메뉴 건너뛰기




Volumn 4, Issue 2, 2011, Pages 159-162

Indispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling: Insights from in vivo models

Author keywords

Animal models; Cbl; E3 ubiquitin ligase; Hematology; Immunology; Leukemia; Protein tyrosine kinase; RING finger; Signal transduction; Stem cell

Indexed keywords

ANIMALIA; EUKARYOTA; MAMMALIA; MURINAE;

EID: 79955947899     PISSN: None     EISSN: 19420889     Source Type: Journal    
DOI: 10.4161/cib.4.2.14716     Document Type: Short Survey
Times cited : (9)

References (36)
  • 1
    • 63749113783 scopus 로고    scopus 로고
    • Tyrosine phosphorylation: thirty years and counting
    • DOI: 10.1016/j.ceb.2009.01.028
    • Hunter T. Tyrosine phosphorylation: thirty years and counting. Curr Opin Cell Biol 2009; 21:140-6; DOI: 10.1016/j.ceb.2009.01.028.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 140-146
    • Hunter, T.1
  • 2
    • 0036587680 scopus 로고    scopus 로고
    • The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system
    • Rao N, Dodge I, Band H. The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leukoc Biol 2002; 71:753-63.
    • (2002) J Leukoc Biol , vol.71 , pp. 753-763
    • Rao, N.1    Dodge, I.2    Band, H.3
  • 3
    • 0035316576 scopus 로고    scopus 로고
    • Cbl: many adaptations to regulate protein tyrosine kinases
    • DOI: 10.1038/35067100
    • Thien CB, Langdon WY. Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2001; 2:294-307; DOI: 10.1038/35067100.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 294-307
    • Thien, C.B.1    Langdon, W.Y.2
  • 4
    • 3142726114 scopus 로고    scopus 로고
    • The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling
    • DOI: 10.1016/j.immuni.2004.06.012
    • Duan L, Reddi AL, Ghosh A, Dimri M, Band H. The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity 2004; 21:7-17; DOI: 10.1016/j.immuni.2004.06.012.
    • (2004) Immunity , vol.21 , pp. 7-17
    • Duan, L.1    Reddi, A.L.2    Ghosh, A.3    Dimri, M.4    Band, H.5
  • 5
    • 28844490931 scopus 로고    scopus 로고
    • The Cbl interactome and its functions
    • DOI: 10.1038/nrm1762
    • Schmidt MHH, Dikic I. The Cbl interactome and its functions. Nat Rev Mol Cell Biol 2005; 6:907-18; DOI: 10.1038/nrm1762.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 907-918
    • Schmidt, M.H.H.1    Dikic, I.2
  • 6
    • 0032217156 scopus 로고    scopus 로고
    • c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
    • Levkowitz G, Waterman H, Zamir E, Kam Z, Oved S, Langdon WY, et al. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev 1998; 12:3663-74.
    • (1998) Genes Dev , vol.12 , pp. 3663-3674
    • Levkowitz, G.1    Waterman, H.2    Zamir, E.3    Kam, Z.4    Oved, S.5    Langdon, W.Y.6
  • 7
    • 0033169024 scopus 로고    scopus 로고
    • The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation
    • DOI: 10.1093/emboj/18.13.3616
    • Lee PS, Wang Y, Dominguez MG, Yeung YG, Murphy MA, Bowtell DD, et al. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J 1999; 18:3616-28; DOI: 10.1093/emboj/18.13.3616.
    • (1999) EMBO J , vol.18 , pp. 3616-3628
    • Lee, P.S.1    Wang, Y.2    Dominguez, M.G.3    Yeung, Y.G.4    Murphy, M.A.5    Bowtell, D.D.6
  • 9
    • 0035555195 scopus 로고    scopus 로고
    • Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells
    • DOI: 10.1038/ni0901-870
    • Fang D, Liu YC. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol 2001; 2:870-5; DOI: 10.1038/ni0901-870.
    • (2001) Nat Immunol , vol.2 , pp. 870-875
    • Fang, D.1    Liu, Y.C.2
  • 11
    • 0032438114 scopus 로고    scopus 로고
    • Altered thymic positive selection and intracellular signals in Cbl-deficient mice
