Temperature-sensitive bacterial pathogens generated by the substitution of essential genes from cold-loving bacteria: Potential use as live vaccines

Journal of Molecular Medicine

Volumn 89, Issue 5, 2011, Pages 437-444

  Duplantis, Barry N ^a   Bosio, Catherine M ^b   Nano, Francis E ^a  

^a UNIVERSITY OF VICTORIA   (Canada)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cold adapted; Essential gene; Francisella; Live vaccine; Psychrophile; Temperature sensitivity

Indexed keywords

LIVE VACCINE;

BACTERIAL GENE; BACTERIAL STRAIN; CHROMOSOME; GENA GENE; GENB GENE; GENC GENE; GEND GENE; GENX GENE; GENY GENE; GENZ GENE; NONHUMAN; PSYCHROPHILIC BACTERIUM; REVIEW; TEMPERATURE SENSITIVITY;

ANIMALS; BACTERIA; FRANCISELLA; GENES, ESSENTIAL; HUMANS; TEMPERATURE; VACCINES, ATTENUATED;

EID: 79955722754     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-010-0721-3     Document Type: Review

References (50)

1. BN Duplantis M Osusky CL Schmerk DR Ross CM Bosio FE Nano 2010 Essential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccines Proc Natl Acad Sci USA 107 13456 13460 20624965 10.1073/pnas.1004119107 1:CAS:528:DC%2BC3cXht1GnsbrJ
2. TH Benzinger 1969 Heat regulation: homeostasis of central temperature in man Physiol Rev 49 671 759 4898601 1:STN:280:DyaE3c%2Fgt1WqtA%3D%3D
3. JG Greiner ME Clegg ML Walsh MD White 2010 No effect of skin temperature on human ventilation response to hypercapnia during light exercise with a normothermic core temperature Eur J Appl Physiol 10.1007/s00421-010-1352-7 20087599
4. D Baxby 1977 The origins of vaccinia virus J Infect Dis 136 453 455 198484 10.1093/infdis/136.3.453 1:STN:280:DyaE1c%2Fgs1yksw%3D%3D (Pubitemid 8193992)
5. LCA Calmette C Guérin L Négre A Bouquet 1927 Sur la vaccination preventive des enfants nouveau-nes contre la tuberculose par le BCG Ann Inst Pasteur 41 201 232
6. BI El'bert IS Tinker TI Puchkeva 1947 The cutaneous method of the specific prophylaxis of tularemia Rostov 6 7 20
7. HT Eigelsbach CM Downs 1961 Prophylactic effectiveness of live and killed tularemia vaccines J Immunol 87 415 425 13889609 1:STN:280: DyaF38%2FjtV2hug%3D%3D
8. GG Mahairas PJ Sabo MJ Hickey DC Singh CK Stover 1996 Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis J Bacteriol 178 1274 1282 8631702 1:CAS:528:DyaK28XhsVSqur4%3D (Pubitemid 26073382)
9. E Salomonsson K Kuoppa AL Forslund C Zingmark I Golovliov A Sjostedt L Noppa A Forsberg 2009 Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensis Infect Immun 77 3424 3431 19506014 10.1128/IAI.00196-09 1:CAS:528:DC%2BD1MXpsFClsr4%3D
10. R Germanier E Fuer 1975 Isolation and characterization of Gal E mutant Ty 21a of Salmonella typhi: a candidate strain for a live, oral typhoid vaccine J Infect Dis 131 553 558 1092768 10.1093/infdis/131.5.553 1:STN:280: DyaE2M7lt1eltw%3D%3D
11. WP Allen 1962 Immunity against tularemia: passive protection of mice by transfer of immune tissues J Exp Med 115 411 420 13860583 10.1084/jem.115.2.411 1:STN:280:DyaF38%2FgtFyhug%3D%3D
12. J Hess C Ladel D Miko SH Kaufmann 1996 Salmonella typhimurium aroA-infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location J Immunol 156 3321 3326 8617956 1:CAS:528: DyaK28XisFaqsLc%3D
