Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 5, 2011, Pages

  Shuvy, Mony ^a   Abedat, Suzan ^a   Beeri, Ronen ^a   Valitsky, Michael ^a   Daher, Sameh ^a   Kott Gutkowski, Miriam ^a   Gal Moscovici, Anca ^a   Sosna, Jacob ^a   Rajamannan, Nalini M ^b   Lotan, Chaim ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Growth arrest specific 6; Uremia

Indexed keywords

GROWTH ARREST SPECIFIC PROTEIN 6; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; AORTA VALVE CALCIFICATION; AORTA VALVE DISEASE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DIET; DOWN REGULATION; FEMALE; GENETIC ANALYSIS; HISTOPATHOLOGY; IMAGING; KIDNEY FAILURE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; UPREGULATION; UREMIA;

ANIMALS; AORTIC VALVE; APOPTOSIS; CALCINOSIS; DISEASE MODELS, ANIMAL; FEMALE; HEART VALVE DISEASES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RALOXIFENE; RATS; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SIGNAL TRANSDUCTION; UREMIA;

EID: 79955784706     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00240.2010     Document Type: Article

References (38)

1. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 15: 827-832, 1990.
2. American Congress of Obstetricians and Gynecologists. ACOG practice bulletin. Selective estrogen receptor modulators. Number 39, October 2002 (replaces Committee Opinion Number 224, October 1999). Int J Gynaecol Obstet 79: 289-298, 2002.
3. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115: 377-386, 2007.
4. Barrett-Connor E, Grady D, Sashegyi A, Anderson PW, Cox DA, Hoszowski K, Rautaharju P, Harper KD. Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial. JAMA 287: 847-857, 2002.
5. Barrett-Connor E, Mosca L, Collins P, Geiger MJ, Grady D, Kornitzer M, McNabb MA, Wenger NK. Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women. N Engl J Med 355: 125-137, 2006.
6. Ben-Sasson SA, Sherman Y, Gavrieli Y. Identification of dying cells-in situ staining. Methods Cell Biol 46: 29-39, 1995.
7. Catty D. (editor) Antibodies: a Practical Approach. Oxford, MA: IRL, 1988, vol. 1.
8. Clark-Greuel JNCJ, Sorichillo E, Narula NR, Rapoport HS, Mohler 3rd ER, Gorman JH 3rd, Gorman RC, Levy RJ. Transforming growth factor-β1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events. Ann Thorac Surg 83: 946-953, 2007.
9. Collett GDM, Sage AP, Kirton JP, Alexander MY, Gilmore AP, Canfield AE. Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells. Circ Res 100: 502-509, 2007.
10. Ding HT, Wang CG, Zhang TL, Wang K. Fibronectin enhances in vitro vascular calcification by promoting osteoblastic differentiation of vascular smooth muscle cells via ERK pathway. J Cell Biochem 99: 1343-1352, 2006.
11. Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101: 660-667, 2000.
12. Giachelli CM. Vascular calcification mechanisms. J Am Soc Nephrol 15: 2959-2964, 2004.
13. Gu X, Masters KS. Role of the MAPK/ERK pathway in valvular interstitial cell calcification. Am J Physiol Heart Circ Physiol 296: H1748-H1757, 2009.
14. Hak AE, Pols HAP, van Hemert AM, Hofman A, Witteman JCM. Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler Thromb Vasc Biol 20: 1926-1931, 2000.
15. Kallio A, Guo T, Lamminen E, Seppanen J, Kangas L, Vaananen HK, Harkonen P. Estrogen and the selective estrogen receptor modulator (SERM) protection against cell death in estrogen receptor alpha and beta expressing U2OS cells. Mol Cell Endocrinol 289: 38-48, 2008.
16. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278: 294-298, 1997.
17. Kume T, Kawamoto T, Akasaka T, Watanabe N, Toyota E, Neishi Y, Wada N, Okahashi N, Yoshida K. Rate of progression of valvular aortic stenosis in patients undergoing dialysis. J Am Soc Echocardiogr 19: 914-918, 2006.
