Gray matter volume deficits are associated with motor and attentional impairments in adolescents with schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 35, Issue 4, 2011, Pages 939-943

  Kumra, Sanjiv ^a,b,c,d   Ashtari, Manzar ^a,b,c,d   Wu, Jinghui ^a,b,c,d   Hongwanishkul, Donaya ^a,b,c,d   White, Tonya ^a,b,c,d   Cervellione, Kelly ^a,b,c,d   Cottone, John ^a,b,c,d   Szeszko, Philip R ^a,b,c,d  

^a UNIVERSITY OF MINNESOTA   (United States)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c ZUCKER HILLSIDE HOSPITAL   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Adolescents; Cortical parcellation; Frontal lobes; MRI; Schizophrenia

Indexed keywords

ARIPIPRAZOLE; CLOZAPINE; OLANZAPINE; QUETIAPINE; RISPERIDONE; ZIPRASIDONE;

ADOLESCENT; ANTERIOR CINGULATE; ARTICLE; ATTENTION DISTURBANCE; BRAIN ATROPHY; BRAIN SIZE; COGNITIVE DEFECT; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; FRONTAL LOBE; GRAY MATTER; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; ORBITAL CORTEX; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; SUPERIOR FRONTAL GYRUS; VERBAL MEMORY; WHITE MATTER;

ADOLESCENT; AGE OF ONSET; ANTIPSYCHOTIC AGENTS; ATTENTION; BRAIN; CEREBRAL CORTEX; CHILD; COGNITION DISORDERS; EXECUTIVE FUNCTION; FEMALE; FRONTAL LOBE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; READING; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SENSATION;

EID: 79956019645     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2011.01.001     Document Type: Article

References (46)

