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Volumn 60, Issue 1, 2011, Pages 1-19

Therapeutic dose as the point of departure in assessing potential health hazards from drugs in drinking water and recycled municipal wastewater

Author keywords

Carcinogenic effects; Drinking water; Drugs or pharmaceuticals; Health effects assessment; Municipal wastewater; Reproductive and developmental effects; Therapeutic dose; Toxicity

Indexed keywords

CARCINOGEN; DRINKING WATER;

EID: 79956004095     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.12.010     Document Type: Article
Times cited : (60)

References (95)
  • 1
    • 0022393967 scopus 로고
    • Isolation and characterization of products from the nitrosation of the alkaloid gramine
    • Ahmad M.U., Libbey L.M., Barbour J.F., Scanlan R.A. Isolation and characterization of products from the nitrosation of the alkaloid gramine. Fd. Chem. Toxic. 1985, 23(9):841-847.
    • (1985) Fd. Chem. Toxic. , vol.23 , Issue.9 , pp. 841-847
    • Ahmad, M.U.1    Libbey, L.M.2    Barbour, J.F.3    Scanlan, R.A.4
  • 4
    • 79956005732 scopus 로고    scopus 로고
    • Australia. Australian Guidelines for Water Recycling (Phase 2) Augmentation of Drinking Water Supplies. 2008. Environmental Protection and Heritage Council, the Natural Resource Management Ministerial Council, and the Australian Health Ministers' Conference. May 2008. ISBN 1 921173 19 X.
    • Australia, 2008. Australian Guidelines for Water Recycling (Phase 2) Augmentation of Drinking Water Supplies. 2008. Environmental Protection and Heritage Council, the Natural Resource Management Ministerial Council, and the Australian Health Ministers' Conference. May 2008. ISBN 1 921173 19 X.
    • (2008)
  • 5
    • 62649114939 scopus 로고    scopus 로고
    • Evaluation of a photocatalytic reactor membrane pilot system for the removal of pharmaceuticals and endocrine disrupting compounds from water
    • Benotti M.J., Stanford B.D., Wert E.C., Snyder S.A. Evaluation of a photocatalytic reactor membrane pilot system for the removal of pharmaceuticals and endocrine disrupting compounds from water. Water Res. 2009, 43(6):1513-1522.
    • (2009) Water Res. , vol.43 , Issue.6 , pp. 1513-1522
    • Benotti, M.J.1    Stanford, B.D.2    Wert, E.C.3    Snyder, S.A.4
  • 6
    • 41949098620 scopus 로고    scopus 로고
    • Human health risk assessments for three neuropharmaceutical compounds in surface waters
    • Bercu J.P., Parke N.J., Fiori J.M., Meyeroff R.D. Human health risk assessments for three neuropharmaceutical compounds in surface waters. Reg. Toxicol. Pharmacol. 2008, 50(3):420-427.
    • (2008) Reg. Toxicol. Pharmacol. , vol.50 , Issue.3 , pp. 420-427
    • Bercu, J.P.1    Parke, N.J.2    Fiori, J.M.3    Meyeroff, R.D.4
  • 8
    • 0036024834 scopus 로고    scopus 로고
    • A broad spectrum analytical scheme for the screening of endocrine disruptors (EDs), pharmaceuticals and personal care products in wastewaters and natural waters
    • Bruchet A., Prompsy C., Filippi G., Souali A. A broad spectrum analytical scheme for the screening of endocrine disruptors (EDs), pharmaceuticals and personal care products in wastewaters and natural waters. Water Sci. Technol. 2002, 46(3):97-104.
    • (2002) Water Sci. Technol. , vol.46 , Issue.3 , pp. 97-104
    • Bruchet, A.1    Prompsy, C.2    Filippi, G.3    Souali, A.4
  • 9
    • 0033947603 scopus 로고    scopus 로고
    • Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate
    • Bull R.J. Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate. Environ. Health Perspect. 2000, 108(Suppl. 2):241-259.
    • (2000) Environ. Health Perspect. , vol.108 , Issue.SUPPL. 2 , pp. 241-259
    • Bull, R.J.1
  • 10
    • 84905567434 scopus 로고    scopus 로고
    • Use of chemical models and structure-activity relationships to identify novel disinfection by-products of potential toxicological concern. In: Karanfil, T., Krasner, S.W., Westerhoff, P., Xie, Y. (Eds.), Occurrence, Formation, Health Effects and Control of Disinfection By-Products in Drinking Water, Chapter 3. ACS Symposia Series
    • Bull, R.J., Reckhow, D.A., 2008. Use of chemical models and structure-activity relationships to identify novel disinfection by-products of potential toxicological concern. In: Karanfil, T., Krasner, S.W., Westerhoff, P., Xie, Y. (Eds.), Occurrence, Formation, Health Effects and Control of Disinfection By-Products in Drinking Water, Chapter 3. ACS Symposia Series, pp. 51-64.
