Synthesis and characterization of photoaffinity probe of acetogenin, a strong inhibitor of mitochondrial complex i

Tetrahedron Letters

Volumn 52, Issue 24, 2011, Pages 3090-3093

  Yamamoto, Shuhei ^a   Abe, Masato ^a   Nakanishi, Sayo ^a   Murai, Masatoshi ^a   Miyoshi, Hideto ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Acetogenins; Mitochondrial complex I; Photoaffinity labeling; Radioiodination; Respiratory enzyme

Indexed keywords

ACETOGENIN; ENZYME INHIBITOR; IODINE 125; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ARTICLE; CHEMICAL STRUCTURE; COW; ENZYME STRUCTURE; ENZYME SUBUNIT; HEART MITOCHONDRION; NONHUMAN; PHOTOAFFINITY LABELING; SYNTHESIS;

BOVINAE;

EID: 79956014391     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.03.149     Document Type: Article

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26. 2O (50 μl) and subjected to HPLC (Shimadzu LC-10 AS) purification using a C18 column (COSMOSIL 5C18-MS-II, 4.6 × 150 mm, Nacalai Tesque) at a flow rate of 0.8 ml/min with isocratic 95% MeOH/water system as an eluent. The fraction was collected every 30 s (400 μl) and the radioactivity was measured by γ-counting system (COBRA™ II, Packard). The strong radioactive fractions, corresponding to a retention time of DANA (14.7 min), were combined and concentrated using vacuum-centrifugal evaporator (Fig. S1).
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