Epileptic Seizure Following IV Tramadol in a Patient with Mental Retardation and Cerebellar Ataxia

Pain Medicine

Volumn 12, Issue 5, 2011, Pages 833-836

  Yarkan Uysal, Hale ^a   Bilimgut, Baǧnu ^a   Dikmen, Bayazit ^a   Inan, Nurten ^a   Ülger, Gülay ^a   Eruyar, Solmaz ^a  

^a ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Analgesia; Hypocalcemia; Seizure; Tramadol

Indexed keywords

CALCIUM; DICLOFENAC; FENTANYL; PARACETAMOL; PHENYTOIN; PROPOFOL; ROCURONIUM; SEVOFLURANE; TRAMADOL; ULTRAMEX; UNCLASSIFIED DRUG; VALPROIC ACID;

ABDOMINAL HYSTERECTOMY; ADULT; ARTICLE; CALCIUM BLOOD LEVEL; CASE REPORT; CEREBELLAR ATAXIA; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ELECTROCARDIOGRAPHY; ENDOTRACHEAL INTUBATION; FEMALE; FOLLOW UP; HUMAN; HYPOCALCEMIA; LABORATORY TEST; LUNG VENTILATION; MENTAL DEFICIENCY; OXIMETER; PAIN; POSTOPERATIVE PAIN; TONIC CLONIC SEIZURE; UTERUS MYOMA; VAGINA BLEEDING; VISUAL ANALOG SCALE;

EID: 79955908796     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2011.01079.x     Document Type: Article

References (24)

1. Dayer P, Collart L, Desmeules J. The pharmacology of tramadol. Drugs 1994;47(suppl 1):3-7. Review.
2. Shipton EA. Tramadol-present and future. Anaesth Intensive Care 2000;28:363-74. Review.
3. Kahn LH, Alferder RJ, Graham DJ. Seizures reported with tramadol. JAMA 1997;278:1661.
4. Raffa RB, Friderichs E, Reimann W, etal. Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. J Pharmacol Exp Ther 1993;267:331-40.
5. Lintz W, Barth H, Osterloh G, Schmidt-Böthelt E. Bioavailability of enteral tramadol formulations. Arzneimittelforschung 1986;36(8):1278-83.
6. Lai J, Ma SW, Porreca F, Raffa RB. Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells. Eur J Pharmacol 1996;316:369-72.
7. Scott LJ, Perry CM. Tramadol: A review of its use in perioperative pain. Drugs 2000;60:139-76.
8. Potschka H, Friderichs E, Löscher W. Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy. Br J Pharmacol 2000;131:203-12.
9. Spiller HA, Gorman SE, Villalobos D, etal. Prospective multicenter evaluation of tramadol exposure. J Toxicol Clin Toxicol 1997;35:361-4.
10. Tobias JD. Seizure after overdose of tramadol. South Med J 1997;90:826-7.
11. Marquardt KA, Alsop JA, Albertson TE. Tramadol exposures reported to statewide poison control system. Ann Pharmacother 2005;39:1039-44.
12. Raffa RB, Stone DJ Jr. Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice. J Pharmacol Exp Ther 2008;325:500-6.
13. Manto M, Marmolino D. Cerebellar ataxias. Curr Opin Neurol 2009;22:419-29. Review.
14. Ide S, Minami M, Ishihara K, etal. Mu opioid receptor-dependent and independent components in effects of tramadol. Neuropharmacology 2006;51:651-8.
15. Rehni AK, Singh I, Kumar M. Tramadol-induced seizurogenic effect: A possible role of opioid-dependent gamma-aminobutyric acid inhibitory pathway. Basic Clin Pharmacol Toxicol 2008;103:262-6.
16. Freye E, Latasch L, Von Bredow G, Neruda B. The opioid tramadol demonstrates excitatory properties of non-opioid character - a preclinical study using alfentanil as a comparison. Schmerz 1998;12:19-24.
17. Sun C, Mtchedlishvili Z, Erisir A, Kapur J. Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy. J Neurosci 2007;27:12641-50.
18. Frink MC, Hennies HH, Englberger W, Haurand M, Wilffert B. Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung 1996;46:1029-36.
19. Frenk H. Pro- and anticonvulsant actions of morphine and the endogenous opioids: Involvement and interactions of multiple opiate and non-opiate systems. Brain Res 1983;287:197-210. Review.
20. Quetglas EG, Azanza JR, Cardenas E, Sadaba B, Campanero MA. Stereoselective pharmacokinetics analysis of tramadol and its main phase I metabolites in healthy subjects after intravenous and oral administration of racemic tramadol. Biopharm Drug Dispos 2007;28:19-33.
21. Sen H, Ozkan S, Dagli G. Epileptic seizure during patient-controlled analgesia with tramadol. Eur J Anaesthesiol 2009;26:447.
22. Talaie H, Panahandeh R, Fayaznouri M, Asadi Z, Abdollahi M. Dose-independent occurrence of seizure with tramadol. J Med Toxicol 2009;5:63-7.
23. Castilla-Guerra L, del Carmen Fernández-Moreno M, López-Chozas JM, Fernández-Bolaños R. Electrolytes disturbances and seizures. Epilepsia 2006;47:1990-8. Review.
24. Vanderburgh K, Hanstch C, Meredith T. Is naloxone contraindicated in tramadol overdose? J Toxicol Clin Toxicol 1998;36:435 [abstract].