    • (2008) , pp. 51-64
    • Bull, R.J.1    Reckhow, D.A.2
  • 11
  • 12
    • 79956025769 scopus 로고
    • CEPA (California Environmental Protection Agency). Safe Drinking Water and Toxic Enforcement Act of 1985) (Proposition 65) Status Report, No Significant Risk Levels for Carcinogens and Acceptable Intake Levels of Reproductive Toxicants Status Report. Office of Environmental Health Hazard Assessment, Sacramento, CA, USA.
    • CEPA (California Environmental Protection Agency). 1993. Safe Drinking Water and Toxic Enforcement Act of 1985) (Proposition 65) Status Report, No Significant Risk Levels for Carcinogens and Acceptable Intake Levels of Reproductive Toxicants Status Report. Office of Environmental Health Hazard Assessment, Sacramento, CA, USA.
    • (1993)
  • 13
    • 0032459770 scopus 로고    scopus 로고
    • Pharmaceuticals in the environment - A human risk?
    • Christensen F.M. Pharmaceuticals in the environment - A human risk?. Reg. Toxicol. Pharmacol. 1998, 28:212-221.
    • (1998) Reg. Toxicol. Pharmacol. , vol.28 , pp. 212-221
    • Christensen, F.M.1
  • 14
    • 8844236997 scopus 로고    scopus 로고
    • Estimating the safe starting dose in phase I clinical trials and no observed effect level on QSAR modeling of the human maximum recommended daily dose
    • Contrera J.F., Matthews E.J., Kruhlak N.L., Benz R.D. Estimating the safe starting dose in phase I clinical trials and no observed effect level on QSAR modeling of the human maximum recommended daily dose. Regul. Toxicol. Pharmacol. 2004, 40:185-206.
    • (2004) Regul. Toxicol. Pharmacol. , vol.40 , pp. 185-206
    • Contrera, J.F.1    Matthews, E.J.2    Kruhlak, N.L.3    Benz, R.D.4
  • 15
    • 79956005266 scopus 로고    scopus 로고
    • Identifying health effects concerns of the water reuse industry and prioritizing research needs for nomination of chemicals for research to appropriate National and International Agencies
    • WateReuse Foundation, Washington DC
    • Cotruvo J.A., Bull R.J., Crook J., Whittaker M. Identifying health effects concerns of the water reuse industry and prioritizing research needs for nomination of chemicals for research to appropriate National and International Agencies. WateReuse Project Report #06-004 2010, WateReuse Foundation, Washington DC.
    • (2010) WateReuse Project Report #06-004
    • Cotruvo, J.A.1    Bull, R.J.2    Crook, J.3    Whittaker, M.4
  • 16
    • 58749109763 scopus 로고    scopus 로고
    • Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment
    • Cunningham V.L., Binks S.P., Olson M.J. Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment. Reg. Toxicol. Pharmacol. 2009, 53:39-45.
    • (2009) Reg. Toxicol. Pharmacol. , vol.53 , pp. 39-45
    • Cunningham, V.L.1    Binks, S.P.2    Olson, M.J.3
  • 17
    • 0033383635 scopus 로고    scopus 로고
    • Pharmaceuticals and personal care products in the environment: agents of subtle change?
    • Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ. Health Perspect. 1999, 107(Suppl. 6):907-938.
    • (1999) Environ. Health Perspect. , vol.107 , Issue.SUPPL. 6 , pp. 907-938
    • Daughton, C.G.1    Ternes, T.A.2
  • 18
    • 0028642271 scopus 로고
    • Developmental toxicity of the HMG-CoA inhibitor, atorvastatin in rats and rabbits
    • Dostal L.A., Schardein J.L., Anderson J.A. Developmental toxicity of the HMG-CoA inhibitor, atorvastatin in rats and rabbits. Teratology 1994, 50(6):387-399.
    • (1994) Teratology , vol.50 , Issue.6 , pp. 387-399
    • Dostal, L.A.1    Schardein, J.L.2    Anderson, J.A.3
  • 19
    • 17144429420 scopus 로고    scopus 로고
    • Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins
    • Edison R.J., Muenke M. Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins. Am. J. Med. Genet. A 2004, 131(3):287-298.
    • (2004) Am. J. Med. Genet. A , vol.131 , Issue.3 , pp. 287-298
    • Edison, R.J.1    Muenke, M.2
  • 20
    • 47349128912 scopus 로고    scopus 로고
    • The role of PPAR-gamma and its interaction with COX-2 in pancreatic cancer
    • Eibl G. The role of PPAR-gamma and its interaction with COX-2 in pancreatic cancer. PPAR Res. 2008, 2008:326915.
    • (2008) PPAR Res. , vol.2008 , pp. 326915
    • Eibl, G.1
  • 21
    • 0018616686 scopus 로고
    • Kinetics and metabolism of carbamazepine during combined antiepileptic drug therapy
    • Eichelbaum M., Kothe K.W., Hoffman F., von Unruh G.E. Kinetics and metabolism of carbamazepine during combined antiepileptic drug therapy. Clin. Pharmacol. Ther. 1979, 26(3):366-371.
    • (1979) Clin. Pharmacol. Ther. , vol.26 , Issue.3 , pp. 366-371
    • Eichelbaum, M.1    Kothe, K.W.2    Hoffman, F.3    von Unruh, G.E.4
  • 23
    • 79955989987 scopus 로고    scopus 로고
    • Facts and Comparisons, Wolters Kluwer, St. Louis, MO 63146.
