CD4+ T cells spontaneously producing human immunodeficiency virus type I in breast milk from women with or without antiretroviral drugs

Retrovirology

Volumn 8, Issue , 2011, Pages

  Valea, Diane ^a,b   Tuaillon, Edouard ^c,d,e   Al Tabaa, Yassine ^c,d   Rouet, François ^a   Rubbo, Pierre Alain ^c,d   Meda, Nicolas ^b   Foulongne, Vincent ^c,e   Bollore, Karine ^c,d   Nagot, Nicolas ^c   Van de Perre, Philippe ^c,e   Vendrell, Jean Pierre ^c,d,e  

^a CENTRE MURAZ   (Burkina Faso)

^b Institut de Recherche en Science de la Santé DRO   (Burkina Faso)

^c UNIV MONTPELLIER   (France)

^d Laboratoire des Cellules Circulantes Rares Humaines (LCCRH)   (France)

^e LAPEYRONIE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD45RA ANTIGEN; CD8 ANTIGEN; GAG PROTEIN; HLA DR ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; LAMIVUDINE; LOPINAVIR; NEVIRAPINE; RITONAVIR; VIRUS RNA; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; VIRUS PROTEIN;

ARTICLE; BLOOD CULTURE; BREAST MILK; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 ANTIGEN SECRETING CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFECTION PREVENTION; MEMORY T LYMPHOCYTE; NEWBORN INFECTION; PERINATAL DRUG EXPOSURE; RNA ANALYSIS; SINGLE DRUG DOSE; SUPERNATANT; T LYMPHOCYTE ACTIVATION; VIREMIA; VIRUS INFECTIVITY; VIRUS LOAD; VIRUS REPLICATION; VIRUS TRANSMISSION; BIOSYNTHESIS; CYTOLOGY; DISEASE TRANSMISSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; IN VITRO STUDY; ISOLATION AND PURIFICATION; PHYSIOLOGY; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY; VIRUS ACTIVATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSPOT ASSAY; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MILK, HUMAN; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRAL PROTEINS; VIRUS ACTIVATION;

EID: 79955862840     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-8-34     Document Type: Article

References (55)