    • Naramura M, Kole HK, Hu RJ, Gu H. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci USA 1998; 95:15547-52.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15547-15552
    • Naramura, M.1    Kole, H.K.2    Hu, R.J.3    Gu, H.4
  • 12
    • 85047692840 scopus 로고    scopus 로고
    • c-Cbl-deficient mice have reduced adiposity, higher energy expenditure and improved peripheral insulin action
    • DOI: 10.1172/JCI21480
    • Molero JC, Jensen TE, Withers PC, Couzens M, Herzog H, Thien CBF, et al. c-Cbl-deficient mice have reduced adiposity, higher energy expenditure and improved peripheral insulin action. J Clin Invest 2004; 114:1326-33; DOI: 10.1172/JCI21480.
    • (2004) J Clin Invest , vol.114 , pp. 1326-1333
    • Molero, J.C.1    Jensen, T.E.2    Withers, P.C.3    Couzens, M.4    Herzog, H.5    Thien, C.B.F.6
  • 13
    • 27944477367 scopus 로고    scopus 로고
    • Androgen-dependent apoptosis in male germ cells is regulated through the protooncoprotein Cbl
    • DOI: 10.1083/jcb.200507076
    • El Chami N, Ikhlef F, Kaszas K, Yakoub S, Tabone E, Siddeek B, et al. Androgen-dependent apoptosis in male germ cells is regulated through the protooncoprotein Cbl. J Cell Biol 2005; 171:651-61; DOI: 10.1083/jcb.200507076.
    • (2005) J Cell Biol , vol.171 , pp. 651-661
    • El Chami, N.1    Ikhlef, F.2    Kaszas, K.3    Yakoub, S.4    Tabone, E.5    Siddeek, B.6
  • 14
    • 0034642499 scopus 로고    scopus 로고
    • Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
    • DOI: 10.1038/35003228
    • Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 2000; 403:211-6; DOI: 10.1038/35003228.
    • (2000) Nature , vol.403 , pp. 211-216
    • Bachmaier, K.1    Krawczyk, C.2    Kozieradzki, I.3    Kong, Y.Y.4    Sasaki, T.5    Oliveira-dos-Santos, A.6
  • 15
    • 0034642534 scopus 로고    scopus 로고
    • Cbl-b regulates the CD28 dependence of T-cell activation
    • DOI: 10.1038/35003235
    • Chiang YJ, Kole HK, Brown K, Naramura M, Fukuhara S, Hu RJ, et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 2000; 403:216-20; DOI: 10.1038/35003235.
    • (2000) Nature , vol.403 , pp. 216-220
    • Chiang, Y.J.1    Kole, H.K.2    Brown, K.3    Naramura, M.4    Fukuhara, S.5    Hu, R.J.6
  • 16
    • 34147150656 scopus 로고    scopus 로고
    • Ablation of Cbl-b provides protection against transplanted and spontaneous tumors
    • DOI: 10.1172/JCI29472
    • Chiang JY, Jang IK, Hodes R, Gu H. Ablation of Cbl-b provides protection against transplanted and spontaneous tumors. J Clin Invest 2007; 117:1029-36; DOI: 10.1172/JCI29472.
    • (2007) J Clin Invest , vol.117 , pp. 1029-1036
    • Chiang, J.Y.1    Jang, I.K.2    Hodes, R.3    Gu, H.4
  • 17
    • 34247387485 scopus 로고    scopus 로고
    • Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells
    • DOI: 10.1084/jem.20061699
    • Loeser S, Loser K, Bijker MS, Rangachari M, van der Burg SH, Wada T, et al. Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med 2007; 204:879-91; DOI: 10.1084/jem.20061699.
    • (2007) J Exp Med , vol.204 , pp. 879-891
    • Loeser, S.1    Loser, K.2    Bijker, M.S.3    Rangachari, M.4    van der Burg, S.H.5    Wada, T.6
  • 18
    • 0036699521 scopus 로고    scopus 로고
    • Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
    • DOI: 10.1038/ng927
    • Yokoi N, Komeda K, Wang H, Yano H, Kitada K, Saitoh Y, et al. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet 2002; 31:391-4; DOI: 10.1038/ng927.
    • (2002) Nat Genet , vol.31 , pp. 391-394
    • Yokoi, N.1    Komeda, K.2    Wang, H.3    Yano, H.4    Kitada, K.5    Saitoh, Y.6
  • 19
