Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  He, Hong ^a   Nehete, Pramod N ^a   Nehete, Bharti ^a   Wieder, Eric ^b   Yang, Guojun ^a   Buchl, Stephanie ^a   Sastry, K Jagannadha ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; BIOLOGICAL MARKER; CYTOKINE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; PHORBOLOL MYRISTATE ACETATE;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FLOW CYTOMETRY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DYSREGULATION; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MEMORY T LYMPHOCYTE; NONHUMAN; PHENOTYPE; PROGNOSIS; RHESUS MONKEY; T LYMPHOCYTE SUBPOPULATION; VIREMIA; VIRUS DETECTION; VIRUS LOAD; ANIMAL; BIOSYNTHESIS; CHRONIC DISEASE; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MACACA MULATTA; PATHOLOGY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME;

ANIMALIA; MACACA MULATTA; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

ANIMALS; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CYTOKINES; DISEASE PROGRESSION; HUMANS; IMMUNOLOGIC MEMORY; IONOMYCIN; MACACA MULATTA; PROGNOSIS; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; TETRADECANOYLPHORBOL ACETATE; VIRAL LOAD; VIREMIA;

EID: 79955932359     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019607     Document Type: Article

References (30)

1. Levy JA, (1993) Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 57: 183-289.
2. Zhang Z, Schuler T, Zupancic M, Wietgrefe S, Staskus KA, et al. (1999) Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science 286: 1353-1357.
3. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, et al. (1995) Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373: 123-126.
4. El-Sadr WM, Lundgren JD, Neaton JD, Gordin F, Abrams D, et al. (2006) CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med 355: 2283-2296.
5. Rodriguez B, Sethi AK, Cheruvu VK, Mackay W, Bosch RJ, et al. (2006) Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection. JAMA 296: 1498-1506.
6. Rosenberg ES, Billingsley JM, Caliendo AM, Boswell SL, Sax PE, et al. (1997) Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 278: 1447-1450.
7. Roederer M, Brenchley JM, Betts MR, De Rosa SC, (2004) Flow cytometric analysis of vaccine responses: how many colors are enough? Clin Immunol 110: 199-205.
8. Pitcher CJ, Quittner C, Peterson DM, Connors M, Koup RA, et al. (1999) HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat Med 5: 518-525.
9. Cohen J, (2002) Vaccines. Monkey puzzles. Science 296: 2325-2326.
10. Feinberg MB, Moore JP, (2002) AIDS vaccine models: challenging challenge viruses. Nat Med 8: 207-210.
11. Acierno PM, Schmitz JE, Gorgone DA, Sun Y, Santra S, et al. (2006) Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys. J Immunol 176: 5338-5345.
12. Nehete PN, Nehete BP, Hill L, Manuri PR, Baladandayuthapani V, et al. (2008) Selective induction of cell-mediated immunity and protection of rhesus macaques from chronic SHIV(KU2) infection by prophylactic vaccination with a conserved HIV-1 envelope peptide-cocktail. Virology 370: 130-141.
13. Nehete PN, Nehete BP, Manuri P, Hill L, Palmer JL, et al. (2005) Protection by dendritic cells-based HIV synthetic peptide cocktail vaccine: preclinical studies in the SHIV-rhesus model. Vaccine 23: 2154-2159.
14. Suryanarayana K, Wiltrout TA, Vasquez GM, Hirsch VM, Lifson JD, (1998) Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction. AIDS Res Hum Retroviruses 14: 183-189.
15. Pitcher CJ, Hagen SI, Walker JM, Lum R, Mitchell BL, et al. (2002) Development and homeostasis of T cell memory in rhesus macaque. J Immunol 168: 29-43.
16. Pala P, Hussell T, Openshaw PJ, (2000) Flow cytometric measurement of intracellular cytokines. J Immunol Methods 243: 107-124.
17. Kalams SA, Walker BD, (1998) The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 188: 2199-2204.
18. Nishimura Y, Igarashi T, Buckler-White A, Buckler C, Imamichi H, et al. (2007) Loss of naive cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques. J Virol 81: 893-902.
19. Mattapallil JJ, Letvin NL, Roederer M, (2004) T-cell dynamics during acute SIV infection. AIDS 18: 13-23.
20. Sallusto F, Geginat J, Lanzavecchia A, (2004) Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22: 745-763.
21. Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, et al. (2006) Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science 312: 1530-1533.
22. Roederer M, Dubs JG, Anderson MT, Raju PA, Herzenberg LA, (1995) CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest 95: 2061-2066.
23. Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, et al. (2007) Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med 204: 2171-2185.
24. Waldrop SL, Davis KA, Maino VC, Picker LJ, (1998) Normal human CD4+ memory T cells display broad heterogeneity in their activation threshold for cytokine synthesis. J Immunol 161: 5284-5295.
25. Waldrop SL, Pitcher CJ, Peterson DM, Maino VC, Picker LJ, (1997) Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J Clin Invest 99: 1739-1750.
26. Bachmann MF, Wolint P, Walton S, Schwarz K, Oxenius A, (2007) Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections. Eur J Immunol 37: 1502-1512.
27. Williams MA, Tyznik AJ, Bevan MJ, (2006) Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature 441: 890-893.
28. Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, et al. (2006) PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 203: 2281-2292.
29. Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, et al. (2009) Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet 373: 1352-1363.
30. Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, et al. (2009) Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med 360: 1815-1826.