메뉴 건너뛰기




Volumn 13, Issue 2, 2011, Pages 129-135

Knocking out angiotensin II in the heart

Author keywords

ACE; ACE2; Angiotensin II; Cardiovascular disease; Chymase; Heart; RAS; Renin; Renin angiotensin system

Indexed keywords

ALISKIREN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN DERIVATIVE; ANGIOTENSIN II; ANGIOTENSIN II [1-9]; ANGIOTENSIN II TYPE 1 RECEPTOR ASSOCIATED PROTEIN; ANGIOTENSIN[1-7]; ANTIHYPERTENSIVE AGENT; CELL PENETRATING PEPTIDE; CHYMASE; CYT006 ANGQB; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PRORENIN; RENIN; RENIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 79955956184     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-011-0180-4     Document Type: Review
Times cited : (12)

References (60)
  • 1
    • 74949092226 scopus 로고    scopus 로고
    • New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism
    • Ferrario CM: New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism. Hypertension 2010, 55(2):445-452.
    • (2010) Hypertension , vol.55 , Issue.2 , pp. 445-452
    • Ferrario, C.M.1
  • 2
    • 43049157967 scopus 로고    scopus 로고
    • Angiotensin-(1-7): Pharmacological properties and pharmacotherapeutic perspectives
    • Iusuf D, Henning RH, van Gilst WH, Roks AJ: Angiotensin-(1-7): pharmacological properties and pharmacotherapeutic perspectives. Eur J Pharmacol 2008, 585(2-3):303-312.
    • (2008) Eur J Pharmacol , vol.585 , Issue.2-3 , pp. 303-312
    • Iusuf, D.1    Henning, R.H.2    Van Gilst, W.H.3    Roks, A.J.4
  • 3
    • 17044370781 scopus 로고    scopus 로고
    • Working outside the system: An update on the unconventional behavior of the renin-angiotensin system components
    • Kurdi M, De Mello WC, Booz GW: Working outside the system: an update on the unconventional behavior of the renin-angiotensin system components. Int J Biochem Cell Biol 2005, 37(7):1357-1367.
    • (2005) Int J Biochem Cell Biol , vol.37 , Issue.7 , pp. 1357-1367
    • Kurdi, M.1    De Mello, W.C.2    Booz, G.W.3
  • 4
    • 77956687283 scopus 로고    scopus 로고
    • The mitochondrial component of intracrine action
    • Re RN, Cook JL: The mitochondrial component of intracrine action. Am J Physiol 2010, 299(3):H577-583.
    • (2010) Am J Physiol , vol.299 , Issue.3
    • Re, R.N.1    Cook, J.L.2
  • 5
    • 50549105060 scopus 로고    scopus 로고
    • Angiotensin II: A hormone involved in and contributing to pro-hypertrophic cardiac networks and target of antihypertrophic cross-talks
    • Schluter KD, Wenzel S: Angiotensin II: a hormone involved in and contributing to pro-hypertrophic cardiac networks and target of antihypertrophic cross-talks. Pharmacol Ther 2008, 119(3):311-325.
    • (2008) Pharmacol Ther , vol.119 , Issue.3 , pp. 311-325
    • Schluter, K.D.1    Wenzel, S.2
  • 6
    • 26044458855 scopus 로고    scopus 로고
    • Angiotensin II induces apoptosis in vivo in skeletal, as well as cardiac, muscle of the rat
    • DOI 10.1113/expphysiol.2005.030908
    • Burniston JG, Saini A, Tan LB, Goldspink DF: Angiotensin II induces apoptosis in vivo in skeletal, as well as cardiac, muscle of the rat. Exp Physiol 2005, 90(5):755-761. (Pubitemid 41406064)
    • (2005) Experimental Physiology , vol.90 , Issue.5 , pp. 755-761
    • Burniston, J.G.1    Saini, A.2    Tan, L.-B.3    Goldspink, D.F.4
  • 7
    • 67049115754 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy
    • This study describes a previously unknown function of the RAS, providing the first evidence that Ang II and its receptors are involved in regulating autophagy in the heart
    • Porrello ER, D'Amore A, Curl CL, et al.: Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy. Hypertension 2009, 53(6):1032-1040. This study describes a previously unknown function of the RAS, providing the first evidence that Ang II and its receptors are involved in regulating autophagy in the heart.