    • Facts and Comparisons® Version 4.0 2008, Facts and Comparisons, Wolters Kluwer, St. Louis, MO 63146.
    • (2008) Facts and Comparisons® Version 4.0
  • 24
    • 0027499718 scopus 로고
    • Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils
    • Furst S.M., Uetrecht J.P. Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils. Biochem. Pharmacol. 1993, 45:1267-1275.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 1267-1275
    • Furst, S.M.1    Uetrecht, J.P.2
  • 25
    • 34247588156 scopus 로고    scopus 로고
    • Pharmaceuticals in on-site sewage treatment and ground water, western Montana
    • Godfrey E., Woessner W.W., Benotti M.J. Pharmaceuticals in on-site sewage treatment and ground water, western Montana. Ground Water 2007, 45(3):263-271.
    • (2007) Ground Water , vol.45 , Issue.3 , pp. 263-271
    • Godfrey, E.1    Woessner, W.W.2    Benotti, M.J.3
  • 26
    • 79956056913 scopus 로고    scopus 로고
    • Carcinogen Potency Database (CPDB) [Online]. Available: <> March 15, 2008.
    • Gold, L. S., Slone, T.H., Manley, M.B., Garfinkel, G.B., Ames, B.N., 2008. Carcinogen Potency Database (CPDB) [Online]. Available: <> March 15, 2008. http://potency.berkeley.edu/pub/tables/chemicalsummary.
    • (2008)
    • Gold, L.S.1    Slone, T.H.2    Manley, M.B.3    Garfinkel, G.B.4    Ames, B.N.5
  • 27
    • 40049088000 scopus 로고    scopus 로고
    • PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators
    • Gonzalez F.J., Shah Y.M. PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology 2008, 246(1):2-8.
    • (2008) Toxicology , vol.246 , Issue.1 , pp. 2-8
    • Gonzalez, F.J.1    Shah, Y.M.2
  • 28
    • 0022540018 scopus 로고
    • Mephalan may be a more potent leukemogen than cyclophosphamide
    • Greene M., Harris HY.E.I.L., Gershensen D.M., et al. Mephalan may be a more potent leukemogen than cyclophosphamide. Ann. Int. Med. 1986, 105:360-367.
    • (1986) Ann. Int. Med. , vol.105 , pp. 360-367
    • Greene, M.1    Harris, H.Y.E.I.L.2    Gershensen, D.M.3
  • 29
    • 0031943859 scopus 로고    scopus 로고
    • Pre- and postnatal toxicity of the HMG-CoA reductase inhibitor, atorvastatin in rats
    • Henck J.W., Craft W.C., Black A., Colgin J., Anderson J.A. Pre- and postnatal toxicity of the HMG-CoA reductase inhibitor, atorvastatin in rats. Tox. Sci. 1998, 41(1):88-99.
    • (1998) Tox. Sci. , vol.41 , Issue.1 , pp. 88-99
    • Henck, J.W.1    Craft, W.C.2    Black, A.3    Colgin, J.4    Anderson, J.A.5
  • 30
    • 49249119674 scopus 로고    scopus 로고
    • A mixture of five phthalate esters inhibits fetal testicular testosterone production in the Sprague-Dawley rat in a cumulative, dose-additive manner
    • Howdeshell K.L., Wilson V.S., Furr J., Lambright C.R., Rider C.V., Blystone C.R., Hotchkiss A.K., Gray L.E. A mixture of five phthalate esters inhibits fetal testicular testosterone production in the Sprague-Dawley rat in a cumulative, dose-additive manner. Toxicol. Sci. 2008, 105(1):153-165.
    • (2008) Toxicol. Sci. , vol.105 , Issue.1 , pp. 153-165
    • Howdeshell, K.L.1    Wilson, V.S.2    Furr, J.3    Lambright, C.R.4    Rider, C.V.5    Blystone, C.R.6    Hotchkiss, A.K.7    Gray, L.E.8
  • 31
    • 0027936936 scopus 로고
    • Prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats by mevalonic acid supplementation
    • Hrab R.V., Hartman H.A., Cox R.H. Prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats by mevalonic acid supplementation. Teratology 1994, 50(1):19-26.
    • (1994) Teratology , vol.50 , Issue.1 , pp. 19-26
    • Hrab, R.V.1    Hartman, H.A.2    Cox, R.H.3
  • 33
    • 79956043612 scopus 로고
    • JECFA,. Joint FAO/WHO Expert Committee on Food Additives. NMRS 53/TRS 539-JECFA 17/18.
    • JECFA, 1873. Joint FAO/WHO Expert Committee on Food Additives. NMRS 53/TRS 539-JECFA 17/18.
    • (1873)
  • 34
    • 79956022502 scopus 로고    scopus 로고
    • JECFA, <>.
    • JECFA, 2008. <>. http://www.who.int/ipcs/food/jecfa/en/.
