-
2
-
-
27744556967
-
Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease
-
Soler-Cataluña, J.J., Martínez-García, M.A., Román Sánchez, P., Salcedo, E., Navarro, M., Ochando, R. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005, 60(11): 925-31.
-
(2005)
Thorax
, vol.60
, Issue.11
, pp. 925-931
-
-
Soler-Cataluña, J.J.1
Martínez-García, M.A.2
Román Sánchez, P.3
Salcedo, E.4
Navarro, M.5
Ochando, R.6
-
3
-
-
0033782528
-
Geographic variations in prevalence and underdiagnosis of COPD: Results of the IBERPOC multicentre epidemiological study
-
Sobradillo Pena, V., Miravitlles, M., Gabriel, R. et al. Geographic variations in prevalence and underdiagnosis of COPD: Results of the IBERPOC multicentre epidemiological study. Chest 2000, 118(4): 981-9.
-
(2000)
Chest
, vol.118
, Issue.4
, pp. 981-989
-
-
Sobradillo Pena, V.1
Miravitlles, M.2
Gabriel, R.3
-
4
-
-
28044444899
-
Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): A prevalence study
-
Menezes, A.M., Perez-Padilla, R., Jardim, J.R. et al. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): A prevalence study. Lancet 2005, 366(9500): 1875-81.
-
(2005)
Lancet
, vol.366
, Issue.9500
, pp. 1875-1881
-
-
Menezes, A.M.1
Perez-Padilla, R.2
Jardim, J.R.3
-
5
-
-
34548267728
-
International variation in the prevalence of COPD (the BOLD Study): A population-based prevalence study
-
Buist, A.S., McBurnie, M.A., Vollmer, W.M. et al. International variation in the prevalence of COPD (the BOLD Study): A population-based prevalence study. Lancet 2007, 370(9589): 741-50.
-
(2007)
Lancet
, vol.370
, Issue.9589
, pp. 741-750
-
-
Buist, A.S.1
McBurnie, M.A.2
Vollmer, W.M.3
-
6
-
-
1842552109
-
Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper
-
ATS/ERS Task Force
-
Celli, B.R., MacNee, W.; ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper. Eur Respir J 2004, 23(6): 932-46.
-
(2004)
Eur Respir J
, vol.23
, Issue.6
, pp. 932-946
-
-
Celli, B.R.1
MacNee, W.2
-
7
-
-
0001074646
-
Subtypes of the type 4 cAMP phosphodiesterases: Structure, regulation and selective inhibition
-
DOI 10.1016/0165-6147(96)10035-3
-
Muller, T., Engels, P., Fozard, J.R. Subtypes of the type 4 cAMP phosphodiesterases: Structure, regulation and selective inhibition. Trends Pharmacol Sci 1996, 17(8): 294-8. (Pubitemid 26261894)
-
(1996)
Trends in Pharmacological Sciences
, vol.17
, Issue.8
, pp. 294-298
-
-
Muller, T.1
Engels, P.2
Fozard, J.R.3
-
8
-
-
0035084103
-
Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro
-
Hatzelmann, A., Schudt, C. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther 2001, 297(1): 267-79.
-
(2001)
J Pharmacol Exp Ther
, vol.297
, Issue.1
, pp. 267-279
-
-
Hatzelmann, A.1
Schudt, C.2
-
9
-
-
77953105482
-
The preclinical pharmacology of roflumilast - A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
-
Hatzelmann, A., Morcillo, E.J., Lungarella, G. et al. The preclinical pharmacology of roflumilast - A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2010, 23(4): 235-56.
-
(2010)
Pulm Pharmacol Ther
, vol.23
, Issue.4
, pp. 235-256
-
-
Hatzelmann, A.1
Morcillo, E.J.2
Lungarella, G.3
-
10
-
-
66649127821
-
Immunologic aspects of chronic obstructive pulmonary disease
-
Cosio, M.G., Saetta, M., Agusti, A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med 2009, 360(23): 2445-54.
