Medical terminations of pregnancy: A viable source of tissue for cell replacement therapy for neurodegenerative disorders

Cell Transplantation

Volumn 20, Issue 4, 2011, Pages 503-513

  Kelly, C M ^a   Precious, S V ^a   Torres, E M ^a   Harrison, A W ^b   Williams, D ^b   Scherf, C ^b   Weyrauch, U M ^a   Lane, E L ^a   Allen, N D ^a   Penketh, R ^b   Amso, N N ^b   Kemp, P J ^b   Dunnett, S B ^a   Rosser, A E ^a,b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Human fetal tissue; Neural transplantation

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN TISSUE; CELL TRANSPLANTATION; CELL VIABILITY; DEGENERATIVE DISEASE; FETUS; FETUS (ANATOMY); HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCEPHALON; NEOCORTEX; NONHUMAN; PREGNANCY TERMINATION; PRIORITY JOURNAL;

ABORTION, INDUCED; ANIMALS; BRAIN; BRAIN TISSUE TRANSPLANTATION; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; FEMALE; FETAL TISSUE TRANSPLANTATION; FETUS; HUMANS; IMMUNOHISTOCHEMISTRY; NEURODEGENERATIVE DISEASES; PREGNANCY; RATS;

RODENTIA;

EID: 79956036048     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X546580     Document Type: Article

References (30)

