메뉴 건너뛰기




Volumn 20, Issue 4, 2011, Pages 836-846

1H NMR metabolomics of earthworm responses to polychlorinated biphenyl (PCB) exposure in soil

Author keywords

Bioavailability; Metabonomics; Pearson correlation; Persistent organic pollutants (POPs); Risk assessment; Sub lethal toxicity

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; ALANINE; AROCLOR; GLUTAMIC ACID; LEUCINE; LYSINE; POLYCHLORINATED BIPHENYL; VALINE;

EID: 79955909102     PISSN: 09639292     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10646-011-0638-9     Document Type: Article
Times cited : (38)

References (78)
  • 2
    • 0034666852 scopus 로고    scopus 로고
    • Aging, bioavailability, and overestimation of risk from environmental pollutants
    • Alexander M (2000) Aging, bioavailability, and overestimation of risk from environmental pollutants. Environ Sci Technol 34:4259-4265
    • (2000) Environ Sci Technol , vol.34 , pp. 4259-4265
    • Alexander, M.1
  • 3
    • 0016596119 scopus 로고
    • Effect of polychlorinated biphenyls and thiamin deficiency on liver metabolism in growing rats
    • Berdanier CD, Tobin RB, Nielsen RC (1975) Effect of polychlorinated biphenyls and thiamin deficiency on liver metabolism in growing rats. J Toxicol Environ Health 1:91-105
    • (1975) J Toxicol Environ Health , vol.1 , pp. 91-105
    • Berdanier, C.D.1    Tobin, R.B.2    Nielsen, R.C.3
  • 6
    • 33846240326 scopus 로고    scopus 로고
    • Statistical strategies for avoiding false discoveries in metabolomics and related experiments
    • DOI 10.1007/s11306-006-0037-z
    • Broadhurst DI, Kell DB (2006) Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2:171-196 (Pubitemid 46099798)
    • (2006) Metabolomics , vol.2 , Issue.4 , pp. 171-196
    • Broadhurst, D.I.1    Kell, D.B.2
  • 7
    • 42049086298 scopus 로고    scopus 로고
    • Evaluation of sample preparation methods for nuclear magnetic resonance metabolic profiling studies with Eisenia fetida
    • DOI 10.1897/07-412.1
    • Brown SAE, Simpson AJ, Simpson MJ (2008) Evaluation of sample preparation methods for nuclear magnetic resonance metabolic profiling studies with Eisenia fetida. Environ Toxicol Chem 27:828-836 (Pubitemid 351518137)
    • (2008) Environmental Toxicology and Chemistry , vol.27 , Issue.4 , pp. 828-836
    • Brown, S.A.E.1    Simpson, A.J.2    Simpson, M.J.3
  • 8
    • 71049131792 scopus 로고    scopus 로고
    • 1H NMR metabolomics of earthworm responses to sub-lethal PAH exposure
    • 1H NMR metabolomics of earthworm responses to sub-lethal PAH exposure. Environ Chem 6:432-440
    • (2009) Environ Chem , vol.6 , pp. 432-440
    • Brown, S.A.E.1    Simpson, A.J.2    Simpson, M.J.3
  • 9
  • 10
    • 33847355511 scopus 로고    scopus 로고
    • Environmental Applications of Metabonomic Profiling
    • Robertson DG, Lindon J (eds) Taylor & Francis, Boca Raton
    • Bundy JG (2005) Environmental Applications of Metabonomic Profiling. In: Robertson DG, Lindon J (eds) Metabonomics in toxicity assessment. Taylor & Francis, Boca Raton, pp 453-498
    • (2005) Metabonomics in Toxicity Assessment , pp. 453-498
    • Bundy, J.G.1
  • 11
    • 14944364239 scopus 로고    scopus 로고
    • Environmental metabonomics: Applying combination biomarker analysis in earthworms at a metal contaminated site
    • DOI 10.1007/s10646-003-4477-1
    • Bundy JG, Spurgeon DJ, Svendsen C, Hankard PK, Weeks JM, Osborn D, Lindon JC, Nicholson JK (2004) Environmental metabonomics: applying combination biomarker analysis in earthworms at a metal contaminated site. Ecotoxicology 13:797-806 (Pubitemid 40380955)
    • (2004) Ecotoxicology , vol.13 , Issue.8 , pp. 797-806
