Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects

Annals of the New York Academy of Sciences

Volumn 1155, Issue , 2009, Pages 132-140

  Santen, Richard ^a,f   Cavalieri, Ercole ^b   Rogan, Eleanor ^b   Russo, Jose ^e   Guttenplan, Joseph ^c   Ingle, James ^d   Yue, Wei ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c NEW YORK UNIVERSITY   (United States)

^d MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^e FOX CHASE CANCER CENTER   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

4 OH estradiol; Breast cancer; Estrogen; Genotoxicity

Indexed keywords

4 HYDROXYESTRADIOL; ADENINE; CATECHOL ESTROGEN; DNA; ESTRADIOL; ESTRADIOL GUANINE; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; GUANINE; UNCLASSIFIED DRUG; WNT1 PROTEIN;

ANIMAL MODEL; BINDING AFFINITY; BREAST; BREAST TUMOR; CANCER RISK; CARCINOGENESIS; CELL CULTURE; CELL PROLIFERATION; CELL STIMULATION; CELL STRAIN MCF 7; COMPARATIVE GENOMIC HYBRIDIZATION; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE COURSE; DNA REPLICATION; ESTROGEN ACTIVITY; ESTROGEN METABOLISM; GENOTOXICITY; HETEROZYGOSITY LOSS; INCIDENCE; MOUSE; MUTATION; NONHUMAN; OVARIECTOMY; SCID MOUSE;

MUS;

EID: 61649123555     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03685.x     Document Type: Conference Paper

References (22)

1. Jemal, A., R. Siegel, E. Ward, et al. 2008. Cancer statistics, 2008. CA: A Cancer J. Clin. 58 : 71 96.
2. Santen, R.J., N.F. Boyd, R.T. Chlebowski, et al. 2007. Critical assessment of new risk factors for breast cancer: Considerations for development of an improved risk prediction model. [Review] [95 refs]. Endocrine-Related Cancer 14 : 169 187.
3. Yager, J.D. & N.E. Davidson. 2006. Estrogen carcinogenesis in breast cancer. [See comment]. [Review] [114 refs]. New Engl. J. Med. 354 : 270 282.
4. Hahn, W.C. & R.A. Weinberg. 2002. Rules for making human tumor cells. [Erratum appears in N Engl J Med. 2003 Feb 13, 348(7):674.]. [Review] [121 refs]. New Engl. J. Med. 347 : 1593 1603.
5. Cavalieri, E., D. Chakravarti, J. Guttenplan, et al. 2006. Catechol estrogen quinones as initiators of breast and other human cancers: Implications for biomarkers of susceptibility and cancer prevention. [Review] [102 refs]. Bioch. Biophys. Acta 1766 : 63 78.
6. Shen, Y.M., A.B. Troxel, S. Vedantam, et al. 2006. Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: Role of reactive oxygen and biological selection. Chem. Res. Toxicol. 19 : 1441 1450.
7. Yue, W., J.P. Wang, Y. Li, et al. 1915. Tamoxifen versus aromatase inhibitors for breast cancer prevention 19. Clin. Cancer Res. 11 (2 Pt 2 925s 930s.
8. Yue, W., R.J. Santen, J.P. Wang, et al. 2003. Genotoxic metabolites of estradiol in breast: Potential mechanism of estradiol induced carcinogenesis. [Review] [42 refs]. J. Steroid Biochem. Mol. Biol. 86 : 477 486.
9. Devanesan, P., R.J. Santen, W.P. Bocchinfuso, et al. 2001. Catechol estrogen metabolites and conjugates in mammary tumors and hyperplastic tissue from estrogen receptor-alpha knock-out (ERKO)/Wnt-1 mice: Implications for initiation of mammary tumors. Carcinogenesis 22 : 1573 1576.
10. Singh, S., D. Chakravarti, J.A. Edney, et al. 2005. Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma. Oncol. Rep. 14 : 1091 1096.
11. Gaikwad, N.W., L. Yang, P. Muti, et al. 2008. The molecular etiology of breast cancer: evidence from biomarkers of risk. Int. J. Cancer 122 : 1949 1957.
12. Cavalieri E., N. Gaiwad, E. Rogan, et al. 2007. Molecular etiology of breast cancer: Potential biomarkers of risk and for use in prevention. Presented at the 30th Annual San Antonio Breast Cancer Research and Treatment Symposium, abstract 5001. Dec. 13-17.
13. Balogh, G.A., I.H. Russo, B.R. Balsara & J. Russo. 2006. Detection of chromosomal aberrations by comparative genomic hybridization during transformation of human breast epithelial cells in vitro. Int. J. Oncol. 29 : 877 881.
14. Huang, Y., S.V. Fernandez, S. Goodwin, et al. 2007. Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol. Cancer Res. 67 : 11147 11157.
15. Russo, J. & I.H. Russo. 2006. The role of estrogen in the initiation of breast cancer. [Review] [83 refs]. J. Steroid Biochem. Mol. Biol. 102 : 89 96.
16. Russo, J., S.V. Fernandez, P.A. Russo, et al. 2006. 17-Beta-estradiol induces transformation and tumorigenesis in human breast epithelial cells. FASEB J. 20 : 1622 1634.
17. Saeed, M., E. Rogan, S.V. Fernandez, et al. 2007. Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol. Int. J. Cancer 120 : 1821 1824.
18. Zhao, Z., W. Kosinska, M. Khmelnitsky, et al. 2006. Mutagenic activity of 4-hydroxyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiol. Chem. Res. Toxicol. 19 : 475 479.
19. Kong, L.Y., P. Szaniszlo, T. Albrecht & J. G. Liehr. 2000. Frequency and molecular analysis of hprt mutations induced by estradiol in Chinese hamster V79 cells. Int. J. Oncol. 17 : 1141 1149.
20. Li, L., M.P. Haynes & J.R. Bender. 2003. Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells. Proc. Natl. Acad. Sci. USA 100 : 4807 4812.
21. Couse, J.F. & K.S. Korach. 1999. Estrogen receptor null mice: What have we learned and where will they lead us? [Erratum appears in Endocr. Rev. 1999 Aug, 20(4): 459]. [Review] [511 refs]. Endocr. Rev. 20 : 358 417.
22. Bocchinfuso, W.P., W.P. Hively, J.F. Couse, et al. 1999. A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Cancer Res. 59 : 1869 1876.