Estrogens in the breast tissue: A systematic review

Cancer Causes and Control

Volumn 22, Issue 4, 2011, Pages 529-540

  Yaghjyan, Lusine ^a   Colditz, Graham A ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

Breast carcinogenesis; Estrogen metabolites; Tissue estrogen metabolism

Indexed keywords

ESTRADIOL; ESTROGEN; ESTRONE;

ALCOHOL CONSUMPTION; BODY MASS; BREAST; BREAST BIOPSY; BREAST CANCER; BREAST CARCINOGENESIS; BREAST FEEDING; CANCER RISK; CIGARETTE SMOKING; ESTROGEN BLOOD LEVEL; ESTROGEN METABOLISM; ESTROGEN SYNTHESIS; HORMONE DETERMINATION; HUMAN; IMMUNOASSAY; ORAL CONTRACEPTION; POSTMENOPAUSE; PREGNANCY; PREMENOPAUSE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; REVIEW; SYSTEMATIC REVIEW;

BREAST; BREAST NEOPLASMS; CARCINOMA; CELL TRANSFORMATION, NEOPLASTIC; ESTROGENS; FEMALE; HUMANS; RISK FACTORS;

EID: 79955757952     PISSN: 09575243     EISSN: 15737225     Source Type: Journal    
DOI: 10.1007/s10552-011-9729-4     Document Type: Review

References (90)

