Enhanced flexor tendon healing through controlled delivery of PDGF-BB

Journal of Orthopaedic Research

Volumn 27, Issue 9, 2009, Pages 1209-1215

  Thomopoulos, Stavros ^a   Das, Rosalina ^a   Silva, Matthew J ^a   Sakiyama Elbert, Shelly ^b   Harwood, Frederick L ^c   Zampiakis, Emmanouil ^a   Kim, H Mike ^a   Amiel, David ^c   Gelberman, Richard H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Controlled delivery; Delivery system; Flexor tendon; Growth factor; Tendon healing

Indexed keywords

COLLAGEN; DNA; FIBRIN; HEPARIN; HYALURONIC ACID; PLATELET DERIVED GROWTH FACTOR BB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL PROLIFERATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DOG; DRUG DELIVERY SYSTEM; DRUG EFFECT; EXTRACELLULAR MATRIX; FLEXOR DIGITORUM PROFUNDUS TENDON; FLEXOR TENDON; FLEXOR TENDON INJURY; FORELIMB; INFLAMMATION; NONHUMAN; PASSIVE MOVEMENT; PRIORITY JOURNAL; PROXIMAL INTERPHALANGEAL JOINT; ROTATION; TENSILE STRENGTH; TREATMENT OUTCOME; WOUND HEALING;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; BIOMECHANICS; CELL DIVISION; DISEASE MODELS, ANIMAL; DOGS; DRUG DELIVERY SYSTEMS; FIBRIN; FORELIMB; PLATELET-DERIVED GROWTH FACTOR; RANGE OF MOTION, ARTICULAR; TENDON INJURIES; TENSILE STRENGTH; WOUND HEALING;

EID: 68849087957     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20875     Document Type: Article

References (33)

