Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: Gene expression profile analysis

Physiological Genomics

Volumn 43, Issue 7, 2011, Pages 372-379

  Pravenec, Michal ^a   Zídek, Václav ^a   Landa, Vladimír ^a   Šimáková, Miroslava ^a   Mlejnek, Petr ^a   Šilhavý, Jan ^a,b   Maxová, Martina ^c   Kazdová, Ludmila ^c   Seidman, Jonathan G ^d   Seidman, Christine E ^d   Eminaga, Seda ^d   Gorham, Joshua ^d   Wang, Jiaming ^e   Kurtz, Theodore W ^e  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b CZECH UNIVERSITY OF LIFE SCIENCES PRAGUE   (Czech Republic)

^c INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adipose tissue; Autocrine effects; Insulin resistance; Transgenic rat

Indexed keywords

ACTIN; GLUCOSE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PYRUVIC ACID; RESISTIN; TRANSCRIPTION FACTOR NRF2;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CALCIUM SIGNALING; CIRCULATION; CONTROLLED STUDY; DIABETOGENESIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUTATHIONE METABOLISM; HIGH THROUGHPUT SCREENING; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; TRANSGENE; TRANSGENIC RAT;

ADIPOSE TISSUE; AGING; ANIMALS; GENE EXPRESSION PROFILING; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED SHR; RATS, TRANSGENIC; RESISTIN;

RATTUS;

EID: 79955759564     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00112.2010     Document Type: Article

References (35)

1. Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409: 729-733, 2001.
2. Ahmed M, Neville MJ, Edelmann MJ, Kessler BM, Karpe F. Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring) 18: 27-34, 2010.
3. Arner P. Resistin: yet another adipokine tells us that men are not mice. Diabetologia 48: 2203-2205, 2005.
4. Barzilai N, Rossetti L. Relationship between changes in body composition and insulin responsiveness in models of the aging rat. Am J Physiol Endocrinol Metab 269: E591-E597, 1995.
5. Bechtold M, Palmer J, Valtos J, Iasiello C, Sowers J. Metabolic syndrome in the elderly. Curr Diab Rep 6: 64-71, 2006.
6. Bertolani C, Sancho-Bru P, Failli P, Bataller R, Aleffi S, DeFranco R, Mazzinghi B, Romagnani P, Milani S, Ginés P, Colmenero J, Parola M, Gelmini S, Tarquini R, Laffi G, Pinzani M, Marra F. Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells. Am J Pathol 169: 2042-2053, 2006.
7. Brozinick JT Jr, Berkemeier BA, Elmendorf JS. "Actin"g on GLUT4: membrane and cytoskeletal components of insulin action. Curr Diab Rev 3: 111-122, 2007.
8. Ducluzeau PH, Fletcher LM, Vidal H, Laville M, Tavare JM. Molecular mechanisms of insulin-stimulated glucose uptake in adipocytes. Diab Metab 28: 85-92, 2002.
9. Eyster CA, Olson AL. Compartmentalization and regulation of insulin signaling to GLUT4 by the cytoskeleton. Vitam Horm 80: 193-215, 2009.
10. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509, 1957.
11. Fu Y, Luo L, Luo N, Garvey WT. Proinflammatory cytokine production and insulin sensitivity regulated by overexpression of resistin in 3T3-L1 adipocytes. Nutr Metab (Lond) 3: 28, 2006.
12. Haluzik M, Haluzikova D. The role of resistin in obesity-induced insulin resistance. Curr Opin Investig Drugs 7: 306-311, 2006.
13. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA 100: 15712-15717, 2003.
14. Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57, 2009.
15. Kim KH, Lee K, Moon YS, Sul HS. A cysteine-rich adipose tissuespecific secretory factor inhibits adipocyte differentiation. J Biol Chem 276: 11252-11256, 2001.
16. Kim JB, Porreca GJ, Song L, Greenway SC, Gorham JM, Church GM, Seidman CE, Seidman JG. Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy. Science 316: 1481-1484, 2007.
17. Kim J, Cha YN, Surh YJ. A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res 690: 12-23, 2010.
18. Kusminski CM, McTernan PG, Kumar S. Role of resistin in obesity, insulin resistance and type II diabetes. Clin Sci (Lond) 109: 243-256, 2005.
19. Moon B, Kwan JJ, Duddy N, Sweeney G, Begum N. Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation. Am J Physiol Endocrinol Metab 285: E106- E115, 2003.
20. Mykkänen L, Laakso M, Pyörälä K. Association of obesity and distribution of obesity with glucose tolerance and cardiovascular risk factors in the elderly. Int J Obes Relat Metab Disord 16: 695-704, 1992
21. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36, 2002.
22. Pravenec M, Kazdova L, Landa V, Zidek V, Mlejnek P, Jansa P, Wang J, Qi N, Kurtz TW. Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat. J Biol Chem 278: 45209-45215, 2003.
23. Pravenec M, Kazdova L, Cahova M, Landa V, Zidek V, Mlejnek P, Simakova M, Wang J, Qi N, Kurtz TW. Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification. Int J Obes (Lond) 30: 1157-1159, 2006.
24. Qatanani M, Szwergold NR, Greaves DR, Ahima RS, Lazar MA. Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J Clin Invest 119: 531-539, 2009.
25. Qi NR, Wang J, Zidek V, Landa V, Mlejnek P, Kazdova L, Pravenec M, Kurtz TW. A new transgenic rat model of hepatic steatosis and the metabolic syndrome. Hypertension 45: 1004-1011, 2005.
26. Rajala MW, Obici S, Scherer PE, Rossetti L. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest 111: 225-230, 2003.
27. Rangwala SM, Rich AS, Rhoades B, Shapiro JS, Obici S, Rossetti L, Lazar MA. Abnormal glucose homeostasis due to chronic hyperresistinemia. Diabetes 53: 1937-1941, 2004.
28. Rea R, Donnelly R. Resistin: an adipocyte-derived hormone. Has it a role in diabetes and obesity? Diab Obes Metab 6: 163-170, 2004.
29. Satoh H, Nguyen MT, Miles PD, Imamura T, Usui I, Olefsky JM. Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats. J Clin Invest 114: 224-231, 2004.
30. Shafrir E, Raz I. Diabetes: mellitus or lipidus? Diabetologia 46: 433-440, 2003.
31. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature 409: 307-312, 2001.
32. Tomaru T, Steger DJ, Lefterova MI, Schupp M, Lazar MA. Adipocyte- specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/ enhancer-binding proteins. J Biol Chem 284: 6116-6125, 2009.
33. Vigouroux C, Bourut C, Guerci B, Ziegler O, Magre J, Capeau J, Meyer L. A new missense mutation in the calcium-sensing receptor in familial benign hypercalcaemia associated with partial lipoatrophy and insulin resistant diabetes. Clin Endocrinol (Oxf) 53: 393-398, 2000.
34. Vrana A, Fabry P, Kazdova L. Effect of dietary fructose on fatty acid synthesis in adipose tissue and on triglyceride concentration in blood in the rat. Nutr Metab 15: 305-313, 1973.
35. Vrána A, Poledne R, Fábry P, Kazdová L. Palmitate and glucose oxidation by diaphragm of rats with fructose-induced hypertriglyceridemia. Metabolism 27: 885-888, 1978.