-
2
-
-
77953182426
-
B cells as therapeutic targets in SLE
-
Sanz, I., Lee, F.E. B cells as therapeutic targets in SLE. Nat Rev Rheumatol 2010, 6(6): 326-37.
-
(2010)
Nat Rev Rheumatol
, vol.6
, Issue.6
, pp. 326-337
-
-
Sanz, I.1
Lee, F.E.2
-
3
-
-
0033532634
-
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
-
DOI 10.1084/jem.189.11.1747
-
Schneider, P., MacKay, F., Steiner, V. et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999, 189(11): 1747-56. (Pubitemid 29272691)
-
(1999)
Journal of Experimental Medicine
, vol.189
, Issue.11
, pp. 1747-1756
-
-
Schneider, P.1
Mackay, F.2
Steiner, V.3
Hofmann, K.4
Bodmer, J.-L.5
Holler, N.6
Ambrose, C.7
Lawton, P.8
Bixler, S.9
Acha-Orbea, H.10
Valmori, D.11
Romero, P.12
Werner-Favre, C.13
Zubler, R.H.14
Browning, J.L.15
Tschopp, J.16
-
4
-
-
33747837100
-
BAFF, APRIL and their receptors: Structure, function and signaling
-
DOI 10.1016/j.smim.2006.04.006, PII S1044532306000844
-
Bossen, C., Schneider, P. BAFF, APRIL and their receptors: Structure, function and signaling. Semin Immunol 2006, 18(5): 263-75. (Pubitemid 44287558)
-
(2006)
Seminars in Immunology
, vol.18
, Issue.5
, pp. 263-275
-
-
Bossen, C.1
Schneider, P.2
-
5
-
-
56249101045
-
Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases
-
Ding, C. Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases. Expert Opin Biol Ther 2008, 8(11): 1805-14.
-
(2008)
Expert Opin Biol Ther
, vol.8
, Issue.11
, pp. 1805-1814
-
-
Ding, C.1
-
6
-
-
39449111352
-
BAFF, APRIL, TWE-APRIL: Who's who?
-
Daridon, C., Youinou, P., Pers, J.O. BAFF, APRIL, TWE-APRIL: Who's who? Autoimmun Rev 2008, 7(4): 267-71.
-
(2008)
Autoimmun Rev
, vol.7
, Issue.4
, pp. 267-271
-
-
Daridon, C.1
Youinou, P.2
Pers, J.O.3
-
7
-
-
77956924542
-
The late news on BAFF in autoimmune diseases
-
Youinou, P., Pers, P.O. The late news on BAFF in autoimmune diseases. Autoimmun Rev 2010, 9(12): 804-6.
-
(2010)
Autoimmun Rev
, vol.9
, Issue.12
, pp. 804-806
-
-
Youinou, P.1
Pers, P.O.2
-
8
-
-
0035175146
-
Synthesis and release of B-lymphocyte stimulator from myeloid cells
-
DOI 10.1182/blood.V97.1.198
-
Nardelli, B., Belvedere, O., Roschke, V. et al. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 2001, 97(1): 198-204. (Pubitemid 32061261)
-
(2001)
Blood
, vol.97
, Issue.1
, pp. 198-204
-
-
Nardelli, B.1
Belvedere, O.2
Roschke, V.3
Moore, P.A.4
Olsen, H.S.5
Migone, T.S.6
Sosnovtseva, S.7
Carrell, J.A.8
Feng, P.9
Giri, J.G.10
Hilbert, D.M.11
-
9
-
-
17344380531
-
TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
-
DOI 10.1038/35010115
-
Gross, J.A., Johnston, J., Mudri, S. et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 2000, 404(6781): 995-9. (Pubitemid 30243593)
-
(2000)
Nature
, vol.404
, Issue.6781
, pp. 995-999
-
-
Gross, J.A.1
Johnston, J.2
Mudri, S.3
Enselman, R.4
Dillon, S.R.5
Madden, K.6
Xu, W.7
Parrish-Novak, J.8
Foster, D.9
Lofton-Day, C.10
Moore, M.11
Littau, A.12
Grossman, A.13
Haugen, H.14
Foley, K.15
Blumberg, H.16
Harrison, K.17
Kindsvogel, W.18
Clegg, C.H.19
-
10
-
-
0035860466
-
BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
-
DOI 10.1126/science.1061965
-
Thompson, J.S., Bixler, S.A., Qian, F. et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 2001, 293(5537): 2108-11. (Pubitemid 32848062)
-
(2001)
Science
, vol.293
, Issue.5537
, pp. 2108-2111
-
-
Thompson, J.S.1
Bixler, S.A.2
Qian, F.3
Vora, K.4
Scott, M.L.5
Cachero, T.G.6
Hession, C.7
Schneider, P.8
Sizing, I.D.9
Mullen, C.10
Strauch, K.11
Zafari, M.12
Benjamin, C.D.13
Tschopp, J.14
Browning, J.L.15
Ambrose, C.16
-
11
-
-
38949206321
-
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts
-
DOI 10.1182/blood-2007-09-110874
-
Bossen, C., Cachera, T,G., Tardivel, A. et al. TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood 2008, 111(3): 1004-12. (Pubitemid 351213377)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1004-1012