18. Liao XB, Zhou XM, Li JM, Yang JF, Tan ZP, Hu ZW, Liu W, Lu Y, Yuan LQ. Taurine inhibits osteoblastic differentiation of vascular smooth muscle cells via the ERK pathway. Amino Acids 34: 525-530, 2008.
19. Lönnstedt IS, T. Replicated microarray data. Stat Sinica 12: 31-46, 2002.
20. Miller JD, Weiss RM, Serrano KM, Brooks RM, 2nd Berry CJ, Zimmerman K, Young SG, Heistad DD. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 119: 2693-2701, 2009.
21. National Institutes of Health. Image J: Image Processing and Analysis in Java (1.29 ed.) (online). http://rsb.info.nih.gov/ij/ [28 February 2011].
22. Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem 271: 30022-30027, 1996.
23. Proudfoot D, Skepper JN, Hegyi L, Bennett MR, Shanahan CM, Weissberg PL. Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 87: 1055-1062, 2000.
24. Qiu P, Moeschberger ML, Cooke GE, Goldschmidt-Clermont PJ. Sample size to test for interaction between a specific exposure and a second risk factor in a pair-matched case-control study. Stat Med 19: 923-935, 2000.
25. Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, Springett M, Orszulak T, Fullerton DA, Tajik AJ, Bonow RO, Spelsberg T. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 107: 2181-2184, 2003.
26. Rajamannan NM, Subramaniam M, Springett M, Sebo TC, Niekrasz M, McConnell JP, Singh RJ, Stone NJ, Bonow RO, Spelsberg TC. Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve. Circulation 105: 2660-2665, 2002.
27. Reiner A, Yekutieli D, Benjamini Y. Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 19: 368-375, 2003.
28. Sawabu T, Seno H, Kawashima T, Fukuda A, Uenoyama Y, Kawada M, Kanda N, Sekikawa A, Fukui H, Yanagita M, Yoshibayashi H, Satoh S, Sakai Y, Nakano T, Chiba T. Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway. Mol Carcinog 46: 155-164, 2007.
29. Schulz E, Arfai K, Liu X, Sayre J, Gilsanz V. Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab 89: 4246-4253, 2004.
30. Sharan R, Maron-Katz A, Shamir R. CLICK and EXPANDER: a system for clustering and visualizing gene expression data. Bioinformatics 19: 1787-1799, 2003.
31. Shuvy M, Abedat S, Beeri R, Danenberg HD, Planer D, Ben-Dov IZ, Meir K, Sosna J, Lotan C. Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats. Cardiovasc Res 79: 492-499, 2008.
32. Shuvy M, Nyska A, Beeri R, Abedat S, Gal-Moscovici A, Rajamannan NM, Lotan C. Histopathology and apoptosis in an animal model of reversible renal injury. Exp Toxicol Pathol; doi:10.1016.j.etp.2010.02.002.
33. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3, 2004.
34. Son BK, Kozaki K, Iijima K, Eto M, Kojima T, Ota H, Senda Y, Maemura K, Nakano T, Akishita M, Ouchi Y. Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway. Circ Res 98: 1024-1031, 2006.
35. Stamatelopoulos KS, Lekakis JP, Poulakaki NA, Papamichael CM, Venetsanou K, Aznaouridis K, Protogerou AD, Papaioannou TG, Kumar S, Stamatelopoulos SF. Tamoxifen improves endothelial function and reduces carotid intima-media thickness in postmenopausal women. Am Heart J 147: 1093-1099, 2004.
36. Val M, Christene H, Giolanta K, Frances C, Brendon N. The antioxidant effect of estrogen and selective estrogen receptor modulators in the inhibition of osteocyte apoptosis in vitro. Bone 40: 674-684, 2007.
37. Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD. Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation 114: 2065-2069, 2006.
38. Xue W, Wallin R, Olmsted-Davis EA, Borras T. Matrix GLA protein function in human trabecular meshwork cells: inhibition of BMP2-induced calcification process. Invest Ophthalmol Vis Sci 47: 997-1007, 2006.