    • (2009) Hypertension , vol.53 , Issue.6 , pp. 1032-1040
    • Porrello, E.R.1    D'Amore, A.2    Curl, C.L.3
  • 8
    • 77953119859 scopus 로고    scopus 로고
    • Impact of acute myocardial ischemia reperfusion on the tissue and blood-borne renin-angiotensin system
    • Oyamada S, Bianchi C, Takai S, et al.: Impact of acute myocardial ischemia reperfusion on the tissue and blood-borne renin-angiotensin system. Basic Res Cardiol 2010, 105(4):513-522.
    • (2010) Basic Res Cardiol , vol.105 , Issue.4 , pp. 513-522
    • Oyamada, S.1    Bianchi, C.2    Takai, S.3
  • 9
    • 33847059651 scopus 로고    scopus 로고
    • Role of N-acetyl-seryl-aspartyl-lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension
    • Peng H, Carretero OA, Liao TD, et al.: Role of N-acetyl-seryl-aspartyl- lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension. Hypertension 2007, 49(3):695-703.
    • (2007) Hypertension , vol.49 , Issue.3 , pp. 695-703
    • Peng, H.1    Carretero, O.A.2    Liao, T.D.3
  • 10
    • 74949129329 scopus 로고    scopus 로고
    • Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function
    • Erdos EG, Tan F, Skidgel RA: Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function. Hypertension 2010, 55(2):214-220.
    • (2010) Hypertension , vol.55 , Issue.2 , pp. 214-220
    • Erdos, E.G.1    Tan, F.2    Skidgel, R.A.3
  • 11
    • 77953025722 scopus 로고    scopus 로고
    • Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB
    • Miguel-Carrasco JL, Zambrano S, Blanca AJ, et al.: Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB. J Inflamm 2010, 7:21.
    • (2010) J Inflamm , vol.7 , pp. 21
    • Miguel-Carrasco, J.L.1    Zambrano, S.2    Blanca, A.J.3
  • 12
    • 68249131003 scopus 로고    scopus 로고
    • Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats
    • Simko F, Pechanova O, Pelouch V, et al.: Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats. J Hypertens Suppl 2009, 27(6):S5-10.
    • (2009) J Hypertens Suppl , vol.27 , Issue.6
    • Simko, F.1    Pechanova, O.2    Pelouch, V.3
  • 13
    • 76149089578 scopus 로고    scopus 로고
    • Role of angiotensin-converting enzyme inhibitors in vascular modulation: Beyond the hypertensive effects
    • This article is a good review of the data obtained from randomized controlled trials evaluating ACE inhibitors. However, it does not include the recent, much discussed ONTARGET study, which suggested that dual blockade with ACE inhibitors and ARBs may have little clinical benefit and may actually be detrimental in some patients
    • Katragadda S, Arora RR: Role of angiotensin-converting enzyme inhibitors in vascular modulation: beyond the hypertensive effects. Am J Ther 2010, 17(1):e11-e23. This article is a good review of the data obtained from randomized controlled trials evaluating ACE inhibitors. However, it does not include the recent, much discussed ONTARGET study, which suggested that dual blockade with ACE inhibitors and ARBs may have little clinical benefit and may actually be detrimental in some patients.
    • (2010) Am J Ther , vol.17 , Issue.1
    • Katragadda, S.1    Arora, R.R.2
  • 14
    • 65549154913 scopus 로고    scopus 로고
    • 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation
    • Jessup M, Abraham WT, Casey DE, et al.: 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009, 119(14):1977-2016.
    • (2009) Circulation , vol.119 , Issue.14 , pp. 1977-2016
    • Jessup, M.1    Abraham, W.T.2    Casey, D.E.3
  • 15
    • 0347600924 scopus 로고    scopus 로고
    • Angiotensin-Converting Enzyme Is Involved in Outside-in Signaling in Endothelial Cells
    • DOI 10.1161/01.RES.0000107195.13573.E4
    • Kohlstedt K, Brandes RP, Muller-Esterl W, et al.: Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res 2004, 94(1):60-67. (Pubitemid 38064099)
    • (2004) Circulation Research , vol.94 , Issue.1 , pp. 60-67
    • Kohlstedt, K.1    Brandes, R.P.2    Muller-Esterl, W.3    Busse, R.4    Fleming, I.5
  • 16
    • 0036023644 scopus 로고    scopus 로고
    • Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases
    • DOI 10.1097/00001573-200207000-00009
    • Dell'Italia LJ, Husain A: Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases. Curr Opin Cardiol 2002, 17(4):374-379. (Pubitemid 34864606)
    • (2002) Current Opinion in Cardiology , vol.17 , Issue.4 , pp. 374-379
    • Dell'Italia, L.J.1    Husain, A.2
  • 17
    • 62549157381 scopus 로고    scopus 로고
    • The intracellular renin-angiotensin system in the heart
    • Kumar R, Singh VP, Baker KM: The intracellular renin-angiotensin system in the heart. Curr Hypertens Rep 2009, 11 (2):104-110.