    • Bundy, J.G.1    Spurgeon, D.J.2    Svendsen, C.3    Hankard, P.K.4    Weeks, J.M.5    Osborn, D.6    Lindon, J.C.7    Nicholson, J.K.8
  • 12
    • 34250827075 scopus 로고    scopus 로고
    • Metabolic profile biomarkers of metal contamination in a sentinel terrestrial species are applicable across multiple sites
    • DOI 10.1021/es0700303
    • Bundy JG, Keun HC, Sidhu JK, Spurgeon DJ, Svendsen C, Kille P, Morgan AJ (2007) Metabolic profile biomarkers of metal contamination in a sentinel terrestrial species are applicable across multiple sites. Environ Sci Technol 41:4458-4464 (Pubitemid 46981743)
    • (2007) Environmental Science and Technology , vol.41 , Issue.12 , pp. 4458-4464
    • Bundy, J.G.1    Keun, H.C.2    Sidhu, J.K.3    Spurgeon, D.J.4    Svendsen, C.5    Kille, P.6    Morgan, A.J.7
  • 13
    • 45449111362 scopus 로고    scopus 로고
    • 'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus
    • Bundy JG, Sidhu JK, Rana F, Spurgeon DJ, Svendsen C, Wren JF, Stürzenbaum SR, Morgan AJ, Kille P (2008) 'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus. BMC Biol 6:25
    • (2008) BMC Biol , vol.6 , pp. 25
    • Bundy, J.G.1    Sidhu, J.K.2    Rana, F.3    Spurgeon, D.J.4    Svendsen, C.5    Wren, J.F.6    Stürzenbaum, S.R.7    Morgan, A.J.8    Kille, P.9
  • 14
    • 20344365760 scopus 로고    scopus 로고
    • The origin of correlations in metabolomics data
    • Camacho D, de la Fuente A, Mendes P (2005) The origin of correlations in metabolomics data. Metabolomics 1:53-63
    • (2005) Metabolomics , vol.1 , pp. 53-63
    • Camacho, D.1    De La Fuente, A.2    Mendes, P.3
  • 15
    • 3242799954 scopus 로고    scopus 로고
    • Canadian Council of Ministers of the Environment (CCME) Canadian Council of Ministers of the Environment, Winnipeg
    • Canadian Council of Ministers of the Environment (CCME) (1999) Canadian soil quality guidelines for the protection of environmental and human health. Canadian Council of Ministers of the Environment, Winnipeg
    • (1999) Canadian Soil Quality Guidelines for the Protection of Environmental and Human Health
  • 16
    • 0026886332 scopus 로고
    • The capacities of earthworms to heal wounds and to destroy allografts are modified by polychlorinated biphenyls (PCB)
    • Cooper EL, Roch P (1992) The capacities of earthworms to heal wounds and to destroy allografts are modified by polychlorinated biphenyls (PCB). J Invertebr Pathol 60:59-63
    • (1992) J Invertebr Pathol , vol.60 , pp. 59-63
    • Cooper, E.L.1    Roch, P.2
  • 17
    • 33645663178 scopus 로고    scopus 로고
    • Scaling and normalization effects in NMR spectroscopic metabonomic data sets
    • Craig A, Cloarec O, Holmes E, Nicholson JK, Lindon JC (2006) Scaling and normalization effects in NMR spectroscopic metabonomic data sets. Anal Chem 78:2262-2267
    • (2006) Anal Chem , vol.78 , pp. 2262-2267
    • Craig, A.1    Cloarec, O.2    Holmes, E.3    Nicholson, J.K.4    Lindon, J.C.5
  • 18
    • 34250078600 scopus 로고
    • Partial least squares (PLS): Its strengths and limitations
    • Cramer RD (1993) Partial least squares (PLS): its strengths and limitations. Perspect Drug Discov Des 1:269-278
    • (1993) Perspect Drug Discov des , vol.1 , pp. 269-278
    • Cramer, R.D.1
  • 20
    • 0015376268 scopus 로고
    • Organochlorine insecticide, herbicide and polychlorinated biphenyl (PCB) inhibition of NaK-ATPase in rainbow trout
    • Davis PW, Friedhoff JM, Wedemeyer GA (1972) Organochlorine insecticide, herbicide and polychlorinated biphenyl (PCB) inhibition of NaK-ATPase in rainbow trout. Bull Environ Contam Toxicol 8:69-72
    • (1972) Bull Environ Contam Toxicol , vol.8 , pp. 69-72
