Simulated microgravity maintains the undifferentiated state and enhances the neural repair potential of bone marrow stromal cells

Stem Cells and Development

Volumn 20, Issue 5, 2011, Pages 893-900

  Yuge, Louis ^a,b   Sasaki, Akira ^a   Kawahara, Yumi ^b,c   Wu, Shu Liang ^a   Matsumoto, Masaya ^a   Manabe, Tomotaka ^a   Kajiume, Teruyuki ^c   Takeda, Masaaki ^c   Magaki, Takuro ^c   Takahashi, Tetsuya ^c   Kurisu, Kaoru ^c   Matsumoto, Masayasu ^c  

^a HIROSHIMA UNIVERSITY   (Japan)

^b Cell Therapy Venture Company   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4;

ARTICLE; BONE MARROW TRANSPLANTATION; BRAIN CONTUSION; CELL CULTURE; CELL DIFFERENTIATION; CELL MEMBRANE; CELL REGENERATION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; MICROGRAVITY; MOTOR PERFORMANCE; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; SIMULATION; STROMA CELL;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; BRAIN INJURIES; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; GRAFT SURVIVAL; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; RECEPTORS, CXCR4; REGENERATIVE MEDICINE; STROMAL CELLS; WEIGHTLESSNESS;

MUS;

EID: 79955756663     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2010.0294     Document Type: Article

References (31)