    • (2008)
  • 35
    • 33846844823 scopus 로고    scopus 로고
    • Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters
    • Kim S.D., Cho J., Kim I.S., Vanderford B.J., Snyder S.A. Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters. Water Res. 2007, 41:1013-1021.
    • (2007) Water Res. , vol.41 , pp. 1013-1021
    • Kim, S.D.1    Cho, J.2    Kim, I.S.3    Vanderford, B.J.4    Snyder, S.A.5
  • 36
    • 58349088276 scopus 로고    scopus 로고
    • Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes
    • Klavarioti M., Mantzavinos D., Kassinos D. Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes. Environ. Int. 2008, 35(2):402-417.
    • (2008) Environ. Int. , vol.35 , Issue.2 , pp. 402-417
    • Klavarioti, M.1    Mantzavinos, D.2    Kassinos, D.3
  • 37
    • 0037085574 scopus 로고    scopus 로고
    • Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: a national reconnaissance
    • Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 2002, 36:1202-1211.
    • (2002) Environ. Sci. Technol. , vol.36 , pp. 1202-1211
    • Kolpin, D.W.1    Furlong, E.T.2    Meyer, M.T.3    Thurman, E.M.4    Zaugg, S.D.5    Barber, L.B.6    Buxton, H.T.7
  • 38
    • 36049043771 scopus 로고    scopus 로고
    • Risks to aquatic organisms posed by human pharmaceutical use
    • Kostich M.S., Lazorchak J.M. Risks to aquatic organisms posed by human pharmaceutical use. Sci. Total Environ. 2008, 389:329-339.
    • (2008) Sci. Total Environ. , vol.389 , pp. 329-339
    • Kostich, M.S.1    Lazorchak, J.M.2
  • 40
    • 0027518356 scopus 로고
    • Caffeine-derived N-nitroso compounds. II. Synthesis and characterization of nitrosation products from caffeidine and caffeidine acid
    • Kumar R., Wacker C.-D., Mende P., Spiegelhalder B., Preussmann R., Siddiqi M. Caffeine-derived N-nitroso compounds. II. Synthesis and characterization of nitrosation products from caffeidine and caffeidine acid. Chem. Res. Toxicol. 1993, 6:50-58.
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 50-58
    • Kumar, R.1    Wacker, C.-D.2    Mende, P.3    Spiegelhalder, B.4    Preussmann, R.5    Siddiqi, M.6
  • 41
    • 0042548456 scopus 로고    scopus 로고
    • Biodegradability of the anti-tumor agent ifosfamide and its occurrence in hospital waste and communal sewage
    • Kümmerer K., Steger-Hartmann T., Meyer M. Biodegradability of the anti-tumor agent ifosfamide and its occurrence in hospital waste and communal sewage. Wat. Res. 1997, 31(11):2705-2710.
    • (1997) Wat. Res. , vol.31 , Issue.11 , pp. 2705-2710
    • Kümmerer, K.1    Steger-Hartmann, T.2    Meyer, M.3
  • 42
    • 0034789817 scopus 로고    scopus 로고
    • Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources - a review
    • Kümmerer K. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources - a review. Chemosphere 2001, 45:957-969.
    • (2001) Chemosphere , vol.45 , pp. 957-969
    • Kümmerer, K.1
  • 44
    • 79956030609 scopus 로고    scopus 로고
    • Leadscope FDA Toxicity Databases: Chemoinformatics Platform for Drug Discovery. <>.
    • Leadscope, 2008. FDA Toxicity Databases: Chemoinformatics Platform for Drug Discovery. <>. http://www.leadscope.com/.
    • (2008)
  • 45
    • 33746346155 scopus 로고    scopus 로고
    • Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada
    • Lishman L., Smyth S.A., Sarafin K., Kleywegt S., Toito J., Peart T., Lee B., Servos M., Beland M., Seto P. Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada. Sci. Total Environ. 2006, 367:544-558.
    • (2006) Sci. Total Environ. , vol.367 , pp. 544-558
    • Lishman, L.1    Smyth, S.A.2    Sarafin, K.3    Kleywegt, S.4    Toito, J.5    Peart, T.6    Lee, B.7    Servos, M.8    Beland, M.9    Seto, P.10
  • 46
    • 0029555342 scopus 로고
    • Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells
    • Liu Z.C., Uetrecht J.P. Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells. J. Pharmacol. Exp. Therapeut. 1995, 275:1476-1483.
    • (1995) J. Pharmacol. Exp. Therapeut. , vol.275 , pp. 1476-1483
    • Liu, Z.C.1    Uetrecht, J.P.2
  • 47
    • 32344449614 scopus 로고    scopus 로고
    • Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in Southern California
    • Loraine G., Pettigrove M.E. Seasonal variations in concentrations of pharmaceuticals and personal care products in drinking water and reclaimed wastewater in Southern California. Environ. Sci. Technol. 2006, 40:687-695.
    • (2006) Environ. Sci. Technol. , vol.40 , pp. 687-695
    • Loraine, G.1    Pettigrove, M.E.2
  • 48
    • 0028962803 scopus 로고
    • In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin using neonatal rat skeletal myocytes
    • Masters B.A., Palmoski M.J., Flint O.P., Gregg R.E., Wang-Iverson D., Durham S.K. In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin using neonatal rat skeletal myocytes. Toxicol. Appl. Pharmacol. 1995, 131(1):163-174.
