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New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism
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Ferrario CM: New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism. Hypertension 2010, 55(2):445-452.
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Angiotensin-(1-7): Pharmacological properties and pharmacotherapeutic perspectives
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17044370781
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Working outside the system: An update on the unconventional behavior of the renin-angiotensin system components
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Kurdi M, De Mello WC, Booz GW: Working outside the system: an update on the unconventional behavior of the renin-angiotensin system components. Int J Biochem Cell Biol 2005, 37(7):1357-1367.
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Kurdi, M.1
De Mello, W.C.2
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77956687283
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The mitochondrial component of intracrine action
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Re RN, Cook JL: The mitochondrial component of intracrine action. Am J Physiol 2010, 299(3):H577-583.
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Am J Physiol
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Angiotensin II: A hormone involved in and contributing to pro-hypertrophic cardiac networks and target of antihypertrophic cross-talks
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Schluter KD, Wenzel S: Angiotensin II: a hormone involved in and contributing to pro-hypertrophic cardiac networks and target of antihypertrophic cross-talks. Pharmacol Ther 2008, 119(3):311-325.
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Pharmacol Ther
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Angiotensin II induces apoptosis in vivo in skeletal, as well as cardiac, muscle of the rat
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DOI 10.1113/expphysiol.2005.030908
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Burniston JG, Saini A, Tan LB, Goldspink DF: Angiotensin II induces apoptosis in vivo in skeletal, as well as cardiac, muscle of the rat. Exp Physiol 2005, 90(5):755-761. (Pubitemid 41406064)
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Goldspink, D.F.4
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7
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67049115754
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Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy
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This study describes a previously unknown function of the RAS, providing the first evidence that Ang II and its receptors are involved in regulating autophagy in the heart
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Porrello ER, D'Amore A, Curl CL, et al.: Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy. Hypertension 2009, 53(6):1032-1040. This study describes a previously unknown function of the RAS, providing the first evidence that Ang II and its receptors are involved in regulating autophagy in the heart.
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Hypertension
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Porrello, E.R.1
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77953119859
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Impact of acute myocardial ischemia reperfusion on the tissue and blood-borne renin-angiotensin system
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Oyamada S, Bianchi C, Takai S, et al.: Impact of acute myocardial ischemia reperfusion on the tissue and blood-borne renin-angiotensin system. Basic Res Cardiol 2010, 105(4):513-522.
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Basic Res Cardiol
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Oyamada, S.1
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Takai, S.3
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9
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33847059651
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Role of N-acetyl-seryl-aspartyl-lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension
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Peng H, Carretero OA, Liao TD, et al.: Role of N-acetyl-seryl-aspartyl- lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension. Hypertension 2007, 49(3):695-703.
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Hypertension
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Peng, H.1
Carretero, O.A.2
Liao, T.D.3
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10
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74949129329
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Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function
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Erdos EG, Tan F, Skidgel RA: Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function. Hypertension 2010, 55(2):214-220.
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Hypertension
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Erdos, E.G.1
Tan, F.2
Skidgel, R.A.3
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11
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77953025722
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Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB
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Miguel-Carrasco JL, Zambrano S, Blanca AJ, et al.: Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB. J Inflamm 2010, 7:21.
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J Inflamm
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Miguel-Carrasco, J.L.1
Zambrano, S.2
Blanca, A.J.3
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12
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68249131003
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Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats
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Simko F, Pechanova O, Pelouch V, et al.: Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats. J Hypertens Suppl 2009, 27(6):S5-10.
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J Hypertens Suppl
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Simko, F.1
Pechanova, O.2
Pelouch, V.3
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13
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76149089578
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Role of angiotensin-converting enzyme inhibitors in vascular modulation: Beyond the hypertensive effects
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This article is a good review of the data obtained from randomized controlled trials evaluating ACE inhibitors. However, it does not include the recent, much discussed ONTARGET study, which suggested that dual blockade with ACE inhibitors and ARBs may have little clinical benefit and may actually be detrimental in some patients
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Katragadda S, Arora RR: Role of angiotensin-converting enzyme inhibitors in vascular modulation: beyond the hypertensive effects. Am J Ther 2010, 17(1):e11-e23. This article is a good review of the data obtained from randomized controlled trials evaluating ACE inhibitors. However, it does not include the recent, much discussed ONTARGET study, which suggested that dual blockade with ACE inhibitors and ARBs may have little clinical benefit and may actually be detrimental in some patients.
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Am J Ther
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Katragadda, S.1
Arora, R.R.2
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14
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65549154913
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2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation
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Jessup M, Abraham WT, Casey DE, et al.: 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009, 119(14):1977-2016.
