Outer membrane protein complex of meningococcus enhances the antipolysaccharide antibody response to pneumococcal polysaccharide-CRM 197 conjugate vaccine

Clinical and Vaccine Immunology

Volumn 18, Issue 5, 2011, Pages 724-729

  Lai, Zengzu ^a,b   Schreiber, John R ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; BACTERIUM ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G3 ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; OUTER MEMBRANE PROTEIN; PNEUMOCOCCAL POLYSACCHARIDE DIPHTHERIA TOXOID CRM197 CONJUGATE VACCINE; POLYSACCHARIDE ANTIBODY; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; MENINGOCOCCOSIS; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; SEROTYPE; SPLEEN CELL;

ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; CYTOKINES; FEMALE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; PNEUMOCOCCAL VACCINES; SPLEEN;

EID: 79955722762     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00053-11     Document Type: Article

References (39)

1. Ambrosino, D. M., et al. 1992. Effect of Haemophilus influenzae polysaccharide outer membrane protein complex conjugate vaccine on macrophages. J. Immunol. 149:3978.
2. Black, S., et al. 2000. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr. Infect. Dis. J. 19:187-195.
3. Black, S. B., et al. 1991. Efficacy in infancy of oligosaccharide conjugate Haemophilus influenzae type b (HbOC) vaccine in a United States population of 61,080 children. Pediatr. Infect. Dis. J. 10:97-104.
4. Borsutzky, S., et al. 2005. The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells. J. Immunol. 174:6308-6313. (Pubitemid 40663823)
5. Chu, R. S., et al. 2000. CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance anti-polysaccharide immunoglobulin (IgG2a) and IgG3 antibodies. Infect. Immun. 68:1450-1456.
6. Cowan, M. J., et al. 1978. Pneumococcal polysaccharide immunization in infants and children. Pediatrics 62:721-727. (Pubitemid 9009878)
7. Donnelly, J. J., R. R. Deck, and M. A. Liu. 1990. Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseriae meningitidis outer membrane protein vaccine. J. Immunol. 143:3071-3079.
8. Douglas, R. M., J. C. Paton, S. J. Duncan, and D. J. Hansman. 1983. Antibody response to pneumococcal vaccination in children younger than five years of age. J. Infect. Dis. 148:131-137.
9. Galil, K., et al. 1999. Reemergence of invasive Haemophilus influenzae type b disease in a well-vaccinated population in remote Alaska. J. Infect. Dis. 179:101.
10. Ganley-Leal, L. M., X. Liu, and L. M. Wetzler. 2006. Toll-like receptor 2-mediated human B cell differentiation. Clin. Immunol. 120:272-284.
11. Granoff, D. M., and S. J. Holmes. 1991. Comparative immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugate vaccines. Vaccine 9:S30.
12. Guttormsen, H. K., et al. 1999. Cognate stimulatory B-cell and T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines. Infect. Immun. 67:6375-6384.
13. Harding, C. V., R. W. Roof, P. M. Allen, and E. R. Unanue. 1991. Effects of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. U. S. A. 88:2740-2744.
14. Hausdorff, W. P., J. Bryant, C. Kloek, P. R. Paradiso, and G. R. Siber. 2000. The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part II. Clin. Infect. Dis. 30:122-140.
15. + T cell cytokine response that correlates with the isotype of antipolysaccharide antibody. J. Infect. Dis. 184:931-935.
16. 197 conjugate vaccine occurs despite vigorous T cell help induced by the carrier protein. J. Infect. Dis. 187:1629-1638.
17. Katsenelson, N., et al. 2007. Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion. Eur. J. Immunol. 37:1785-1795.
