Interplay between CD8α+ dendritic cells and monocytes in response to listeria monocytogenes infection attenuates T cell responses

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Kapadia, Dilnawaz ^a   Sadikovic, Aida ^a   Vanloubbeeck, Yannick ^a   Brockstedt, Dirk ^b   Fong, Lawrence ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Aduro BioTech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CD11 ANTIGEN; CD8ALPHA ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12P70; TUMOR NECROSIS FACTOR ALPHA; CD8 ANTIGEN; CD8 ANTIGEN, ALPHA CHAIN; GAMMA INTERFERON; INTERLEUKIN 12; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CD11B+ DENDRITIC CELL; CD8ALPHA+ DENDRITIC CELL; CELL LEVEL; CELL POPULATION; COCULTURE; CONTROLLED STUDY; CROSS PRESENTATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INFECTION SENSITIVITY; INFLAMMATION; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGE ACTIVATION; MONOCYTE; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CD8+ T LYMPHOCYTE; CHEMISTRY; CYTOLOGY; EXPERIMENTAL MELANOMA; HYBRIDOMA; METABOLISM; MICROBIOLOGY; TRANSGENIC MOUSE;

LISTERIA MONOCYTOGENES; MUS;

ANIMALS; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; HYBRIDOMAS; INTERFERON-GAMMA; INTERLEUKIN-12; LISTERIA MONOCYTOGENES; LISTERIOSIS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79955777161     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019376     Document Type: Article

References (49)