13. RJ North 1973 Importance of thymus-derived lymphocytes in cell-mediated immunity to infection Cell Immunol 7 166 176 4540430 10.1016/0008-8749(73)90193- 7 1:STN:280:DyaE3s7ltVWisw%3D%3D
14. IM Orme FM Collins 1983 Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients J Exp Med 158 74 83 6602861 10.1084/jem.158.1.74 1:STN:280:DyaL3s3ktVCltQ%3D%3D (Pubitemid 13073513)
15. MH Larsen K Biermann B Chen T Hsu VK Sambandamurthy AA Lackner PP Aye P Didier D Huang L Shao H Wei NL Letvin R Frothingham BF Haynes ZW Chen WR Jacobs Jr 2009 Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates Vaccine 27 4709 4717 19500524 10.1016/j.vaccine.2009.05.050 1:CAS:528:DC%2BD1MXotFCjtbs%3D
16. P Conradt J Hess SH Kaufmann 1999 Cytolytic T-cell responses to human dendritic cells and macrophages infected with Mycobacterium bovis BCG and recombinant BCG secreting listeriolysin Microbes Infect 1 753 764 10816080 10.1016/S1286-4579(99)80077-X 1:STN:280:DC%2BD3c3ntlGqsA%3D%3D
17. R Sun YA Skeiky A Izzo V Dheenadhayalan Z Imam E Penn K Stagliano S Haddock S Mueller J Fulkerson C Scanga A Grover SC Derrick S Morris DM Hone MA Horwitz SH Kaufmann JC Sadoff 2009 Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis Vaccine 27 4412 4423 19500523 10.1016/j.vaccine.2009. 05.048 1:CAS:528:DC%2BD1MXotFCrtrs%3D
18. L Bao W Chen H Zhang X Wang 2003 Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guerin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis Infect Immun 71 1656 1661 12654778 10.1128/IAI.71.4.1656-1661.2003 1:CAS:528:DC%2BD3sXislOiu7k%3D (Pubitemid 36368694)
19. I Sugawara L Sun S Mizuno T Taniyama 2009 Protective efficacy of recombinant BCG Tokyo (Ag85A) in rhesus monkeys (Macaca mulatta) infected intratracheally with H37Rv Mycobacterium tuberculosis Tuberculosis 89 62 67 19028143 10.1016/j.tube.2008.09.008 1:STN:280:DC%2BD1M%2Fmt1CitQ%3D%3D
20. WS Chalmers J Simpson SJ Lee W Baxendale 1997 Use of a live chlamydial vaccine to prevent ovine enzootic abortion Vet Rec 141 63 67 9257434 10.1136/vr.141.3.63 1:STN:280:DyaK2svgtFOjuw%3D%3D (Pubitemid 27353169)
21. MW Jackwood YM Saif 1985 Efficacy of a commercial turkey coryza vaccine (Art-Vax) in turkey poults Avian Dis 29 1130 1139 3833219 10.2307/1590467 1:STN:280:DyaL287os1Ggsg%3D%3D
22. AA Jacobs D Goovaerts PJ Nuijten RP Theelen OM Hartford TJ Foster 2000 Investigations towards an efficacious and safe strangles vaccine: submucosal vaccination with a live attenuated Streptococcus equi Vet Rec 147 563 567 11104039 10.1136/vr.147.20.563 1:STN:280:DC%2BD3M7lt1WhsA%3D%3D
23. CJ Morrow JF Markham KG Whithear 1998 Production of temperature-sensitive clones of Mycoplasma synoviae for evaluation as live vaccines Avian Dis 42 667 670 9876833 10.2307/1592700 1:STN:280:DyaK1M%2FpsVWisQ%3D%3D (Pubitemid 29025812)
24. HF Maassab DC DeBorde 1985 Development and characterization of cold-adapted viruses for use as live virus vaccines Vaccine 3 355 369 3909681 10.1016/0264-410X(85)90124-0 1:STN:280:DyaL28%2FpvFWhtA%3D%3D (Pubitemid 16201989)
25. HF Maassab ML Bryant 1999 The development of live attenuated cold-adapted influenza virus vaccine for humans Rev Med Virol 9 237 244 10578119 10.1002/(SICI)1099-1654(199910/12)9:4<237::AID-RMV252>3.0.CO;2-G 1:STN:280:DC%2BD3c%2FkslamsQ%3D%3D
