The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling

Biochemical Pharmacology

Volumn 81, Issue 2, 2011, Pages 222-232

  Valdez, Benigno C ^a,c   Li, Yang ^a   Murray, David ^b   Champlin, Richard E ^a   Andersson, Borje S ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b CROSS CANCER INSTITUTE   (Canada)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Busulfan; Chromatin remodeling; Clofarabine; Fludarabine; Synergistic cytotoxicity

Indexed keywords

ATM PROTEIN; BUSULFAN; CLOFARABINE; DEFEROXAMINE; FLUDARABINE; HISTONE H3; HISTONE H4;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL CYCLE; CELL SURVIVAL; CHROMATIN ASSEMBLY AND DISASSEMBLY; CYTOTOXICITY; DNA ALKYLATION; DNA CROSS LINKING; DNA DAMAGE; DOWN REGULATION; DRUG POTENTIATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; METHYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADENINE NUCLEOTIDES; ANTINEOPLASTIC AGENTS; ARABINONUCLEOSIDES; BUSULFAN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA, MYELOID, ACUTE; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS; VIDARABINE;

EID: 78650172293     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.09.027     Document Type: Article

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