Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian and breast cancer

International Journal of Molecular Medicine

Volumn 28, Issue 1, 2011, Pages 109-114

  Shi, Pengcheng ^a   Zhang, Yan ^b   Tong, Xiaowen ^b   Yang, Y U ^a   Shao, Zhiming ^a  

^a FUDAN UNIVERSITY   (China)

^b TONGJI UNIVERSITY   (China)

Author keywords

Cell cycle; Dihydrotestosterone; Direct binding; Ovarian and breast cancer; p27; S phase kinase associated protein 2

Indexed keywords

ANDROSTANOLONE; PRASTERONE; PROTEIN P27; S PHASE KINASE ASSOCIATED PROTEIN 2; TESTOSTERONE;

ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION;

BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DEHYDROEPIANDROSTERONE; DIHYDROTESTOSTERONE; FEMALE; HUMANS; OVARIAN NEOPLASMS; PHOSPHORYLATION; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TESTOSTERONE; UBIQUITIN;

EID: 79955834271     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.677     Document Type: Article

References (35)

1. Vermeulen A: Plasma levels and secretion rate of steroids with anabolic activity in man. Environ Qual Saf Suppl 5: 171-180, 1976.
2. Burger HG: Androgen production in women. Fertil Steril 77 (Suppl. 4): S3-S5, 2002.
3. Luu-The V and Labrie F: The intracrine sex steroid biosynthesis pathways. Prog Brain Res 181: 177-192, 2010.
4. Jegou B, Dacheux JL, Terqui M, et al: Studies of the androgen binding protein in the rete testis fluid of the ram and its relation to sexual season. Mol Cell Endocrinol 9: 335-346, 1978.
5. Sawaya ME, Honig LS and Hsia SL: Increased androgen binding capacity in sebaceous glands in scalp of male-pattern baldness. J Invest Dermatol 92: 91-95, 1989. (Pubitemid 19027698)
6. Hida N, Poulin R, Veilleux R and Labrie F: Differential androgen sensitivity is associated with clonal heterogeneity in steroid metabolism, ornithine decarboxylase regulation and IL-1alpha action in mouse mammary tumor cells. J Steroid Biochem Mol Biol 71: 71-81, 1999.
7. Bellemare V, Faucher F, Breton R and Luu-The V: Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone. BMCBiochem 6: 12, 2005.
8. Stoner E: The clinical development of a 5 alpha-reductase inhibitor, finasteride. J Steroid Biochem Mol Biol 37: 375-378, 1990.
9. Mani A and Gelmann EP: The ubiquitin-proteasome pathway and its role in cancer. J Clin Oncol 23: 4776-4789, 2005. (Pubitemid 46224082)
10. Chu IM, Hengst L and Slingerland JM: The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 8: 253-267, 2008. (Pubitemid 351430863)
11. Suzuki T, Miki Y, Takagi K, et al: Androgens in human breast carcinoma. Med Mol Morphol 43: 75-81, 2010.
12. Nam EJ and Kim YT: Alteration of cell-cycle regulation in epithelial ovarian cancer. Int J Gynecol Cancer 18: 1169-1182, 2008.
13. Lin HY, Sun M, Lin C, et al: Androgen-induced human breast cancer cell proliferation is mediated by discrete mechanisms in estrogen receptor-alpha-positive and -negative breast cancer cells. J Steroid Biochem Mol Biol 113: 182-188, 2009.
14. Krysiak R, Frysz-Naglak D and Okopien B: Current views on the role of dehydroepiandrosterone in physiology, pathology and therapy. Pol Merkur Lekarski 24: 66-71, 2008 (In Polish).
15. Santen R, Cavalieri E, Rogan E, et al: Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects. Ann NY Acad Sci 1155: 132-140, 2009.
16. Miyoshi Y, Murase K, Saito M and Oh K: Prediction of hormone sensitivity for breast cancers. Breast Cancer 17: 86-91, 2010.
17. Fan L, Zheng Y, Yu KD, et al: Breast cancer in a transitional society over 18 years: trends and present status in Shanghai, China. Breast Cancer Res Treat 117: 409-416, 2009.
18. Yin W, Di G, Zhou L, et al: Time-varying pattern of recurrence risk for Chinese breast cancer patients. Breast Cancer Res Treat 114: 527-535, 2009.
19. Ma C, Niu X, Luo J, et al: Combined effects of lapatinib and bortezomib in human epidermal receptor 2 (HER2)-overexpressing breast cancer cells and activity of bortezomib against lapatinib-resistant breast cancer cells. Cancer Sci 101: 2220-2226, 2010.
20. Malewicz B, Wang Z, Jiang C, et al: Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplements. Carcinogenesis 27: 1739-1747, 2006. (Pubitemid 44288657)
21. Greeve MA, Allan RK, Harvey JM and Bentel JM: Inhibition of MCF-7 breast cancer cell proliferation by 5alpha-dihydro-testosterone; a role for p21(Cip1/Waf1). J Mol Endocrinol 32: 793-810, 2004. (Pubitemid 38877685)
22. Sobell HM: Actinomycin and DNA transcription. Proc Natl Acad Sci USA 82: 5328-5331, 1985.
23. Kamura T, Hara T, Matsumoto M, et al: Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol 6: 1229-1235, 2004. (Pubitemid 39625122)
24. Kepinski S and Leyser O: The Arabidopsis F-box protein TIR1 is an auxin receptor. Nature 435: 446-451, 2005. (Pubitemid 40734236)
25. Dharmasiri N, Dharmasiri S and Estelle M: The F-box protein TIR1 is an auxin receptor. Nature 435: 441-445, 2005. (Pubitemid 40734235)
26. Berger AH and Pandolfi PP: Haplo-insufficiency: a driving force in cancer. J Pathol 223: 138-147, 2011.
27. Fero ML, Randel E, Gurley KE, et al: The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 396: 177-180, 1998. (Pubitemid 28523620)
28. Signoretti S, Di Marcotullio L, Richardson A, et al: Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J Clin Invest 110: 633-641, 2002. (Pubitemid 34988787)
29. Strom A and Hartman J: Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci USA 101: 1566-1571, 2004. (Pubitemid 38236167)
30. Berta L, Fronticelli Baldelli C, Fazzari A, et al: Sex steroid receptors, secondary bile acids and colorectal cancer. A possible mechanism of interaction. Panminerva Med 45: 261-266, 2003.
31. Provost PR, Blomquist CH, Godin C, et al: Androgen formation and metabolism in the pulmonary epithelial cell line A549: expression of 17beta-hydroxysteroid dehydrogenase type 5 and 3alpha-hydroxysteroid dehydrogenase type 3. Endocrinology 141: 2786-2794, 2000. (Pubitemid 32250440)
32. Watson PA, Kim K, Chen KS and Gould MN: Androgen-dependent mammary carcinogenesis in rats transgenic for the Neu proto-oncogene. Cancer Cell 2: 67-79, 2002. (Pubitemid 41043989)
33. Zhou W, Yang Q, Low CB, et al: Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process. J Biol Chem 284: 23980-23988, 2009.
34. Kajihara R, Fukushige S, Shioda N, et al: CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells. Biochem Biophys Res Commun 401: 350-355, 2010.
35. Borriello A, Cucciolla V, Criscuolo M, et al: Retinoic acid induces p27Kip1 nuclear accumulation by modulating its phosphorylation. Cancer Res 66: 4240-4248, 2006.