-
-
Bossen, C.1
Cachero, T.G.2
Tardivel, A.3
Ingold, K.4
Willen, L.5
Dobles, M.6
Scott, M.L.7
Maquelin, A.8
Belnoue, E.9
Siegrist, C.-A.10
Chevrier, S.11
Acha-Orbea, H.12
Leung, H.13
Mackay, F.14
Tschopp, J.15
Schneider, P.16
-
12
-
-
0037097665
-
Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators
-
Hsu, B.L., Harless, S.M., Lindsley, R.C., Hilbert, D.M., Cancro, M.P. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol 2002, 168(12): 5993-6. (Pubitemid 34620011)
-
(2002)
Journal of Immunology
, vol.168
, Issue.12
, pp. 5993-5996
-
-
Hsu, B.L.1
Harless, S.M.2
Lindsley, R.C.3
Hilbert, D.M.4
Cancro, M.P.5
-
13
-
-
0016653937
-
Evidence of the clonal abortion theory of B-lymphocyte tolerance
-
Nossal, G.J.V., Pike, B.L. Evidence of the clonal abortion theory of B-lymphocyte tolerance. J Immunol 1975, 141: 904-17.
-
(1975)
J Immunol
, vol.141
, pp. 904-917
-
-
Nossal, G.J.V.1
Pike, B.L.2
-
14
-
-
66449126945
-
The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
-
Cancro, M.P., D'Cruz, D., Khamashta, M.A. The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. J Clin Invest 2009, 119(5): 1066-73.
-
(2009)
J Clin Invest
, vol.119
, Issue.5
, pp. 1066-1073
-
-
Cancro, M.P.1
D'Cruz, D.2
Khamashta, M.A.3
-
15
-
-
55749115444
-
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
-
Scholz, J.L., Crowley, J.E., Tomayko, M.M. et al. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci U S A 2008, 105(40): 15517-22.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.40
, pp. 15517-15522
-
-
Scholz, J.L.1
Crowley, J.E.2
Tomayko, M.M.3
-
16
-
-
0033428703
-
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
-
DOI 10.1084/jem.190.11.1697
-
Mackay, F., Woodcock, S.A., Lawton, P. et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999, 190(11): 1697-710. (Pubitemid 30002351)
-
(1999)
Journal of Experimental Medicine
, vol.190
, Issue.11
, pp. 1697-1710
-
-
Mackay, F.1
Woodcock, S.A.2
Lawton, P.3
Ambrose, C.4
Baetscher, M.5
Schneider, P.6
Tschopp, J.7
Browning, J.L.8
-
17
-
-
0035860559
-
An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
-
DOI 10.1126/science.1061964
-
Schiemann, B., Gommerman, J.L., Vora, K. et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001, 293(5537): 2111-4. (Pubitemid 32848063)
-
(2001)
Science
, vol.293
, Issue.5537
, pp. 2111-2114
-
-
Schiemann, B.1
Gommerman, J.L.2
Vora, K.3
Cachero, T.G.4
Shutga-Morskaya, S.5
Dobles, M.6
Frew, E.7
Scott, M.L.8
-
18
-
-
0035803468
-
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen
-
DOI 10.1084/jem.194.11.1691
-
Schneider, P., Takatsuka, H., Wilson, A. et al. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J Exp Med 2001, 194(11): 1691-7. (Pubitemid 33126819)
-
(2001)
Journal of Experimental Medicine
, vol.194
, Issue.11
, pp. 1691-1697
-
-
Schneider, P.1
Takatsuka, H.2
Wilson, A.3
Mackay, F.4
Tardivel, A.5
Lens, S.6
Cachero, T.G.7
Finke, D.8
Beermann, F.9
Tschopp, J.10
-
19
-
-
0034972257
-
Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
-
DOI 10.1002/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO;2-S
-
Cheema, G.S., Roschke, V., Hilbert, D.M., Stohl, W. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum 2001, 44(6): 1313-9. (Pubitemid 32537529)
-
(2001)
Arthritis and Rheumatism
, vol.44
, Issue.6
, pp. 1313-1319
-
-
Cheema, G.S.1
Roschke, V.2
Hilbert, D.M.3
Stohl, W.4
-
20
-
-
70350520105
-
B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: Disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels
-
Collins, C.E., Gavin, A.L., Migone, T.S., Hilbert, D.M., Nemazee, D., Stohl, W. B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: Disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels. Arthritis Res Ther 2006, 8(1): R6.