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(2009)
Circulation
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, pp. 1977-2016
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Jessup, M.1
Abraham, W.T.2
Casey, D.E.3
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15
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Angiotensin-Converting Enzyme Is Involved in Outside-in Signaling in Endothelial Cells
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DOI 10.1161/01.RES.0000107195.13573.E4
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Kohlstedt K, Brandes RP, Muller-Esterl W, et al.: Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res 2004, 94(1):60-67. (Pubitemid 38064099)
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Fleming, I.5
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16
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0036023644
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Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases
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DOI 10.1097/00001573-200207000-00009
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Dell'Italia LJ, Husain A: Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases. Curr Opin Cardiol 2002, 17(4):374-379. (Pubitemid 34864606)
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Current Opinion in Cardiology
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Dell'Italia, L.J.1
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62549157381
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The intracellular renin-angiotensin system in the heart
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Kumar R, Singh VP, Baker KM: The intracellular renin-angiotensin system in the heart. Curr Hypertens Rep 2009, 11 (2):104-110.
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Curr Hypertens Rep
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Kumar, R.1
Singh, V.P.2
Baker, K.M.3
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18
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33750032795
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Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models
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DOI 10.1016/j.pharmthera.2006.05.008, PII S0163725806001069
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Miyazaki M, Takai S, Jin D, Muramatsu M: Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models. Pharmacol Ther 2006, 112 (3):668-676. (Pubitemid 44573489)
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Miyazaki, M.1
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Muramatsu, M.4
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19
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77951171609
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Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents
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This study suggests that, rather than inhibiting local generation of Ang II, chronic ACE inhibition actually plays a direct role in maintaining Ang II levels in the cardiac interstitium by inducing chymasedependent Ang II synthesis
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Wei CC, Hase N, Inoue Y, et al.: Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest 2010, 120(4):1229-1239. This study suggests that, rather than inhibiting local generation of Ang II, chronic ACE inhibition actually plays a direct role in maintaining Ang II levels in the cardiac interstitium by inducing chymasedependent Ang II synthesis.
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J Clin Invest
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Wei, C.C.1
Hase, N.2
Inoue, Y.3
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20
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44949253157
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Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart
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This study provides the first evidence that Ang-(1-12) can serve as an alternative precursor for Ang II synthesis
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Trask AJ, Jessup JA, Chappell MC, Ferrario CM: Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. Am J Physiol 2008, 294(5):H2242-2247. This study provides the first evidence that Ang-(1-12) can serve as an alternative precursor for Ang II synthesis.
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(2008)
Am J Physiol
, vol.294
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Trask, A.J.1
Jessup, J.A.2
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Ferrario, C.M.4
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21
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62349100153
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Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: Effects of PA12 upon cardiac haemodynamics
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Prosser HC, Forster ME, Richards AM, Pemberton CJ: Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics. Cardiovasc Res 2009, 82(1):40-50.
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Cardiovasc Res
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Prosser, H.C.1
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Pemberton, C.J.4
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22
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77956199892
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New approaches to blockade of the renin-angiotensin-aldosterone system: Chymase as an important target to prevent organ damage
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Takai S, Jin D, Miyazaki M: New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage. J Pharmacol Sci 2010, 113 (4):301-309.
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J Pharmacol Sci
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Takai, S.1
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23
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58149328554
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Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis
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Singh VP, Le B, Khode R, et al.: Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes 2008, 57(12):3297-3306.
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Diabetes
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Singh, V.P.1
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24
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72849131772
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Cytosolic renin is targeted to mitochondria and induces apoptosis in H9c2 rat cardiomyoblasts
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Wanka H, Kessler N, Ellmer J, et al.: Cytosolic renin is targeted to mitochondria and induces apoptosis in H9c2 rat cardiomyoblasts. J Cell Mol Med 2009, 13(9A):2926-2937.
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J Cell Mol Med
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Wanka, H.1
Kessler, N.2
Ellmer, J.3
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25
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77952420302
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Cardiac mast cell proteases do not contribute to the regulation of the rat coronary vascular responsiveness to arterial delivered angiotensin I and II
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Bispo-da-Silva LB, Sivieri-Jr DO, Prado CM, et al.: Cardiac mast cell proteases do not contribute to the regulation of the rat coronary vascular responsiveness to arterial delivered angiotensin I and II. Vascul Pharmacol 2010, 53(1-2):22-27.
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Bispo-da-Silva, L.B.1
Sivieri Jr., D.O.2
Prado, C.M.3
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26
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68549104288
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Cardiac Renin levels are not influenced by the amount of resident mast cells
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Krop M, van Veghel R, Garrelds IM, et al.: Cardiac Renin levels are not influenced by the amount of resident mast cells. Hypertension 2009, 54(2):315-321.
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Krop, M.1
Van Veghel, R.2
Garrelds, I.M.3
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27
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33645509515
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Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion
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Mackins CJ, Kano S, Seyedi N, et al.: Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. J Clin Invest 2006, 116(4):1063-1070.
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Mackins, C.J.1
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28
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77952498608
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Direct renin inhibitors as antihypertensive agents
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This review article gives a good overview of the function and effectiveness of currently available direct renin inhibitors
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Israili ZH, Velasco M, Bermudez V: Direct renin inhibitors as antihypertensive agents. Am J Ther 2010, 17(3):237-254. This review article gives a good overview of the function and effectiveness of currently available direct renin inhibitors.