1. UNAIDS AIDS Epidemic Update. Geneva 2007, UNAIDS., http://data.unaids.org/pub/epislides/2007/2007_epiupdate_en.pdf
2. Coutsoudis A, Dabis F, Fawzi W, Gaillard P, Haverkamp G, Harris DR, Jackson JB, Leroy V, Meda N, Msellati P, et al. Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis. J Infect Dis 2004, 189:2154-2166.
3. Fawzi W, Msamanga G, Spiegelman D, Renjifo B, Bang H, Kapiga S, Coley J, Hertzmark E, Essex M, Hunter D. Transmission of HIV-1 through breastfeeding among women in Dar es Salaam, Tanzania. J Acquir Immune Defic Syndr 2002, 31:331-338. 10.1097/00126334-200211010-00010, 12439210.
4. Nduati R, John G, Mbori-Ngacha D, Richardson B, Overbaugh J, Mwatha A, Ndinya-Achola J, Bwayo J, Onyango FE, Hughes J, Kreiss J. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial. Jama 2000, 283:1167-1174. 10.1001/jama.283.9.1167, 10703779.
5. Scarlatti G. Mother-to-child transmission of HIV-1: advances and controversies of the twentieth centuries. AIDS Rev 2004, 6:67-78.
6. John GC, Nduati RW, Mbori-Ngacha DA, Richardson BA, Panteleeff D, Mwatha A, Overbaugh J, Bwayo J, Ndinya-Achola JO, Kreiss JK. Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections. J Infect Dis 2001, 183:206-212. 10.1086/317918, 11120927.
7. Pillay K, Coutsoudis A, York D, Kuhn L, Coovadia HM. Cell-free virus in breast milk of HIV-1-seropositive women. J Acquir Immune Defic Syndr 2000, 24:330-336.
8. Richardson BA, John-Stewart GC, Hughes JP, Nduati R, Mbori-Ngacha D, Overbaugh J, Kreiss JK. Breast-milk infectivity in human immunodeficiency virus type 1-infected mothers. J Infect Dis 2003, 187:736-740. 10.1086/374272, 12599046.
9. Rousseau CM, Nduati RW, Richardson BA, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK, Overbaugh J. Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmission. J Infect Dis 2004, 190:1880-1888. 10.1086/425076, 15499546.
10. Rousseau CM, Nduati RW, Richardson BA, Steele MS, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK, Overbaugh J. Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease. J Infect Dis 2003, 187:741-747. 10.1086/374273, 12599047.
11. Semba RD, Kumwenda N, Hoover DR, Taha TE, Quinn TC, Mtimavalye L, Biggar RJ, Broadhead R, Miotti PG, Sokoll LJ, et al. Human immunodeficiency virus load in breast milk, mastitis, and mother-to-child transmission of human immunodeficiency virus type 1. J Infect Dis 1999, 180:93-98. 10.1086/314854, 10353866.
12. Shapiro RL, Ndung'u T, Lockman S, Smeaton LM, Thior I, Wester C, Stevens L, Sebetso G, Gaseitsiwe S, Peter T, Essex M. Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk. J Infect Dis 2005, 192:713-719. 10.1086/432489, 16088820.
13. Van de Perre P. Mother-to-child transmission of HIV-1: the 'all mucosal' hypothesis as a predominant mechanism of transmission. Aids 1999, 13:1133-1138. 10.1097/00002030-199906180-00018, 10397545.
14. Van de Perre P, Simonon A, Hitimana DG, Dabis F, Msellati P, Mukamabano B, Butera JB, Van Goethem C, Karita E, Lepage P. Infective and anti-infective properties of breastmilk from HIV-1-infected women. Lancet 1993, 341:914-918. 10.1016/0140-6736(93)91210-D, 8096264.
15. Koulinska IN, Villamor E, Chaplin B, Msamanga G, Fawzi W, Renjifo B, Essex M. Transmission of cell-free and cell-associated HIV-1 through breast-feeding. J Acquir Immune Defic Syndr 2006, 41:93-99. 10.1097/01.qai.0000179424.19413.24, 16340480.
16. Manigart O, Crepin M, Leroy V, Meda N, Valea D, Janoff EN, Rouet F, Dequae-Merchadoux L, Dabis F, Rouzioux C, Van de Perre P. Effect of perinatal zidovudine prophylaxis on the evolution of cell-free HIV-1 RNA in breast milk and on postnatal transmission. J Infect Dis 2004, 190:1422-1428. 10.1086/424569, 15378434.
17. Thomas T, Masaba R, Ndivo R, Zeh C, Borkowf C, Thigpen M, De Cock K, Amornkul P, Greenberg A, M F, . Team KBS Prevention of mother-to-child transmission of HIV-1 among breastfeeding mothers using HAART: the Kisumu breastfeeding study, Kisumu, Kenya, 2003-2007. Boston, Abstract 45. aLB 2008, Infections tCoRaO, Team KBS.
18. Dimitrov DS, Willey RL, Sato H, Chang LJ, Blumenthal R, Martin MA. Quantitation of human immunodeficiency virus type 1 infection kinetics. J Virol 1993, 67:2182-2190. 240333, 8445728.
19. Shen L, Siliciano RF. Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection. J Allergy Clin Immunol 2008, 122:22-28. 10.1016/j.jaci.2008.05.033, 18602567.