    • (2009) Curr Hypertens Rep , vol.11 , Issue.2 , pp. 104-110
    • Kumar, R.1    Singh, V.P.2    Baker, K.M.3
  • 18
    • 33750032795 scopus 로고    scopus 로고
    • Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models
    • DOI 10.1016/j.pharmthera.2006.05.008, PII S0163725806001069
    • Miyazaki M, Takai S, Jin D, Muramatsu M: Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models. Pharmacol Ther 2006, 112 (3):668-676. (Pubitemid 44573489)
    • (2006) Pharmacology and Therapeutics , vol.112 , Issue.3 , pp. 668-676
    • Miyazaki, M.1    Takai, S.2    Jin, D.3    Muramatsu, M.4
  • 19
    • 77951171609 scopus 로고    scopus 로고
    • Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents
    • This study suggests that, rather than inhibiting local generation of Ang II, chronic ACE inhibition actually plays a direct role in maintaining Ang II levels in the cardiac interstitium by inducing chymasedependent Ang II synthesis
    • Wei CC, Hase N, Inoue Y, et al.: Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest 2010, 120(4):1229-1239. This study suggests that, rather than inhibiting local generation of Ang II, chronic ACE inhibition actually plays a direct role in maintaining Ang II levels in the cardiac interstitium by inducing chymasedependent Ang II synthesis.
    • (2010) J Clin Invest , vol.120 , Issue.4 , pp. 1229-1239
    • Wei, C.C.1    Hase, N.2    Inoue, Y.3
  • 20
    • 44949253157 scopus 로고    scopus 로고
    • Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart
    • This study provides the first evidence that Ang-(1-12) can serve as an alternative precursor for Ang II synthesis
    • Trask AJ, Jessup JA, Chappell MC, Ferrario CM: Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. Am J Physiol 2008, 294(5):H2242-2247. This study provides the first evidence that Ang-(1-12) can serve as an alternative precursor for Ang II synthesis.
    • (2008) Am J Physiol , vol.294 , Issue.5
    • Trask, A.J.1    Jessup, J.A.2    Chappell, M.C.3    Ferrario, C.M.4
  • 21
    • 62349100153 scopus 로고    scopus 로고
    • Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: Effects of PA12 upon cardiac haemodynamics
    • Prosser HC, Forster ME, Richards AM, Pemberton CJ: Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics. Cardiovasc Res 2009, 82(1):40-50.
    • (2009) Cardiovasc Res , vol.82 , Issue.1 , pp. 40-50
    • Prosser, H.C.1    Forster, M.E.2    Richards, A.M.3    Pemberton, C.J.4
  • 22
    • 77956199892 scopus 로고    scopus 로고
    • New approaches to blockade of the renin-angiotensin-aldosterone system: Chymase as an important target to prevent organ damage
    • Takai S, Jin D, Miyazaki M: New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage. J Pharmacol Sci 2010, 113 (4):301-309.
    • (2010) J Pharmacol Sci , vol.113 , Issue.4 , pp. 301-309
    • Takai, S.1    Jin, D.2    Miyazaki, M.3
  • 23
    • 58149328554 scopus 로고    scopus 로고
    • Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis
    • Singh VP, Le B, Khode R, et al.: Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes 2008, 57(12):3297-3306.
    • (2008) Diabetes , vol.57 , Issue.12 , pp. 3297-3306
    • Singh, V.P.1    Le, B.2    Khode, R.3
  • 24
    • 72849131772 scopus 로고    scopus 로고
    • Cytosolic renin is targeted to mitochondria and induces apoptosis in H9c2 rat cardiomyoblasts
    • Wanka H, Kessler N, Ellmer J, et al.: Cytosolic renin is targeted to mitochondria and induces apoptosis in H9c2 rat cardiomyoblasts. J Cell Mol Med 2009, 13(9A):2926-2937.