    • (1995) Toxicol. Appl. Pharmacol. , vol.131 , Issue.1 , pp. 163-174
    • Masters, B.A.1    Palmoski, M.J.2    Flint, O.P.3    Gregg, R.E.4    Wang-Iverson, D.5    Durham, S.K.6
  • 49
    • 37349099580 scopus 로고    scopus 로고
    • Potential adverse effects of phthalate acid esters on human health: a review of recent studies on reproduction
    • Matsumoto M., Hirat-Koizumi M., Ema M. Potential adverse effects of phthalate acid esters on human health: a review of recent studies on reproduction. Regul. Toxicol. Pharmacol. 2008, 50(1):37-49.
    • (2008) Regul. Toxicol. Pharmacol. , vol.50 , Issue.1 , pp. 37-49
    • Matsumoto, M.1    Hirat-Koizumi, M.2    Ema, M.3
  • 50
    • 8844287955 scopus 로고    scopus 로고
    • Assessment of health effects of chemicals in humans I. QSAR estimation of the maximum recommended therapeutic dose (MRTD) and no effect level (NOEL) of organic chemicals based upon clinical trial data
    • Matthews E.J., Kruhlak N.L., Benz R.D., Contrera J.F. Assessment of health effects of chemicals in humans I. QSAR estimation of the maximum recommended therapeutic dose (MRTD) and no effect level (NOEL) of organic chemicals based upon clinical trial data. Curr. Drug Discovery Technol. 2004, 1:61-76.
    • (2004) Curr. Drug Discovery Technol. , vol.1 , pp. 61-76
    • Matthews, E.J.1    Kruhlak, N.L.2    Benz, R.D.3    Contrera, J.F.4
  • 51
    • 79956029645 scopus 로고    scopus 로고
    • Facts and Comparisons staff. Personal communication, 08-06-08.
    • Meaves, C., 2008. Facts and Comparisons staff. Personal communication, 08-06-08.
    • (2008)
    • Meaves, C.1
  • 52
    • 0029071838 scopus 로고
    • Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC
    • Mirvish S.S. Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett. 1995, 93:17-48.
    • (1995) Cancer Lett. , vol.93 , pp. 17-48
    • Mirvish, S.S.1
  • 53
    • 0036332795 scopus 로고    scopus 로고
    • Factors controlling nitrosamine formation during wastewater chlorination
    • Mitch W.A., Sedlak D.L. Factors controlling nitrosamine formation during wastewater chlorination. Water Sci. Technol.: Water Supply 2002, 2(3):191-198.
    • (2002) Water Sci. Technol.: Water Supply , vol.2 , Issue.3 , pp. 191-198
    • Mitch, W.A.1    Sedlak, D.L.2
  • 54
    • 0030989616 scopus 로고    scopus 로고
    • Oxidation of dichlofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid
    • Miyamoto G., Zahid N., Uetrecht J.P. Oxidation of dichlofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid. Chem. Res. Toxicol. 1997, 1997(10):414-419.
    • (1997) Chem. Res. Toxicol. , vol.1997 , Issue.10 , pp. 414-419
    • Miyamoto, G.1    Zahid, N.2    Uetrecht, J.P.3
  • 56
    • 0003938534 scopus 로고    scopus 로고
    • NRC, National Research Council, National Academy Press, Washington, DC
    • Copper in Drinking Water 2000, NRC, National Research Council, National Academy Press, Washington, DC.
    • (2000) Copper in Drinking Water
  • 57
    • 79956055426 scopus 로고
    • NTP, Toxicology and carcinogenesis studies of 5,5-diphenylhydantoin (CAS No. 57-41-0)(Phenytoin) in F344/N rats and B6C3F1 mice (Feed studies). TR-404 - National Toxicology Program, NIEHS, Research Triangle Park, NC.
    • NTP, 1993. Toxicology and carcinogenesis studies of 5,5-diphenylhydantoin (CAS No. 57-41-0)(Phenytoin) in F344/N rats and B6C3F1 mice (Feed studies). TR-404 - National Toxicology Program, NIEHS, Research Triangle Park, NC.
    • (1993)
  • 58
    • 79956049389 scopus 로고    scopus 로고
    • NTP Toxicology and carcinogenesis studies of ethinyl estradiol (CAS No. 57-63-6) in Sprague-Dawley rats (Feed studies). TR-548 - Abstract - National Toxicology Program. <>.
    • NTP, 2008. Toxicology and carcinogenesis studies of ethinyl estradiol (CAS No. 57-63-6) in Sprague-Dawley rats (Feed studies). TR-548 - Abstract - National Toxicology Program. <>. http://ntp.niehs.nih.gov/?objectid=D7C7E75B-F1F6-975E-7960632E81DA3E97.
    • (2008)
  • 59
    • 79956029253 scopus 로고    scopus 로고
    • NTP. National Toxicology Program Website. <>.