1. Eliassen AH, Hankinson SE (2008) Endogenous hormone levels and risk of breast, endometrial and ovarian cancers: prospective studies. Adv Exp Med Biol 630:148-165
2. Giese RW (2003) Measurement of endogenous estrogens: analytical challenges and recent advances. J Chromatogr A 1000(1-2):401-412 (Pubitemid 36638467)
3. Pattarozzi A, Gatti M, Barbieri F et al (2008) 17beta-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment. Mol Pharmacol 73(1):191-202 (Pubitemid 350294210)
4. LaMarca HL, Rosen JM (2007) Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage. Breast Cancer Res 9(4):304
5. Russo J, Fernandez SV, Russo PA et al (2006) 17-Beta-estradiol induces transformation, tumorigenesis in human breast epithelial cells. FASEB J 20(10):1622-1634 (Pubitemid 44943799)
6. Seeger H, Deuringer FU, Wallwiener D, Mueck AO (2004) Breast cancer risk during HRT: influence of estradiol metabolites on breast cancer and endothelial cell proliferation. Maturitas 49(3):235-240 (Pubitemid 39370791)
7. Johansson CM, Anderson TJ, Bergstrom R, Lindgren A, Persson IR (1998) Epithelial proliferation in the normal human breast in relation to endogenous hormones and oral contraceptive use. Breast 7:162-167 (Pubitemid 28339866)
8. Sutherland RL, Prall OW, Watts CK, Musgrove EA (1998) Estrogen progestin regulation of cell cycle progression. J Mammary Gland Biol Neoplasia 3(1):63-72 (Pubitemid 128513220)
9. Foidart JM, Colin C, Denoo X et al (1998) Estradiol, progesterone regulate the proliferation of human breast epithelial cells. Fertil Steril 69(5):963-969 (Pubitemid 28193936)
10. Pike MC, Spicer DV, Dahmoush L, Press MF (1993) Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev 15(1):17-35 (Pubitemid 23269068)
11. Henderson BE, Feigelson HS (2000) Hormonal carcinogenesis. Carcinogenesis 21(3):427-433 (Pubitemid 30137927)
12. Clemons M, Goss P (2001) Estrogen and the risk ofbreast cancer. N Engl J Med 344(4):276-285
13. Rosner B, Colditz GA (1996) Nurses' health study: log-incidence mathematical model of breast cancer incidence. J Natl Cancer Inst 88(6):359-364 (Pubitemid 26094243)
14. Paffenbarger RS Jr, Kampert JB, Chang HG (1980) Characteristics that predict risk of breast cancer before, after the menopause. Am J Epidemiol 112(2):258-268 (Pubitemid 10018964)
15. Zhu BT, Conney AH (1998) Functional role of estrogen metabolism in target cells: review, perspectives. Carcinogenesis 19(1):1-27 (Pubitemid 28376821)
16. Westerlind KC, Gibson KJ, Evans GL, Turner RT (2000) The catechol estrogen, 4-hydroxyestrone, has tissue-specific estrogen actions. J Endocrinol 167(2):281-287
17. Telang NT, Suto A, Wong GY, Osborne MP, Bradlow HL (1992) Induction by estrogen metabolite 16 alpha-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. J Natl Cancer Inst 84(8):634-638
18. McCormack VA, Dowsett M, Folkerd E et al (2009) Sex steroids, growth factors and mammographic density: a cross-sectional study of UK postmenopausal Caucasian and Afro-Caribbean women. Breast Cancer Res 11(3):R38
19. Levina VV, Nolen B, Su Y et al (2009) Biological significance of prolactin in gynecologic cancers. Cancer Res 69(12):5226-5233
20. Dabrosin C (2005) Positive correlation between estradiol and vascular endothelial growth factor but not fibroblast growth factor-2 in normal human breast tissue in vivo. Clin Cancer Res 11(22):8036-8041 (Pubitemid 41698745)
21. Tamimi RM, Byrne C, Colditz GA, Hankinson SE (2007) Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst 99(15):1178-1187 (Pubitemid 47233068)
22. Zhu BT (1998) Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis 19:1-27 (Pubitemid 28376821)
23. Gruber CJ, Tschugguel W, Schneeberger C, Huber JC (2002) Production and actions of estrogens. N Engl J Med 346(5):340-352
24. Sasano H, Miki Y, Nagasaki S, Suzuki T (2009) In situ estrogen production, its regulation in human breast carcinoma: from endocrinology to intracrinology. Pathol Int 59(11):777-789
25. Sasano H, Nagasaki S, Miki Y, Suzuki T (2009) New developments in intracrinology of human breast cancer: estrogen sulfatase and sulfotransferase. Ann N Y Acad Sci 1155:76-79
26. Recchione CVE, Manzari A, Cavalerri A, Martinetti A, Secreto G (1995) Testosterone, dihydrotestosterone and oestradiol levels in postmenopausal breast cancer tissues. Steroid Biochem Molec Biol 52(6):541-546