18. Kayhty, H., V. Karanko, H. Peltola, and P. H. Makela. 1984. Serum antibodies after vaccination with Haemophilus influenzae type b capsular polysaccharide and responses to reimmunization: no evidence of immunologic tolerance or memory. Pediatrics 74:857-865.
19. Latz, E., J. Franko, D. T. Golenbock, and J. R. Schreiber. 2004. Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity. J. Immunol. 172:2431-2438.
20. Massari, P., et al. 2002. Immune stimulation by neisserial porins is toll-like receptor 2 and Myd88 dependent. J. Immunol. 168:1533-1537. (Pubitemid 34135744)
21. 197 conjugate vaccines in a murine model. Vaccine 19:1159-1166.
22. McCool, T. L., C. V. Harding, N. S. Greenspan, and J. R. Schreiber. 1999. Band T-cell immune responses to pneumococcal conjugate vaccines: divergence between carrier- and polysaccharide-specific immunogenicity. Infect. Immun. 67:4862-4869.
23. McLay, J., et al. 2002. Gamma 3 gene-disrupted mice selectively deficient in the dominant IgG subclass made to bacterial polysaccharides. II. Increased susceptibility to fatal pneumococcal sepsis due to absence of anti-polysaccharide IgG3 is corrected by induction of anti-polysaccharide IgG1. J. Immunol. 168:3437-3443.
24. Mond, J. J., A. Lees, and C. M. Snapper. 1995. T cell-independent antigens type 2. Annu. Rev. Immunol. 13:655-692.
25. Ng, L. G., et al. 2006. BAFF costimulation of Toll-like receptor activated B-1 cells. Eur. J. Immunol. 36:1837-1846.
26. Pone, E. J., et al. 2010. Toll-like receptors and B cell receptors synergize to induce immunoglobulin class switch DNA recombination: relevance to microbial antibody responses. Crit. Rev. Immunol. 30:1-29.
27. 197 in United States infants. Pediatrics 101:604-611.
28. Schneerson, R., O. Barrera, A. Sutton, and J. B. Robbins. 1980. Preparation, characterization and immunogenicity of Haemophilus influenzae type b polysaccharide- protein conjugates. J. Exp. Med. 152:361-376.
29. Shinefield, H. R., et al. 1999. Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers. Pediatr. Infect. Dis. J. 18:757-763.
30. Smith, D. H., G. Peter, D. L. Ingram, A. L. Harding, and P. Anderson. 1973. Responses of children immunized with the capsular polysaccharide of Haemophilus influenzae, type b. Pediatrics 52:637-644.
31. Stein, K. E. 1992. Thymus-independent and thymus-dependent responses to polysaccharide antigens. J. Infect. Dis. 165(Suppl. 1):S49-S52.
32. Taillardet, M., et al. 2009. The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells. Blood 114:4432-4440.
33. Taillardet, M., et al. 2010. Toll-like receptor agonists allow generation of long-lasting antipneumococcal humoral immunity to a plain polysaccharide vaccine. J. Infect. Dis. 202:470-479.
34. Uchida, T., A. M. Pappenheimer, Jr., and A. A. Harper. 1972. Reconstitution of diphtheria toxin from two nontoxic cross-reacting mutant proteins. Science 175:901-903.
35. Unanue, E. R., and J. C. Cerottini. 1989. Antigen presentation. FASEB J. 13:2496-2502.
36. Vasilevsky, S., et al. 2008. B and CD4+ T-cell expression of TLR2 is critical for optimal induction of a T-cell-dependent humoral immune response to intact Streptococcus pneumoniae. Eur. J. Immunol. 38:3316-3326.
37. Wetzler, L. M. 1994. Immunopotentiating ability of neisserial outer membrane proteins: use as an adjuvant for poorly immunogenic substances and potential use as vaccines. Ann. N. Y. Acad. Sci. 730:367-370.
38. Wetzler, L. M., Y. Ho, and H. Reiser. 1996. Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate. J. Exp. Med. 183:1151-1159.
39. Zhang, Q., et al. 2010. Bacterial lipoproteins differentially regulate human primary and memory CD4+ T and B cell responses to pneumococcal protein antigens through toll-like receptor 2. J. Infect. Dis. 201:1753-1763.