    • (2009) J Cell Mol Med , vol.13 , Issue.9 A , pp. 2926-2937
    • Wanka, H.1    Kessler, N.2    Ellmer, J.3
  • 25
    • 77952420302 scopus 로고    scopus 로고
    • Cardiac mast cell proteases do not contribute to the regulation of the rat coronary vascular responsiveness to arterial delivered angiotensin I and II
    • Bispo-da-Silva LB, Sivieri-Jr DO, Prado CM, et al.: Cardiac mast cell proteases do not contribute to the regulation of the rat coronary vascular responsiveness to arterial delivered angiotensin I and II. Vascul Pharmacol 2010, 53(1-2):22-27.
    • (2010) Vascul Pharmacol , vol.53 , Issue.1-2 , pp. 22-27
    • Bispo-da-Silva, L.B.1    Sivieri Jr., D.O.2    Prado, C.M.3
  • 26
    • 68549104288 scopus 로고    scopus 로고
    • Cardiac Renin levels are not influenced by the amount of resident mast cells
    • Krop M, van Veghel R, Garrelds IM, et al.: Cardiac Renin levels are not influenced by the amount of resident mast cells. Hypertension 2009, 54(2):315-321.
    • (2009) Hypertension , vol.54 , Issue.2 , pp. 315-321
    • Krop, M.1    Van Veghel, R.2    Garrelds, I.M.3
  • 27
    • 33645509515 scopus 로고    scopus 로고
    • Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion
    • Mackins CJ, Kano S, Seyedi N, et al.: Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. J Clin Invest 2006, 116(4):1063-1070.
    • (2006) J Clin Invest , vol.116 , Issue.4 , pp. 1063-1070
    • Mackins, C.J.1    Kano, S.2    Seyedi, N.3
  • 28
    • 77952498608 scopus 로고    scopus 로고
    • Direct renin inhibitors as antihypertensive agents
    • This review article gives a good overview of the function and effectiveness of currently available direct renin inhibitors
    • Israili ZH, Velasco M, Bermudez V: Direct renin inhibitors as antihypertensive agents. Am J Ther 2010, 17(3):237-254. This review article gives a good overview of the function and effectiveness of currently available direct renin inhibitors.
    • (2010) Am J Ther , vol.17 , Issue.3 , pp. 237-254
    • Israili, Z.H.1    Velasco, M.2    Bermudez, V.3
  • 29
    • 77957251826 scopus 로고    scopus 로고
    • Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats
    • van Esch JH, Moltzer E, van Veghel R, et al.: Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats. J Hypertens 2010, 28(10):2145-2155.
    • (2010) J Hypertens , vol.28 , Issue.10 , pp. 2145-2155
    • Van Esch, J.H.1    Moltzer, E.2    Van Veghel, R.3
  • 30
    • 79958249630 scopus 로고    scopus 로고
    • Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
    • McMurray JJ, Pitt B, Latini R, et al.: Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail 2008, 1(1):17-24.
    • (2008) Circ Heart Fail , vol.1 , Issue.1 , pp. 17-24
    • McMurray, J.J.1    Pitt, B.2    Latini, R.3
  • 31
    • 61349170589 scopus 로고    scopus 로고
    • Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
    • Solomon SD, Appelbaum E, Manning WJ, et al.: Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 2009, 119(4):530-537.
    • (2009) Circulation , vol.119 , Issue.4 , pp. 530-537
    • Solomon, S.D.1    Appelbaum, E.2    Manning, W.J.3
  • 32
    • 39749098706 scopus 로고    scopus 로고
    • Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide
    • This study provides evidence that binding of renin or prorenin to the (pro)renin receptor can trigger Ang II-independent cellular signaling that is not blocked by renin inhibition
    • Feldt S, Batenburg WW, Mazak I, et al.: Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 2008, 51(3):682-688. This study provides evidence that binding of renin or prorenin to the (pro)renin receptor can trigger Ang II-independent cellular signaling that is not blocked by renin inhibition.
    • (2008) Hypertension , vol.51 , Issue.3 , pp. 682-688
    • Feldt, S.1    Batenburg, W.W.2    Mazak, I.3
  • 33
    • 66249098883 scopus 로고    scopus 로고
    • Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy
    • Ferrario CM, Varagic J, Habibi J, et al.: Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol 2009, 296(4):H1184-1192.