    • NTP, 2009. National Toxicology Program Website. <>. http://ntp-server.niehs.nih.gov/.
    • (2009)
  • 60
    • 0029160914 scopus 로고
    • Role of reactive metabolites in drug-induced hepatitis
    • Pessayre D. Role of reactive metabolites in drug-induced hepatitis. J. Hepatol. 1995, 23(Suppl. 1):16-24.
    • (1995) J. Hepatol. , vol.23 , Issue.SUPPL. 1 , pp. 16-24
    • Pessayre, D.1
  • 61
    • 3242714803 scopus 로고    scopus 로고
    • Transformation of aromatic ether and amine-containing pharmaceuticals during chlorine disinfection
    • Pinkston R.E., Sedlak D.L. Transformation of aromatic ether and amine-containing pharmaceuticals during chlorine disinfection. Environ. Sci. Technol. 2004, 38:4019-4025.
    • (2004) Environ. Sci. Technol. , vol.38 , pp. 4019-4025
    • Pinkston, R.E.1    Sedlak, D.L.2
  • 62
    • 0031573943 scopus 로고    scopus 로고
    • The effects of angiotensin II and specific antagonist receptor blockers on embryonic cardiac development and looping patterns
    • Price R.L., Carver W., Simpson D.G., Fu L., Zhao J., Borg T.K., Terracio L. The effects of angiotensin II and specific antagonist receptor blockers on embryonic cardiac development and looping patterns. Dev. Biol. 1997, 192(2):572-584.
    • (1997) Dev. Biol. , vol.192 , Issue.2 , pp. 572-584
    • Price, R.L.1    Carver, W.2    Simpson, D.G.3    Fu, L.4    Zhao, J.5    Borg, T.K.6    Terracio, L.7
  • 63
    • 0028347920 scopus 로고
    • Caffeine-derived N-nitroso compounds. IV. Kinetics of mononitrosocaffeidine demethylation by rat liver microsomes
    • Razda R., Frei E., Spiegelhalder B., Siddiqi M. Caffeine-derived N-nitroso compounds. IV. Kinetics of mononitrosocaffeidine demethylation by rat liver microsomes. Cancer Lett. 1994, 79(1):117-122.
    • (1994) Cancer Lett. , vol.79 , Issue.1 , pp. 117-122
    • Razda, R.1    Frei, E.2    Spiegelhalder, B.3    Siddiqi, M.4
  • 64
    • 0029982224 scopus 로고    scopus 로고
    • Differential effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on development of young rats
    • Reijneveld J.C., Root R.W., Bredman J.J., Joles J.A., Bar P.R. Differential effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on development of young rats. Pediatr. Res. 1996, 39(6):1028-1035.
    • (1996) Pediatr. Res. , vol.39 , Issue.6 , pp. 1028-1035
    • Reijneveld, J.C.1    Root, R.W.2    Bredman, J.J.3    Joles, J.A.4    Bar, P.R.5
  • 65
    • 40349110847 scopus 로고    scopus 로고
    • A mixture of seven antiandrogens induces reproductive malformations in rats
    • Rider C.V., Furr J., Wilson V.S., Gray L.E. A mixture of seven antiandrogens induces reproductive malformations in rats. Int. J. Androl. 2008, 31:249-262.
    • (2008) Int. J. Androl. , vol.31 , pp. 249-262
    • Rider, C.V.1    Furr, J.2    Wilson, V.S.3    Gray, L.E.4
  • 66
    • 79956002792 scopus 로고    scopus 로고
    • RxList <>.
    • RxList, 2007. <>. http://www.rxlist.com/script/main/hp.asp.
    • (2007)
  • 67
    • 33745204653 scopus 로고    scopus 로고
    • Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver
    • Rusyn I., Peters J.M., Cunningham M.L. Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Crit. Rev. Toxicol. 2006, 36(5):459-479.
    • (2006) Crit. Rev. Toxicol. , vol.36 , Issue.5 , pp. 459-479
    • Rusyn, I.1    Peters, J.M.2    Cunningham, M.L.3
  • 68
    • 33749585599 scopus 로고    scopus 로고
    • The steroid biosynthesis pathway as a target for endocrine-disrupting chemicals
    • Sanderson J.T. The steroid biosynthesis pathway as a target for endocrine-disrupting chemicals. Toxicol. Sci. 2006, 94(1):3-21.
    • (2006) Toxicol. Sci. , vol.94 , Issue.1 , pp. 3-21
    • Sanderson, J.T.1
  • 69
    • 0018776747 scopus 로고
    • Carcinogenic action of low-dose cyclophosphamide giver orally to Sprague-Dawley rats in a lifetime experiment
    • Schmahl D., Habs M. Carcinogenic action of low-dose cyclophosphamide giver orally to Sprague-Dawley rats in a lifetime experiment. Int. J. Cancer 1979, 23:706-712.
    • (1979) Int. J. Cancer , vol.23 , pp. 706-712
    • Schmahl, D.1    Habs, M.2
  • 73
    • 0029122952 scopus 로고
    • Defining the susceptible period of developmental toxicity for the AT1-selective angiotensin II receptor antagonist losartan in rats
    • Spence S.G., Allen H.L., Cukierski M.A., Manson J.M., Robertson R.T., Eydelloth R.S. Defining the susceptible period of developmental toxicity for the AT1-selective angiotensin II receptor antagonist losartan in rats. Teratology 1995, 51(6):367-382.