27. Pasqualini JR, Chetrite G, Blacker C et al (1996) Concentrations of estrone, estradiol, estrone sulfate, evaluation of sulfatase, aromatase activities in pre-and postmenopausal breast cancer patients. J Clin Endocrinol Metab 81(4):1460-1464 (Pubitemid 26118577)
28. Geisler J (2003) Breast cancer tissue estrogens and their manipulation with aromatase inhibitors and inactivators. J Steroid Biochem Mol Biol 86:245-253 (Pubitemid 37420000)
29. Labrie F, Luu-The V, Labrie C et al (2003) Endocrine, intracrine sources of androgens in women: inhibition of breast cancer, other roles of androgens, their precursor dehydroepiandrosterone. Endocr Rev 24(2):152-182 (Pubitemid 36515283)
30. Guillemette C, Belanger A, Lepine J (2004) Metabolic inactiva- tion of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Breast Cancer Res 6(6):246-254 (Pubitemid 39440253)
31. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL (2005) Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Breast Cancer Res 7(6):R909-R921
32. Chetrite GS, Cortes-Prieto J, Philippe JC, Wright F, Pasqualini JR (2000) Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues. J Steroid Biochem Mol Biol 72(1-2):23-27 (Pubitemid 30145713)
33. Riza E, dos Santos Silva I, De Stavola B et al (2001) Urinary estrogen metabolites, mammographic parenchymal patterns in postmenopausal women. Cancer Epidemiol Biomarkers Prev 10(6):627-634 (Pubitemid 32703196)
34. Greendale GA, Palla SL, Ursin G et al (2005) The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study. Am J Epidemiol 162(9):826-834 (Pubitemid 41541366)
35. Tamimi RM, Hankinson SE, Colditz GA, Byrne C (2005) Endogenous sex hormone levels and mammographic density among postmenopausal women. Cancer Epidemiol Biomarkers Prev 14(11 Pt 1):2641-2647 (Pubitemid 41752727)
36. Bremnes Y, Ursin G, Bjurstam N et al (2007) Endogenous sex hormones, prolactin and mammographic density in postmenopausal Norwegian women. Int J Cancer 121(11):2506-2511 (Pubitemid 350022421)
37. Johansson H, Gandini S, Bonanni B et al (2008) Relationships between circulating hormone levels, mammographic percent density, breast cancer risk factors in postmenopausal women. Breast Cancer Res Treat 108(1):57-67 (Pubitemid 351623237)
38. Thomas H, Reeves G, Key T (1997) Endogenous estrogen and postmenopausal breast cancer: a quantitative review. Cancer Causes Control 8(6):922-928 (Pubitemid 27485468)
39. Sheila Dawling DLH, Nady R, Fritz FP (2004) In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol. Chem Res Toxicol 17:1258-1264
40. Leane Lehmann JW (2008) Gene expression of 17b-estradiol- metabolizing isozymes: comparison of normal human mammary gland to normal human liver and to cultured human breast adenocarcinoma cells. Adv Exp Med Biol Hormonal Carcinogenesis V 617:617-624
41. Rosselli MDR (2006) Estrogen metabolism and reproduction-is there a relationship? J für Fertilität und Reproduktion 16:19-23
42. Liehr JG (2001) Genotoxicity of the steroidal oestrogens oestrone and oestradiol: possible mechanism of uterine and mammary cancer development. Human Reproduction Update 2001 7(3):273-281 (Pubitemid 32440289)
43. Westerlind KCGK, Evans GL, Turner RT (2000) The catechol estrogen, 4-hydroxyestrone, has tissue-specific estrogen actions. J Endocrinol 167:281-287
44. Telang NTSA, Wong GY, Osborne MP, Bradlow HL (1992) Induction by estrogen metabolite 16a-hydroxestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. J Natl Cancer Inst 84:634-638
45. Osborne MPBH, Wong GYC, Telang NT (1993) Upregulation of estradiol C16alpha-hydroxylation in human breast tissue: a potential biomarker of breast cancer risk. J Natl Cancer Inst 85:1917-1920
46. Santen RJ, Santner SJ, Pauley RJ et al (1997) Estrogen production via the aromatase enzyme in breast carcinoma: which cell type is responsible? J Steroid Biochem Mol Biol 61(3-6):267-271 (Pubitemid 27455688)
47. Shekhar M, Pauley R, Heppner G (2003) Host microenvironment in breast cancer development: Extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast. Breast Cancer Res 5(3):130-135 (Pubitemid 36519405)
48. Reed MJ, Purohit A (1997) Breast cancer and the role of cyto- kines in regulating estrogen synthesis: an emerging hypothesis. Endocr Rev 18(5):701-715 (Pubitemid 27435541)