    • (2009) Am J Physiol , vol.296 , Issue.4
    • Ferrario, C.M.1    Varagic, J.2    Habibi, J.3
  • 34
    • 77954619980 scopus 로고    scopus 로고
    • Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression
    • Tadevosyan A, Maguy A, Villeneuve LR, et al.: Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J Biol Chem 2010, 285(29):22338-22349.
    • (2010) J Biol Chem , vol.285 , Issue.29 , pp. 22338-22349
    • Tadevosyan, A.1    Maguy, A.2    Villeneuve, L.R.3
  • 35
    • 22544448655 scopus 로고    scopus 로고
    • The AT2 receptor - A matter of love and hate
    • DOI 10.1016/j.peptides.2005.03.010, PII S0196978105001257, International Symposium on Peptides Receptors, from Gene to Therapy
    • Steckelings UM, Kaschina E, Unger T: The AT2 receptor - a matter of love and hate. Peptides 2005, 26(8):1401-1409. (Pubitemid 41021474)
    • (2005) Peptides , vol.26 , Issue.8 , pp. 1401-1409
    • Steckelings, U.M.1    Kaschina, E.2    Unger, T..3
  • 36
    • 70349298656 scopus 로고    scopus 로고
    • Achieving blood pressure goals: Should angiotensin II receptor blockers become first-line treatment in hypertension?
    • Weber M: Achieving blood pressure goals: should angiotensin II receptor blockers become first-line treatment in hypertension? J Hypertens Suppl 2009, 27(5):S9-14.
    • (2009) J Hypertens Suppl , vol.27 , Issue.5
    • Weber, M.1
  • 37
    • 77956224989 scopus 로고    scopus 로고
    • Comparing angiotensin II receptor blockers on benefits beyond blood pressure
    • This article is a good review of clinical data on the effectiveness of ARBs in treating cardiovascular diseases
    • Siragy HM: Comparing angiotensin II receptor blockers on benefits beyond blood pressure. Adv Ther 2010, 27(5):257-284. This article is a good review of clinical data on the effectiveness of ARBs in treating cardiovascular diseases.
    • (2010) Adv Ther , vol.27 , Issue.5 , pp. 257-284
    • Siragy, H.M.1
  • 38
    • 71549127400 scopus 로고    scopus 로고
    • Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): A randomised, double-blind trial
    • Konstam MA, Neaton JD, Dickstein K, et al.: Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial. Lancet 2009, 374(9704):1840-1848.
    • (2009) Lancet , vol.374 , Issue.9704 , pp. 1840-1848
    • Konstam, M.A.1    Neaton, J.D.2    Dickstein, K.3
  • 40
    • 0037134407 scopus 로고    scopus 로고
    • Novel AT(1) receptor-independent functions of losartan
    • Sadoshima J: Novel AT(1) receptor-independent functions of losartan. Circ Res 2002, 90(7):754-756.
    • (2002) Circ Res , vol.90 , Issue.7 , pp. 754-756
    • Sadoshima, J.1
  • 41
    • 77954030665 scopus 로고    scopus 로고
    • Angiotensin-receptor blockade and risk of cancer: Meta-analysis of randomised controlled trials
    • In this meta-analysis, Sipahi et al. suggest that ARB use may be associated with an increased risk of cancer
    • Sipahi I, Debanne SM, Rowland DY, et al.: Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials. Lancet Oncol 2010, 11(7):627-636. In this meta-analysis, Sipahi et al. suggest that ARB use may be associated with an increased risk of cancer.
    • (2010) Lancet Oncol , vol.11 , Issue.7 , pp. 627-636
    • Sipahi, I.1    Debanne, S.M.2    Rowland, D.Y.3
  • 43
    • 77951499906 scopus 로고    scopus 로고
    • Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice
    • This transgenic mouse study provides evidence that the endogenous AT1R inhibitor, ATRAP, may be an effective way to suppress Ang II-induced cardiac hypertrophy
    • Wakui H, Tamura K, Tanaka Y, et al.: Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice. Hypertension 2010, 55(5):1157-1164. This transgenic mouse study provides evidence that the endogenous AT1R inhibitor, ATRAP, may be an effective way to suppress Ang II-induced cardiac hypertrophy.