    • (1995) Teratology , vol.51 , Issue.6 , pp. 367-382
    • Spence, S.G.1    Allen, H.L.2    Cukierski, M.A.3    Manson, J.M.4    Robertson, R.T.5    Eydelloth, R.S.6
  • 74
    • 0029166273 scopus 로고
    • Evaluation of the reproductive and developmental toxicity of the ATI-selective angiotensin II receptor antagonist losartan in rats
    • Spence S.G., Cukierski M.A., Manson J.M., Robertson R.T., Eydelloth R.S. Evaluation of the reproductive and developmental toxicity of the ATI-selective angiotensin II receptor antagonist losartan in rats. Teratology 1995, 51(6):383-397.
    • (1995) Teratology , vol.51 , Issue.6 , pp. 383-397
    • Spence, S.G.1    Cukierski, M.A.2    Manson, J.M.3    Robertson, R.T.4    Eydelloth, R.S.5
  • 76
    • 0021072407 scopus 로고
    • Regulation of rat liver hydroxymethylglutaryl Coenzyme A reductase by a new class of noncompetitive inhibitors
    • Stacpoole P.W., Harwood H.J., Varnado C.E. Regulation of rat liver hydroxymethylglutaryl Coenzyme A reductase by a new class of noncompetitive inhibitors. J. Clin. Invest. 1983, 72:1575-1585.
    • (1983) J. Clin. Invest. , vol.72 , pp. 1575-1585
    • Stacpoole, P.W.1    Harwood, H.J.2    Varnado, C.E.3
  • 77
    • 0002837142 scopus 로고    scopus 로고
    • Trace analysis of the antineoplastics ifosfamide in the sewage water by two-step solid phase extraction and gas-chromatography-mass spectrometry
    • Steger-Hartmann T., Kümmer K., Schecker J. Trace analysis of the antineoplastics ifosfamide in the sewage water by two-step solid phase extraction and gas-chromatography-mass spectrometry. J. Chromatogr. A 1996, 726:179-184.
    • (1996) J. Chromatogr. A , vol.726 , pp. 179-184
    • Steger-Hartmann, T.1    Kümmer, K.2    Schecker, J.3
  • 78
    • 0031105636 scopus 로고    scopus 로고
    • Biological degradation of cyclophosphamide and its occurrence in sewage water
    • Steger-Hartmann T., Kümmer K., Hartmann A. Biological degradation of cyclophosphamide and its occurrence in sewage water. Ecotoxicol. Environ. Safety 1997, 36:174-177.
    • (1997) Ecotoxicol. Environ. Safety , vol.36 , pp. 174-177
    • Steger-Hartmann, T.1    Kümmer, K.2    Hartmann, A.3
  • 79
    • 34547688006 scopus 로고    scopus 로고
    • The occurrence of micropollutants in the aquatic environment: a new challenge for water management
    • Ternes T. The occurrence of micropollutants in the aquatic environment: a new challenge for water management. Water Sci. Technol. 2007, 55(12):327-332.
    • (2007) Water Sci. Technol. , vol.55 , Issue.12 , pp. 327-332
    • Ternes, T.1
  • 80
    • 10644220428 scopus 로고    scopus 로고
    • Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process
    • Thomas P.M., Foster G.D. Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process. Environ. Toxicol. Chem. 2005, 24(1):25-30.
    • (2005) Environ. Toxicol. Chem. , vol.24 , Issue.1 , pp. 25-30
    • Thomas, P.M.1    Foster, G.D.2
  • 81
    • 0028911862 scopus 로고
    • Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine induced agranulocytosis
    • Uetrecht J.P., Ma H.M., MacKnight E., McClelland R. Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine induced agranulocytosis. Chem. Res. Toxicol. 1995, 8:226-233.
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 226-233
    • Uetrecht, J.P.1    Ma, H.M.2    MacKnight, E.3    McClelland, R.4
  • 82
    • 0026066014 scopus 로고
    • N-Chlorination and oxidation of procainamide by myeloperoxidase: toxicological implications
    • Uetrecht J.P., Zahid N. N-Chlorination and oxidation of procainamide by myeloperoxidase: toxicological implications. Chem. Res. Toxicol. 1991, 4:218-222.
    • (1991) Chem. Res. Toxicol. , vol.4 , pp. 218-222
    • Uetrecht, J.P.1    Zahid, N.2
  • 83
    • 79956045287 scopus 로고    scopus 로고
    • US EPA Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures. EPA/630/R-00/002.
    • US EPA, 2000. Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures. EPA/630/R-00/002.
    • (2000)
  • 84
    • 79956031412 scopus 로고    scopus 로고
    • US EPA, A Review of the Reference Dose and Reference Concentration Processes. EPA/630/P-02/002F. Final Report December
    • US EPA, 2002. A Review of the Reference Dose and Reference Concentration Processes. EPA/630/P-02/002F. Final Report December, 2002.