-
(2009)
N Engl J Med
, vol.360
, Issue.23
, pp. 2445-2454
-
-
Cosio, M.G.1
Saetta, M.2
Agusti, A.3
-
11
-
-
19444363467
-
PDE4 inhibitors as new anti-inflammatory drugs: Effects on cell trafficking and cell adhesion molecules expression
-
Sanz, M.J., Cortijo, J., Morcillo, E.J. PDE4 inhibitors as new anti-inflammatory drugs: Effects on cell trafficking and cell adhesion molecules expression. Pharmacol Ther 2005, 106(3): 269-97.
-
(2005)
Pharmacol Ther
, vol.106
, Issue.3
, pp. 269-297
-
-
Sanz, M.J.1
Cortijo, J.2
Morcillo, E.J.3
-
12
-
-
36749063803
-
Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
-
Grootendorst, D.C., Gauw, S.A., Verhoosel, R.M. et al. Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax 2007, 62(12): 1081-7.
-
(2007)
Thorax
, vol.62
, Issue.12
, pp. 1081-1087
-
-
Grootendorst, D.C.1
Gauw, S.A.2
Verhoosel, R.M.3
-
13
-
-
0031045482
-
Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD
-
Keatings, V.M., Jatakanon, A., Worsdell, Y.M., Barnes, P.J. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med 1997, 155(2): 542-8.
-
(1997)
Am J Respir Crit Care Med
, vol.155
, Issue.2
, pp. 542-548
-
-
Keatings, V.M.1
Jatakanon, A.2
Worsdell, Y.M.3
Barnes, P.J.4
-
14
-
-
33845764714
-
Dose proportional intraindividual single- and repeated-dose pharmacokinetics of roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor
-
Bethke, T.D., Bohmer, G.M., Hermann, R. et al. Dose proportional intraindividual single- and repeated-dose pharmacokinetics of roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor. J Clin Pharmacol 2007, 47(1): 26-36.
-
(2007)
J Clin Pharmacol
, vol.47
, Issue.1
, pp. 26-36
-
-
Bethke, T.D.1
Bohmer, G.M.2
Hermann, R.3
-
15
-
-
0037425745
-
Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: A randomised controlled trial
-
TRial of Inhaled Steroids ANd long-acting beta2 agonists study group
-
Calverley, P., Pauwels, R., Vestbo, J. et al.; TRial of Inhaled Steroids ANd long-acting beta2 agonists study group. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: A randomised controlled trial. Lancet 2003, 361(9356): 449-56.
-
(2003)
Lancet
, vol.361
, Issue.9356
, pp. 449-456
-
-
Calverley, P.1
Pauwels, R.2
Vestbo, J.3
-
16
-
-
0036181956
-
A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
-
Casaburi, R., Mahler, D.A., Jones, P.W. et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J 2002, 19(2): 217-24.
-
(2002)
Eur Respir J
, vol.19
, Issue.2
, pp. 217-224
-
-
Casaburi, R.1
Mahler, D.A.2
Jones, P.W.3
-
17
-
-
0036305399
-
A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol
-
Donohue, J.F., van Noord, J.A., Bateman, E.D. et al. A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 2002, 122(1): 47-55.
-
(2002)
Chest
, vol.122
, Issue.1
, pp. 47-55
-
-
Donohue, J.F.1
Van Noord, J.A.2
Bateman, E.D.3
-
18
-
-
0037246566
-
Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease
-
Szafranski, W., Cukier, A., Ramirez, A. et al. Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease. Eur Respir J 2003, 21(1): 74-81.
-
(2003)
Eur Respir J
, vol.21
, Issue.1
, pp. 74-81
-
-
Szafranski, W.1
Cukier, A.2
Ramirez, A.3
-
19
-
-
34447310046
-
Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease
-
Calverley, P.M., Sanchez-Toril, F., McIvor, A., Teichmann, P., Bredenbroeker, D., Fabbri, L.M. Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007, 176(2): 154-61.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, Issue.2
, pp. 154-161
-
-
Calverley, P.M.1
Sanchez-Toril, F.2
McIvor, A.3
Teichmann, P.4
Bredenbroeker, D.5
Fabbri, L.M.6
-
20
-
-
69149103642
-
Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials
-
Calverley, P.M., Rabe, K.F., Goehring, U.M., Kristiansen, S., Fabbri, L.M., Martinez, F.J. Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomised clinical trials. Lancet 2009, 374(9691): 685-94.
