Comparison of analytical methods to detect instability of etanercept during thermal stress testing

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 78, Issue 2, 2011, Pages 213-221

  Maarschalkerweerd, Andreas Van ^a   Wolbink, Gert Jan ^b   Stapel, Steven O ^b   Jiskoot, Wim ^a   Hawe, Andrea ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b SANQUIN RESEARCH   (Netherlands)

Author keywords

Aggregation; Bis ANS; Conformational changes; Enbrel; Extrinsic fluorescence; Protein stability

Indexed keywords

4,4' DIANILINO 1,1' BINAPTHYL 5,5' DISULFONIC ACID DIPOTASSIUM; ETANERCEPT; FLUORESCENT DYE; SULFONIC ACID DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CIRCULAR DICHROISM; COVALENT BOND; DRUG CONFORMATION; DRUG DEGRADATION; DRUG PROTEIN BINDING; DRUG STABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAR ULTRAVIOLET CIRCULAR DICHROISM SPECTROSCOPY; FLUORESCENCE ANALYSIS; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID SIZE EXCLUSION CHROMATOGRAPHY; HYDROPHOBICITY; INTERMETHOD COMPARISON; LIGHT OBSCURATION; LIGHT SCATTERING; POLYACRYLAMIDE GEL ELECTROPHORESIS; REACTION TIME; TEMPERATURE; TEMPERATURE STRESS; THERMOSTABILITY; TIME SERIES ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

ANTIRHEUMATIC AGENTS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HOT TEMPERATURE; IMMUNOGLOBULIN G; RECEPTORS, TUMOR NECROSIS FACTOR; SPECTROMETRY, FLUORESCENCE;

EID: 79955840195     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.01.012     Document Type: Article

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