1. Chen J, Y Li and M Chopp. (2000). Intracerebral transplantation of bone marrow with BDNF after MCAo in rat. Neuropharmacology 39:711-716. (Pubitemid 30103675)
2. Bang OY, JS Lee, PH Lee and G Lee. (2005). Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 57:874-882. (Pubitemid 40798626)
3. Chen J, Y Li, L Wang, Z Zhang, D Lu, M Lu and M Chopp. (2001). Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32:1005-1011. (Pubitemid 32285175)
4. Honma T, O Honmou, S Iihoshi, K Harada, K Houkin, H Hamada and JD Kocsis. (2006). Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Exp Neurol 199:56-66.
5. Li Y, J Chen, CL Zhang, L Wang, D Lu, M Katakowski, Q Gao, LH Shen, J Zhang, M Lu and M Chopp. (2005). Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells. Glia 49:407-417. (Pubitemid 40222918)
6. Hung SC, DM Yang, CF Chang, RJ Lin, JS Wang, HL Low- Tone andWK Yang. (2004). Immortalization without neoplastic transformation of human mesenchymal stem cells by transduction with HPV16 E6=E7 genes. Int J Cancer 110:313-319. (Pubitemid 38649880)
7. Zhang X, Y Soda, K Takahashi, Y Bai, A Mitsuru, K Igura, H Satoh, S Yamaguchi, K Tani, A Tojo and TA Takahashi. (2006). Successful immortalization of mesenchymal progenitor cells derived from human placenta and the differentiation abilities of immortalized cells. Biochem Biophys Res Commun 351:853-859. (Pubitemid 44715863)
8. Hirasaka K, T Nikawa, L Yuge, I Ishihara, A Higashibata, N Ishioka, A Okubo, T Miyashita, N Suzue, T Ogawa, M Oarada and K Kishi. (2005). Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-kB-signaling. BBA Mol Cell Res 1743:130-140. (Pubitemid 40380613)
9. Yuge L, I Hide, T Kumagai, Y Kumei, S Takeda, M Kanno, M Sugiyama and K Kataoka. (2003). Cell differentiation and p38 (MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat. In Vitro Cell Dev Biol Anim 39:89-97. (Pubitemid 36944614)
10. Yuge L, T Kajiume, H Tahara, Y Kawahara, C Umeda, R Yoshimoto, SL Wu, K Yamaoka, M Asashima, K Kataoka and T Ide. (2006). Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation. Stem Cells Dev 15:921-929. (Pubitemid 46147862)
11. Plett PA, R Abonour, SM Frankovitz and CM Orschell. (2004). Impact of modeled microgravity on migration, differentiation, and cell cycle control of primitive human hematopoietic progenitor cells. Exp Hematol 32:773-781. (Pubitemid 39092743)
12. Cook JL, V Marcheselli, J Alam, PL Deininger and NG Bazan. (1998). Temporal changes in gene expression following cryogenic rat brain injury. Brain Res Mol Brain Res 55:9-19. (Pubitemid 28236586)
13. Katano H, A Masago, S Harada, A Iwata and K Yamada. (1998). Differential induction of immediate early gene mRNAs following cryogenic and impact trauma with= without craniotomy in rats. Brain Res 800:69-77. (Pubitemid 28361923)
14. Morita-Fujimura Y, M Fujimura, M Kawase and PH Chan. (1999). Early decrease in apurinic=apyrimidinic endonuclease is followed by DNA fragmentation after cold injuryinduced brain trauma in mice. Neuroscience 93:1465-1473. (Pubitemid 29397575)
15. Gonzalez R, CB Maki, J Pacchiarotti, S Csontos, JK Pham, N Slepko, A Patel and F Silva. (2007). Pluripotent marker expression and differentiation of human second trimester mesenchymal stem cells. Biochem Biophys Res Commun 362:491-497. (Pubitemid 47332437)
16. Roche S, MJ Richard and MC Favrot. (2007). Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression. J Cell Biochem 101:271-280. (Pubitemid 46698863)
17. Carlsson SI, MT Bertilaccio, E Ballabio and JA Maier. (2003). Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization. Biochim Biophys Acta 1642:173-179. (Pubitemid 37315660)
18. Higashibata A, M Imamizo-Sato, M Seki, T Yamazaki and N Ishioka. (2006). Influence of simulated microgravity on the activation of the small GTPase Rho involved in cytoskeletal formation-molecular cloning and sequencing of bovine leukemia- associated guanine nucleotide exchange factor. BMC Biochem 7:19.
19. Takeda M, T Magaki, T Okazaki, Y Kawahara, T Manabe, L Yuge and K Kurisu. (2009). Effects of simulated microgravity on proliferation and chemosensitivity in malignant glioma cells. Neurosci Lett 463:54-59.
20. Iihoshi S, O Honmou, K Houkin, K Hashi and JD Kocsis. (2004). A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats. Brain Res 1007:1-9. (Pubitemid 38520167)
21. Masada T, Y Hua, G Xi, SR Ennis and RF Keep. (2001). Attenuation of ischemic brain edema and cerebrovascular injury after ischemic preconditioning in the rat. J Cereb Blood Flow Metab 21:22-33. (Pubitemid 32016836)
22. Nomura T, O Honmou, K Harada, K Houkin, H Hamada and JD Kocsis. (2005). I.V. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Neuroscience 136:161-169. (Pubitemid 41483844)
23. Shen LH, Y Li, J Chen, A Zacharek, Q Gao, A Kapke, M Lu, K Raginski, P Vanguri, A Smith and M Chopp. (2007). Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J Cereb Blood Flow Metab 27:6-13. (Pubitemid 46006579)
24. Lu D, A Mahmood, L Wang, Y Li, M Lu and M Chopp. (2001). Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport 12:559-563. (Pubitemid 32173965)
25. Lu J, S Moochhala, XL Moore, KC Ng, MH Tan, LK Lee, B He, MC Wong and EA Ling. (2006). Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury. Neurosci Lett 398:12-17.
26. Shichinohe H, S Kuroda, JB Lee, G Nishimura, S Yano, T Seki, J Ikeda, M Tamura and Y Iwasaki. (2004). In vivo tracking of bone marrow stromal cells transplanted into mice cerebral infarct by fluorescence optical imaging. Brain Res Protoc 13:166-175. (Pubitemid 39030777)
27. Chen X, Y Li, L Wang, M Katakowski, L Zhang, J Chen, Y Xu, SC Gautam and M Chopp. (2002). Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology 22:275-279. (Pubitemid 36142758)
28. Crigler L, RC Robey, A Asawachaicharn, D Gaupp and DG Phinney. (2006). Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis. Exp Neurol 198:54-64. (Pubitemid 43243744)
29. Qu R, Y Li, Q Gao, L Shen, J Zhang, Z Liu, X Chen and M Chopp. (2007). Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts. Neuropathology 27:355-363. (Pubitemid 47063283)
30. Chiba S, R Ikeda, MS Kurokawa, H Yoshikawa, M Takeno, H Nagafuchi, M Tadokoro, H Sekino, T Hashimoto and N Suzuki. (2004). Anatomical and functional recovery by embryonic stem cell-derived neural tissue of a mouse model of brain damage. J Neurol Sci 219:107-117. (Pubitemid 38406006)
31. Ji JF, BP He, ST Dheen and SS Tay. (2004). Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. Stem Cells 22:415-427. (Pubitemid 38736625)