    • (2010) Hypertension , vol.55 , Issue.5 , pp. 1157-1164
    • Wakui, H.1    Tamura, K.2    Tanaka, Y.3
  • 44
    • 77952988031 scopus 로고    scopus 로고
    • Limiting angiotensin II signaling with a cell-penetrating peptide mimicking the second intracellular loop of the angiotensin II type-I receptor
    • Yu J, Taylor L, Mierke D, et al.: Limiting angiotensin II signaling with a cell-penetrating peptide mimicking the second intracellular loop of the angiotensin II type-I receptor. Chem Biol Drug Des 2010, 76(1):70-76.
    • (2010) Chem Biol Drug des , vol.76 , Issue.1 , pp. 70-76
    • Yu, J.1    Taylor, L.2    Mierke, D.3
  • 45
    • 37549028011 scopus 로고    scopus 로고
    • Angiotensin II-induced vasodilation via type 2 receptor: Role of bradykinin and nitric oxide
    • Yayama K, Okamoto H: Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide. Int Immunopharmacol 2008, 8(2):312-318.
    • (2008) Int Immunopharmacol , vol.8 , Issue.2 , pp. 312-318
    • Yayama, K.1    Okamoto, H.2
  • 46
    • 74949119893 scopus 로고    scopus 로고
    • Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: Loss of angiotensin II type 2 receptor-mediated vasodilation
    • This study provides evidence that AT2R function may switch from relaxant to constrictor under hypertensive conditions, suggesting that further investigation of its signaling mechanisms is required to better understand what effects AT2R agonists may have in a clinical setting
    • Moltzer E, Verkuil AV, van Veghel R, et al.: Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation. Hypertension 2010, 55(2):516-522. This study provides evidence that AT2R function may switch from relaxant to constrictor under hypertensive conditions, suggesting that further investigation of its signaling mechanisms is required to better understand what effects AT2R agonists may have in a clinical setting.
    • (2010) Hypertension , vol.55 , Issue.2 , pp. 516-522
    • Moltzer, E.1    Verkuil, A.V.2    Van Veghel, R.3
  • 47
    • 58149375072 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor stimulation: A novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?
    • Kaschina E, Grzesiak A, Li J, et al.: Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 2008, 118(24):2523-2532.
    • (2008) Circulation , vol.118 , Issue.24 , pp. 2523-2532
    • Kaschina, E.1    Grzesiak, A.2    Li, J.3
  • 48
    • 42649108055 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 gene targeting studies in mice: Mixed messages
    • DOI 10.1113/expphysiol.2007.040014
    • Gurley SB, Coffman TM: Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages. Exp Physiol 2008, 93 (5):538-542. (Pubitemid 351595062)
    • (2008) Experimental Physiology , vol.93 , Issue.5 , pp. 538-542
    • Gurley, S.B.1    Coffman, T.M.2
  • 49
    • 39749202869 scopus 로고    scopus 로고
    • Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology
    • DOI 10.1161/HYPERTENSIONAHA.107.100693, PII 0000426820080300000025
    • Der Sarkissian S, Grobe JL, Yuan L, et al.: Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology. Hypertension 2008, 51 (3):712-718. (Pubitemid 351301525)
    • (2008) Hypertension , vol.51 , Issue.3 , pp. 712-718
    • Der Sarkissian, S.1    Grobe, J.L.2    Yuan, L.3    Narielwala, D.R.4    Walter, G.A.5    Katovich, M.J.6    Raizada, M.K.7
  • 50
    • 70350457666 scopus 로고    scopus 로고
    • Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
    • Kassiri Z, Zhong J, Guo D, et al.: Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail 2009, 2(5):446-455.
    • (2009) Circ Heart Fail , vol.2 , Issue.5 , pp. 446-455
    • Kassiri, Z.1    Zhong, J.2    Guo, D.3
  • 51
    • 77952511816 scopus 로고    scopus 로고
    • Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
    • Trask AJ, Groban L, Westwood BM, et al.: Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens 2010, 23 (6):687-693.
    • (2010) Am J Hypertens , vol.23 , Issue.6 , pp. 687-693
    • Trask, A.J.1    Groban, L.2    Westwood, B.M.3
  • 52
    • 77955981900 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction
    • 718 p following 728
    • Zhong J, Basu R, Guo D, et al.: Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation 2010, 122(7):717-728, 718 p following 728.