1. Bachoud-Levi, A. C.; Gaura, V.; Brugieres, P.; Lefaucheur, J. P.; Boisse, M. F.; Maison, P.; Baudic, S.; Ribeiro, M. J.; Bourdet, C.; Remy, P.; Cesaro, P.; Hantraye, P.; Peschanski, M. Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: A long-term follow-up study. Lancet Neurol. 5(4): 303-309; 2006.
2. Ben-Ari, Y. Excitatory actions of GABA during development: The nature of the nurture. Nat. Rev. Neurosci. 3(9): 728-739; 2002.
3. Branch, D. W.; Ducat, L.; Fantel, A.; Low, W. C.; Zhou, F. C.; Dayton, D. H.; Gill, 3rd, T. J. Suitability of fetal tissues from spontaneous abortions and from ectopic pregnancies for transplantation. Human Fetal Tissue Working Group. JAMA 273(1): 66-68; 1995.
4. Brundin, P.; Strecker, R. E.; Widner, H.; Clarke, D. J.; Nilsson, O. G.; Astedt, B.; Lindvall, O.; Bjorklund, A. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: Immunological aspects, spontaneous and drug-induced behaviour, and dopamine release. Exp. Brain Res. 70(1): 192-208; 1988.
5. Department of Health. Abortion statistics, England and Wales: 2007. London, UK: Department of Health; 2007.
6. Department of Health. Guidance on the supply of fetal tissue for research diagnosis and therapy. London, UK: Department of Health; 1995.
7. el-Refaey, H.; Rajasekar, D.; Abdalla, M.; Calder, L.; Templeton, A. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N. Engl. J. Med. 332(15): 983-987; 1995.
8. Evtouchenko, L.; Studer, L.; Spenger, C.; Dreher, E.; Seiler, R. W. A mathematical model for the estimation of human embryonic and fetal age. Cell Transplant. 5: 453-464; 1996.
9. Farrington, M.; Wreghitt, T. G.; Lever, A. M. L.; Dunnett, S. B.; Rosser, A. E.; Barker, R. A. Neural transplantation in Huntington's disease: The NEST-UK donor tissue microbiological screening program and review of the literature. Cell Transplant. 15(4): 279-294; 2006.
10. Folkerth, R. D.; Durso, R. Survival and proliferation of nonneural tissues, with obstruction of cerebral ventricles, in a parkinsonian patient treated with fetal allografts. Neurology 46(5): 1219-1225; 1996.
11. Hainline, B. E.; Padilla, L. M.; Chong, S. K.; Heifetz, S. A.; Palmer, C.; Zhou, F. C. Fetal tissue derived from spontaneous pregnancy losses is insufficient for human transplantation. Obstet. Gynecol. 85(4): 619-624; 1995.
12. Hurelbrink, C. B.; Armstrong, R. J.; Barker, R. A.; Dunnett, S. B.; Rosser, A. E. Hibernated human fetal striatal tissue: Successful transplantation in a rat model of Huntington's disease. Cell Transplant. 9(6): 743-749; 2000.
13. Hurelbrink, C. B.; Barker, R. A. Migration of cells from primary transplants of allo-and xenografted foetal striatal tissue in the adult rat brain. Eur. J. Neurosci. 21(6): 1503-1510; 2005.
14. Hurelbrink, C. B.; Tyers, P.; Armstrong, R. J.; Dunnett, S. B.; Barker, R. A.; Rosser, A. E. Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival: Implications for clinical trials in Huntington's disease. Cell Transplant. 12(7): 687-695; 2003.
15. Kelly, C. M.; Precious, S. V.; Penketh, R.; Amso, N.; Dunnett, S. B.; Rosser, A. E. Striatal graft projections are influenced by donor cell type and not the immunogenic background. Brain 130(5): 1317-1329; 2007.
16. Kelly, C. M.; Precious, S. V.; Scherf, C.; Penketh, R.; Amso, N. N.; Battersby, A.; Allen, N. D.; Dunnett, S. B.; Rosser, A. E. Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression. Nat. Methods 6(4): 271-273; 2009.
17. Lane, E. L.; Handley, O. J.; Rosser, A. E.; Dunnett, S. B. Potential cellular and regenerative approaches for the treatment of Parkinson's disease. Neuropsychiatr. Dis. Treat. 4(5): 835-845; 2008.
18. Lindvall, O.; Bjorklund, A. Cell therapy in Parkinson's disease. NeuroRx 1(4): 382-393; 2004.
19. Lindvall, O.; Rehncrona, S.; Brundin, P.; Gustavii, B.; Astedt, B.; Widner, H.; Lindholm, T.; Bjorklund, A.; Leenders, K. L.; Rothwell, J. C. Neural transplantation in Parkinson's disease: The Swedish experience. Prog. Brain Res. 82: 729-734; 1990.
20. Mamelak, A. N.; Eggerding, F. A.; Oh, D. S.; Wilson, E.; Davis, R. L.; Spitzer, R.; Hay, J. A.; Caton, 3rd, W. L. Fatal cyst formation after fetal mesencephalic allograft transplant for Parkinson's disease. J. Neurosurg. 89(4): 592-598; 1998.
21. Marchenko, S.; Flanagan, L. Counting human neural stem cells. J. Vis. Exp. (7): 262; 2007.
22. Mendez, I.; Vinuela, A.; Astradsson, A.; Mukhida, K.; Hallett, P.; Robertson, H.; Tierney, T.; Holness, R.; Dagher, A.; Trojanowski, J. Q.; Isacson, O. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat. Med. 14(5): 507-509; 2008.
23. Polkinghorne, J. Review of the guidance on the research use of fetuses and fetal material. London, UK: Her Majesty's Stationary Office; 1989.
24. Redmond, Jr., D. E.; Elsworth, J. D.; Roth, R. H.; Leranth, C.; Collier, T. J.; Blanchard, B.; Bjugstad, K. B.; Samulski, R. J.; Aebischer, P.; Sladek, Jr., J. R. Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF. J. Comp. Neurol. 515(1): 31-40; 2009.
25. Redmond, Jr., D. E.; Vinuela, A.; Kordower, J. H.; Isacson, O. Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's disease. Neurobiol. Dis. 29(1): 103-116; 2008.
26. Rosser, A. E.; Barker, R. A.; Armstrong, R. J.; Elneil, S.; Jain, M.; Hurelbrink, C. B.; Prentice, A.; Carne, C.; Thornton, S.; Hutchinson, H.; Dunnett, S. B. Staging and preparation of human fetal striatal tissue for neural transplantation in Huntington's disease. Cell Transplant. 12(7): 679-686; 2003.
27. Rosser, A. E.; Dunnett, S. B. Cell transplantation for Huntington's disease. Lancet Neurol. 5(4): 284-285; 2006.
28. Stromberg, I.; Bygdeman, M.; Goldstein, M.; Seiger, A.; Olson, L. Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: Evidence for functional reinnervation. Neurosci. Lett. 71(3): 271-276; 1986.
29. West, M. J. Stereological methods for estimating the total number of neurons and synapses: Issues of precision and bias. Trends Neurosci. 22(2): 51-61; 1999.
30. Winkler, C.; Kirik, D.; Bjorklund, A. Cell transplantation in Parkinson's disease: How can we make it work? Trends Neurosci. 28(2): 86-92; 2005.