Discovery of novel small molecule activators of β-catenin signaling

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Verkaar, Folkert ^a,b   van der Stelt, Mario ^a   Blankesteijn, W Matthijs ^b   van der Doelen, Antoon A ^a   Zaman, Guido J R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; BETA CATENIN; BETA GALACTOSIDASE; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3; SOTRASTAURIN; WNT PROTEIN; GLYCOGEN SYNTHASE KINASE;

ANIMAL CELL; ARTICLE; ASSAY; BETA GALACTOSIDASE FRAGMENT COMPLEMENTATION ASSAY; CELL NUCLEUS; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; FEMALE; HUMAN; HUMAN CELL; MOLECULAR LIBRARY; NONHUMAN; OSTEOSARCOMA; PROTEIN STABILITY; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CHO CELL; CRICETULUS; DRUG DESIGN; HAMSTER; HELA CELL; METABOLISM; PROTEIN BINDING; TUMOR CELL LINE;

ANIMALS; BETA CATENIN; BETA-GALACTOSIDASE; CELL LINE; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; CYTOPLASM; DRUG DESIGN; GLYCOGEN SYNTHASE KINASES; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 79955706249     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019185     Document Type: Article

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