    • (2010) Circulation , vol.122 , Issue.7 , pp. 717-728
    • Zhong, J.1    Basu, R.2    Guo, D.3
  • 53
    • 74949087578 scopus 로고    scopus 로고
    • Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases
    • Ferreira AJ, Santos RA, Bradford CN, et al.: Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases. Hypertension 2010, 55(2):207-213.
    • (2010) Hypertension , vol.55 , Issue.2 , pp. 207-213
    • Ferreira, A.J.1    Santos, R.A.2    Bradford, C.N.3
  • 54
    • 58149352445 scopus 로고    scopus 로고
    • Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart
    • This study suggests that the beneficial effects of ACE2 activity in the heart may be due in part to the resultant increase in Ang-(1-7) levels, rather than simply the degradation of Ang II
    • Mercure C, Yogi A, Callera GE, et al.: Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart. Circ Res 2008, 103(11):1319-1326. This study suggests that the beneficial effects of ACE2 activity in the heart may be due in part to the resultant increase in Ang-(1-7) levels, rather than simply the degradation of Ang II.
    • (2008) Circ Res , vol.103 , Issue.11 , pp. 1319-1326
    • Mercure, C.1    Yogi, A.2    Callera, G.E.3
  • 55
    • 77951890433 scopus 로고    scopus 로고
    • Circulating rather than cardiac angiotensin-(1-7) stimulates cardioprotection after myocardial infarction
    • Wang Y, Qian C, Roks AJ, et al.: Circulating rather than cardiac angiotensin-(1-7) stimulates cardioprotection after myocardial infarction. Circ Heart Fail 2010, 3(2):286-293.
    • (2010) Circ Heart Fail , vol.3 , Issue.2 , pp. 286-293
    • Wang, Y.1    Qian, C.2    Roks, A.J.3
  • 56
    • 77951293287 scopus 로고    scopus 로고
    • Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro
    • This study is the first to demonstrate a role for Ang-(1-9) in the regulation of cardiac hypertrophy
    • Ocaranza MP, Lavandero S, Jalil JE, et al.: Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro. J Hypertens 2010, 28(5):1054-1064. This study is the first to demonstrate a role for Ang-(1-9) in the regulation of cardiac hypertrophy.
    • (2010) J Hypertens , vol.28 , Issue.5 , pp. 1054-1064
    • Ocaranza, M.P.1    Lavandero, S.2    Jalil, J.E.3
  • 57
    • 64849108788 scopus 로고    scopus 로고
    • Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2
    • Masson R, Nicklin SA, Craig MA, et al.: Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2. Hypertension 2009, 53 (4):694-700.
    • (2009) Hypertension , vol.53 , Issue.4 , pp. 694-700
    • Masson, R.1    Nicklin, S.A.2    Craig, M.A.3
  • 58
    • 73749086318 scopus 로고    scopus 로고
    • Not just angiotensinases: New roles for the angiotensin-converting enzymes
    • Lambert DW, Clarke NE, Turner AJ: Not just angiotensinases: new roles for the angiotensin-converting enzymes. Cell Mol Life Sci 2010, 67(1):89-98.
    • (2010) Cell Mol Life Sci , vol.67 , Issue.1 , pp. 89-98
    • Lambert, D.W.1    Clarke, N.E.2    Turner, A.J.3
  • 59
    • 71649090306 scopus 로고    scopus 로고
    • Immunization against angiotensins for the treatment of hypertension
    • Maurer P, Bachmann MF: Immunization against angiotensins for the treatment of hypertension. Clin Immunol 2010, 134(1):89-95.
    • (2010) Clin Immunol , vol.134 , Issue.1 , pp. 89-95
    • Maurer, P.1    Bachmann, M.F.2
  • 60
    • 74949103515 scopus 로고    scopus 로고
    • The use of ultralow doses of antibodies to C-terminal fragment of angiotensin II AT1 receptor (kardos) in the therapy of arterial hypertension
    • Petrov VI, Nedogoda SV, Epshtein OI, et al.: The use of ultralow doses of antibodies to C-terminal fragment of angiotensin II AT1 receptor (kardos) in the therapy of arterial hypertension. Bull Exp Biol Med 2009, 148(2):332-334.
    • (2009) Bull Exp Biol Med , vol.148 , Issue.2 , pp. 332-334
    • Petrov, V.I.1    Nedogoda, S.V.2    Epshtein, O.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.