-
(2009)
Lancet
, vol.374
, Issue.9691
, pp. 685-694
-
-
Calverley, P.M.1
Rabe, K.F.2
Goehring, U.M.3
Kristiansen, S.4
Fabbri, L.M.5
Martinez, F.J.6
-
21
-
-
69149098943
-
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: Two randomised clinical trials
-
Fabbri, L.M., Calverley, P., Izquierdo, J.L. et al. Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: Two randomised clinical trials. Lancet 2009, 374(9691): 695-703.
-
(2009)
Lancet
, vol.374
, Issue.9691
, pp. 695-703
-
-
Fabbri, L.M.1
Calverley, P.2
Izquierdo, J.L.3
-
22
-
-
0001139661
-
Safety of once-daily roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, in patients with COPD
-
Abst 595
-
Bredenbröker, D., Syed, J., Leichtl, S., Rathgeb, F., Wurst, W. Safety of once-daily roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, in patients with COPD. Am J Respir Crit Care Med 2002, 165(7, Suppl.): Abst 595.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, Issue.7 SUPPL.
-
-
Bredenbröker, D.1
Syed, J.2
Leichtl, S.3
Rathgeb, F.4
Wurst, W.5
-
23
-
-
11844307130
-
Roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor, is effective in the treatment of chronic obstructive pulmonary disease
-
Abst 2330
-
Bredenbröker, D., Syed, J., Leichtl, S., Rathgeb, F., Wurst, W. Roflumilast, a new orally active, selective phosphodiesterase 4 inhibitor, is effective in the treatment of chronic obstructive pulmonary disease. Eur Respir J 2002, (Suppl. 38): Abst 2330.
-
(2002)
Eur Respir J
, Issue.SUPPL. 38
-
-
Bredenbröker, D.1
Syed, J.2
Leichtl, S.3
Rathgeb, F.4
Wurst, W.5
-
24
-
-
0000619359
-
Efficacy of once-daily roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, in chronic obstructive pulmonary disease
-
Abst 229
-
Leichtl, S., Syed, J., Bredenbröker, D., Rahtgeb, F., Wurst, W. Efficacy of once-daily roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002, 165(7, Suppl.): Abst 229.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, Issue.7 SUPPL.
-
-
Leichtl, S.1
Syed, J.2
Bredenbröker, D.3
Rahtgeb, F.4
Wurst, W.5
-
25
-
-
0000619359
-
Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, is safe and well tolerated in patients with chronic obstructive pulmonary disease
-
Leichtl, S., Syed, J., Bredenbröker, D., Rahtgeb, F., Wurst, W. Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, is safe and well tolerated in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002, 165(7, Suppl.): A229.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, Issue.7 SUPPL.
-
-
Leichtl, S.1
Syed, J.2
Bredenbröker, D.3
Rahtgeb, F.4
Wurst, W.5
-
26
-
-
84878713530
-
Efficacy and safety of once-daily roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, in COPD
-
Schmid-Wirlitsch, C., Braman, S.S., Hubbard, R.C., Bredenbroeker, D., Bethke, T.D. Efficacy and safety of once-daily roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, in COPD. US COPD Coalition, National COPD Conference, On-Site Program Book 2003, 67.
-
US COPD Coalition, National COPD Conference, On-Site Program Book 2003
, pp. 67
-
-
Schmid-Wirlitsch, C.1
Braman, S.S.2
Hubbard, R.C.3
Bredenbroeker, D.4
Bethke, T.D.5
-
27
-
-
84878713530
-
Long-term safety and tolerability of once-daily roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, in COPD
-
Bredenbröker, D., Hubbard, R.C., Schmid-Wirlitsch, C., Bethke, T.D. Long-term safety and tolerability of once-daily roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, in COPD. US COPD Coalition, National COPD Conference, On-Site Program Book 2003, 67.