26. RB Belshe KM Edwards T Vesikari SV Black RE Walker M Hultquist G Kemble EM Connor 2007 Live attenuated versus inactivated influenza vaccine in infants and young children N Engl J Med 356 685 696 17301299 10.1056/NEJMoa065368 1:CAS:528:DC%2BD2sXhsleltLc%3D
27. JC King Jr J Treanor PE Fast M Wolff L Yan D Iacuzio B Readmond D O'Brien K Mallon WE Highsmith JS Lambert RB Belshe 2000 Comparison of the safety, vaccine virus shedding, and immunogenicity of influenza virus vaccine, trivalent, types A and B, live cold-adapted, administered to human immunodeficiency virus (HIV)-infected and non-HIV-infected adults J Infect Dis 181 725 728 10669363 10.1086/315246 (Pubitemid 30131847)
28. H Munier-Lehmann V Chenal-Francisque M Ionescu P Christova J Foulon E Carniel O Barzu 2003 Relationship between bacterial virulence and nucleotide metabolism: a mutaction in the adenylate kinase gene renders Yersinia pestis avirulent J Biochem 373 515 522 10.1042/BJ20030284 1:CAS:528: DC%2BD3sXmsFGrtLs%3D (Pubitemid 36897853)
29. A Rodolakis A Souriau 1983 Response of ewes to temperature-sensitive mutants of Chlamydia psittaci (var ovis) obtained by NTG mutagenesis Ann Rech Vét 14 155 161 6614792 1:STN:280:DyaL3szgslSmtw%3D%3D
30. JI Glass N Assad-Garcia N Alperovich S Yooseph MR Lewis M Maruf CA Hutchison 3rd HO Smith JC Venter 2006 Essential genes of a minimal bacterium Proc Natl Acad Sci USA 103 425 430 16407165 10.1073/pnas.0510013103 1:CAS:528:DC%2BD28XpsVSltA%3D%3D (Pubitemid 43122417)
31. BJ Akerley EJ Rubin VL Novick K Amaya N Judson JJ Mekalanos 2002 A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae Proc Natl Acad Sci USA 99 966 971 11805338 10.1073/pnas.012602299 1:CAS:528:DC%2BD38Xht1WisbY%3D (Pubitemid 34106619)
32. RA Forsyth RJ Haselbeck KL Ohlsen RT Yamamoto H Xu JD Trawick D Wall L Wang V Brown-Driver JM Froelich C KG P King M McCarthy C Malone B Misiner D Robbins Z Tan ZY Zhu Zy G Carr DA Mosca C Zamudio JG Foulkes JW Zyskind 2002 A genome-wide strategy for the identification of essential genes in Staphylococcus aureus Mol Microbiol 43 1387 1400 11952893 10.1046/j.1365-2958.2002.02832.x 1:CAS:528:DC%2BD38XivFymu7Y%3D (Pubitemid 34595533)
33. LA Gallagher E Ramage MA Jacobs R Kaul M Brittnacher C Manoil 2007 A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogate Proc Natl Acad Sci USA 104 1009 1014 17215359 10.1073/pnas.0606713104 1:CAS:528:DC%2BD2sXhtVShsLo%3D (Pubitemid 46154727)
34. SY Gerdes MD Scholle JW Campbell G Balazsi E Ravasz MD Daugherty AL Somera NC Kyrpides I Anderson MS Gelfand A Bhattacharya V Kapatral M D'Souza MV Baev F Mseeh MY Fonstein R Overbeek A-L Barabasi ZN Oltvai AL Osterman 2003 Experimental determination and system level analysis of essential genes in Escherichia coli MG1655 J Bacteriol 185 5673 5684 13129938 10.1128/JB.185.19. 5673-5684.2003 1:CAS:528:DC%2BD3sXnslGlt7w%3D (Pubitemid 37176479)
35. MA Jacobs A Alwood I Thaipisuttikul D Spencer E Haugen S Ernst O Will R Kaul C Raymond R Levy L Chun-Rong D Guenthner D Bovee MV Olson C Manoil 2003 Comprehensive transposon mutant library of Pseudomonas aeruginosa Proc Natl Acad Sci USA 100 14339 14344 14617778 10.1073/pnas.2036282100 1:CAS:528: DC%2BD3sXpsFGhsrw%3D (Pubitemid 37499238)
36. K Knuth H Niesalla CJ Hueck TM Fuchs 2004 Large-scale identification of essential Salmonella genes by trapping lethal insertions Mol Microbiol 51 1729 1744 15009898 10.1046/j.1365-2958.2003.03944.x 1:CAS:528:DC%2BD2cXivFCrs7c%3D (Pubitemid 38406545)