1. Pamer EG, (2004) Immune responses to Listeria monocytogenes. Nat Rev Immunol 4: 812-823.
2. Zenewicz LA, Shen H, (2007) Innate and adaptive immune responses to Listeria monocytogenes: a short overview. Microbes Infect 9: 1208-1215.
3. Neuenhahn M, Busch DH, (2007) Unique functions of splenic CD8alpha+ dendritic cells during infection with intracellular pathogens. Immunol Lett 114: 66-72.
4. Cossart P, Toledo-Arana A, (2008) Listeria monocytogenes, a unique model in infection biology: an overview. Microbes Infect 10: 1041-1050.
5. Serbina NV, Jia T, Hohl TM, Pamer EG, (2008) Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol 26: 421-452.
6. Serbina NV, Salazar-Mather TP, Biron CA, Kuziel WA, Pamer EG, (2003) TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19: 59-70.
7. Conlan JW, North RJ, (1994) Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody. J Exp Med 179: 259-268.
8. Rogers HW, Unanue ER, (1993) Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect Immun 61: 5090-5096.
9. Unanue ER, (1997) Inter-relationship among macrophages, natural killer cells and neutrophils in early stages of Listeria resistance. Curr Opin Immunol 9: 35-43.
10. Czuprynski CJ, Brown JF, Wagner RD, Steinberg H, (1994) Administration of antigranulocyte monoclonal antibody RB6-8C5 prevents expression of acquired resistance to Listeria monocytogenes infection in previously immunized mice. Infect Immun 62: 5161-5163.
11. Dunn PL, North RJ, (1991) Early gamma interferon production by natural killer cells is important in defense against murine listeriosis. Infect Immun 59: 2892-2900.
12. Huang S, Hendriks W, Althage A, Hemmi S, Bluethmann H, et al. (1993) Immune response in mice that lack the interferon-gamma receptor. Science 259: 1742-1745.
13. Rothe J, Lesslauer W, Lotscher H, Lang Y, Koebel P, et al. (1993) Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364: 798-802.
14. Pfeffer K, Matsuyama T, Kundig TM, Wakeham A, Kishihara K, et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457-467.
15. O'Connell RM, Saha SK, Vaidya SA, Bruhn KW, Miranda GA, et al. (2004) Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med 200: 437-445.
16. Carrero JA, Calderon B, Unanue ER, (2004) Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection. J Exp Med 200: 535-540.
17. Auerbuch V, Brockstedt DG, Meyer-Morse N, O'Riordan M, Portnoy DA, (2004) Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes. J Exp Med 200: 527-533.
18. Conlan JW, (1996) Early pathogenesis of Listeria monocytogenes infection in the mouse spleen. J Med Microbiol 44: 295-302.
19. Steinman RM, Hemmi H, (2006) Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 311: 17-58.
20. Steinman RM, (2007) Dendritic cells: understanding immunogenicity. Eur J Immunol 37 (Suppl 1): S53-60.
21. Shortman K, Liu YJ, (2002) Mouse and human dendritic cell subtypes. Nat Rev Immunol 2: 151-161.
22. Shortman K, Naik SH, (2007) Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 7: 19-30.
23. Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, et al. (2002) In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17: 211-220.
24. Pron B, Boumaila C, Jaubert F, Berche P, Milon G, et al. (2001) Dendritic cells are early cellular targets of Listeria monocytogenes after intestinal delivery and are involved in bacterial spread in the host. Cell Microbiol 3: 331-340.
25. Neuenhahn M, Kerksiek KM, Nauerth M, Suhre MH, Schiemann M, et al. (2006) CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen. Immunity 25: 619-630.
26. Belz GT, Shortman K, Bevan MJ, Heath WR, (2005) CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo. J Immunol 175: 196-200.
27. Iyoda T, Shimoyama S, Liu K, Omatsu Y, Akiyama Y, et al. (2002) The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J Exp Med 195: 1289-1302.
28. Kim TS, Braciale TJ, (2009) Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses. PLoS One 4: e4204.
29. Bedoui S, Whitney PG, Waithman J, Eidsmo L, Wakim L, et al. (2009) Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol 10: 488-495.
30. Le Borgne M, Etchart N, Goubier A, Lira SA, Sirard JC, et al. (2006) Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity 24: 191-201.
31. Mosser DM, Edwards JP, (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969.
32. Torres D, Barrier M, Bihl F, Quesniaux VJ, Maillet I, et al. (2004) Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect Immun 72: 2131-2139.
33. Humann J, Lenz LL, (2010) Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J Immunol 184: 5172-5178.
34. Mempel TR, Henrickson SE, Von Andrian UH, (2004) T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427: 154-159.
35. Mora JR, Bono MR, Manjunath N, Weninger W, Cavanagh LL, et al. (2003) Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 424: 88-93.
36. Sanderson S, Shastri N, (1994) LacZ inducible, antigen/MHC-specific T cell hybrids. Int Immunol 6: 369-376.
37. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, et al. (1994) T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
38. Zijlstra M, Bix M, Simister NE, Loring JM, Raulet DH, et al. (1990) Beta2-Microglobulin deficient mice lack CD4-8+ cytolytic T cells. Nature 344: 742-746.
39. Koller BH, Marrack P, Kappler JW, Smithies O, (1990) Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 248: 1227-1230.
40. Kang SJ, Liang HE, Reizis B, Locksley RM, (2008) Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29: 819-833.
41. Tam MA, Wick MJ, (2006) Differential expansion, activation and effector functions of conventional and plasmacytoid dendritic cells in mouse tissues transiently infected with Listeria monocytogenes. Cell Microbiol 8: 1172-1187.
42. Tada Y, Asahina A, Takekoshi T, Kishimoto E, Mitsui H, et al. (2006) Interleukin 12 production by monocytes from patients with psoriasis and its inhibition by ciclosporin A. Br J Dermatol 154: 1180-1183.
43. Jiang J, Lau LL, Shen H, (2003) Selective depletion of nonspecific T cells during the early stage of immune responses to infection. J Immunol 171: 4352-4358.
44. Merrick JC, Edelson BT, Bhardwaj V, Swanson PE, Unanue ER, (1997) Lymphocyte apoptosis during early phase of Listeria infection in mice. Am J Pathol 151: 785-792.
45. Lu L, Bonham CA, Chambers FG, Watkins SC, Hoffman RA, et al. (1996) Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis. J Immunol 157: 3577-3586.
46. Ren G, Su J, Zhao X, Zhang L, Zhang J, et al. (2008) Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide. J Immunol 181: 3277-3284.
47. Brockstedt DG, Giedlin MA, Leong ML, Bahjat KS, Gao Y, et al. (2004) Listeria-based cancer vaccines that segregate immunogenicity from toxicity. Proc Natl Acad Sci U S A 101: 13832-13837.
48. Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, et al. (1993) Vaccination with irradiated tumor cells engineered to secrete GM-CSF stimulates potent, specific, and long lasting anti-tumor immunity. Proc Natl Acad Sci USA 90: 3539-3543.
49. Brockstedt DG, Bahjat KS, Giedlin MA, Liu W, Leong M, et al. (2005) Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity. Nat Med 11: 853-860.