-
US COPD Coalition, National COPD Conference, On-Site Program Book 2003
, pp. 67
-
-
Bredenbröker, D.1
Hubbard, R.C.2
Schmid-Wirlitsch, C.3
Bethke, T.D.4
-
28
-
-
79955940191
-
Longterm safety of roflumilast in the treatment of chronic obstructive pulmonary disease
-
Abst 805S
-
Van Noord, J.A., Bateman, E.D., Steffen, H., Timar, M., Schmid-Wirlitsch, C., Bredenbroeker, D., Bethke, T.D. Longterm safety of roflumilast in the treatment of chronic obstructive pulmonary disease. Chest 2004, 126(4, Suppl.): Abst 805S.
-
(2004)
Chest
, vol.126
, Issue.4 SUPPL.
-
-
Van Noord, J.A.1
Bateman, E.D.2
Steffen, H.3
Timar, M.4
Schmid-Wirlitsch, C.5
Bredenbroeker, D.6
Bethke, T.D.7
-
29
-
-
33646938884
-
The effect of roflumilast treatment and subsequent withdrawal in patients with COPD
-
Boszormenyi-Nagy, G., Pieters, W.R., Steffen, H., Timar, M., Vinkler, I., Teichmann, P., Bredenbroeker, D. The effect of roflumilast treatment and subsequent withdrawal in patients with COPD. Proc Am Thorac Soc 2005, 2(Abstracts Issue): A544.
-
Proc Am Thorac Soc 2005
, vol.2
, Issue.ABSTRACTS ISSUE
-
-
Boszormenyi-Nagy, G.1
Pieters, W.R.2
Steffen, H.3
Timar, M.4
Vinkler, I.5
Teichmann, P.6
Bredenbroeker, D.7
-
30
-
-
11144345553
-
Safety profile of roflumilast, a novel, selective phosphodiesterase 4 inhibitor, in patients with moderate to severe COPD
-
Bateman, E.D., Holmes, M., Muir, J.F., Andrae, K., Witte, S., Bredenbroeker, D. Safety profile of roflumilast, a novel, selective phosphodiesterase 4 inhibitor, in patients with moderate to severe COPD. Am J Respir Crit Care Med 2004, 169(7, Suppl.): A596.
-
(2004)
Am J Respir Crit Care Med
, vol.169
, Issue.7 SUPPL.
-
-
Bateman, E.D.1
Holmes, M.2
Muir, J.F.3
Andrae, K.4
Witte, S.5
Bredenbroeker, D.6
-
31
-
-
11144324071
-
Roflumilast, a novel, selective phosphodiesterase 4 inhibitor, improves quality of life and lowers exacerbation rate in patients with moderate to severe COPD
-
O'Donnell, D., Muir, J.F., Jenkins, C., Plit, M., Brockhaus, F., Witte, S., Bredenbroeker, D. Roflumilast, a novel, selective phosphodiesterase 4 inhibitor, improves quality of life and lowers exacerbation rate in patients with moderate to severe COPD. Am J Respir Crit Care Med 2004, 169(7, Suppl.): A602.
-
(2004)
Am J Respir Crit Care Med
, vol.169
, Issue.7 SUPPL.
-
-
O'Donnell, D.1
Muir, J.F.2
Jenkins, C.3
Plit, M.4
Brockhaus, F.5
Witte, S.6
Bredenbroeker, D.7
-
32
-
-
79955941639
-
FEV1: A useful outcome measure of lung function in COPD as assessed in a large clinical study with roflumilast
-
Abst 342
-
O'Donnell, D., Rabe, K.F., Jenkins, C., Muir, J.F., Witte, S., Bredenbröker, D. FEV1: A useful outcome measure of lung function in COPD as assessed in a large clinical study with roflumilast. Eur Respir J 2004, 24(Suppl. 48): Abst 342.
