Adipose tissue dysfunction in polycystic ovary syndrome

Current Diabetes Reports

Volumn 11, Issue 3, 2011, Pages 179-184

  Villa, Jennifer ^a   Pratley, Richard E ^a  

^a University of Vermont Colchester Research Facility   (United States)

Author keywords

Adipocyte; Adipokine; Androgen; Insulin resistance; Metabolic syndrome

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; C REACTIVE PROTEIN; LEPTIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; RETINOL BINDING PROTEIN 4;

ABDOMINAL FAT; ADIPOCYTE; ADIPOSE TISSUE; BODY FAT DISTRIBUTION; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; GENE EXPRESSION PROFILING; HUMAN; HYPERTROPHY; IMMUNOCOMPETENT CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; NONHUMAN; OBESITY; OVARY POLYCYSTIC DISEASE; PROTEIN FUNCTION; PROTEIN SECRETION; REVIEW; TISSUE DIFFERENTIATION;

ADIPOKINES; ADIPOSE TISSUE; ANIMALS; FEMALE; HUMANS; INSULIN RESISTANCE; POLYCYSTIC OVARY SYNDROME;

EID: 79955879441     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-011-0189-8     Document Type: Review

References (47)

1. March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ: The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod 2010, 25:544-551. This study compares the prevalence of PCOS using various diagnostic criteria and indicates that PCOS may be much more prevalent than commonly appreciated.
2. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-7.
3. Diamanti-Kandarakis E, Papavassiliou AG. Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol Med. 2006;12(7):324-32. (Pubitemid 44094292)
4. Diamanti-Kandarakis E, Papavassiliou AG, Kandarakis SA, Chrousos GP. Pathophysiology and types of dyslipidemia in PCOS. Trends Endocrinol Metab. 2007;18(7):280-5. (Pubitemid 47332216)
5. Escobar-Morreale HF, Luque-Ramírez M, González F. Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. Fertil Steril. 2011;95(3):1048-58.
6. Moran LJ, Misso ML, Wild RA, Norman RJ. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2010, 16(4):347-63. This study highlights the markedly increased risk for diabetes among women with PCOS.
7. Tomlinson J, Millward A, Stenhouse E, Pinkney J. Type 2 diabetes and cardiovascular disease in polycystic ovary syndrome: what are the risks and can they be reduced? Diabet Med. 2010;27(5):498-515.
8. Alvarez-Blasco F, Botella-Carretero JI, San Millán JL, Escobar-Morreale HF. Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Arch Intern Med. 2006;166(19):2081-6. (Pubitemid 44631395)
9. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89(6):2745-9. (Pubitemid 38766360)
10. Escobar-Morreale H, San Milla J, Abdominal adiposity and the polycystic ovary syndrome TRENDS in Endocrinology and Metabolism Vol.18 No.7
11. Albu JB, Kovera AJ, Frager DH, Johnson JA, Pi-Sunyer FX. Visceral fat and race-dependent health risks in obese non-diabetic premenopausal women. Diabetes. 1997;46:456-62. (Pubitemid 27090276)
12. Marsden P, Murdoch A, Taylor R. Tissue insulin sensitivity and body weight in polycystic ovary syndrome. Clin Endocrinol. 2001;55:191-9. (Pubitemid 32868583)
13. Mannerås-Holm L, Leonhardt H, Kullberg J, Jennische A, et al. Adipose Tissue Has Aberrant Morphology and Function in PCOS: Enlarged Adipocytes and Low Serum Adiponectin, But Not Circulating Sex Steroids, Are Strongly Associated with Insulin Resistance. J. Clin. Endocrinol. Metab. 2011, 96:E304-E311. This study comprehensively examines adipose tissue morphology and function in women with PCOS.
14. Carmina E, Bucchieri S, Esposito A, Del Puente A, et al. Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance. J Clin Endocrinol Metab. 2007;92:E2500-5.
15. Lee YH, Pratley RE. The evolving role of inflammation in obesity and the metabolic syndrome. Curr Diab Rep. 2005;5(1):70-5. (Pubitemid 40277804)
16. Hausman DB, DiGirolamo M, Bartness TJ, Hausman GJ, Martin RJ. The biology of white adipocyte proliferation. Obes Rev. 2001;2(4):239-54. (Pubitemid 33755900)
17. Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796-808. (Pubitemid 38063703)
18. Kershaw EE. Flier JS Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89:2548-56. (Pubitemid 38766330)
19. Salans LB, Cushman SW, Weismann RE. Studies of human adipose tissue. Adipose cell size and number in nonobese and obese patients. J Clin Invest. 1973;52:929-41.
20. Weyer C, Foley JE, Bogardus C, Tataranni PA, Pratley RE. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance. Diabetologia. 2000;43:1498-506. (Pubitemid 32734855)
21. Leonhardt W, Hanefeld M, Schneider H, Haller H. Human adipocyte volumes: maximum size, and correlation to weight index in maturity onset-diabetes. Diabetologia. 1972;8:287-91.