    • Davis, P.W.1    Friedhoff, J.M.2    Wedemeyer, G.A.3
  • 23
    • 0035154335 scopus 로고    scopus 로고
    • Polycyclic aromatic hydrocarbon-polluted dredged peat sediments and earthworms: A mutual interference
    • DOI 10.1023/A:1008954706150
    • Eijsackers H, Van Gestel CAM, De Jonge S, Muijs B, Slijkerman D (2001) Polycyclic aromatic hydrocarbon-polluted dredged peat sediments and earthworms: a mutual interference. Ecotoxicology 10:35-50 (Pubitemid 32128504)
    • (2001) Ecotoxicology , vol.10 , Issue.1 , pp. 35-50
    • Eijsackers, H.1    Van Gestel, C.A.M.2    De Jonge, S.3    Muijs, B.4    Slijkerman, D.5
  • 25
    • 0003826721 scopus 로고    scopus 로고
    • Multi- and megavariate data analysis part I basic principles and applications
    • Umetrics, Umeå
    • Eriksson L, Johansson E, Kettaneh-Wold N, Trygg J, Wikström C, Wold S (2006) Multi- and megavariate data analysis part I basic principles and applications. Umetrics, Umeå
    • (2006)
    • Eriksson, L.1    Johansson, E.2    Kettaneh-Wold, N.3    Trygg, J.4    Wikström, C.5    Wold, S.6
  • 28
    • 0001501332 scopus 로고    scopus 로고
    • 1H NMR spectroscopic investigations of tissue metabolite biomarker response to Cu(II) exposure in terrestrial invertebrates: Identification of free histidine as a novel biomarker of exposure to copper in earthworms
    • Gibb JOT, Svendsen C, Weeks JM, Nicholson JK (1997) 1H NMR spectroscopic investigations of tissue metabolite biomarker response to Cu(II) exposure in terrestrial invertebrates: Identification of free histidine as a novel biomarker of exposure to copper in earthworms. Biomarkers 2:295-302 (Pubitemid 127699916)
    • (1997) Biomarkers , vol.2 , Issue.5 , pp. 295-302
    • Gibb, J.O.T.1    Svendsen, C.2    Weeks, J.M.3    Nicholson, J.K.4
  • 33
    • 67650367153 scopus 로고    scopus 로고
    • The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins
    • Hughes SL, Bundy JG, Want EJ, Kille P, Stürzenbaum SR (2009) The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins. J Proteome Res 8:3512-3519
    • (2009) J Proteome Res , vol.8 , pp. 3512-3519
    • Hughes, S.L.1    Bundy, J.G.2    Want, E.J.3    Kille, P.4    Stürzenbaum, S.R.5
  • 35
    • 36048932994 scopus 로고    scopus 로고
    • The application of MANOVA to analyse Arabidopsis thaliana metabolomic data from factorially designed experiments
    • DOI 10.1007/s11306-007-0065-3
    • Johnson HE, Lloyd AJ, Mur LAJ, Smith AR, Causton DR (2007) The application of MANOVA to analyse Arabidopsis thaliana metabolomic data from factorially designed experiments. Metabolomics 3:517-530 (Pubitemid 350090679)
    • (2007) Metabolomics , vol.3 , Issue.4 , pp. 517-530
    • Johnson, H.E.1    Lloyd, A.J.2    Mur, L.A.J.3    Smith, A.R.4    Causton, D.R.5
  • 36
    • 67650963690 scopus 로고    scopus 로고
    • Effects of local point source polychlorinated biphenyl (PCB) contamination on bone mineral density in deer mice (Peromyscus maniculatus)
    • Johnson KE, Knopper LD, Schneider DC, Ollson CA, Reimer KJ (2009) Effects of local point source polychlorinated biphenyl (PCB) contamination on bone mineral density in deer mice (Peromyscus maniculatus). Sci Total Environ 407:5050-5055
    • (2009) Sci Total Environ , vol.407 , pp. 5050-5055
    • Johnson, K.E.1    Knopper, L.D.2    Schneider, D.C.3    Ollson, C.A.4    Reimer, K.J.5
  • 37
    • 43049181666 scopus 로고    scopus 로고
    • A metabolomics based approach to assessing the toxicity of the polyaromatic hydrocarbon pyrene to the earthworm Lumbricus rubellus
    • DOI 10.1016/j.chemosphere.2007.08.056, PII S0045653507010910
