ApoB-100 and HSP60 peptides exert a synergetic role in inhibiting early atherosclerosis in immunized apoe-null mice

Protein and Peptide Letters

Volumn 18, Issue 7, 2011, Pages 733-740

  Li, Jingjing ^a   Zhao, Xiuyun ^a   Zhang, Shichao ^a   Wang, Shengying ^a   Du, Peng ^b   Qi, Gaofu ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b HUBEI UNIVERSITY   (China)

Author keywords

ApoB 100; Atherosclerosis; Heat shock protein 60; Vaccine

Indexed keywords

APOLIPOPROTEIN B100; APOLIPOPROTEIN E; CHAPERONIN; HYBRID PROTEIN;

ANIMAL; ARTICLE; ATHEROSCLEROSIS; CD4+ T LYMPHOCYTE; DENDRITIC CELL; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MOUSE; MOUSE MUTANT; POLYACRYLAMIDE GEL ELECTROPHORESIS;

ANIMALS; APOLIPOPROTEIN B-100; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CD4-POSITIVE T-LYMPHOCYTES; CHAPERONIN 60; DENDRITIC CELLS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MALE; MICE; MICE, KNOCKOUT; RECOMBINANT FUSION PROTEINS;

ANIMALIA; ESCHERICHIA COLI; LOTUS; MUS;

EID: 79955783955     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986611795445987     Document Type: Article

References (23)

1. Hansson, G.K. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med., 2005, 352, 1685-95.
2. Epstein, S.E. The multiple mechanisms by which infection may contribute to atherosclerosis development and course. Circ. Res., 2002, 90, 2-4. (Pubitemid 34074598)
3. Buono, C.; Come, C.E.; Stavrakis, G.; Maguire, G.F.; Connelly, P.W.; Lichtman, A.H. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLRdeficient mouse. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 454-60. (Pubitemid 36337222)
4. Branen, L.; Hovgaard, L.; Nitulescu, M.; Bengtsson, E.; Nilsson, J.; Jovinge, S. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler. Thromb. Vasc. Biol., 2004, 24, 2137-42. (Pubitemid 39482442)
5. Mallat, Z.; Besnard, S.; Duriez, M.; Deleuze, V.; Emmanuel, F.; Bureau, M.F.; Soubrier, F.; Esposito, B.; Duez, H.; Fievet, C.; Staels, B.; Duverger, N.; Scherman, D.; Tedgui, A. Protective role of interleukin-10 in atherosclerosis. Circ. Res., 1999, 85, e17-e24.
6. Grainger, D.J. Transforming growth factor β and atherosclerosis: so far, so good for the protective cytokine hypothesis. Arterioscler. Thromb. Vasc. Biol., 2004, 24, 399-404. (Pubitemid 38326130)
7. Shah, P.K.; Chyu, K.Y.; Fredrikson, G.N.; Nilsson, J. Immunomodulation of atherosclerosis with a vaccine. Nat. Rev. Cardiol., 2005, 2, 639-646. (Pubitemid 43012601)
8. Maron, R.; Sukhova, G.; Faria, A.M.; Hoffmann, E.; Mach, F.; Libby, P.; Weiner, H.L. Mucosal administration of heat shock protein- 65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation, 2002, 106, 1708-1715.
9. Van Puijvelde, G.H.M.; Van Es, T.; Van Wanrooij, E.J.A.; Habets, K.L.L.; De Vos, P.; Van der Zee, R.; Van Eden, W.; Van Berkel Th, J.C.; Kuiper, J. Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 2007, 27, 2677-2683. (Pubitemid 350158922)
10. Fredrikson, G.N.; Söderberg, I.; Lindholm, M.; Dimayuga, P.; Chyu, K.Y.; Shah, P.K.; Nilsson, J. Inhibition of atherosclerosis in ApoE-null mice by immunization with ApoB-100 peptide sequences. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 879-884. (Pubitemid 36566181)
11. Fredrikson, G.N.; Björkbacka, H.; Söderberg, I.; Ljungcrantz, I.; Nilsson, J. Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodies. J. Intern. Med., 2008, 264, 563-570.
12. Rittershaus, C.W.; Miller, D.P.; Thomas, L.J.; Picard, M.D.; Honan, C.M.; Emmett, C.D.; Pettey, C.L.; Adari, H.; Hammond, R.A.; Beattie, D.T.; Callow, A.D.; Marsh, H.C.; Ryan, U.S. Vaccineinduced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 2000, 20, 2106-2112.
13. Lamb, D.J.; Avades, T.Y.; Ferns, G.A.A. Endogenous neutralizing antibodies against platelet-derived growth factor-AA inhibit atherogenesis in the cholesterol-fed rabbit. Arterioscler. Thromb. Vasc. Biol., 2001, 21, 997-1003. (Pubitemid 34168659)
14. Hauer, A.D; Van Puijvelde, G.H.M.; Peterse, N.; De Vos, P.; Van Weel, V.; Van Wanrooij, E.J.A.; Biessen, E.A.L.; Quax, P.H.A.; Niethammer, A.G.; Reisfeld, R.A.; Van Berkel, T.J.C.; Kuiper, J. Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 2007, 27, 2050-2057. (Pubitemid 47312317)
15. Lu, X.; Chen, D.; Endresz, V.; Xia, M.; Faludi, I.; Burian, K.; Szabo, A.; Csanadi, A.; Miczak, A.; Gonczol, E.; Kakkar, V. Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice. Atherosclerosis, 2010, 212, 472-480.
16. Thim, L. Trefoil peptides: from structure to function. Cell. Mol. Life Sci., 1997, 53, 888-903. (Pubitemid 28021502)
17. Qi, G.; Li, J.; Wang, S.; Xin, S.; Du, P.; Zhang, Q.; Zhao, X. A chimeric peptide of intestinal trefoil factor containing cholesteryl estertransfer protein B cell epitope significantly inhibits atherosclerosis in rabbits after oral administration. Peptides, 2011, doi:10.1016/j.peptides.2010.12.014
18. Trevejo, J.M.; Marino, M.W.; Philpott, N.; Josien, R.; Richards, E.C.; Elkon, K.B.; Falck-Pedersen, E. TNF-a-dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection. Proc. Natl. Acad. Sci. USA, 2001, 98, 12162-12167. (Pubitemid 32959844)
19. -/- mice. Lupus, 2008,17, 1070-1078.
20. Elizabeth, R.; Vijaya, D.; William, H.F.; Kirk, S. Vaccines in development to prevent and treat atherosclerotic disease. Cardiol. Rev., 2008, 16, 288-300.
21. Vigouroux, S.; Yvon, E.; Biagi, E.; Brenner, M.K. Antigen-induced regulatory T cells. Blood, 2004, 104, 26-33. (Pubitemid 38879832)
22. Savellano, M.D.; Pogue, B.W.; Hoopes, P.J.; Vitetta, E.S.; Paulsen, K.D. Multiepitope HER2 targeting enhances photoimmunotherapy of HER2-overexpressing cancer cells with pyropheophorbide-a immunoconjugates. Cancer Res., 2005, 65, 6371-6379. (Pubitemid 40994424)
23. Hermansson, A.; Ketelhuth, D.F.; Strodthoff, D.; Wurm, M.; Hansson, E.M.; Nicoletti, A.; Paulsson-Berne, G.; Hansson, G.K. Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis. J. Exp. Med., 2010, 207, 1081-1093.