Beneficial effects of rosuvastatin on aortic adverse remodeling in nitric oxide-deficient rats

Experimental and Toxicologic Pathology

Volumn 63, Issue 5, 2011, Pages 473-478

  Neto Ferreira, Rodrigo ^a   Novaes Rocha, Vinícius ^a   da Silva Torres, Thiago ^a   Mandarim de Lacerda, Carlos Alberto ^a   de Carvalho, Jorge Jose ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Hypertension; L NAME; Nitric oxide; Rats; Statin; Vascular remodeling

Indexed keywords

CHOLESTEROL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; ROSUVASTATIN; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKENING; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CELL STRUCTURE; CELL VACUOLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOPLASM; DRUG EFFICACY; ELASTIC FIBER; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HEART MUSCLE TENSION; HYPERTENSION; NONHUMAN; RAT; SMOOTH MUSCLE FIBER; STRESS; TENSILE STRESS; THORACIC AORTA; TRIACYLGLYCEROL BLOOD LEVEL; ULTRASTRUCTURE;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FLUOROBENZENES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION; IMMUNOHISTOCHEMISTRY; LIPIDS; MICROSCOPY, ELECTRON, TRANSMISSION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PYRIMIDINES; RATS; RATS, WISTAR; SULFONAMIDES; TUNICA INTIMA;

RATTUS; RATTUS NORVEGICUS;

EID: 79955972411     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2010.03.007     Document Type: Article

References (30)

1. Alvarez de Sotomayor M., Perez-Guerrero C., Herrera M.D., Marhuenda E. Effects of chronic treatment with simvastatin on endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 1999, 17:769-776.
2. Babal P., Pechanova O., Bernatova I., Stvrtina S. Chronic inhibition of NO synthesis produces myocardial fibrosis and arterial media hyperplasia. Histol Histopathol 1997, 12:623-629.
3. Bayraktutan U. Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth. J Mol Cell Cardiol 2004, 36:277-286.
4. Belay B., Belamarich P.F., Tom-Revzon C. The use of statins in pediatrics: knowledge base, limitations, and future directions. Pediatrics 2007, 119:370-380.
5. Bernatova I., Pechanova O., Kristek F. Mechanism of structural remodelling of the rat aorta during long-term NG-nitro-l-arginine methyl ester treatment. Jpn J Pharmacol 1999, 81:99-106.
6. Bezerra D.G., Mandarim-de-Lacerda C.A. Beneficial effect of simvastatin and pravastatin treatment on adverse cardiac remodelling and glomeruli loss in spontaneously hypertensive rats. Clin Sci (Lond) 2005, 108:349-355.
7. Carallo C., Irace C., Pujia A., De Franceschi M.S., Crescenzo A., Motti C., et al. Evaluation of common carotid hemodynamic forces. Relations with wall thickening. Hypertension 1999, 34:217-221.
8. Cernadas M.R., Sanchez de Miguel L., Garcia-Duran M., Gonzalez-Fernandez F., Millas I., Monton M., et al. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Circ Res 1998, 83:279-286.
9. Davignon J., Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004, 109:III27-III32.
10. Fullmer H.M., Lillie R.D. A selective stain for elastic tissue (orcinol-new fuchsin). Stain Technol 1956, 31:27-29.
11. Girerd X., Giral P. Risk stratification for the prevention of cardiovascular complications of hypertension. Curr Med Res Opin 2004, 20:1137-1142.
12. Greenwood J., Mason J.C. Statins and the vascular endothelial inflammatory response. Trends Immunol 2007, 28:88-98.
13. Ii M., Losordo D.W. Statins and the endothelium. Vasc Pharmacol 2007, 46:1-9.
14. Kiyan J, Kusch A, Tkachuk S, Kramer J, Haller H, Dietz R, et al. Rosuvastatin regulates vascular smooth muscle cell phenotypic modulation in vascular remodeling: role for the urokinase receptor. Atherosclerosis 2007.
15. Loch D., Levick S., Hoey A., Brown L. Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats. J Cardiovasc Pharmacol 2006, 47:396-404.
16. Maejima Y., Adachi S., Morikawa K., Ito H., Isobe M. Nitric oxide inhibits myocardial apoptosis by preventing caspase-3 activity via S-nitrosylation. J Mol Cell Cardiol 2005, 38:163-174.
17. Mandarim-de-Lacerda C.A., Fernandes-Santos C., Aguila M.B. Image analysis and quantitative morphology. Histology protocols: methods in molecular biology 2010, 211-225. Humana Press, New Jersey. T.D. Hewitson, J.A. Darby (Eds.).
18. Mendonca L.S., Fernandes-Santos C., Mandarim-de-Lacerda C.A. Cardiac and aortic structural alterations due to surgically-induced menopause associated with renovascular hypertension in rats. Int J Exp Pathol 2007, 88:301-309.
19. Nicholls S.J., Tuzcu E.M., Sipahi I., Grasso A.W., Schoenhagen P., Hu T., et al. Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis. JAMA 2007, 297:499-508.
20. Pereira L.M., Bezerra D.G., Mandarim-de-Lacerda C.A. Aortic wall remodeling in rats with nitric oxide deficiency treated by enalapril or verapamil. Pathol Res Pract 2004, 200:211-217.
21. Pereira L.M.M., Vianna G.M.M., Mandarim-de-Lacerda C.A. Stereology of the myocardium in hypertensive rats. Differences in relation to the time of inhibition of nitric oxide synthesis. Virchows Arch 1998, 433:369-373.
22. Prado C.M., Rossi M.A. Circumferential wall tension due to hypertension plays a pivotal role in aorta remodelling. Int J Exp Pathol 2006, 87:425-436.
23. Ribeiro M.O., Antunes E., Nucci G., Lovisolo S.M., Zatz R. Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension. Hypertension 1992, 20:298-303.
24. Rossi M.A., Colombini-Netto M. Chronic inhibition of NO synthesis per se promotes structural intimal remodeling of the rat aorta. J Hypert 2001, 19:1567-1579.
25. Sicard P., Delemasure S., Korandji C., Segueira-Le Grand A., Lauzier B., Guilland J.C., et al. Anti-hypertensive effects of Rosuvastatin are associated with decreased inflammation and oxidative stress markers in hypertensive rats. Free Radic Res 2008, 42:226-236.
26. Srinivasan S.R., Myers L., Berenson G.S. Changes in metabolic syndrome variables since childhood in prehypertensive and hypertensive subjects: the bogalusa heart study. Hypertension 2006, 48:33-39.
27. Suh J.W., Choi D.J., Chang H.J., Cho Y.S., Youn T.J., Chae I.H., et al. HMG-CoA reductase inhibitor improves endothelial dysfunction in spontaneous hypertensive rats via down-regulation of caveolin-1 and activation of endothelial nitric oxide synthase. J Korean Med Sci 2010, 25:16-23.
28. Susic D., Varagic J., Ahn J., Slama M., Frohlich E.D. Beneficial pleiotropic vascular effects of rosuvastatin in two hypertensive models. J Am Coll Cardiol 2003, 42:1091-1097.
29. Virdis A., Colucci R., Versari D., Ghisu N., Fornai M., Antonioli L., et al. Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids. Hypertension 2009, 53:1008-1016.
30. Zhou M.S., Schulman I.H., Raij L. Nitric oxide, angiotensin II, and hypertension. Semin Nephrol 2004, 24:366-378.