    • (2002)
  • 85
    • 79956017903 scopus 로고    scopus 로고
    • US EPA, 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F. Final report, March
    • US EPA, 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F. Final report, March 2005.
    • (2005)
  • 86
    • 79956022498 scopus 로고    scopus 로고
    • US EPA, Contaminant Candidate List 3 Chemicals: Classification of the PCCL to CCL. EPA 815-R-08-004, Feb. 2008 draft. EPA Office of Ground Water and Drinking Water. <>.
    • US EPA, 2008a. Contaminant Candidate List 3 Chemicals: Classification of the PCCL to CCL. EPA 815-R-08-004, Feb. 2008 draft. EPA Office of Ground Water and Drinking Water. <>. http://www.epa.gov/safewater.
    • (2008)
  • 87
    • 79956052426 scopus 로고    scopus 로고
    • US EPA, Chemicals Reported in Articles Reviewed from the OW PPCP Inventory. COMPREHENSIVE TABLE (Inventory July 3, 2008).
    • US EPA, 2008b. Chemicals Reported in Articles Reviewed from the OW PPCP Inventory. COMPREHENSIVE TABLE (Inventory July 3, 2008).
    • (2008)
  • 88
    • 79956043609 scopus 로고    scopus 로고
    • US FDA. US Food and Drug Administration. CDER Report to the Nation 2005: Improving Public Health through Human Drugs. Rockville, MD. <>.
    • US FDA, 2005. US Food and Drug Administration. CDER Report to the Nation 2005: Improving Public Health through Human Drugs. Rockville, MD. <>. http://www.fda.gov/cder/reports/rtn/2005/rtn2005.pdf.
    • (2005)
  • 89
    • 79956016658 scopus 로고    scopus 로고
    • US FDA. US Food and Drug Administration Maximum Recommended Therapeutic Dose (MRTD) Database. <>.
    • US FDA, 2007. US Food and Drug Administration Maximum Recommended Therapeutic Dose (MRTD) Database. <>. http://www.fda.gov/cder/Offices/OPS_IO/MRTD.htm.
    • (2007)
  • 90
    • 79956006584 scopus 로고    scopus 로고
    • US FDA. US Food and Drug Adminstration. Drug Information. Preventable Adverse Drug Reactions: A Focus on Drug Interactions. <>.
    • US FDA, 2008a. US Food and Drug Adminstration. Drug Information. Preventable Adverse Drug Reactions: A Focus on Drug Interactions. <>. http://www.fda.gov/CDER/DRug/drugReactions/default.htm.
    • (2008)
  • 91
    • 79956048609 scopus 로고    scopus 로고
    • US FDA, US Food and Drug Administration. Index to Drug-Specific Information. <>.
    • US FDA, 2008b. US Food and Drug Administration. Index to Drug-Specific Information. <>. http://www.fda.gov/cder/DrugSafety/DrugIndex.htm.
    • (2008)
  • 92
    • 79955984419 scopus 로고    scopus 로고
    • US FDA, US Food and Drug Administration. Office of Non-Prescription Drugs: Consumer Information: Safe Use of Over-the-Counter Drug Products. <>.
    • US FDA, 2008c. US Food and Drug Administration. Office of Non-Prescription Drugs: Consumer Information: Safe Use of Over-the-Counter Drug Products. <>. http://www.fda.gov/cder/offices/OTC/consumer.htm.
    • (2008)
  • 93
    • 79956053680 scopus 로고    scopus 로고
    • US FDA. US Food and Drug Administration. MedWatch: The FDA Safety Information and Adverse Event Reporting Program. <>.
    • US FDA, 2008d. US Food and Drug Administration. MedWatch: The FDA Safety Information and Adverse Event Reporting Program. <>. http://www.accessdatga.fda.gov/scripts/medwatch.
    • (2008)
  • 94
    • 79956016657 scopus 로고    scopus 로고
    • Desk Based Review of Current Knowledge of Pharmaceuticals in Drinking Water and Estimation of Potential Levels. Watts and Crane Associates Final Report to Drinking Water Inspectorate of UK Contract No. CSA7184/WT02046/DWI 70/2/213.
    • Watts, C., Maycock, D., Crane, M., Fawell, J., 2007. Desk Based Review of Current Knowledge of Pharmaceuticals in Drinking Water and Estimation of Potential Levels. Watts and Crane Associates Final Report to Drinking Water Inspectorate of UK Contract No. CSA7184/WT02046/DWI 70/2/213.
    • (2007)
    • Watts, C.1    Maycock, D.2    Crane, M.3    Fawell, J.4
  • 95
    • 0037447750 scopus 로고    scopus 로고
    • Indirect human exposure to pharmaceuticals via drinking water
    • Webb S., Ternes T., Gibert M., Olejniczak K. Indirect human exposure to pharmaceuticals via drinking water. Toxicol. Lett. 2003, 142:157-167.
    • (2003) Toxicol. Lett. , vol.142 , pp. 157-167
    • Webb, S.1    Ternes, T.2    Gibert, M.3    Olejniczak, K.4


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