22. Faulds G, Rydén M, Ek I, Wahrenberg H, Arner P. Mechanisms behind lipolytic catecholamine resistance of subcutaneous fat cells in the polycystic ovarian syndrome. J Clin Endocrinol Metab. 2003;88(5):2269-73. (Pubitemid 36549907)
23. Ek I, Arner P, Bergqvist A, Carlstrom K, Wahrenberg H. Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: a possible link to insulin resistance? J Clin Endocrinol Metab. 1997;82:1147-53. (Pubitemid 27166656)
24. Ek I, Arner P, Ryde M, Holm C, Thorne A, Hoffstedt J, et al. A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance. Diabetes. 2002;51:484-92. (Pubitemid 34764807)
25. Seow KM, Tsai YL, Hwang JL, Hsu WY, Ho LT, Juan CC. Omental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome. Hum Reprod. 2009;24(8):1982-8.
26. Dicker A, Ryden M, Nashund E, Muehlen IE, Wiren M, Lafontan M, et al. Effect of testosterone on lipolysis in human preadipocytes from different fat depots. Diabetologia. 2004;47:420-8. (Pubitemid 38491238)
27. Rosenbaum D, Haber RS, Dunaif A. Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes. Am J Physiol. 1993;264:E197-202.
28. Chang W, Goodarzi M, Williams H, Magoffin D, Pall M, Azziz R. Adipocytes from women with polycystic ovary syndrome demonstrate altered phosphorylation and activity of glycogen synthase kinase 3. Fertil Steril. 2008;90(6):2291-7.
29. Corbould A, Dunaif A. The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome. Metab Clin Exp. 2007;56:716-22. (Pubitemid 46574736)
30. Corbould A. Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women. J Endocrinol. 2007;192:585-94. (Pubitemid 46455961)
31. Danforth Jr E. Failure of adipocyte differentiation causes type II diabetes mellitus? Nat Genet. 2000;26(1):13.
32. Permana PA, Nair S, Lee YH, Luczy-Bachman G, Vozarova De Courten B, Tataranni PA. Subcutaneous abdominal preadipocyte differentiation in vitro inversely correlates with central obesity. Am J Physiol Endocrinol Metab. 2004;286(6):E958-62.
33. Yang X, Jansson PA, Nagaev I, Jack MM, Carvalho E, Sunnerhagen KS, et al. Evidence of impaired adipogenesis in insulin resistance. Biochem Biophys Res Commun. 2004;317(4):1045-51. (Pubitemid 38496415)
34. Corton M, Botella-Carretero J, Benguria A, Villuendas G, Zaballos A, et al. Differential gene expression profile in omental adipose tissue in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2007;92:328-37. (Pubitemid 46075011)
35. Gupta V, Bhasin S, Guo W, Singh R, Miki R, Chauhan P, et al. Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Mol Cell Endocrinol. 2008;296(1-2):32-40.
36. Roland AV, Nunemaker CS, Keller SR, Moenter SM. Prenatal androgen exposure programs metabolic dysfunction in female mice. J Endocrinol. 2010;207(2):213-23.
37. Lee YH, Nair S, Rousseau E, Allison DB, Page GP, Tataranni PA, et al. Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. Diabetologia. 2005;48(9):1776-83. (Pubitemid 41317831)
38. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32. (Pubitemid 24365442)
39. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and obRNA in obese and weight-reduced subjects. Nat Med. 1995;1:1155-61.
40. Mantzoros CS, Dunaif A, Flier JS. Leptin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab. 1997;82 (6):1687-91. (Pubitemid 127495169)
41. Carmina E, Bucchieri S, Mansueto P, Rini G, Ferin M, Lobo R. Circulating levels of adipose products and differences in fat distribution in the ovulatory and anovulatory phenotypes of polycystic ovary syndrome. Fertility and Sterility 2009, 91(4) supplement: 1332-1335. In this study, differences in several adipokines were demonstrated in ovulatory and anovulatory women with PCOS.
42. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86:E1930-5.
43. O'Connor A, Phelan N, Kyaw T, Boran G, Gibney J, Roche HM. High-molecular-weight adiponectin is selectively reduced in women with polycystic ovary syndrome independent of body mass index and severity of insulin resistance. J Clin Endocrinol Metab. 2010;95:1378-85.
44. Toulis KA, Goulis DG, Farmakiotis D, Georgopolous NA, Katsikis I, Tarlatzis BC, Papadimas I, Panidis D. Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis. Human Reproduction Update 2009; 15 (3): 297-307. This systematic review documents the low levels of adiponectin observed in women with PCOS.
45. Murat Y, Bukan N, Demirci H, Ozturk C, Kan E, Ayvaz G, et al. Serum resistin and adiponectin levels in women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25(4):246-52.
46. Mlinar B, Pfeifer M, Vrtachnik-Bokal E, Jensterle M, Marc J. Decreased lipin 1β expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome. Eur J Endocrinol. 2008;159:833-9.
47. Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-20.