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Volumn 878, Issue 3-4, 2010, Pages 333-339
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Simultaneous determination of ABT-888, a poly (ADP-ribose) polymerase inhibitor, and its metabolite in human plasma by liquid chromatography/tandem mass spectrometry
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Author keywords
ABT 888; High performance liquid chromatography; LC MS MS; Mass spectrometry; PARP inhibitor; Pharmacokinetics
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Indexed keywords
ABT-888;
ANALYTES;
BIOANALYTICAL METHODS;
CANCER PATIENTS;
CONCENTRATION RANGES;
ELECTROSPRAYS;
ETHYL ACETATES;
HUMAN PLASMAS;
INTERNAL STANDARDS;
LC-MS/MS;
LINEAR CALIBRATION CURVE;
LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY;
LIQUID-LIQUID EXTRACTION;
LOWER LIMITS OF QUANTITATIONS;
MOBILE PHASE;
ORAL ADMINISTRATION;
PARP-INHIBITOR;
PLASMA CONCENTRATION;
POLY POLYMERASE;
REVERSED-PHASE LIQUID CHROMATOGRAPHY;
SAMPLE PREPARATION;
SIMULTANEOUS DETERMINATIONS;
TANDEM MASS SPECTROMETRY;
CHROMATOGRAPHIC ANALYSIS;
CHROMATOGRAPHY;
ELECTROSPRAY IONIZATION;
ESTERS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
METABOLISM;
METABOLITES;
ORGANIC ACIDS;
PHARMACOKINETICS;
PLASMA (HUMAN);
PLASMAS;
SOLVENT EXTRACTION;
LIQUIDS;
2 (2 METHYL 2 PYRROLIDINYL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE;
A 925088;
DRUG METABOLITE;
IRINOTECAN;
METHANOL;
UNCLASSIFIED DRUG;
ARTICLE;
BLOOD ANALYSIS;
CLINICAL ARTICLE;
CLINICAL TRIAL;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
DRUG BLOOD LEVEL;
DRUG STRUCTURE;
ELECTROSPRAY;
HUMAN;
HUMAN EXPERIMENT;
MULTIPLE CYCLE TREATMENT;
PRIORITY JOURNAL;
REVERSED PHASE LIQUID CHROMATOGRAPHY;
TANDEM MASS SPECTROMETRY;
BENZIMIDAZOLES;
CALIBRATION;
CHROMATOGRAPHY, LIQUID;
DRUG STABILITY;
ENZYME INHIBITORS;
HUMANS;
POLY(ADP-RIBOSE) POLYMERASES;
QUALITY CONTROL;
REFERENCE STANDARDS;
TANDEM MASS SPECTROMETRY;
TIME FACTORS;
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EID: 74049132367
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.11.037 Document Type: Article |
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Times cited : (22)
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References (11)
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