ZAS3 promotes TNFα-induced apoptosis by blocking NFκB-activated expression of the anti-apoptotic genes TRAF1 and TRAF2

BMB Reports

Volumn 44, Issue 4, 2011, Pages 267-272

  Shin, Dong Hyeon ^a   Park, Kye Won ^b   Wu, Lai Chu ^c,d   Hong, Joung Woo ^a  

^a Kyung Hee University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c OHIO STATE UNIVERSITY   (United States)

^d THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Anti apoptosis; NF B; TNF signaling; Tumor suppression; ZAS3

Indexed keywords

CASPASE; DNA BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; ZAS3 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL STRAIN HEK293; GEL MOBILITY SHIFT ASSAY; GENETICS; HUMAN; METABOLISM;

APOPTOSIS; CASPASES; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEK293 CELLS; HUMANS; NF-KAPPA B; TNF RECEPTOR-ASSOCIATED FACTOR 1; TNF RECEPTOR-ASSOCIATED FACTOR 2; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79955991902     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.4.267     Document Type: Article

References (31)

1. Sen, R. and Baltimore, D. (1986) Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46, 705-716.
2. Singh, H., Sen, R., Baltimore, D. and Sharp, P. A. (1986) A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature 319, 154-158.
3. Chen, F., Castranova, V., Shi, X. and Demers, L. M. (1999) New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin. Chem. 45, 7-17.
4. Ghosh, S., May, M. J. and Kopp, E. B. (1998) NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260.
5. Perkins, N. D. (2000) The Rel/NF-κB family: friend and foe. Trends Biochem. Sci. 25, 434-440.
6. Cabannes, E., Khan, G., Aillet, F., Jarrett, R. F. and Hay, R. T. (1999) Mutations in the IκBα gene in Hodgkin's disease suggest a tumour suppressor role for IκBα. Oncogene 18, 3063-3070.
7. Baldwin, A. S. Jr. (2001) Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J. Clin. Invest. 107, 241-246.
8. Arsura, M., Mercurio, F., Oliver, A. L., Thorgeirsson, S. S. and Sonenshein, G. E. (2000) Role of the IκB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells. Mol. Cell Biol. 20, 5381-5391.
9. Sovak, M. A., Bellas, R. E., Kim, D. W., Zanieski, G. J., Rogers, A. E., Traish, A. M. and Sonenshein, G. E. (1997) Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer. J. Clin. Invest. 100, 2952-2960.
10. Aggarwal, B. B. (2000) Tumour necrosis factors receptor associated signaling molecules and their role in activation of apoptosis, JNK and NF-κB. Ann. Rheum. Dis. 59 (Suppl 1), i6-16.
11. Chen, G. and Goeddel, D. V. (2002) TNF-R1 signaling: a beautiful pathway. Science 296, 1634-1635.
12. Hsu, H., Xiong, J. and Goeddel, D. V. (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 81, 495-504.
13. Fernandes-Alnemri, T., Armstrong, R. C., Krebs, J., Srinivasula, S. M., Wang, L., Bullrich, F., Fritz, L. C., Trapani, J. A., Tomaselli, K. J., Litwack, G. and Alnemri, E. S. (1996) In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADDlike domains. Proc. Natl. Acad. Sci. U.S.A. 93, 7464-7469.
14. Wang, C. Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V. and Baldwin, A. S. Jr. (1998) NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 1680-1683.
15. Wu, L. C., Mak, C. H., Dear, N., Boehm, T., Foroni, L. and Rabbitts, T. H. (1993) Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination. Nucleic Acids Res. 21, 5067-5073.
16. Allen, C. E., Mak, C. H. and Wu, L. C. (2002) The κB transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study. BMC Immunol. 3, 10.
17. Mak, C. H., Strandtmann, J. and Wu, L. C. (1994) The V(D)J recombination signal sequence and κB binding protein Rc binds DNA as dimers and forms multimeric structures with its DNA ligands. Nucleic Acids Res. 22, 383-390.
18. Allen, C. E., Muthusamy, N., Weisbrode, S. E., Hong, J. W. and Wu, L. C. (2002) Developmental anomalies and neoplasia in animals and cells deficient in the large zinc finger protein KRC. Genes Chromosomes Cancer 35, 287-298.
19. Allen, C. E. and Wu, L. C. (2000) Downregulation of KRC induces proliferation, anchorage independence, and mitotic cell death in HeLa cells. Exp. Cell Res. 260, 346-356.
20. Hong, J. W., Allen, C. E. and Wu, L. C. (2003) Inhibition of NF-κB by ZAS3, a zinc-finger protein that also binds to the κB motif. Proc. Natl. Acad. Sci. U.S.A. 100, 12301-12306.
21. Hong, J. W. and Wu, L. C. (2010) ZAS3 represses NFκBdependent transcription by direct competition for DNA binding. BMB Rep. 43, 807-812.
22. Brockman, J. A., Scherer, D. C., McKinsey, T. A., Hall, S. M., Qi, X., Lee, W. Y. and Ballard, D. W. (1995) Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-κB activation. Mol. Cell Biol. 15, 2809-2818.
23. Guttridge, D. C., Albanese, C., Reuther, J. Y., Pestell, R. G. and Baldwin, A. S. Jr. (1999) NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell Biol. 19, 5785-5799.
24. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., Litwack, G. and Alnemri, E. S. (1996) Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. 93, 14486-14491.
25. Chen, D., Li, X., Zhai, Z. and Shu, H. B. (2002) A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-κB activation. J. Biol. Chem. 277, 15985-15991.
26. Takeuchi, M., Rothe, M. and Goeddel, D. V. (1996) Anatomy of TRAF2. Distinct domains for nuclear factor-κB activation and association with tumor necrosis factor signaling proteins. J. Biol. Chem. 271, 19935-19942.
27. Wu, L. C. (2002) ZAS: C2H2 zinc finger proteins involved in growth and development. Gene Expr. 10, 137-152.
28. Song, H. Y., Regnier, C. H., Kirschning, C. J., Goeddel, D. V. and Rothe, M. (1997) Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc. Natl. Acad. Sci. U.S.A. 94, 9792-9796.
29. Wajant, H. and Scheurich, P. (2001) Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling. Int. J. Biochem. Cell Biol. 33, 19-32.
30. Sanda, T., Iida, S., Ogura, H., Asamitsu, K., Murata, T., Bacon, K. B., Ueda, R. and Okamoto, T. (2005) Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor. Clin. Cancer Res. 11, 1974-1982.
31. Tanaka, A., Muto, S., Konno, M., Itai, A. and Matsuda, H. (2006) A new IκB kinaseβ inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res. 66, 419-426.