Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation

Stem Cells and Development

Volumn 15, Issue 6, 2006, Pages 921-929

  Yuge, Louis ^a,b   Kajiume, Teruyuki ^a   Tahara, Hidetoshi ^a   Kawahara, Yumi ^a   Umeda, Chika ^a   Yoshimoto, Meiko ^a   Wu, Shu Liang ^a   Yamaoka, Kazuko ^a   Asashima, Makoto ^c   Kataoka, Katsuko ^b   Ide, Toshinori ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; BETA1 INTEGRIN; COLLAGEN TYPE 1; HERMES ANTIGEN; THY 1 ANTIGEN;

ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DEVICE; EXPLANT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYALINE CARTILAGE; IN VITRO STUDY; MESENCHYMAL STEM CELL; MICROGRAVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMULATION; TELOMERE;

CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL DIVISION; FLOW CYTOMETRY; HUMANS; KINETICS; MESENCHYMAL STEM CELLS; WEIGHTLESSNESS;

MUS;

EID: 33846421603     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2006.15.921     Document Type: Article

References (33)

1. Prockop DJ. (1997). Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71-74.
2. Caplan AI. (1994). The mesengenic process. Clin Plastic Surg 21:429-435.
3. Okamoto T, T Aoyama, T Nakayama, T Hosaka, K Nishijo, T Nakamura, T Kiyono and J Toguchida. (2002). Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells. Biochem Biophys Res Commun 295:354-361.
4. Pittenger MF, AM Mackay, SC Beck, RK Jaiswal, R Douglas, JD Mosca, MA Moorman, DW Simonetti, S Craig and DR Marshak. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147.
5. Caplan AI and SP Bruder. (2001). Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med 7:259-264.
6. Zayzafoon M, WE Gathings and JM McDonald. (2004). Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis. Endocrinology 145:2421-2432.
7. Meyers VE, M Zayzafoon, SR Gonda, WE Gathings and JM McDonald. (2004). Modeled microgravity disrupts collagen I/integrin signaling during osteoblastic differentiation of human mesenchymal stem cells. J Cell Biochem 93:697-707.
8. Ontiveros C and LR McCabe. (2003). Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation. J Cell Biochem 88:427-437.
9. Narayanan R, CL Smith and NL Weigel. (2002). Vector-averaged gravity-induced changes in cell signaling and vitamin D receptor activity in MG-63 cells are reversed by a 1,25-(OH)(2)D(3) analog, EB1089. Bone 31:381-388.
10. Sarkar D, T Nagaya, K Koga, Y Nomura, R Gruener and H Seo. (2000). Culture in vector-averaged gravity under clinostat rotation results in apoptosis of osteoblastic ROS17/2.8 cells. J Bone Miner Res 15:489-498.
11. Kobayashi K, F Kambe, K Kurokouchi, T Sakai, N Ishiguro, H Iwata, K Koga, R Gruener and H Seo. (2000). TNF-alpha-dependent activation of NF-kappa B in human osteoblastic HOS-TE85 cells is repressed in vector-averaged gravity using clinostat rotation. Biochem Biophys Res Commun 279:258-264.
12. Yuge L, I Hide, T Kumagai, Y Kumei, S Takeda, M Kanno, M Sugiyama and K Kataoka. (2003). Cell differentiation and p38 (MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat. In Vitro Cell Dev Biol Anim 39:89-97.
13. Ichigi J and M Asashima. (2001). Dome formation and tubule morphogenesis by Xenopus kidney A6 cell cultures exposed to microgravity simulated with a 3D-clinostat and to hypergravity. In Vitro Cell Dev Biol Anim 37:31-44.
14. Hirasaka K, T Nikawa, L Yuge, I Ishihara, A Higashibata, N Ishioka, A Okubo, T Miyashita, N Suzue, T Ogawa, M Oarada and K Kishi. (2005). Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-kappa B signaling. BBA-Mol Cell Res 1743:130-140.
15. Tahara H, T Nakanishi, M Kitamoto, R Nakashio, JW Shay, E Tahara, G Kajiyama and T Ide. (1995). Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res 55:2734-2736.
16. Nakayama J, H Tahara, E Tahara, M Saito, K Ito, H Nakamura, T Nakanishi, T Ide and F Ishikawa. (1998). Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nature Genet 18:65-68.
17. Chomczynski P and N Sacchi. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
18. Colter DC, I Sekiya and DJ Prockop. (2001). Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proc Natl Acad Sci USA 98:7841-7845.
19. Unsworth BR and PI Lelkes. (1998). Growing tissues in microgravity. Nature Med 4:901-907.
20. Tsao YD, TJ Goodwin, DA Wolf and GF Spaulding. (1992). Responses of gravity level variations on the NASA/JSC bioreactor system. Physiologist 35:S49-S50.
21. Schwarz RP, TJ Goodwin and DA Wolf. (1992). Cell culture for three-dimensional modeling in rotating-wall vessels: an application of simulated microgravity. J Tissue Cult Methods 14:51-57.
22. Tobin BW, SK Leeper-Woodford, BB Hashemi, SM Smith and CF Sams. (2001). Altered TNF-α, glucose, insulin, and amino acids in islets of Langerhans cultured in a microgravity model system. Am J Physiol Endocrinol Metab 280:E92-E102.
23. Marimuthu KM, AH Sparrow and LA Schairer. (1970). The cytological effects of space flight factors, vibration, clinostat and radiation on root tip cells of Tradescantia. Radiat Res 42:105-119.
24. Schatten H, ML Lewis and A Chakrabarti. (2001). Space-flight and clinorotation cause cytoskeleton and mitochondria changes and increases in apoptosis in cultured cells. Acta Astronaut 49:399-418.
25. Liu L, CM DiGirolamo, PA Navarro, MA Blasco and DL Keefe. (2004). Telomerase deficiency impairs differentiation of mesenchymal stem cells. Exp Cell Res 294:1-8.
26. Parsch D, J Fellenberg, TH Brummendorf, AM Eschlbeck and W Richter. (2004). Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes. J Mol Med 82:49-55.
27. Peretti GM, LJ Bonassar, EM Caruso, MA Randolph, CA Trahan and DJ Zaleske. (1999). Biomechanical analysis of a chondrocyte-based repair model of articular cartilage. Tissue Eng 5:317-326.
28. Rotter N, LJ Bonassar, G Tobias, M Lebl, AK Roy and CA Vacanti. (2002). Age dependence of biochemical and biomechanical properties of tissue-engineered human septal cartilage. Biomaterials 23:3087-3094.
29. Shukunami C and Y Hiraki. (2001). Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation. Osteoarthritis Cartilage 9:891-101.
30. Costa C, JL Brokaw, Y Wang and WL Fodor. (2003). Delayed rejection of porcine cartilage is averted by transgenic expression of alpha, 2-fucosyltransferase. FASEB J 17:109-111.
31. Haisch A, A Groger, C Radke, J Ebmeyer, H Sudhoff, G Grasnick, V Jahnke, GR Burmester and M Sittinger. (2000). Macroencapsulation of human cartilage implants: pilot study with polyelectrolyte complex membrane encapsulation. Biomaterials 21:1561-1566.
32. Puelacher WC, J Wisser, CA Vacanti, NF Ferraro, D Jaramillo and JP Vacanti. (1994). Temporomandibular joint disc replacement made by tissue-engineered growth of cartilage. J Oral Maxillofac Surg 52:1172-1178.
33. Liechty KW, TC MacKenzie, AF Shaaban, A Radu, AM Moseley, R Deans, DR Marshak and AW Flake. (2000). Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nature Med 6:1282-1286.