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Volumn 96, Issue 5, 2011, Pages 640-643

Impact of molecular prognostic factors in cytogenetically normal acute myeloid leukemia at diagnosis and relapse

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ASXL1 GENE; BAALC GENE; CANCER DIAGNOSIS; CEBPA GENE; CYTOGENETICS; DISEASE MARKER; EDITORIAL; ERG GENE; EVI1 GENE; FLT3 GENE; GENE MUTATION; HUMAN; IDH1 GENE; IDH2 GENE; LEUKEMIA RELAPSE; MLL GENE; MN1 GENE; NONHUMAN; NPM1 GENE; NRAS GENE; PROGNOSIS; RUNX1 GENE; TET2 GENE; WT1 GENE;

EID: 79955727148     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.042739     Document Type: Editorial
Times cited : (11)

References (36)
  • 1
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mrózek K, Dodge RK, Carroll AJ, Edwards CG, Arthur DC, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002;100(13):4325-36.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4325-4336
    • Byrd, J.C.1    Mrózek, K.2    Dodge, R.K.3    Carroll, A.J.4    Edwards, C.G.5    Arthur, D.C.6
  • 2
    • 16544369516 scopus 로고    scopus 로고
    • Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia
    • Bullinger L, Döhner K, Bair E, Fröhling S, Schlenk RF, Tibshirani R, et al. Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med. 2004;350(16):1605-16.
    • (2004) N Engl J Med , vol.350 , Issue.16 , pp. 1605-1616
    • Bullinger, L.1    Döhner, K.2    Bair, E.3    Fröhling, S.4    Schlenk, R.F.5    Tibshirani, R.6
  • 3
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications
    • Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol. 2011;29(5):475-86.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 475-486
    • Marcucci, G.1    Haferlach, T.2    Dohner, H.3
  • 6
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453-74.
    • (2010) Blood , vol.115 , Issue.3 , pp. 453-474
    • Döhner, H.1    Estey, E.H.2    Amadori, S.3    Appelbaum, F.R.4    Büchner, T.5    Burnett, A.K.6
  • 8
    • 77956265489 scopus 로고    scopus 로고
    • IDH mutations in glioma and acute myeloid leukemia
    • Dang L, Jin S, Su SM. IDH mutations in glioma and acute myeloid leukemia. Trends Mol Med. 2010;16(9):387-97.
    • (2010) Trends Mol Med , vol.16 , Issue.9 , pp. 387-397
    • Dang, L.1    Jin, S.2    Su, S.M.3
  • 10
    • 79954448043 scopus 로고    scopus 로고
    • RUNX1 mutations in acute myeloid leukemia: Results from a comprehensive genetic and clinical analysis from the AML Study Group
    • Gaidzik VI, Bullinger L, Schlenk RF, Zimmermann AS, Röck J, Paschka P, et al. RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML Study Group. J Clin Oncol. 2011;29(10):1364-72.
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1364-1372
    • Gaidzik, V.I.1    Bullinger, L.2    Schlenk, R.F.3    Zimmermann, A.S.4    Röck, J.5    Paschka, P.6
  • 11
    • 67650312343 scopus 로고    scopus 로고
    • Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Langer C, Marcucci G, Holland KB, Radmacher MD, Maharry K, Paschka P, et al. Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2009;27(19):3198-204.
    • (2009) J Clin Oncol , vol.27 , Issue.19 , pp. 3198-3204
    • Langer, C.1    Marcucci, G.2    Holland, K.B.3    Radmacher, M.D.4    Maharry, K.5    Paschka, P.6
  • 12
    • 45949110015 scopus 로고    scopus 로고
    • High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: A Cancer and Leukemia Group B (CALGB) study
    • Langer C, Radmacher MD, Ruppert AS, Whitman SP, Paschka P, Mrózek K, et al. High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study. Blood. 2008;111(11):5371-9.
    • (2008) Blood , vol.111 , Issue.11 , pp. 5371-5379
    • Langer, C.1    Radmacher, M.D.2    Ruppert, A.S.3    Whitman, S.P.4    Paschka, P.5    Mrózek, K.6
  • 13
    • 34548234969 scopus 로고    scopus 로고
    • High expression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Whitman SP, Vukosavljevic T, Paschka P, Langer C, et al. High expression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2007;25(22):3337-43.
    • (2007) J Clin Oncol , vol.25 , Issue.22 , pp. 3337-3343
    • Marcucci, G.1    Maharry, K.2    Whitman, S.P.3    Vukosavljevic, T.4    Paschka, P.5    Langer, C.6
  • 14