    • Jones OAH, Spurgeon DJ, Svendsen C, Griffin JL (2008) A metabolomics based approach to assessing the toxicity of the polyaromatic hydrocarbon pyrene to the earthworm Lumbricus rubellus. Chemosphere 71:601-609 (Pubitemid 351635614)
    • (2008) Chemosphere , vol.71 , Issue.3 , pp. 601-609
    • Jones, O.A.H.1    Spurgeon, D.J.2    Svendsen, C.3    Griffin, J.L.4
  • 38
    • 0018776799 scopus 로고
    • The effect of polychlorinated biphenyls on adenosine triphosphatase activity
    • DOI 10.1016/S0041-008X(79)80021-6
    • La Rocca PT, Carlson GP (1979) The effect of polychlorinated biphenyls on adenosine triphosphatase activity. Toxicol Appl Pharmacol 48:185-192 (Pubitemid 9189425)
    • (1979) Toxicology and Applied Pharmacology , vol.48 , Issue.1 I , pp. 185-192
    • La, R.P.T.1    Carlson, G.P.2
  • 40
    • 20344368357 scopus 로고    scopus 로고
    • 1H-NMR spectroscopy for the characterization of endogenous metabolites in earthworms with biochemical biomarker potential
    • DOI 10.1007/s11306-005-4435-4
    • Lenz EM, Weeks JM, Lindon JC, Osborn D, Nicholson JK (2005) Qualitative high field 1H-NMR spectroscopy for the characterization of endogenous metabolites in earthworms with biochemical biomarker potential. Metabolomics 1:123-136 (Pubitemid 40778833)
    • (2005) Metabolomics , vol.1 , Issue.2 , pp. 123-136
    • Lenz, E.M.1    Weeks, J.M.2    Lindon, J.C.3    Osborn, D.4    Nicholson, J.K.5
  • 41
    • 33847057322 scopus 로고    scopus 로고
    • Effects of aqueous exposure to polychlorinated biphenyls (Aroclor 1254) on physiology and behavior of smolt development of Atlantic salmon
    • DOI 10.1016/j.aquatox.2006.12.018, PII S0166445X07000161
    • Lerner DT, Björnsson BT, McCormick SD (2007) Effects of aqueous exposure to polychlorinated biphenyls (Aroclor 1254) on physiology and behavior of smolt development of Atlantic salmon. Aquat Toxicol 81:329-336 (Pubitemid 46273704)
    • (2007) Aquatic Toxicology , vol.81 , Issue.3 , pp. 329-336
    • Lerner, D.T.1    Bjornsson, B.T.2    McCormick, S.D.3
  • 42
    • 77649189032 scopus 로고    scopus 로고
    • Development of ecotoxicoproteomics on the freshwater amphipod Gammarus pulex: Identification of PCB biomarkers in glycolysis and glutamate pathways
    • Leroy D, Haubruge E, De Pauw E, Thomé JP, Francis F (2010) Development of ecotoxicoproteomics on the freshwater amphipod Gammarus pulex: identification of PCB biomarkers in glycolysis and glutamate pathways. Ecotoxicol Environ Saf 73:343-352
    • (2010) Ecotoxicol Environ Saf , vol.73 , pp. 343-352
    • Leroy, D.1    Haubruge, E.2    De Pauw, E.3    Thomé, J.P.4    Francis, F.5
  • 45
    • 77953290866 scopus 로고    scopus 로고
    • Correlations of Eisenia fetida metabolic responses to extractable phenanthrene concentrations through time
    • McKelvie JR, Wolfe DM, Celejewski M, Simpson AJ, Simpson MJ (2010) Correlations of Eisenia fetida metabolic responses to extractable phenanthrene concentrations through time. Environ Pollut 158:2150-2157
    • (2010) Environ Pollut , vol.158 , pp. 2150-2157
    • McKelvie, J.R.1    Wolfe, D.M.2    Celejewski, M.3    Simpson, A.J.4    Simpson, M.J.5
  • 46
    • 0030917399 scopus 로고    scopus 로고
    • Use of plant and earthworm bioassays to evaluate remediation of soil from a site contaminated with polychlorinated biphenyls
    • Meier JR, Chang LW, Jacobs S, Torsella J, Meckes MC, Smith MK (1997) Use of plant and earthworm bioassays to evaluate remediation of soil from a site contaminated with polychlorinated biphenyls. Environ Toxicol Chem 16:928-938 (Pubitemid 27199703)
    • (1997) Environmental Toxicology and Chemistry , vol.16 , Issue.5 , pp. 928-938