49. Roy D, Cai Q, Felty Q, Narayan S (2007) Estrogen-induced generation of reactive oxygen, nitrogen species, gene damage, estrogen-dependent cancers. J Toxicol Environ Health B Crit Rev 10(4):235-257 (Pubitemid 47057178)
50. Mueck AO, Seeger H (2007) Breast cancer: are oestrogen metabolites carcinogenic? Maturitas 57(1):42-46 (Pubitemid 46602890)
51. Li T, Sun L, Miller N et al (2005) The association of measured breast tissue characteristics with mammographic density, other risk factors for breast cancer. Cancer Epidemiol Biomarkers Prev 14(2):343-349 (Pubitemid 40270095)
52. Ernster VL, Wrensch MR, Petrakis NL et al (1987) Benign, malignant breast disease: initial study results of serum, breast fluid analyses of endogenous estrogens. J Natl Cancer Inst 79(5):949-960 (Pubitemid 17165264)
53. Recchione C, Venturelli E, Manzari A et al (1995) Testosterone, dihydrotestosterone, oestradiol levels in postmenopausal breast cancer tissues. J Steroid Biochem Mol Biol 52(6):541-546
54. Vermeulen A, Deslypere JP, Paridaens R et al (1986) Aromatase, 17 beta-hydroxysteroid dehydrogenase, intratissular sex hormone concentrations in cancerous, normal glandular breast tissue in postmenopausal women. Eur J Cancer Clin Oncol 22(4):515-525 (Pubitemid 16113813)
55. van Landeghem AA, Poortman J, Nabuurs M, Thijssen JH (1985) Endogenous concentration, subcellular distribution of estrogens in normal, malignant human breast tissue. Cancer Res 45(6):2900-2906 (Pubitemid 15232767)
56. Beattie CW, Briele HA, Hart G, Das Gupta TK (1983) Estradiol and progesterone in human breast cancer cytosols and their relationship to receptor incidence. Cancer Invest 1(3):199-206 (Pubitemid 13036484)
57. Garvin S, Dabrosin C (2008) In vivo measurement of tumor estradiol and vascular endothelial growth factor in breast cancer patients. BMC Cancer 8:73
58. O'Brien SN, Anandjiwala J, Price TM (1997) Differences in the estrogen content of breast adipose tissue in women by menopausal status, hormone use. Obstet Gynecol 90(2):244-248 (Pubitemid 27318841)
59. Blankenstein MA, Maitimu-Smeele I, Donker GH et al (1992) On the significance of in situ production of oestrogens in human breast cancer tissue. J Steroid Biochem Mol Biol 41(3-8): 891-896
60. Thijssen JH, Blankenstein MA, Donker GH, Daroszewski J (1991) Endogenous steroid hormones and local aromatase activity in the breast. J Steroid Biochem Mol Biol 39(5B):799-804
61. Lonning PE, Helle H, Duong NK et al (2009) Tissue estradiol is selectively elevated in receptor positive breast cancers while tumour estrone is reduced independent of receptor status. J Steroid Biochem Mol Biol 117(1-3):31-41
62. Reed MJ, Aherne GW, Ghilchik MW, Patel S, Chakraborty J (1991) Concentrations of oestrone and 4-hydroxyandrostenedione in malignant and normal breast tissues. Int J Cancer 49(4):562-565
63. Bonney RC, Reed MJ, Davidson K, Beranek PA, James VH (1983) The relationship between 17 beta-hydroxysteroid dehydrogenase activity, oestrogen concentrations in human breast tumours, in normal breast tissue. Clin Endocrinol (Oxf) 19(6):727-739 (Pubitemid 14242386)
64. Hankinson SE, Willett WC, Manson JE et al (1995) Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. J Natl Cancer Inst 87(17):1297-1302
65. Hankinson SE, Eliassen AH (2007) Endogenous estrogen, testosterone, progesterone levels in relation to breast cancer risk. J Steroid Biochem Mol Biol 106(1-5):24-30 (Pubitemid 47371201)
66. Missmer SA, Spiegelman D, Bertone-Johnson ER et al (2006) Reproducibility of plasma steroid hormones, prolactin, insulinlike growth factor levels among premenopausal women over a 2-to 3-year period. Cancer Epidemiol Biomarkers Prev 15(5):972-978 (Pubitemid 43823526)
67. Michaud DS, Manson JE, Spiegelman D et al (1999) Reproducibility of plasma, urinary sex hormone levels in premenopausal women over a one-year period. Cancer Epidemiol Biomarkers Prev 8(12):1059-1064 (Pubitemid 30004902)
68. Thomas HV, Key TJ, Allen DS et al (1997) A prospective study of endogenous serum hormone concentrations and breast cancer risk in premenopausal women on the island of Guernsey. Br J Cancer 75(7):1075-1079 (Pubitemid 27122629)