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Wu YZ, Radmacher MD, Mrózek K, Margeson D, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2010;28(14):2348-55.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3    Radmacher, M.D.4    Mrózek, K.5    Margeson, D.6
  • 15
    • 77649096189 scopus 로고    scopus 로고
    • ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: A comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays
    • Metzeler KH, Dufour A, Benthaus T, Hummel M, Sauerland MC, Heinecke A, et al. ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays. J Clin Oncol. 2009;27(30):5031-8.
    • (2009) J Clin Oncol , vol.27 , Issue.30 , pp. 5031-5038
    • Metzeler, K.H.1    Dufour, A.2    Benthaus, T.3    Hummel, M.4    Sauerland, M.C.5    Heinecke, A.6
  • 16
    • 79954428737 scopus 로고    scopus 로고
    • TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Metzeler KH, Maharry K, Radmacher MD, Mrózek K, Margeson D, Becker H, et al. TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2011;29(10):1373-81.
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1373-1381
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3    Mrózek, K.4    Margeson, D.5    Becker, H.6
  • 17
    • 53749099948 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: A Cancer and Leukemia Group B study
    • Neubauer A, Maharry K, Mrózek K, Thiede C, Marcucci G, Paschka P, et al. Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: a Cancer and Leukemia Group B study. J Clin Oncol. 2008;26(28):4603-9.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4603-4609
    • Neubauer, A.1    Maharry, K.2    Mrózek, K.3    Thiede, C.4    Marcucci, G.5    Paschka, P.6
  • 18
    • 53749101166 scopus 로고    scopus 로고
    • Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Paschka P, Marcucci G, Ruppert AS, Whitman SP, Mrózek K, Maharry K, et al. Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2008;26(28):4595-602.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4595-4602
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3    Whitman, S.P.4    Mrózek, K.5    Maharry, K.6
  • 19
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Krönke J, Bullinger L, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol. 2010;28(22):3636-43.
    • (2010) J Clin Oncol , vol.28 , Issue.22 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3    Habdank, M.4    Krönke, J.5    Bullinger, L.6
  • 20
    • 79251585678 scopus 로고    scopus 로고
    • Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Schwind S, Maharry K, Radmacher MD, Mrózek K, Holland KB, Margeson D, et al. Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2010;28(36):5257-64.
    • (2010) J Clin Oncol , vol.28 , Issue.36 , pp. 5257-5264
    • Schwind, S.1    Maharry, K.2    Radmacher, M.D.3    Mrózek, K.4    Holland, K.B.5    Margeson, D.6
  • 21
    • 73949090504 scopus 로고    scopus 로고
    • AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: Prognostic implication and interaction with other gene alterations
    • Tang JL, Hou HA, Chen CY, Liu CY, Chou WC, Tseng MH, et al. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood. 2009;114(26):5352-61.
    • (2009) Blood , vol.114 , Issue.26 , pp. 5352-5361
    • Tang, J.L.1    Hou, H.A.2    Chen, C.Y.3    Liu, C.Y.4    Chou, W.C.5    Tseng, M.H.6
  • 23
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005;352(3):254-66.
    • (2005) N Engl J Med , vol.352 , Issue.3 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3    Alcalay, M.4    Rosati, R.5    Pasqualucci, L.6
  • 24
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
    • Döhner K, Schlenk RF, Habdank M, Scholl C, Rücker FG, Corbacioglu A, et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood. 2005;106(12):3740-6.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3740-3746
    • Döhner, K.1    Schlenk, R.F.2    Habdank, M.3    Scholl, C.4    Rücker, F.G.5    Corbacioglu, A.6
  • 25
    • 77449140390 scopus 로고    scopus 로고
    • Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: A Cancer and Leukemia Group B study
    • Becker H, Marcucci G, Maharry K, Radmacher MD, Mrózek K, Margeson D, et al. Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study. J Clin Oncol. 2009;28(4):596-604.