    • Meier, J.R.1    Chang, L.W.2    Jacobs, S.3    Torsella, J.4    Meckes, M.C.5    Smith, M.K.6
  • 47
    • 32044454046 scopus 로고    scopus 로고
    • Metabolomic networks in plants: Transitions from pattern recognition to biological interpretation
    • DOI 10.1016/j.biosystems.2005.05.017, PII S0303264705001206
    • Morgenthal K, Weckwerth W, Steuer R (2006) Metabolomic networks in plants: transitions from pattern recognition to biological interpretation. BioSystems 83:108-117 (Pubitemid 43199812)
    • (2006) BioSystems , vol.83 , Issue.2-3 SPEC. ISS. , pp. 108-117
    • Morgenthal, K.1    Weckwerth, W.2    Steuer, R.3
  • 48
    • 31544443894 scopus 로고    scopus 로고
    • Toxicological considerations of contaminants in the terrestrial environment for ecological risk assessment
    • O'Halloran K (2006) Toxicological considerations of contaminants in the terrestrial environment for ecological risk assessment. Hum Ecol Risk Assess 12:74-83
    • (2006) Hum Ecol Risk Assess , vol.12 , pp. 74-83
    • O'Halloran, K.1
  • 51
    • 60649117985 scopus 로고    scopus 로고
    • Spectral relative standard deviation: A practical benchmark in metabolomics
    • Parsons HM, Ekman DR, Collette TW, Viant MR (2009) Spectral relative standard deviation: a practical benchmark in metabolomics. Analyst 134:478-485
    • (2009) Analyst , vol.134 , pp. 478-485
    • Parsons, H.M.1    Ekman, D.R.2    Collette, T.W.3    Viant, M.R.4
  • 52
    • 70149113077 scopus 로고    scopus 로고
    • R Development Core Team R Foundation for Statistical Computing, Vienna, Austria
    • R Development Core Team (2009) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria
    • (2009) R: A Language and Environment for Statistical Computing
  • 53
    • 20544466649 scopus 로고    scopus 로고
    • Metabonomics in toxicology: A review
    • Robertson DG (2005) Metabonomics in toxicology: a review. Toxicol Sci 85:809-822
    • (2005) Toxicol Sci , vol.85 , pp. 809-822
    • Robertson, D.G.1
  • 54
    • 61849091454 scopus 로고    scopus 로고
    • NMR-based metabolomics using earthworms as potential indicators for soil health
    • Rochfort SJ, Ezernieks V, Yen AL (2009) NMR-based metabolomics using earthworms as potential indicators for soil health. Metabolomics 5:95-107
    • (2009) Metabolomics , vol.5 , pp. 95-107
    • Rochfort, S.J.1    Ezernieks, V.2    Yen, A.L.3
  • 57
    • 34447120314 scopus 로고    scopus 로고
    • Visualization and analysis of molecular data
    • Scholz M, Selbig J (2007) Visualization and analysis of molecular data. Methods Mol Biol 358:87-104
    • (2007) Methods Mol Biol , vol.358 , pp. 87-104
    • Scholz, M.1    Selbig, J.2
  • 58
    • 0344663969 scopus 로고    scopus 로고
    • Bioavailability of hydrophobic organic contaminants in soils: Fundamental concepts and techniques for analysis
    • DOI 10.1046/j.1351-0754.2003.0564.x
    • Semple KT, Morriss AWJ, Paton GI (2003) Bioavailability of hydrophobic organic contaminants in soils: fundamental concepts and techniques for analysis. Eur J Soil Sci 54:809-818 (Pubitemid 37502505)
    • (2003) European Journal of Soil Science , vol.54 , Issue.4 , pp. 809-818
    • Semple, K.T.1    Morriss, A.W.J.2    Paton, G.I.3
  • 59
    • 21244439545 scopus 로고    scopus 로고
    • Purge NMR: Effective and easy solvent suppression
    • DOI 10.1016/j.jmr.2005.05.008, PII S1090780705001631
    • Simpson AJ, Brown SA (2005) Purge NMR: effective and easy solvent suppression. J Magn Reson 175:340-346 (Pubitemid 40891690)
    • (2005) Journal of Magnetic Resonance , vol.175 , Issue.2 , pp. 340-346
    • Simpson, A.J.1    Brown, S.A.2
  • 60