-
(2006)
Arthritis Res Ther
, vol.8
, Issue.1
-
-
Collins, C.E.1
Gavin, A.L.2
Migone, T.S.3
Hilbert, D.M.4
Nemazee, D.5
Stohl, W.6
-
21
-
-
70350527321
-
B lymphocyte stimulator expression in and juvenile idiopathic arthritis patients
-
Hong, S.D., Reiff, A., Yang, H.T. et al. B lymphocyte stimulator expression in and juvenile idiopathic arthritis patients. Arthritis Rheum 2009, 60(11): 3400-9.
-
(2009)
Arthritis Rheum
, vol.60
, Issue.11
, pp. 3400-3409
-
-
Hong, S.D.1
Reiff, A.2
Yang, H.T.3
-
22
-
-
10744224617
-
B Lymphocyte Stimulator Overexpression in Patients with Systemic Lupus Erythematosus: Longitudinal Observations
-
DOI 10.1002/art.11354
-
Stohl, W., Metyas, S., Tan, S.M. et al. B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: Longitudinal observations. Arthritis Rheum 2003, 48(12): 3475-86. (Pubitemid 37531913)
-
(2003)
Arthritis and Rheumatism
, vol.48
, Issue.12
, pp. 3475-3486
-
-
Stohl, W.1
Metyas, S.2
Tan, S.-M.3
Cheema, G.S.4
Oamar, B.5
Xu, D.6
Roschke, V.7
Wu, Y.8
Baker, K.P.9
Hilbert, D.M.10
-
23
-
-
49449092839
-
Association of plasma lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
-
Petri, M., Stohl, W., Chatham, W. et al. Association of plasma lymphocyte stimulator levels and disease activity in systemic lupus erythematosus. Arthritis Rheum 2008, 58(8): 2453-9.
-
(2008)
Arthritis Rheum
, vol.58
, Issue.8
, pp. 2453-2459
-
-
Petri, M.1
Stohl, W.2
Chatham, W.3
-
24
-
-
0242495115
-
Generation and Characterization of LymphoStat-B, a Human Monoclonal Antibody That Antagonizes the Bioactivities of B Lymphocyte Stimulator
-
DOI 10.1002/art.11299
-
Baker, K.P., Edwards, B.M., Main, S.H. et al. Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator. Arthritis Rheum 2003, 48(11): 3253-65. (Pubitemid 37409340)
-
(2003)
Arthritis and Rheumatism
, vol.48
, Issue.11
, pp. 3253-3265
-
-
Baker, K.P.1
Edwards, B.M.2
Main, S.H.3
Choi, G.H.4
Wager, R.E.5
Halpern, W.G.6
Lappin, P.B.7
Riccobene, T.8
Abramian, D.9
Sekut, L.10
Sturm, B.11
Poortman, C.12
Minter, R.R.13
Dobson, C.L.14
Williams, E.15
Carmen, S.16
Smith, R.17
Roschke, V.18
Hilbert, D.M.19
Vaughan, T.J.20
Albert, V.R.21
more..
-
25
-
-
33646827589
-
Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: Pharmacokinetic, pharmacodynamic and toxicologic effects
-
Halpern, W.G., Lappin, P., Zanardi, T., Cai, W., Corcoran, M., Zhong, J., Baker, K.P. Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: Pharmacokinetic, pharmacodynamic and toxicologic effects. Toxicol Sci 2006, 91(2): 586-99.
-
(2006)
Toxicol Sci
, vol.91
, Issue.2
, pp. 586-599
-
-
Halpern, W.G.1
Lappin, P.2
Zanardi, T.3
Cai, W.4
Corcoran, M.5
Zhong, J.6
Baker, K.P.7
-
26
-
-
54349100000
-
Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: A phase I trial in patients with systemic lupus erythematosus
-
Furie, R., Stohl, W., Ginzler, E.M. et al. Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: A phase I trial in patients with systemic lupus erythematosus. Arthritis Res Ther 2008, 10(5): R109.
-
(2008)
Arthritis Res Ther
, vol.10
, Issue.5
-
-
Furie, R.1
Stohl, W.2
Ginzler, E.M.3
-
27
-
-
69749120918
-
A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus
-
Wallace, D.J., Stohl, W., Furie, R.A. et al. A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Arthritis Rheum 2009, 61(9): 1168-78.