    • (2009) J Clin Oncol , vol.28 , Issue.4 , pp. 596-604
    • Becker, H.1    Marcucci, G.2    Maharry, K.3    Radmacher, M.D.4    Mrózek, K.5    Margeson, D.6
  • 26
    • 77954494236 scopus 로고    scopus 로고
    • FLT3 inhibitors for the treatment of acute myeloid leukemia
    • Wiernik PH. FLT3 inhibitors for the treatment of acute myeloid leukemia. Clin Adv Hematol Oncol. 2010;8(6):429-36,444.
    • (2010) Clin Adv Hematol Oncol , vol.8 , Issue.6
    • Wiernik, P.H.1
  • 27
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A Cancer and Leukemia Group B study
    • Whitman SP, Archer KJ, Feng L, Baldus C, Becknell B, Carlson BD, et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a Cancer and Leukemia Group B study. Cancer Res. 2001;61(19):7233-9.
    • (2001) Cancer Res , vol.61 , Issue.19 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3    Baldus, C.4    Becknell, B.5    Carlson, B.D.6
  • 28
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, Schaich M, Schäkel U, Platzbecker U, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99(12):4326-35.
    • (2002) Blood , vol.99 , Issue.12 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3    Schaich, M.4    Schäkel, U.5    Platzbecker, U.6
  • 29
    • 55549103713 scopus 로고    scopus 로고
    • Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Radmacher MD, Mrózek K, Vukosavljevic T, Paschka P, et al. Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B study. J Clin Oncol. 2008;26(31):5078-87.
    • (2008) J Clin Oncol , vol.26 , Issue.31 , pp. 5078-5087
    • Marcucci, G.1    Maharry, K.2    Radmacher, M.D.3    Mrózek, K.4    Vukosavljevic, T.5    Paschka, P.6
  • 30
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Wu YZ, Radmacher MD, Mrózek K, Margeson D, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2010;28(14):2348-55.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3    Radmacher, M.D.4    Mrózek, K.5    Margeson, D.6
  • 31
    • 34250011216 scopus 로고    scopus 로고
    • Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: A Cancer and Leukemia Group B study
    • Whitman SP, Ruppert AS, Marcucci G, Mrózek K, Paschka P, Langer C, et al. Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study. Blood. 2007;109(12):5164-7.
    • (2007) Blood , vol.109 , Issue.12 , pp. 5164-5167
    • Whitman, S.P.1    Ruppert, A.S.2    Marcucci, G.3    Mrózek, K.4    Paschka, P.5    Langer, C.6
  • 34
    • 79955706968 scopus 로고    scopus 로고
    • FLT3-internal tandem duplication and age are the major prognostic factors in relapsed acute myeloid leukemia with normal karyotype
    • Wagner K, Damm F, Thol F, Göhring G, Görlich K, Heuser M, et al. FLT3-internal tandem duplication and age are the major prognostic factors in relapsed acute myeloid leukemia with normal karyotype. Haematologica 2011;96(5):681-6.
    • (2011) Haematologica , vol.96 , Issue.5 , pp. 681-686
    • Wagner, K.1    Damm, F.2    Thol, F.3    Göhring, G.4    Görlich, K.5    Heuser, M.6
  • 35
    • 77954474254 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for FLT3 mutant AML patients in first relapse
    • Levis M, Ravandi F, Wang ES, Baer MR, Perl A, Coutre S, et al. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for FLT3 mutant AML patients in first relapse. ASH Annual Meeting Abstracts 2009;114:788.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 788
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3    Baer, M.R.4    Perl, A.5    Coutre, S.6
  • 36
    • 79955726330 scopus 로고    scopus 로고
    • Sorafenib in combination with standard induction and consolidation therapy in elderly AML patients: Results from a randomized, placebocontrolled phase II trial
    • Serve H, Wagner R, Sauerland C, Brunnberg U, Krug U, Schaich M, et al. Sorafenib in combination with standard induction and consolidation therapy in elderly AML patients: results from a randomized, placebocontrolled phase II trial. ASH Annual Meeting Abstracts 2010;116:333.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 333
    • Serve, H.1    Wagner, R.2    Sauerland, C.3    Brunnberg, U.4    Krug, U.5    Schaich, M.6


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