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Volumn 879, Issue 19, 2011, Pages 1537-1543
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Validation and implementation of a liquid chromatography/tandem mass spectrometry assay for quantitation of the total and unbound RO4929097, a γ-secretase inhibitor targeting Notch signaling, in human plasma
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Author keywords
Secretase inhibitor; High performance liquid chromatography; LC MS MS; Mass spectrometry; Pharmacokinetics; RO4929097
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Indexed keywords
ACCURACY AND PRECISION;
BIOANALYTICAL METHODS;
CALIBRATION CURVES;
CANCER PATIENTS;
CHROMATOGRAPHIC SEPARATIONS;
CONCENTRATION RANGES;
ETHYL ACETATES;
HUMAN PLASMAS;
ISOCRATIC MOBILE PHASE;
LC-MS/MS;
LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY;
LIQUID-LIQUID EXTRACTION;
LOWER LIMITS OF QUANTITATIONS;
NOTCH SIGNALING;
ORAL ADMINISTRATION;
PHOSPHATE BUFFER SOLUTIONS;
RO4929097;
SAMPLE PREPARATION;
SECRETASES;
TANDEM MASS SPECTROMETRY;
CHROMATOGRAPHY;
FORMIC ACID;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
MASS SPECTROMETRY;
PHARMACOKINETICS;
PLASMA (HUMAN);
PLASMAS;
SIGNALING;
SOLVENT EXTRACTION;
LIQUIDS;
ACETIC ACID ETHYL ESTER;
GAMMA SECRETASE INHIBITOR;
NOTCH RECEPTOR;
RO 4929097;
UNCLASSIFIED DRUG;
ANALYTIC METHOD;
ARTICLE;
DRUG BLOOD LEVEL;
HUMAN;
LIMIT OF QUANTITATION;
LIQUID LIQUID EXTRACTION;
PRIORITY JOURNAL;
REVERSED PHASE LIQUID CHROMATOGRAPHY;
SIGNAL TRANSDUCTION;
TANDEM MASS SPECTROMETRY;
VALIDATION PROCESS;
AMYLOID PRECURSOR PROTEIN SECRETASES;
ANALYSIS OF VARIANCE;
BENZAZEPINES;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
CHROMATOGRAPHY, REVERSE-PHASE;
DRUG STABILITY;
ENZYME INHIBITORS;
HUMANS;
LEAST-SQUARES ANALYSIS;
PROTEIN BINDING;
RECEPTORS, NOTCH;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
SIGNAL TRANSDUCTION;
TANDEM MASS SPECTROMETRY;
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EID: 79955883715
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2011.03.045 Document Type: Article |
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Times cited : (6)
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References (9)
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