    • 34547684387 scopus 로고    scopus 로고
    • E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
    • DOI: 10.1038/nm1607
    • Bachmaier K, Toya S, Gao X, Triantafillou T, Garrean S, Park GY, et al. E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Nat Med 2007; 13:920-6; DOI: 10.1038/nm1607.
    • (2007) Nat Med , vol.13 , pp. 920-926
    • Bachmaier, K.1    Toya, S.2    Gao, X.3    Triantafillou, T.4    Garrean, S.5    Park, G.Y.6
  • 20
    • 34948865755 scopus 로고    scopus 로고
    • Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice
    • DOI: 10.2337/db06-1768
    • Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Harada N, et al. Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes 2007; 56:2511-22; DOI: 10.2337/db06-1768.
    • (2007) Diabetes , vol.56 , pp. 2511-2522
    • Hirasaka, K.1    Kohno, S.2    Goto, J.3    Furochi, H.4    Mawatari, K.5    Harada, N.6
  • 21
    • 79551641951 scopus 로고    scopus 로고
    • Cbl-b regulates airway mucosal tolerance to aeroallergen
    • DOI: 10.1111/j.1365-2222.2010.03593x
    • Oh SY, Park J, Zheng T, Kim Y, Wu F, Cho SH, et al. Cbl-b regulates airway mucosal tolerance to aeroallergen. Clin Exp Allergy 2010; 41:434-42; DOI: 10.1111/j.1365-2222.2010.03593x.
    • (2010) Clin Exp Allergy , vol.41 , pp. 434-442
    • Oh, S.Y.1    Park, J.2    Zheng, T.3    Kim, Y.4    Wu, F.5    Cho, S.H.6
  • 22
    • 0036911112 scopus 로고    scopus 로고
    • c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation
    • DOI: 10.1038/ni855
    • Naramura M, Jang I, Kole H, Huang F, Haines D, Gu H. c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol 2002; 3:1192-9; DOI: 10.1038/ni855.
    • (2002) Nat Immunol , vol.3 , pp. 1192-1199
    • Naramura, M.1    Jang, I.2    Kole, H.3    Huang, F.4    Haines, D.5    Gu, H.6
  • 25
    • 33749536260 scopus 로고    scopus 로고
    • Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins
    • DOI: 10.1016/j.immuni.2006.08.021
    • Huang F, Kitaura Y, Jang I, Naramura M, Kole HH, Liu L, et al. Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins. Immunity 2006; 25:571-81; DOI: 10.1016/j.immuni.2006.08.021.
    • (2006) Immunity , vol.25 , pp. 571-581
    • Huang, F.1    Kitaura, Y.2    Jang, I.3    Naramura, M.4    Kole, H.H.5    Liu, L.6
  • 26
    • 34248512113 scopus 로고    scopus 로고
    • Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b
    • DOI: 10.1016/j.immuni.2007.03.015
    • Kitaura Y, Jang IK, Wang Y, Han Y, Inazu T, Cadera EJ, et al. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 2007; 26:567-78; DOI: 10.1016/j.immuni.2007.03.015.
    • (2007) Immunity , vol.26 , pp. 567-578
    • Kitaura, Y.1    Jang, I.K.2    Wang, Y.3    Han, Y.4    Inazu, T.5    Cadera, E.J.6
  • 27
    • 77958001789 scopus 로고    scopus 로고
    • Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells
    • DOI: 10.1073/pnas.1007575107
    • Naramura M, Nandwani N, Gu H, Band V, Band H. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci USA 2010; 107:16274-9; DOI: 10.1073/pnas.1007575107.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16274-16279
    • Naramura, M.1    Nandwani, N.2    Gu, H.3    Band, V.4    Band, H.5
  • 28
    • 42149188212 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells
    • DOI: 10.1101/gad.1651408
    • Rathinam C, Thien CBF, Langdon WY, Gu H, Flavell RA. The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells. Genes Dev 2008; 22:992-7; DOI: 10.1101/gad.1651408.
    • (2008) Genes Dev , vol.22 , pp. 992-997
    • Rathinam, C.1    Thien, C.B.F.2    Langdon, W.Y.3    Gu, H.4    Flavell, R.A.5
  • 29
    • 0037450822 scopus 로고    scopus 로고