1. Feuerstein M, Miller VL, Burrell LM, et al. 1998. Occupational upper extremity disorders in the federal workforce. Prevalence, health care expenditures, and patterns of work disability. J Occup Environ Med 40:546-555.
2. Kelsey JL. 1997. Upper extremity disorders: frequency, impact and cost. New York, NY: Churchill Livingstone.
3. Woo SL, Gelberman RH, Cobb NG, et al. 1981. The importance of controlled passive mobilization on flexor tendon healing. A biomechanical study. Acta Orthop Scand 52:615-622.
4. Takai S, Woo SL, Horibe S, et al. 1991. The effects of frequency and duration of controlled passive mobilization on tendon healing. J Orthop Res 9:705-713.
5. Silva MJ, Brodt MD, Boyer MI, et al. 1999. Effects of increased in vivo excursion on digital range of motion and tendon strength following flexor tendon repair. J Orthop Res 17:777-783.
6. Lieber RL, Amiel D, Kaufman KR, et al. 1996. Relationship between joint motion and flexor tendon force in the canine forelimb. J Hand Surg [Am] 21:957-962.
7. Boyer MI, Gelberman RH, Burns ME, et al. 2001. Intrasynovial flexor tendon repair. An experimental study comparing low and high levels of in vivo force during rehabilitation in canines. J Bone Joint Surg Am 83-A:891-899.
8. Thomopoulos S, Harwood FL, Silva MJ, et al. 2005. Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro. J Hand Surg [Am] 30:441-447.
9. Gelberman RH, Thomopoulos S, Sakiyama-Elbert SE, et al. 2007. The early effects of sustained platelet-derived growth factor administration on the functional and structural properties of repaired intrasynovial flexor tendons: an in vivo biomechanic study at 3 weeks in canines. J Hand Surg [Am] 32:373-379.
10. Thomopoulos S, Zaegel M, Das R, et al. 2007. PDGF-BB released in tendon repair using a novel delivery system promotes cell proliferation and collagen remodeling. J Orthop Res 25:1358-1368.
11. Molloy T, Wang Y, Murrell G. 2003. The roles of growth factors in tendon and ligament healing. Sports Med 33:381-394.
12. Sakiyama-Elbert S, Das R, Gelberman RH, et al. 2008. Controlled release kinetics and biologic activity of PDGF-BB for use in flexor tendon repair. J Hand Surg [Am] 33:1548-1557.
13. Robinson SN, Talmadge JE. 2002. Sustained release of growth factors. In Vivo 16:535-540.
14. Gelberman RH, Boyer MI, Brodt MD, et al. 1999. The effect of gap formation at the repair site on the strength and excursion of intrasynovial flexor tendons. An experimental study on the early stages of tendon-healing in dogs. J Bone Joint Surg Am 81:975-982.
15. Sakiyama-Elbert SE, Hubbell JA. 2000. Development of fibrin derivatives for controlled release of heparin-binding growth factors. J Control Release 65:389-402.
16. Potenza AD. 1962. Tendon healing within the flexor digital sheath in the dog. J Bone Joint Surg Am 44-A:49-64.
17. Lieber RL, Silva MJ, Amiel D, et al. 1999. Wrist and digital joint motion produce unique flexor tendon force and excursion in the canine forelimb. J Biomech 32:175-181.
18. Winters SC, Gelberman RH, Woo SL, et al. 1998. The effects of multiple-strand suture methods on the strength and excursion of repaired intrasynovial flexor tendons: a biomechanical study in dogs. J Hand Surg [Am] 23:97-104.
19. Ohashi M, Ide S, Sawaguchi A, et al. 2008. Histochemical localization of the extracellular matrix components in the annular ligament of rat stapediovestibular joint with special reference to fibrillin, 36-kDa microfibril-associated glycoprotein (MAGP-36), and hyaluronic acid. Med Mol Morphol 41:28-33.
20. Shimizu C, Yoshioka M, Coutts RD, et al. 1998. Long-term effects of hyaluronan on experimental osteoarthritis in the rabbit knee. Osteoarthritis Cartilage 6:1-9.
21. Silva MJ, Boyer MI, Ditsios K, et al. 2002. The insertion site of the canine flexor digitorum profundus tendon heals slowly following injury and suture repair. J Orthop Res 20:447-453.
22. Zhao C, Amadio PC, Paillard P, et al. 2004. Digital resistance and tendon strength during the first week after flexor digitorum profundus tendon repair in a canine model in vivo. J Bone Joint Surg Am 86-A:320-327.
23. May EJ, Silfverskiold KL. 1993. Rate of recovery after flexor tendon repair in zone II. A prospective longitudinal study of 145 digits. Scand J Plast Reconstr Surg Hand Surg 27:89-94.
24. Silfverskiold KL, May EJ. 1993. Gap formation after flexor tendon repair in zone II. Results with a new controlled motion programme. Scand J Plast Reconstr Surg Hand Surg 27:263-268.
25. Boyer MI, Goldfarb CA, Gelberman RH. 2005. Recent progress in flexor tendon healing. The modulation of tendon healing with rehabilitation variables. J Hand Ther 18:80-85 quiz 86.
26. Suzuki M, Asplund T, Yamashita H, et al. 1995. Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C. Biochem J 307:817-821.
27. Bartold PM. 1993. Platelet-derived growth factor stimulates hyaluronate but not proteoglycan synthesis by human gingival fibroblasts in vitro. J Dent Res 72:1473-1480.
28. Papakonstantinou E, Karakiulakis G, Roth M, et al. 1995. Platelet-derived growth factor stimulates the secretion of hyaluronic acid by proliferating human vascular smooth muscle cells. Proc Natl Acad Sci USA 92:9881-9885.
29. Tiedemann K, Malmstrom A, Westergren-Thorsson G. 1997. Cytokine regulation of proteoglycan production in fibroblasts: separate and synergistic effects. Matrix Biol 15:469-478.
30. Sun Y, Berger EJ, Zhao C, et al. 2006. Expression and mapping of lubricin in canine flexor tendon. J Orthop Res 24:1861-1868.
31. Sun Y, Chen MY, Zhao C, et al. 2008. The effect of hyaluronidase, phospholipase, lipid solvent and trypsin on the lubrication of canine flexor digitorum profundus tendon. J Orthop Res 26:1225-1229.
32. Miller JA, Ferguson RL, Powers DL, et al. 1997. Efficacy of hyaluronic acid/nonsteroidal anti-inflammatory drug systems in preventing postsurgical tendon adhesions. J Biomed Mater Res 38:25-33.
33. Zhao C, Sun YL, Amadio PC, et al. 2006. Surface treatment of flexor tendon autografts with carbodiimide-derivatized hyaluronic Acid. An in vivo canine model. J Bone Joint Surg Am 88:2181-2191.