1. Axelrod B.N., Ryan J.J., Ward L.C. Evaluation of seven-subtest short forms of the Wechsler Adult Intelligence Scale-III in a referred sample. Arch Clin Neuropsychol 2001, 16:1-8.
2. Bertolino A., Kumra S., Callicott J.H., Mattay V.S., Lestz R.M., Jacobsen L., et al. Common pattern of cortical pathology in childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging. Am J Psychiatry 1998, 155:1378-1383.
3. Cannon M., Jones P., Huttunen M.O., Tanskanen A., Huttunen T., Rabe-Hesketh S., et al. School performance in Finnish children and later development of schizophrenia: a population-based longitudinal study. Arch Gen Psychiatry 1999, 56:457-463.
4. Cervellione K.L., Burdick K.E., Cottone J.G., Rhinewine J.P., Kumra S. Neurocognitive deficits in adolescents with schizophrenia: longitudinal stability and utility for short-term functional outcome. J Am Acad Child Adolesc Psychiatry 2007, 46:867-878.
5. Cornblatt B., Obuchowski M., Andreasen A. Attention, clinical symptoms and pharmacology in schizophrenia. Schizophr Res 1997, 24:212-213.
6. Delis D.C., Kramer J.H., Kaplan E., Ober B.A. California verbal learning test manual 1987, Psychological Corporation, Texas. 2nd ed.
7. Dickstein D.P., Milham M.P., Nugent A.C., Drevets W.C., Charney D.S., Pine D.S., et al. Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study. Arch Gen Psychiatry 2005, 62:734-741.
8. Donders J., Strom D. The effect of traumatic brain injury on children with learning disability. Pediatr Rehabil 1997, 1:179-184.
9. Dorph-Petersen K.A., Pierri J.N., Perel J.M., Sun Z., Sampson A.R., Lewis D.A. The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: a comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology 2005, 30:1649-1661.
10. Fuster J. Frontal lobe and cognitve development. J Neurocytol 2002, 31:373-385.
11. Giedd J.N. Neuroimaging of pediatric neuropsychiatric disorders: is a picture really worth a thousand words?. Arch Gen Psychiatry 2001, 58:443-444.
12. Gogtay N.G.J., Lusk L., Hayashi K.M., Greenstein D., Vaituzis A.C., Nugent T.F., et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci 2004, 101:8174-8179.
13. Gur R.E., Cowell P.E., Latshaw A., Turetsky B.I., Grossman R.I., Arnold S.E., et al. Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia. Arch Gen Psychiatry 2000, 57:761-768.
14. Heaton R.K., Chelune G.J., Talley J.L., Kay G.G., Curtiss G. Wisconsin Card Sorting Test manual: revised and expanded 1993, Psychological Assessment Resources, Florida.
15. Hollingshead AB, Redlich FC. Social class and mental illness: a community study. 1958. Comment in: Am J Public Health 2007;97:1755.
16. James A., James S., Smith D., Javaloyes A. Cerbellar, prefrontal cortex, and thalamic volumes over two time points in adolescent-onset schizophrenia. Am J Psychiatry 2004, 161:1023-1029.
17. Kaufman J., Birmaher B., Brent D., Rao U., Flynn C., Morci P., et al. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997, 36:980-988.
18. Kimling-Erlenmeyer L. Neurobehavioral deficits in offspring of schizophrenic parents: liability indicators and predictors of illness. Am J Med Genet 2000, 97:65-71.
19. Kumra S., Ashtari M., Cervellione K.L., Henderson I., Kester H., Roofeh D., et al. White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. J Am Acad Child Adolesc Psychiatry 2005, 44:934-941.
20. Kumra S., Ashtari M., McMeniman M., Vogel J., Augustin R., Becker D., et al. Reduced frontal white matter integrity in early-onset schizophrenia: a preliminary study. Biol Psychiatry 2004, 55:1138-1145.
21. Kumra S., Giedd J., Vaituzis A., Jacobsen L., McKenna K., Bedwell J., et al. Childhood-onset psychotic disorders: magnetic resonance imaging of volumetric differences in brain structure. Am J Psychiatry 2000, 157:1467-1474.
22. Lewis D., Cruz D., Eggam S., Erickson S. Postnatal development of prefrontal inhibitory circuits and the pathophysiology of cognitive dysfunction on schizophrenia. Ann NY Acad Sci 2004, 1021:64-66.
23. Lieberman J., Stroup T., McEvoy J., Swartz M., Rosenheck R., Perkins D., et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005, 353:1209-1223.
24. Matthews C.G., Klove H. Instruction manual for the adult neuropsychology test battery 1964, University of Wisconsin Medical School, Wisconsin.
25. Miller D.D., Andreasen N.C., O'Leary D.S., Rezai K., Watkins G.L., Ponto L.L., et al. Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography. Neuropsychopharmacology 1997, 17:230-240.
26. Molina V., Reig S., Sarramea F., Sanz J., Francisco Artaloytia J., Luque R., et al. Anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia. Psychiatry Res 2003, 124:153-161.
27. Ono M., Kubick S., Abernathey C.D. Atlas of the cerebral sulci 1990, Thieme, Japan. 1st ed.
28. Otsu A., Hoshina K., Kurozumi S., Hashimoto Y., Ishimoto S. Effect of TEI-2117, a new antithrombotic compound, on arachidonic acid metabolism. Rinsho Byori 1979, Suppl. 40:117-121.
29. Rademacher J., Galaburda A.M., Kennedy D.N., Filipek P.A., Caviness V.S. Human cerebral cortex: localization parcellation and morphometry with magnetic resonance imaging. J Cogn Neurosci 1992, 4:352-374.
30. Rapoport J., Giedd J., Blumenthal J., Hamburger S.D., Jeffries N., Fernadez T., et al. Progressive cortical change during adolescence in childhood-onset schizophrenia: a longitudinal magnetic resonance imaging study. Arch Gen Psychiatry 1999, 56:649-664.
31. Rapoport J.L., Giedd J., Kumra S., Jacobsen L., Smith A., Lee P., et al. Childhood-onset schizophrenia: progressive ventricular change during adolescence. Arch Gen Psychiatry 1997, 54:897-903.
32. Reitan R.M. Manual for administration of neurocognitive test batteries for adults and children 1979, Reitan Neurocognitive Laboratory, Tucson, AZ.
33. Rhinewine J., Lencz T., Thaden E., Cervellione K., Burdick K., Henderson I., et al. Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlates. Biol Psychiatry 2005, 58:705-712.
34. Sanides F., Hoffman J. Cyto- and myeloarchitecture of the visual cortex of the cat and of the surrounding integration cortices. J Hirnforsch 1969, 11:79-104.
35. Selemon L.D., Goldman-Rakic P.S. The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biol Psychiatry 1999, 45:17-25.
36. Selemon L.D., Mrzljak J., Kleinman J.E., Herman M.M., Goldman-Rakic P.S. Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9. Arch Gen Psychiatry 2003, 60:69-77.
37. Smith S.M. Fast robust automated brain extraction. Hum Brain Mapp 2002, 17:143-155.
38. Sowell E., Levitt J., Thompson P., Holmes C., Blanton R., Kornsand D., et al. Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance images. Am J Psychiatry 2000, 157:1475-1484.
39. Sullivan E.V., Shear P.K., Lim K.O., Zipursky R.B., Pfefferbaum A cognitive and motor impairments are related to gray matter volume deficits in schizophrenia. Biol Psychiatry 1996, 39:234-240.
40. Szeszko P.R., Bilder R.M., Lencz T., Pollack S., Alvir J.M., Ashtari M., et al. Investigation of frontal lobe subregions in first-episode schizophrenia. Psychiatry Res 1999, 90:1-15.
41. Szeszko P.R., Bilder R.M., Lencz T., Ashtari M., Goldman R.S., Reiter G., et al. Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia. Schizophr Res 2000, 43:97-108.
42. Szeszko P.R., MacMillan S., McMeniman M., Chen S., Baribault K., Lim K.O., et al. Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder. Am J Psychiatry 2004, 161:1049-1056.
43. Thompson P.M., Vidal C., Giedd J.N., Gochman P., Blumenthal J., Nicolson R., et al. Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia. Proc Natl Acad Sci 2001, 98:11650-11655.
44. Vidal C., Rapoport J., Hayashi K., Geaga J., Sui Y., McLemore L., et al. Dynamically spreading frontal and cingulate deficits mapped in adolescents with schizophrenia. Arch Gen Psychiatry 2006, 63:25-34.
45. Wechsler D. Manual for the Wechsler Intelligence Scale for Children 1991, The Psychological Corporation, Texas. 3rd ed.
46. Wechsler D. Wechsler Adult Intelligence Scale 1997, Harcourt Assessment, Texas. 3rd ed. (WAIS-3®).