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(2010)
Am J Ther
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, pp. 237-254
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Israili, Z.H.1
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Bermudez, V.3
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29
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77957251826
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Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats
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van Esch JH, Moltzer E, van Veghel R, et al.: Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats. J Hypertens 2010, 28(10):2145-2155.
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J Hypertens
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Van Esch, J.H.1
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Van Veghel, R.3
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30
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Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
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McMurray JJ, Pitt B, Latini R, et al.: Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail 2008, 1(1):17-24.
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Circ Heart Fail
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McMurray, J.J.1
Pitt, B.2
Latini, R.3
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31
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61349170589
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Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
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Solomon SD, Appelbaum E, Manning WJ, et al.: Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 2009, 119(4):530-537.
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Solomon, S.D.1
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Manning, W.J.3
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32
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39749098706
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Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide
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This study provides evidence that binding of renin or prorenin to the (pro)renin receptor can trigger Ang II-independent cellular signaling that is not blocked by renin inhibition
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Feldt S, Batenburg WW, Mazak I, et al.: Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 2008, 51(3):682-688. This study provides evidence that binding of renin or prorenin to the (pro)renin receptor can trigger Ang II-independent cellular signaling that is not blocked by renin inhibition.
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(2008)
Hypertension
, vol.51
, Issue.3
, pp. 682-688
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Feldt, S.1
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Mazak, I.3
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Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy
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Ferrario CM, Varagic J, Habibi J, et al.: Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol 2009, 296(4):H1184-1192.
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Am J Physiol
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Ferrario, C.M.1
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34
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Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression
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Tadevosyan A, Maguy A, Villeneuve LR, et al.: Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J Biol Chem 2010, 285(29):22338-22349.
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J Biol Chem
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Tadevosyan, A.1
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The AT2 receptor - A matter of love and hate
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DOI 10.1016/j.peptides.2005.03.010, PII S0196978105001257, International Symposium on Peptides Receptors, from Gene to Therapy
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Steckelings UM, Kaschina E, Unger T: The AT2 receptor - a matter of love and hate. Peptides 2005, 26(8):1401-1409. (Pubitemid 41021474)
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Peptides
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Achieving blood pressure goals: Should angiotensin II receptor blockers become first-line treatment in hypertension?
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Weber M: Achieving blood pressure goals: should angiotensin II receptor blockers become first-line treatment in hypertension? J Hypertens Suppl 2009, 27(5):S9-14.
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J Hypertens Suppl
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Weber, M.1
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37
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77956224989
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Comparing angiotensin II receptor blockers on benefits beyond blood pressure
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This article is a good review of clinical data on the effectiveness of ARBs in treating cardiovascular diseases
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Siragy HM: Comparing angiotensin II receptor blockers on benefits beyond blood pressure. Adv Ther 2010, 27(5):257-284. This article is a good review of clinical data on the effectiveness of ARBs in treating cardiovascular diseases.
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Adv Ther
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, pp. 257-284
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Siragy, H.M.1
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Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): A randomised, double-blind trial
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Konstam MA, Neaton JD, Dickstein K, et al.: Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial. Lancet 2009, 374(9704):1840-1848.
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Lancet
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Sadoshima J: Novel AT(1) receptor-independent functions of losartan. Circ Res 2002, 90(7):754-756.
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Sadoshima, J.1
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41
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77954030665
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Angiotensin-receptor blockade and risk of cancer: Meta-analysis of randomised controlled trials
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In this meta-analysis, Sipahi et al. suggest that ARB use may be associated with an increased risk of cancer
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Sipahi I, Debanne SM, Rowland DY, et al.: Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials. Lancet Oncol 2010, 11(7):627-636. In this meta-analysis, Sipahi et al. suggest that ARB use may be associated with an increased risk of cancer.
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Lancet Oncol
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Sipahi, I.1
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34249100267
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The role of angiotensin AT1 receptor associated protein in renin-angiotensin system regulation and function
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Tamura K, Tanaka Y, Tsurumi Y, et al.: The role of angiotensin AT1 receptor-associated protein in renin-angiotensin system regulation and function. Curr Hypertens Rep 2007, 9(2):121-127. (Pubitemid 46779376)
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Current Hypertension Reports
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Tamura, K.1
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Masuda, S.-I.7
Matsuda, M.8
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43
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77951499906
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Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice
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This transgenic mouse study provides evidence that the endogenous AT1R inhibitor, ATRAP, may be an effective way to suppress Ang II-induced cardiac hypertrophy
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Wakui H, Tamura K, Tanaka Y, et al.: Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice. Hypertension 2010, 55(5):1157-1164. This transgenic mouse study provides evidence that the endogenous AT1R inhibitor, ATRAP, may be an effective way to suppress Ang II-induced cardiac hypertrophy.
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(2010)
Hypertension
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Wakui, H.1
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44
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Limiting angiotensin II signaling with a cell-penetrating peptide mimicking the second intracellular loop of the angiotensin II type-I receptor
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Yu J, Taylor L, Mierke D, et al.: Limiting angiotensin II signaling with a cell-penetrating peptide mimicking the second intracellular loop of the angiotensin II type-I receptor. Chem Biol Drug Des 2010, 76(1):70-76.
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