The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction

Aging Cell

Volumn 10, Issue 3, 2011, Pages 483-492

  Minor, Robin K ^a   López, Miguel ^b,c   Younts, Caitlin M ^a   Jones, Bruce ^a   Pearson, Kevin J ^a,d   Michael Anson, Robert ^a,e   Diéguez, Carlos ^b,c   de Cabo, Rafael ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c Instituto de Salud Carlos III   (Spain)

^d UNIVERSITY OF KENTUCKY   (United States)

^e CCBC School of Mathematics and Science   (United States)

Author keywords

Calorie restriction; Hypothalamus; Monosodium glutamate; Neuroendocrine; Neuropeptide Y; Tumorigenesis

Indexed keywords

ADIPONECTIN; GLUTAMATE SODIUM; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; CALORIC RESTRICTION; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; GENE INACTIVATION; MOUSE; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; SKIN CARCINOGENESIS;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; APPETITE; ARCUATE NUCLEUS; CALORIC RESTRICTION; FEMALE; HUNGER; MALE; MICE; MICE, KNOCKOUT; NEOPLASMS, EXPERIMENTAL; NEURONS; NEUROPEPTIDE Y; PAPILLOMA; RNA, MESSENGER; SKIN NEOPLASMS; SODIUM GLUTAMATE; TETRADECANOYLPHORBOL ACETATE;

MUS;

EID: 79955967115     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00693.x     Document Type: Article

References (48)