-
(2004)
Eur Respir J
, vol.24
, Issue.SUPPL. 48
-
-
O'Donnell, D.1
Rabe, K.F.2
Jenkins, C.3
Muir, J.F.4
Witte, S.5
Bredenbröker, D.6
-
33
-
-
23744451716
-
Roflumilast - An oral antiinflammatory treatment for chronic obstructive pulmonary disease: A randomised controlled trial
-
Rabe, K.F., Bateman, E.D., O'Donnell, D., Witte, S., Bredenbroker, D., Bethke, T.D. Roflumilast - An oral antiinflammatory treatment for chronic obstructive pulmonary disease: A randomised controlled trial. Lancet 2005, 366(9485): 563-71.
-
(2005)
Lancet
, vol.366
, Issue.9485
, pp. 563-571
-
-
Rabe, K.F.1
Bateman, E.D.2
O'Donnell, D.3
Witte, S.4
Bredenbroker, D.5
Bethke, T.D.6
-
34
-
-
84878730209
-
Efficacy and safety of roflumilast in a large COPD study
-
Abst
-
Rabe, K.F., O'Donnell, D., Corey, R., Andrae, K., Witte, S. Efficacy and safety of roflumilast in a large COPD study. 11th Conf Eur Soc Gen Pract Family Med (Sept 3-7, Kos Island) 2005, Abst.
-
11th Conf Eur Soc Gen Pract Family Med (Sept 3-7, Kos Island) 2005
-
-
Rabe, K.F.1
O'Donnell, D.2
Corey, R.3
Andrae, K.4
Witte, S.5
-
35
-
-
84878718597
-
Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor improves lung function and quality of life in patients with COPD
-
Abst
-
Rabe, K.F., O'Donnell, D., Adler, L. et al. Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor improves lung function and quality of life in patients with COPD. COPD Cong (June 9-11, Birmingham) 2004, Abst.
-
COPD Cong (June 9-11, Birmingham) 2004
-
-
Rabe, K.F.1
O'Donnell, D.2
Adler, L.3
-
36
-
-
11344262873
-
Roflumilast, an oral, once-daily PDE4 inhibitor, improves lung function and reduces exacerbation rates in patients with COPD
-
Abst 267
-
Rabe, K.F., O'Donnell, D., Muir, J.F., Jenkins, C., Witte, S., Bredenbröker, D., Bethke, T.D. Roflumilast, an oral, once-daily PDE4 inhibitor, improves lung function and reduces exacerbation rates in patients with COPD. Eur Respir J 2004, 24(Suppl. 48): Abst 267.
-
(2004)
Eur Respir J
, vol.24
, Issue.SUPPL. 48
-
-
Rabe, K.F.1
O'Donnell, D.2
Muir, J.F.3
Jenkins, C.4
Witte, S.5
Bredenbröker, D.6
Bethke, T.D.7
-
37
-
-
28444462237
-
Roflumilast improves lung function and quality of life in chronic obstructive pulmonary disease
-
Abst 709S
-
Rabe, K.F., O'Donnell, D., Bateman, E.D., Andrae, K., Witte, S., Bredenbroeker, D. Roflumilast improves lung function and quality of life in chronic obstructive pulmonary disease. Chest 2004, 126(4, Suppl.): Abst 709S.
-
(2004)
Chest
, vol.126
, Issue.4 SUPPL.
-
-
Rabe, K.F.1
O'Donnell, D.2
Bateman, E.D.3
Andrae, K.4
Witte, S.5
Bredenbroeker, D.6
-
38
-
-
11144260570
-
Roflumilast, a novel, selective phosphodiesterase 4 inhibitor, improves lung function in patients with moderate to severe COPD
-
Rabe, K.F., Chapman, K.R., Joubert, J., Vetter, N., Witte, S., Bredenbroeker, D. Roflumilast, a novel, selective phosphodiesterase 4 inhibitor, improves lung function in patients with moderate to severe COPD. Am J Respir Crit Care Med 2004, 169(7, Suppl.): A518.
-
(2004)
Am J Respir Crit Care Med
, vol.169
, Issue.7 SUPPL.
-
-
Rabe, K.F.1
Chapman, K.R.2
Joubert, J.3
Vetter, N.4
Witte, S.5
Bredenbroeker, D.6
|