37. K Kobayashi SD Ehrlich A Albertini G Amati KK Andersen M Arnaud K Asai S Ashikaga S Aymerich P Bessieres, et al. 2003 Essential Bacillus subtilis genes Proc Natl Acad Sci USA 100 4678 4683 12682299 10.1073/pnas.0730515100 1:CAS:528:DC%2BD3sXjt12ns7o%3D (Pubitemid 36457789)
38. NR Salama B Shepherd S Falkow 2004 Global transposon mutagenesis and essential gene analysis of Helicobacter pylori J Bacteriol 186 7926 7935 15547264 10.1128/JB.186.23.7926-7935.2004 1:CAS:528:DC%2BD2cXhtVequ7fK (Pubitemid 39552503)
39. CM Sassetti DH Boyd EJ Rubin 2003 Genes required for mycobacterial growth defined by high density mutagenesis Mol Microbiol 48 77 84 12657046 10.1046/j.1365-2958.2003.03425.x 1:CAS:528:DC%2BD3sXislOrsLY%3D (Pubitemid 36411469)
40. JA Thanassi SL Hartman-Neumann TJ Dougherty BA Dougherty MJ Pucci 2002 Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae Nucl Acids Res 30 3152 3162 12136097 10.1093/nar/gkf418 1:CAS:528:DC%2BD38Xlslyjsro%3D (Pubitemid 34846179)
41. V de Berardinis D Vallenet V Castelli M Besnard A Pinet C Cruaud S Samair C Lechaplais G Gyapay C Richez M Durot A Kreimeyer F Le Fevre V Schachter V Pezo V Doring C Scarpelli C Medigue GN Cohen P Marliere M Salanoubat J Weissenbach 2008 A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP1 Mol Syst Biol 4 174 18319726
42. Y Ji B Zhang SF Van WP Horn G Woodnutt MK Burnham M Rosenberg 2001 Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA Science 293 2266 2269 11567142 10.1126/science. 1063566 1:CAS:528:DC%2BD3MXntFCqsrY%3D (Pubitemid 32900238)
43. N Judson JJ Mekalanos 2000 TnAraOut, a transposon-based approach to identify and characterize essential bacterial genes Nat Biotechnol 18 740 745 10.1038/77305 10888841 10.1038/77305 1:CAS:528:DC%2BD3cXltFCju7o%3D (Pubitemid 30460689)
44. RY Morita 1975 Psychrophilic bacteria Bacteriol Rev 39 144 167 1095004
45. JW Deming 2002 Psychrophiles and polar regions Curr Opin Microbiol 5 301 309 12057685 10.1016/S1369-5274(02)00329-6 1:CAS:528:DC%2BD38XktFynsLc%3D (Pubitemid 34614943)
46. G Feller C Gerday 1997 Psychrophilic enzymes: molecular basis of cold adaptation Cell Mol Life Sci 53 830 841 9413552 10.1007/s000180050103 1:CAS:528:DyaK2sXnsFOns7k%3D (Pubitemid 27507534)
47. G Feller C Gerday 2003 Psychrophilic enzymes: hot topics in cold adaptation Nat Rev Microbiol 1 200 208 15035024 10.1038/nrmicro773 1:CAS:528:DC%2BD3sXpsVaqsrY%3D
48. D Georlette V Blaise T Collins S D'Amico E Gratia A Hoyoux JC Marx G Sonan G Feller C Gerday 2004 Some like it cold: biocatalysis at low temperatures FEMS Microbiol Rev 28 25 42 14975528 10.1016/j.femsre.2003.07.003 1:CAS:528:DC%2BD2cXht1yrsbY%3D (Pubitemid 38224505)
49. V de Lorenzo 2010 Genes that move the window of viability of life: Lessons from bacteria thriving at the cold extreme: mesophiles can be turned into extremophiles by substituting essential genes Bioessays 33 38 42 10.1002/bies.201000101
50. MH Wahdan C Serie Y Cerisier S Sallam R Germanier 1982 A controlled field trial of live Salmonella typhi strain Ty 21a oral vaccine against typhoid: three-year results J Infect Dis 145 292 295 7037982 10.1093/infdis/145.3.292 1:STN:280:DyaL387ktl2isQ%3D%3D (Pubitemid 12152119)