Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor ε1 subunit

Journal of Neuroscience

Volumn 18, Issue 17, 1998, Pages 6704-6712

  Kiyama, Yuji ^a   Manabe, Toshiya ^a   Sakimura, Kenji ^b,c   Kawakami, Fumiko ^a   Mori, Hisashi ^a   Mishina, Masayoshi ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Contextual learning; Fear conditioning; GluR 1 subunit; Hippocampus; LTP; Memory; NMDA receptor channel; Threshold

Indexed keywords

GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONDITIONING; ELECTROPHYSIOLOGY; FEAR; HIPPOCAMPUS; LEARNING; LONG TERM POTENTIATION; MEMORY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL;

EID: 0032171371     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-17-06704.1998     Document Type: Article

References (28)

1. Bach ME, Hawkins RD, Osman M, Kandel ER, Mayford M (1995) Impairment of spatial but not contextual memory in CaM KII mutant mice with a selective loss of hippocampal LTP in the range of θ frequency. Cell 81:905-915.
2. Bannerman DM, Good MA, Butcher SP, Ramsay M, Morris RG (1995) Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature 378:182-186.
3. Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
4. Cline HT, Debski EA, Constantine-Paton M (1987) N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes. Proc Natl Acad Sci USA 84:4342-4345.
5. Collingridge GL, Kehl SJ, McLennan H (1983) Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol (Lond) 334:33-46.
6. Crawley JN (1996) Unusual behavioral phenotypes of inbred mouse strains. Trends Neurosci 19:181-182.
7. + signaling requirements for long-term depression in the hippocampus. Neuron 16:825-833.
8. Ebralidze AK, Rossi DJ, Tonegawa S, Slater NT (1996) Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene. J Neurosci 16:5014-5025.
9. Fanselow MS (1980) Conditioned and unconditional components of post-shock freezing. Pavlov J Biol Sci 15:177-182.
10. Fanselow MS (1984) What is conditioned fear? Trends Neurosci 7:460-462.
11. Fanselow MS (1986) Associative vs topographical accounts of the immediate shock-freezing deficit in rats: implications for the response selection rules governing species-specific defensive reactions. Learn Motiv 17:16-39.
12. Forrest D, Yuzaki M, Scares HD, Ng L, Luk DC, Sheng M, Stewart CL, Morgan JI, Connor JA, Curran T (1994) Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron 13:325-338.
13. Gerlai R (1996) Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci 19:177-181.
14. Hollmann M, Boulter J, Maron C, Beasley L, Sullivan J, Pecht G, Heinemann S (1993) Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor. Neuron 10:943-954.
15. Ikeda K, Nagasawa M, Mori H, Araki K, Sakimura K, Watanabe M, Inoue Y, Mishina M (1992) Cloning and expression of the ε4 subunit of the NMDA receptor channel. FEBS Lett 313:34-38.
16. Ikeda K, Araki K, Takayama C, Inoue Y, Yagi T, Aizawa S, Mishina M (1995) Reduced spontaneous activity of mice defective in the ε4 subunit of the NMDA receptor channel. Mol Brain Res 33:61-71.
17. Ito I, Futai K, Katagiri H, Watanabe M, Sakimura K, Mishina M, Sugiyama H (1997) Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor ε1 or ε2 subunit. J Physiol (Lond) 500:401-408.
18. Kadotani H, Hirano T, Masugi M, Nakamura K, Nakao K, Katsuki M, Nakanishi S (1996) Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci 16:7859-7867.
19. Kim JJ, Fanselow MS (1992) Modality-specific retrograde amnesia of fear. Science 256:675-677.
20. Kim JJ, DeCola P, Landeira-Fernandez J, Fanselow MS (1991) N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning. Behav Neurosci 105:126-133.
21. Kim JJ, Fanselow MS, DeCola JP, Landeira-Fernandez J (1992) Selective impairment of long-term but not short-term conditional fear by the N-methyl-D-aspartate antagonist APV. Behav Neurosci 106:591-596.
22. Kleinschmidt A, Bear MF, Singer W (1987) Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortex. Science 238:355-358.
23. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, Mishina M (1992) Molecular diversity of the NMDA receptor channel. Nature 358:36-41.
24. Kutsuwada T, Sakimura K, Manabe T, Takayama C, Katakura N, Kushiya E, Natsume R, Watanabe M, Inoue Y, Yagi T, Aizawa S, Arakawa M, Takahashi T, Nakamura Y, Mori H, Mishina M (1996) Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor ε2 subunit mutant mice. Neuron 16:333-344.
25. Lathe R (1996) Mice, gene targeting, and behavior: more than just genetic background. Trends Neurosci 19:183-186.
26. LeDoux JE (1995) Emotion: clues from the brain. Annu Rev Psychol 46:209-235.
27. Li Y, Erzurumlu RS, Chen C, Jhaveri S, Tonegawa S (1994) Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knock-out mice. Cell 76:427-437.
28. Lynch G, Larson J, Kelso S, Barrionuevo G, Schottler F (1983) Intracellular injections of EGTA block induction of hippocampal long-term potentiation. Nature 305:719-721.