1. Abel EL, Angel JM, Kiguchi K, DiGiovanni J (2009) Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat. Protoc. 4, 1350-1362.
2. Ahima RS, Flier JS (2000) Adipose tissue as an endocrine organ. Trends Endocrinol. Metab. 11, 327-332.
3. Barb D, Williams CJ, Neuwirth AK, Mantzoros CS (2007) Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am. J. Clin. Nutr. 86, s858-s866.
4. Bartke A (2005) Role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology 146, 3718-3723.
5. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7, 947-953.
6. Bi S (2007) Role of dorsomedial hypothalamic neuropeptide Y in energy homeostasis. Peptides 28, 352-356.
7. Birt DF, Przybyszewski J, Wang W, Stewart J, Liu Y (2004) Identification of molecular targets for dietary energy restriction prevention of skin carcinogenesis: an idea cultivated by Edward Bresnick. J. Cell. Biochem. 91, 258-264.
8. Broberger C (1999) Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y. Brain Res. 848, 101-113.
9. Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T (1998) The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl Acad. Sci. USA 95, P15043-P15048.
10. Chakravarthy MV, Zhu Y, López M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD, Semenkovich CF (2007) Brain fatty acid synthase activates PPAR-alpha to maintain energy homeostasis. J. Clin. Invest. 117, 2539-2552.
11. Cohen PS, Cooper MJ, Helman LJ, Thiele CJ, Seeger RC, Israel MA (1990) Neuropeptide Y expression in the developing adrenal gland and in childhood neuroblastoma tumors. Cancer Res. 50, 6055-6061.
12. Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, Tanen M, Berg AH, O'Rahilly S, Savage DB, Chatterjee K, Weiss S, Larson PJ, Gottesdiener KM, Gertz BJ, Charron MJ, Scherer PE, Moller DE (2002) Induction of adipocytes complement-related protein of 30kDa by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 143, 998-1007.
13. Erickson JC, Clegg KE, Palmiter RD (1996) Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381, 415-421.
14. Finkel T, Serrano M, Blasco MA (2007) The common biology of cancer and ageing. Nature 448, 767-774.
15. Frederich RC, Hamann A, Anderson S, Löllmann B, Lowell BB, Flier JS (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1, 1311-1314.
16. Guillod-Maximin E, Roy AF, Vacher CM, Aubourg A, Bailleux V, Lorsignol A, Pénicaud L, Parquet M, Taouis M (2009) Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons. J. Endocrinol. 200, 93-105.
17. Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC (2003) Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu. Rev. Med. 54, 131-152.
18. Huypens P (2007) Leptin controls adiponectin production via the hypothalamus. Med. Hypotheses 68, 87-90.
19. Kadowaki T, Yamauchi T (2005) Adiponectin and adiponectin receptors. Endocr. Rev. 26, 439-451.
20. Kallingal GJ, Mintz EM (2007) Gastrin releasing peptide and neuropeptide Y exert opposing actions on circadian phase. Neurosci. Lett. 422, 59-63.
21. Kalra SP (2008) Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches. Nutrition 24, 820-826.
22. Kitlinska J, Abe K, Kuo L, Pons J, Yu M, Li L, Tilan J, Everhart L, Lee EW, Zukowska Z, Toretsky JA (2005) Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors. Cancer Res. 65, 1719-1728.
23. Körner M, Waser B, Reubi JC (2008) High expression of neuropeptide Y1 receptors in ewing sarcoma tumors. Clin. Cancer Res. 14, 5043-5049.
24. Kritchevsky D (2002) Caloric restriction and experimental carcinogenesis. Hybrid. Hybridomics 21, 147-151.
25. Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T, Suzuki R, Satoh H, Tsuchida A, Moroi M, Sugi K, Noda T, Ebinuma H, Ueta Y, Kondo T, Araki E, Ezaki O, Nagai R, Tobe K, Terauchi Y, Ueki K, Minokoshi Y, Kadowaki T (2007) Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab. 6, 55-68.
26. Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C, López M (2010) Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. FASEB J. 24, 2670-2679.
27. López M, Lelliott CJ, Tovar S, Kimber W, Gallego R, Virtue S, Blount M, Vázquez MJ, Finer N, Powles TJ, O'Rahilly S, Saha AK, Diéguez C, Vidal-Puig AJ (2006) Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. Diabetes 55, 1327-1336.
28. López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A (2008) Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab. 7, 389-399.
29. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A (2010) Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat. Med. 16, 1001-1008.
30. Ma XH, Muzumdar R, Yang XM, Gabriely I, Berger R, Barzilai N (2002) Aging is associated with resistance to effects of leptin on fat distribution and insulin action. J. Gerontol. A Biol. Sci. Med. Sci. 57, B225-B231.
31. McCay CM, Crowell MF (1934) Prolonging the life span. Sci. Mon. 39, 405-414.
32. McCay CM, Crowell MF, Maynard LA (1935) The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr. 10, 63-79.
33. Minor RK, Villarreal J, McGraw M, Percival SS, Ingram DK, de Cabo R (2008) Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behav. Brain Res. 189, 202-211.
34. Minor RK, Chang JW, de Cabo R (2009) Hungry for life: how the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction. Mol. Cell. Endocrinol. 299, 79-88.
35. Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, Mobbs CV (1999) Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology 140, 4551-4557.
36. Olney JW (1969) Brain lesions, obesity, and other disturbance in mice treated with monosodium glutamate. Science 164, 719-721.
37. Paxinos G, Watson C (1986) The Rat Brain in Stereotaxic Coordinates. Sydney, NSW: Academic Press.
38. Pizzi WJ, Barnhart JE (1976) Effects of monosodium glutamate on somatic development, obesity and activity in the mouse. Pharmacol. Biochem. Behav. 5, 551-557.
39. Rämö OJ, Balasubramaniam A, Sheriff S, Rogers DH, McCullough PJ, Bell RH (1990) Neuropeptide Y and peptide YY stimulate the growth of exocrine pancreatic carcinoma cells. Neuropeptides 15, 101-106.
40. Rous P (1914) The influence of diet on transplanted and spontaneous mouse tumors. J. Exp. Med. 20, 433-451.
41. Ruscica M, Dozio E, Boghossian S, Bovo G, Martos Riaño V, Motta M, Magni P (2006) Activation of the Y1 receptor by neuropeptide Y regulates the growth of prostate cancer cells. Endocrinology 147, 1466-1473.
42. deS Senanayake P, Denker J, Bravo EL, Graham RM (1995) Production, characterization, and expression of neuropeptide Y by human pheochromocytoma. J. Clin. Invest. 96, 2503-2509.
43. Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A, Kahn SE, Baskin DG, Woods SC, Figlewicz DP (1992) Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130, 3608-3616.
44. Stefan N, Vozarova B, Funahashi T, Matsuzawa Y, Ravussin E, Weyer C, Tataranni PA (2002) Plasma adiponectin levels are not associated with fat oxidation in humans. Obes. Res. 10, 1016-1020.
45. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, MacKellar W, Rosteck PR, Schoner B, Smith D, Tinsley FC, Zhang X, Heiman M (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530-532.
46. Tatar M, Bartke A, Antebi A (2003) The endocrine regulation of aging by insulin-like signals. Science 299, 1346-1351.
47. Weindruch R, Walford RL (1988) The Retardation of Aging and Disease by Dietary Restriction. Springfield, IL: Charles C Thomas Publisher LTD.
48. Zhu M, Lee GD, Ding L, Hu J, Qiu G, de Cabo R, Bernier M, Ingram DK, Zou S (2007) Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp. Gerontol. 42, 733-744.