20. Lehman DA, Chung MH, John-Stewart GC, Richardson BA, Kiarie J, Kinuthia J, Overbaugh J. HIV-1 persists in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission. Aids 2008, 22:1475-1485. 10.1097/QAD.0b013e328302cc11, 2765916, 18614871.
21. Becquart P, Petitjean G, Tabaa YA, Valea D, Huguet MF, Tuaillon E, Meda N, Vendrell JP, Van de Perre P. Detection of a large T-cell reservoir able to replicate HIV-1 actively in breast milk. Aids 2006, 20:1453-1455. 10.1097/01.aids.0000233581.64467.55, 16791022.
22. Chun TW, Justement JS, Lempicki RA, Yang J, Dennis G, Hallahan CW, Sanford C, Pandya P, Liu S, McLaughlin M, et al. Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals. Proc Natl Acad Sci USA 2003, 100:1908-1913. 10.1073/pnas.0437640100, 149932, 12552096.
23. Petitjean G, Al Tabaa Y, Tuaillon E, Mettling C, Baillat V, Reynes J, Segondy M, Vendrell JP. Unintegrated HIV-1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy-treated patients. Retrovirology 2007, 4:60. 10.1186/1742-4690-4-60, 2048509, 17727722.
24. Weinberg A, Song LY, Wilkening C, Sevin A, Blais B, Louzao R, Stein D, Defechereux P, Durand D, Riedel E, et al. Optimization and limitations of use of cryopreserved peripheral blood mononuclear cells for functional and phenotypic T-cell characterization. Clin Vaccine Immunol 2009, 16:1176-1186. 10.1128/CVI.00342-08, 2725535, 19515870.
25. Sabbaj S, Ghosh MK, Edwards BH, Leeth R, Decker WD, Goepfert PA, Aldrovandi GM. Breast milk-derived antigen-specific CD8+ T cells: an extralymphoid effector memory cell population in humans. J Immunol 2005, 174:2951-2956.
26. Ogra SS, Ogra PL. Immunologic aspects of human colostrum and milk. I. Distribution characteristics and concentrations of immunoglobulins at different times after the onset of lactation. J Pediatr 1978, 92:546-549. 10.1016/S0022-3476(78)80285-6, 416193.
27. Tuaillon E, Al Tabaa Y, Baillat V, Segondy M, Picot MC, Reynes J, Vendrell JP. Close association of CD8+/CD38 bright with HIV-1 replication and complex relationship with CD4+ T-cell count. Cytometry B Clin Cytom 2009, 76:249-260.
28. Richie ER, Bass R, Meistrich ML, Dennison DK. Distribution of T lymphocyte subsets in human colostrum. J Immunol 1982, 129:1116-1119.
29. Richie ER, Steinmetz KD, Meistrich ML, Ramirez I, Hilliard JK. T lymphocytes in colostrum and peripheral blood differ in their capacity to form thermostable E rosettes. J Immunol 1980, 125:2344-2346.
30. Tuaillon E, Valea D, Becquart P, Al Tabaa Y, Meda N, Bollore K, Van de Perre P, Vendrell JP. Human milk-derived B cells: a highly activated switched memory cell population primed to secrete antibodies. J Immunol 2009, 182:7155-7162. 10.4049/jimmunol.0803107, 19454712.
31. Wirt DP, Adkins LT, Palkowetz KH, Schmalstieg FC, Goldman AS. Activated and memory T lymphocytes in human milk. Cytometry 1992, 13:282-290. 10.1002/cyto.990130310, 1533582.
32. Fondere JM, Petitjean G, Huguet MF, Salhi SL, Baillat V, Macura-Biegun A, Becquart P, Reynes J, Vendrell JP. Human immunodeficiency virus type 1 (HIV-1) antigen secretion by latently infected resting CD4+ T lymphocytes from HIV-1-infected individuals. J Virol 2004, 78:10536-10542. 10.1128/JVI.78.19.10536-10542.2004, 516381, 15367620.
33. Chun TW, Carruth L, Finzi D, Shen X, DiGiuseppe JA, Taylor H, Hermankova M, Chadwick K, Margolick J, Quinn TC. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997, 387:183-188. 10.1038/387183a0, 9144289.
34. Furtado MR, Callaway DS, Phair JP, Kunstman KJ, Stanton JL, Macken CA, Perelson AS, Wolinsky SM. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999, 340:1614-1622. 10.1056/NEJM199905273402102, 10341273.
35. Edwards BH, Bansal A, Sabbaj S, Bakari J, Mulligan MJ, Goepfert PA. Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma. J Virol 2002, 76:2298-2305. 10.1128/jvi.76.5.2298-2305.2002, 135950, 11836408.
36. John-Stewart G, Mbori-Ngacha D, Ekpini R, Janoff EN, Nkengasong J, Read JS, Van de Perre P, Newell ML. Breast-feeding and Transmission of HIV-1. J Acquir Immune Defic Syndr 2004, 35:196-202. 10.1097/00126334-200402010-00015, 14722454.
37. Kourtis AP, Butera S, Ibegbu C, Beled L, Duerr A. Breast milk and HIV-1: vector of transmission or vehicle of protection?. Lancet Infect Dis 2003, 3:786-793. 10.1016/S1473-3099(03)00832-6, 14652204.
38. Becquart P, Chomont N, Roques P, Ayouba A, Kazatchkine MD, Belec L, Hocini H. Compartmentalization of HIV-1 between breast milk and blood of HIV-infected mothers. Virology 2002, 300:109-117. 10.1006/viro.2002.1537, 12202211.