    • A mouse with a lossof-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase
    • Thien CBF, Scaife RM, Papadimitriou JM, Murphy MA, Bowtell DDL, Langdon WY. A mouse with a lossof-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase. J Exp Med 2003; 197:503-13.
    • (2003) J Exp Med , vol.197 , pp. 503-513
    • Thien, C.B.F.1    Scaife, R.M.2    Papadimitriou, J.M.3    Murphy, M.A.4    Bowtell, D.D.L.5    Langdon, W.Y.6
  • 30
    • 27744485874 scopus 로고    scopus 로고
    • Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion
    • DOI: 10.1038/sj.emboj.7600841
    • Thien CBF, Blystad FD, Zhan Y, Lew AM, Voigt V, Andoniou CE, et al. Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J 2005; 24:3807-19; DOI: 10.1038/sj.emboj.7600841.
    • (2005) EMBO J , vol.24 , pp. 3807-3819
    • Thien, C.B.F.1    Blystad, F.D.2    Zhan, Y.3    Lew, A.M.4    Voigt, V.5    Andoniou, C.E.6
  • 31
    • 77951230459 scopus 로고    scopus 로고
    • c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol-3-kinase/Akt pathway
    • DOI: 10.1074/jbc.M109.094920
    • Thien CBF, Dagger SA, Steer JH, Koentgen F, Jansen ES, Scott CL, et al. c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol-3-kinase/Akt pathway. J Biol Chem 2010; 285:10969-81; DOI: 10.1074/jbc.M109.094920.
    • (2010) J Biol Chem , vol.285 , pp. 10969-10981
    • Thien, C.B.F.1    Dagger, S.A.2    Steer, J.H.3    Koentgen, F.4    Jansen, E.S.5    Scott, C.L.6
  • 32
    • 35548995466 scopus 로고    scopus 로고
    • The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgEactivated mast cells
    • DOI: 10.1016/j.molimm.2007.08.002
    • Oksvold MP, Dagger SA, Thien CBF, Langdon WY. The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgEactivated mast cells. Mol Immunol 2008; 45:925-36; DOI: 10.1016/j.molimm.2007.08.002.
    • (2008) Mol Immunol , vol.45 , pp. 925-936
    • Oksvold, M.P.1    Dagger, S.A.2    Thien, C.B.F.3    Langdon, W.Y.4
  • 33
    • 0029124883 scopus 로고
    • Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl
    • Yoon CH, Lee J, Jongeward GD, Sternberg PW. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl. Science 1995; 269:1102-5.
    • (1995) Science , vol.269 , pp. 1102-1105
    • Yoon, C.H.1    Lee, J.2    Jongeward, G.D.3    Sternberg, P.W.4
  • 34
    • 0034192088 scopus 로고    scopus 로고
    • The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells
    • Rao N, Lupher ML, Ota S, Reedquist KA, Druker BJ, Band H. The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells. J Immunol 2000; 164:4616-26.
    • (2000) J Immunol , vol.164 , pp. 4616-4626
    • Rao, N.1    Lupher, M.L.2    Ota, S.3    Reedquist, K.A.4    Druker, B.J.5    Band, H.6
  • 35
    • 77957965853 scopus 로고    scopus 로고
    • Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling
    • DOI: 10.1016/j.ccr.2010.09.008
    • Rathinam C, Thien CBF, Flavell RA, Langdon WY. Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling. Cancer Cell 2010; 18:341-52; DOI: 10.1016/j.ccr.2010.09.008.
    • (2010) Cancer Cell , vol.18 , pp. 341-352
    • Rathinam, C.1    Thien, C.B.F.2    Flavell, R.A.3    Langdon, W.Y.4
  • 36
    • 77955117637 scopus 로고    scopus 로고
    • Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms
    • DOI: 10.1158/1078-0432.CCR-09-2341
    • Ogawa S, Shih L, Suzuki T, Otsu M, Nakauchi H, Koeffler HP, et al. Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms. Clin Cancer Res 2010; 16:3825-31; DOI: 10.1158/1078-0432.CCR-09-2341.
    • (2010) Clin Cancer Res , vol.16 , pp. 3825-3831
    • Ogawa, S.1    Shih, L.2    Suzuki, T.3    Otsu, M.4    Nakauchi, H.5    Koeffler, H.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.