69. Boyapati SM, Shu XO, Gao YT et al (2004) Correlation of blood sex steroid hormones with body size, body fat distribution, other known risk factors for breast cancer in post-menopausal Chinese women. Cancer Causes Control 15(3):305-311 (Pubitemid 38988039)
70. Potischman N, Swanson CA, Siiteri P, Hoover RN (1996) Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status. J Natl Cancer Inst 88(11):756-758 (Pubitemid 26195024)
71. Kopelman PG, Pilkington TR, White N, Jeffcoate SL (1980) Abnormal sex steroid secretion, binding in massively obese women. Clin Endocrinol (Oxf) 12(4):363-369 (Pubitemid 10131711)
72. Zumoff B (1982) Relationship of obesity to blood estrogens. Cancer Res 42(8 Suppl):3289s-3294s (Pubitemid 12022710)
73. De Pergola G, Giorgino F, Cospite MR et al (1993) Relation between sex hormones, serum lipoprotein, lipoprotein(a) concentrations in premenopausal obese women. Arterioscler Thromb 13(5):675-679 (Pubitemid 23141756)
74. Grenman S, Ronnemaa T, Irjala K, Kaihola HL, Gronroos M (1986) Sex steroid, gonadotropin, Cortisol, prolactin levels in healthy, massively obese women: correlation with abdominal fat cell size, effect of weight reduction. J Clin Endocrinol Metab 63(6):1257-1261 (Pubitemid 17206415)
75. Van Beek AP, de Ruijter-Heijstek FC, Jansen H, Erkelens DW, de Bruin TW (2004) Sex steroids, plasma lipoprotein levels in healthy women: The importance of androgens in the estrogen-deficient state. Metabolism 53(2):187-192 (Pubitemid 38168890)
76. Caron P, Audet-Walsh E, Lepine J, Belanger A, Guillemette C (2009) Profiling endogenous serum estrogen and estrogen-glu- curonides by liquid chromatography-tandem mass spectrometry. Anal Chem 81(24):10143-10148
77. Blankenstein MA, van de Ven J, Maitimu-Smeele I et al (1999) Intratumoral levels of estrogens in breast cancer. J Steroid Biochem Mol Biol 69(1-6):293-297 (Pubitemid 29305549)
78. Chatterton RT Jr, Geiger AS, Khan SA et al (2004) Variation in estradiol, estradiol precursors, estrogen-related products in nipple aspirate fluid from normal premenopausal women. Cancer Epidemiol Biomarkers Prev 13(6):928-935 (Pubitemid 38756702)
79. Dabrosin C (2005) Increased extracellular local levels of estradiol in normal breast in vivo during the luteal phase of the menstrual cycle. J Endocrinol 187(1):103-108 (Pubitemid 41556405)
80. Yue W, Wang JP, Hamilton CJ, Demers LM, Santen RJ (1998) In situ aromatization enhances breast tumor estradiol levels and cellular proliferation. Cancer Res 58(5):927-932 (Pubitemid 28182460)
81. Xu X, Veenstra TD, Fox SD et al (2005) Measuring fifteen endogenous estrogens simultaneously in human urine by highperformance liquid chromatography-mass spectrometry. Anal Chem 77(20):6646-6654 (Pubitemid 41504449)
82. Falk RT, Xu X, Keefer L, Veenstra TD, Ziegler RG (2008) A liquid chromatography-mass spectrometry method for the simultaneous measurement of 15 urinary estrogens, estrogen metabolites: assay reproducibility, interindividual variability. Cancer Epidemiol Biomarkers Prev 17(12):3411-3418
83. Carlstrom K (1996) Low endogenous estrogen levels-analytical problems and tissue sensitivity. Acta Obstet Gynecol Scand Suppl 163:11-15
84. Nelson RE, Grebe SK, DJ OK, Singh RJ (2004) Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol, estrone in human plasma. Clin Chem 50(2):373-384 (Pubitemid 38156379)
85. Bay K, Andersson AM, Skakkebaek NE (2004) Estradiol levels in prepubertal boys, girls-analytical challenges. Int J Androl 27(5):266-273 (Pubitemid 39371849)
86. Blonder J, Johann DJ, Veenstra TD et al (2008) Quantitation of steroid hormones in thin fresh frozen tissue sections. Anal Chem 80(22):8845-8852
87. Xu X, Roman JM, Issaq HJ et al (2007) Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry. Anal Chem 79(20):7813-7821 (Pubitemid 47622412)
88. Xu X, Keefer LK, Ziegler RG, Veenstra TD (2007) A liquid chromatography-mass spectrometry method for the quantitative analysis of urinary endogenous estrogen metabolites. Nat Protoc 2(6):1350-1355 (Pubitemid 46952316)
89. Xu X, Othman Eel D, Issaq HJ et al (2008) Multiplexed quantitation of endogenous estrogens, estrogen metabolites in human peritoneal fluid. Electrophoresis 29(12):2706-2713 (Pubitemid 351911898)
90. Mady EA, Ramadan EE, Ossman AA (2000) Sex steroid hormones in serum and tissue of benign and malignant breast tumor patients. Dis Markers 16(3-4):151-157 (Pubitemid 32591573)