    • 65049089975 scopus 로고    scopus 로고
    • Environmental metabolomics: New insights into earthworm ecotoxicity and contaminant bioavailability in soil
    • Simpson MJ, McKelvie JR (2009) Environmental metabolomics: new insights into earthworm ecotoxicity and contaminant bioavailability in soil. Anal Bioanal Chem 394:137-149
    • (2009) Anal Bioanal Chem , vol.394 , pp. 137-149
    • Simpson, M.J.1    McKelvie, J.R.2
  • 63
    • 1542401163 scopus 로고    scopus 로고
    • A practical guide to dose-response analyses and risk assessment in occupational epidemiology
    • DOI 10.1097/01.ede.0000100287.45004.e7
    • Steenland K, Deddens JA (2004) A practical guide to dose-response analyses and risk assessment in occupational epidemiology. Epidemiology 15:63-70 (Pubitemid 40416998)
    • (2004) Epidemiology , vol.15 , Issue.1 , pp. 63-70
    • Steenland, K.1    Deddens, J.A.2
  • 64
    • 33748475897 scopus 로고    scopus 로고
    • Review: On the analysis and interpretation of correlations in metabolomic data
    • Steuer R (2006) Review: on the analysis and interpretation of correlations in metabolomic data. Brief Bioinform 7:151-158
    • (2006) Brief Bioinform , vol.7 , pp. 151-158
    • Steuer, R.1
  • 67
    • 5544260474 scopus 로고
    • United States Environmental Protection Agency (EPA) United States Environmental Protection Agency, Washington DC, USA
    • United States Environmental Protection Agency (EPA) (1990) Guidance on remedial actions for superfund sites with PCB contamination. United States Environmental Protection Agency, Washington DC, USA
    • (1990) Guidance on Remedial Actions for Superfund Sites with PCB Contamination
  • 72
    • 52649126218 scopus 로고    scopus 로고
    • Recent developments in environmental metabolomics
    • Viant MR (2008) Recent developments in environmental metabolomics. Mol Biosyst 4:980-986
    • (2008) Mol Biosyst , vol.4 , pp. 980-986
    • Viant, M.R.1
  • 73
    • 0029299736 scopus 로고
    • PCBs increase molecular-related activities (lysozyme, antibacterial, hemolysis, proteases) but inhibit macrophage-related functions (phagocytosis, wound healing) in earthworms
    • Ville P, Roch P, Cooper EL, Masson P, J- Narbonne (1995) PCBs increase molecular-related activities (lysozyme, antibacterial, hemolysis, proteases) but inhibit macrophage-related functions (phagocytosis, wound healing) in earthworms. J Invertebr Pathol 65:217-224
    • (1995) J Invertebr Pathol , vol.65 , pp. 217-224
    • Ville, P.1    Roch, P.2    Cooper, E.L.3    Masson, P.4    Narbonne, J.5
  • 74
    • 79957688504 scopus 로고    scopus 로고
    • The potential of metabolomic approaches for investigating mode(s) of action of xenobiotics: Case study with carbon tetrachloride
    • doi:10.1016/j.mrgentox.2010.02.013
    • Vulimiri SV, Berger A, Sonawane B (2010) The potential of metabolomic approaches for investigating mode(s) of action of xenobiotics: Case study with carbon tetrachloride. Mutat Res. doi:10.1016/j.mrgentox.2010.02.013
    • (2010) Mutat Res
    • Vulimiri, S.V.1    Berger, A.2    Sonawane, B.3
  • 75
    • 0033982341 scopus 로고    scopus 로고
    • An NMR-based metabonomic investigation of the toxic effects of 3- trifluoromethyl-aniline on the earthworm Eisenia veneta
    • Warne MA, Lenz EM, Osborn D, Weeks JM, Nicholson JK (2000) An NMR-based metabonomic investigation of the toxic effects of 3- trifluoromethyl-aniline on the earthworm Eisenia veneta. Biomarkers 5:56-72 (Pubitemid 30041344)
    • (2000) Biomarkers , vol.5 , Issue.1 , pp. 56-72
    • Warne, M.A.1    Lenz, E.M.2    Osborn, D.3    Weeks, J.M.4    Nicholson, J.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.