SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs

Epilepsia

Volumn 52, Issue 5, 2011, Pages 1000-1009

  Thompson, Christopher H ^a   Kahlig, Kristopher M ^a   George Jr , Alfred L ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

Alternative splicing; Antiepileptic drugs; Ion channel gene defects

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE; PHENYTOIN; SODIUM CHANNEL NAV1.1;

ALTERNATIVE RNA SPLICING; ARTICLE; BETA CHAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIVITY; EPILEPSY; EXON; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HYPOTHESIS; PATCH CLAMP; PHARMACOGENETICS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE; WHOLE CELL;

ALTERNATIVE SPLICING; ANTICONVULSANTS; EPILEPSY; HUMANS; NERVE TISSUE PROTEINS; PHENYTOIN; PROTEIN ISOFORMS; SODIUM CHANNELS; TRIAZINES;

EID: 79955893880     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03040.x     Document Type: Article

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