (sNT) in adjuvant colon cancer: Results of the phase III placebo-controlled, double blind NCCTG trial N04c7. J Clin Oncol. 2008; ASCO Annual Meeting Proceeding, Part I, 26(15S):4009.
  • 58
    • 77949448392 scopus 로고    scopus 로고
    • Grothey A, Hart LL, Rowland KM, et al. Intermittent oxaliplatin (oxali) and time-to-treatment-failure (TTF) in metastatic colorectal cancer (mCRC): Final results of the phase III CONcePT trial. J Clin Oncol. 2008; ASCO Annual Meeting Proceeding, Part I, 26(15S):4010.
    • Grothey A, Hart LL, Rowland KM, et al. Intermittent oxaliplatin (oxali) and time-to-treatment-failure (TTF) in metastatic colorectal cancer (mCRC): Final results of the phase III CONcePT trial. J Clin Oncol. 2008; ASCO Annual Meeting Proceeding, Part I, 26(15S):4010.
  • 59
    • 77949434294 scopus 로고    scopus 로고
    • Cassidy J, Bjarnason GA, Hickish T, et al: Randomized double blind (DB) placebo (Plcb) controlled phase III study assessing the efficacy of xaliproden (X) in reducing the cumulative peripheral sensory neuropathy (PSN) induced by the oxaliplatin (Ox) and 5-FU/LV combination (FOLFOX-4) in first-line treatment of patients (pts) with metastatic colorectal cancer (MCRC). J Clin Oncol. 2006; ASCO Annual Meeting Proceedings, Part I, 24(18S):3507.
    • Cassidy J, Bjarnason GA, Hickish T, et al: Randomized double blind (DB) placebo (Plcb) controlled phase III study assessing the efficacy of xaliproden (X) in reducing the cumulative peripheral sensory neuropathy (PSN) induced by the oxaliplatin (Ox) and 5-FU/LV combination (FOLFOX-4) in first-line treatment of patients (pts) with metastatic colorectal cancer (MCRC). J Clin Oncol. 2006; ASCO Annual Meeting Proceedings, Part I, 24(18S):3507.


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