Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum

Channels

Volumn 5, Issue 3, 2011, Pages

  Wang, Jun ^a   Lanfranco, Maria Fe ^a   Gibb, Stuart L ^a   Ron, Dorit ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Addiction; Alcohol; Dorsal striatum; Fyn; NMDA receptor

Indexed keywords

ALCOHOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PROTEIN KINASE FYN; PROTEIN SUBUNIT;

ADAPTATION; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; BRAIN ELECTROPHYSIOLOGY; BRAIN LEVEL; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DORSOLATERAL STRIATUM; DORSOMEDIAL STRIATUM; EXPOSURE; LONG TERM POTENTIATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; POSTSYNAPTIC POTENTIAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SYNAPTIC TRANSMISSION; UPREGULATION;

EID: 79955708029     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.5.3.14856     Document Type: Article

References (15)

1. Belin D, Jonkman S, Dickinson A, Robbins TW, Everitt BJ. Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction. Behav Brain Res 2009; 199:89-102.
2. Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW. Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci 2008; 363:3125-35.
3. Everitt BJ, Robbins TW. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 2005; 8:1481-9. (Pubitemid 41573659)
4. Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi JA, Chaudhri N, et al. Ethanol induces longterm facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci 2007; 27:3593-602. (Pubitemid 46515141)
5. Joel D, Weiner I. The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum. Neuroscience 2000; 96:451-74. (Pubitemid 30136312)
6. Voorn P, Vanderschuren LJ, Groenewegen HJ, Robbins TW, Pennartz CM. Putting a spin on the dorsal-ventral divide of the striatum. Trends Neurosci 2004; 27:468-74. (Pubitemid 38951039)
7. Yin HH, Knowlton BJ. The role of the basal ganglia in habit formation. Nat Rev Neurosci 2006; 7:464-76. (Pubitemid 44012286)
8. Gerdeman GL, Partridge JG, Lupica CR, Lovinger DM. It could be habit forming: drugs of abuse and striatal synaptic plasticity. Trends Neurosci 2003; 26:184-92. (Pubitemid 36412000)
9. Wang J, Lanfranco MF, Gibb SL, Yowell QV, Carnicella S, Ron D. Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse. J Neurosci 2010; 30:10187-98.
10. Paoletti P, Neyton J. NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 2007; 7:39-47. (Pubitemid 46238036)
11. Yaka R, Phamluong K, Ron D. Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neurosci 2003; 23:3623-32. (Pubitemid 36958470)
12. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 1992; 256:1217-21.
13. Standaert DG, Testa CM, Young AB, Penney JB Jr. Organization of N-methyl-D-aspartate glutamate receptor gene expression in the basal ganglia of the rat. J Comp Neurol 1994; 343:1-16. (Pubitemid 24129523)
14. Kiyama Y, Manabe T, Sakimura K, Kawakami F, Mori H, Mishina M. Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit. J Neurosci 1998; 18:6704-12. (Pubitemid 28388002)
15. Partridge JG, Tang KC, Lovinger DM. Regional and postnatal heterogeneity of activity-dependent long-term changes in synaptic efficacy in the dorsal striatum. J Neurophysiol 2000; 84:1422-9.