39. Chun TW, Nickle DC, Justement JS, Large D, Semerjian A, Curlin ME, O'Shea MA, Hallahan CW, Daucher M, Ward DJ, et al. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J Clin Invest 2005, 115:3250-3255. 10.1172/JCI26197, 1265878, 16276421.
40. Yerly S, Perneger TV, Vora S, Hirschel B, Perrin L. Decay of cell-associated HIV-1 DNA correlates with residual replication in patients treated during acute HIV-1 infection. Aids 2000, 14:2805-2812. 10.1097/00002030-200012220-00001, 11153661.
41. Lewis P, Nduati R, Kreiss JK, John GC, Richardson BA, Mbori-Ngacha D, Ndinya-Achola J, Overbaugh J. Cell-free human immunodeficiency virus type 1 in breast milk. J Infect Dis 1998, 177:34-39. 10.1086/513816, 9419167.
42. Head JR, Beer AE, Billingham RE. Significance of the cellular component of the maternal immunologic endowment in milk. Transplant Proc 1977, 9:1465-1471.
43. Schlesinger JJ, Covelli HD. Evidence for transmission of lymphocyte responses to tuberculin by breast-feeding. Lancet 1977, 2:529-532.
44. Alfsen A, Yu H, Magerus-Chatinet A, Schmitt A, Bomsel M. HIV-1-infected blood mononuclear cells form an integrin- and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer. Mol Biol Cell 2005, 16:4267-4279. 10.1091/mbc.E05-03-0192, 1196336, 15975901.
45. Bedri A, Gudetta B, Isehak A, Kumbi S, Lulseged S, Mengistu Y, Bhore AV, Bhosale R, Varadhrajan V, Gupte N, et al. Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India and Uganda: an analysis of three randomised controlled trials. Lancet 2008, 372:300-313.
46. Gray GE, Urban M, Chersich MF, Bolton C, van Niekerk R, Violari A, Stevens W, McIntyre JA. A randomized trial of two postexposure prophylaxis regimens to reduce mother to-child HIV-1 transmission in infants of untreated mothers. Aids 2005, 19:1289-1297. 10.1097/01.aids.0000180100.42770.a7, 16052084.
47. Jackson JB, Musoke P, Fleming T, Guay LA, Bagenda D, Allen M, Nakabiito C, Sherman J, Bakaki P, Owor M, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. Lancet 2003, 362:859-868. 10.1016/S0140-6736(03)14341-3, 13678973.
48. Kumwenda NI, Hoover DR, Mofenson LM, Thigpen MC, Kafulafula G, Li Q, Mipando L, Nkanaunena K, Mebrahtu T, Bulterys M, et al. Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. N Engl J Med 2008, 359:119-129. 10.1056/NEJMoa0801941, 18525035.
49. Leroy V, Karon JM, Alioum A, Ekpini ER, van de Perre P, Greenberg AE, Msellati P, Hudgens M, Dabis F, Wiktor SZ. Postnatal transmission of HIV-1 after a maternal short course zidovudine peripartum regimen in West Africa. Aids 2003, 17:1493-1501. 10.1097/00002030-200307040-00010, 12824787.
50. Taha TE, Kumwenda NI, Gibbons A, Broadhead RL, Fiscus S, Lema V, Liomba G, Nkhoma C, Miotti PG, Hoover DR. Short postexposure prophylaxis in newborn babies to reduce mother-to-child transmission of HIV-1: NVAZ randomised clinical trial. Lancet 2003, 362:1171-1177. 10.1016/S0140-6736(03)14538-2, 14568737.
51. Wade NA, Birkhead GS, Warren BL, Charbonneau TT, French PT, Wang L, Baum JB, Tesoriero JM, Savicki R. Abbreviated regimens of zidovudine prophylaxis and perinatal transmission of the human immunodeficiency virus. N Engl J Med 1998, 339:1409-1414. 10.1056/NEJM199811123392001, 9811915.
52. Rezk NL, White N, Bridges AS, Abdel-Megeed MF, Mohamed TM, Moselhy SS, Kashuba AD. Studies on antiretroviral drug concentrations in breast milk: validation of a liquid chromatography-tandem mass spectrometric method for the determination of 7 anti 628 human immunodeficiency virus medications. Ther Drug Monit 2008, 30:611-619. 10.1097/FTD.0b013e318186e08e, 2901847, 18758393.
53. The Kesho Bora Study Group Triple-antiretroviral prophylaxis during pregnancy and breastfeeding compared to short-ARV prophylaxis to prevent mother-to-child transmission of HIV-I: the Kesho Bora randomized controlled clinical trial. Lancet Infect Dis 2011, 11:171-180. The Kesho Bora Study Group.
54. Petitjean G, Becquart P, Tuaillon E, Al Tabaa Y, Valea D, Huguet MF, Meda N, Van de Perre P, Vendrell JP. Isolation and characterization of HIV-1-infected resting CD4+ T lymphocytes in breast milk. J Clin Virol 2007, 39:1-8. 10.1016/j.jcv.2007.02.004, 17387039.
55. Rouet F, Rouzioux C. The measurement of HIV-1 viral load in resource-limited settings: how and where?. Clin Lab 2007, 53:135-148.