-
(2009)
Arthritis Rheum
, vol.61
, Issue.9
, pp. 1168-1178
-
-
Wallace, D.J.1
Stohl, W.2
Furie, R.A.3
-
28
-
-
75749134960
-
Belimumab, a BLyS-specific inhibitor, reduced disease activity, flares and prednisone use in patients with active SLE: Efficacy and safety results from the phase 3 BLISS-52 study
-
Oct 17-21, Phitdelphia Abst 204 B
-
Navarra, S., Guzman, R., Gallacher, A. et al. Belimumab, a BLyS-specific inhibitor, reduced disease activity, flares and prednisone use in patients with active SLE: efficacy and safety results from the phase 3 BLISS-52 study. Am Coll Rheum/Assoc Rheum Health Profess Annu Sci Meet (Oct 17-21, Phitdelphia) 2009, Abst 204 B.
-
(2009)
Am Coll Rheum/Assoc Rheum Health Profess Annu Sci Meet
-
-
Navarra, S.1
Guzman, R.2
Gallacher, A.3
-
29
-
-
78649958105
-
Belimumab, a BLyS-specific inhibitor, reduces disease activity and severe flares in seropositive SLE: BLySS-76 study
-
van Vollenhoven, R.F., Zamani, O., Wallace, D.J. et al. Belimumab, a BLyS-specific inhibitor, reduces disease activity and severe flares in seropositive SLE: BLySS-76 study. Ann Rheum Dis 2010, 69(Suppl. 3): 74.
-
(2010)
Ann Rheum Dis
, vol.69
, Issue.SUPPL. 3
, pp. 74
-
-
Van Vollenhoven, R.F.1
Zamani, O.2
Wallace, D.J.3
-
30
-
-
69749096135
-
Novel evidence-based systemic lupus erythematosus responder index
-
Furie, R.A., Petri, M.A., Wallace, D.J. et al. Novel evidence-based systemic lupus erythematosus responder index. Arthritis Rheum 2009, 61(9): 1143-51.
-
(2009)
Arthritis Rheum
, vol.61
, Issue.9
, pp. 1143-1151
-
-
Furie, R.A.1
Petri, M.A.2
Wallace, D.J.3
-
31
-
-
77749344259
-
Four year experience of belimumab, a BlySspecific inhibitor, in systemic lupus erythematosus (SLE)
-
Oct 17-21, Phitdelphia Abst 2069
-
Petri, M.A., Furie, R., Merrill, J.T. et al. Four year experience of belimumab, a BlySspecific inhibitor, in systemic lupus erythematosus (SLE). Am Coll Rheum/Assoc Rheum Health Profess Annu Sci Meet (Oct 17-21, Phitdelphia) 2009, Abst 2069.
-
(2009)
Am Coll Rheum/Assoc Rheum Health Profess Annu Sci Meet
-
-
Petri, M.A.1
Furie, R.2
Merrill, J.T.3
-
32
-
-
79953167706
-
Belimumab, a BLyS-specific inhibitor, significantly improved physichal functioning, fatigue, and other health-related quality of life (HRQoL) measures in patients with seropositive systemic lupus erythematosus (SLE): BLISS-52 study
-
Tanasescu, C., Gallacher, A., Garcia, M. et al. Belimumab, a BLyS-specific inhibitor, significantly improved physichal functioning, fatigue, and other health-related quality of life (HRQoL) measures in patients with seropositive systemic lupus erythematosus (SLE): BLISS-52 study. Ann Rheum Dis 2010, 69(Suppl. 3): 556.
-
(2010)
Ann Rheum Dis
, vol.69
, Issue.SUPPL. 3
, pp. 556
-
-
Tanasescu, C.1
Gallacher, A.2
Garcia, M.3
-
33
-
-
79953191650
-
Belimumab, a BLyS-specific inhibitor, significantly reduced autoantibodies and normalized low complement in patients with seropositive systemic lupus erythematosus (SLE): BLISS-52 study
-
Levy, R.A., Ilianova, E., Ionescu, R. et al. Belimumab, a BLyS-specific inhibitor, significantly reduced autoantibodies and normalized low complement in patients with seropositive systemic lupus erythematosus (SLE): BLISS-52 study. Ann Rheum Dis 2010, 69(Suppl. 3): 556.
-
(2010)
Ann Rheum Dis
, vol.69
, Issue.SUPPL. 3
, pp. 556
-
-
Levy, R.A.1
Ilianova, E.2
Ionescu, R.3
|