The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders

IDrugs

Volumn 9, Issue 1, 2006, Pages 35-38

  Testappen, George C ^a   Gaviraghi, Giovanni ^a   Caricasole, Andrea ^a  

^a Siena Biotech SpA   (Italy)

Author keywords

Alzheimer's disease; DKK1; Neurodegenerative disorder; Wnt modulator; Wnt signaling

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 AMINO 4 [3,4 (METHYLENEDIOXY)BENZYLAMINO] 6 (3 METHOXYPHENYL)PYRIMIDINE; ANTIDIABETIC AGENT; AR A 014418; BIS 7 AZAINDOLYLMALEIMIDE DERIVATIVE; CHIR 99021; ENZYME INHIBITOR; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; LIPOPROTEIN RECEPTOR; MEMANTINE; TAU PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CELL DIFFERENTIATION; CELL INTERACTION; CELL PROLIFERATION; DEGENERATIVE DISEASE; DIABETES MELLITUS; DRUG MECHANISM; DRUG STRUCTURE; HOMEOSTASIS; HUMAN; MOLECULAR MECHANICS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING;

ANIMALS; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HOMEOSTASIS; HUMANS; INDOLES; LITHIUM CHLORIDE; MALEIMIDES; MODELS, BIOLOGICAL; NERVOUS SYSTEM; NEURODEGENERATIVE DISEASES; PYRIDINES; PYRIMIDINES; SIGNAL TRANSDUCTION; THIAZOLES; UREA; WNT PROTEINS;

EID: 31144465524     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Logan CY, Nusse R: The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 20:781-810.
2. Fuentealba RA, Farias G, Scheu J, Bronfman M, Marzolo MP, Inestrosa NC: Signal transduction during amyloid-β-peptide neurotoxicity: Role in Alzheimer disease. Brain Res Brain Res Rev (2004) 47(1-3): 275-289.
3. Mudher A, Lovestone S: Alzheimer's disease-do tauists and baptists finally shake hands? Trends Neurosci (2002) 25(1):22-26.
4. Cappuccio I, Calderone A, Busceti CL, Biagioni F, Pontarelli F, Bruno V, Storto M, Terstappen GC, Gaviraghi G, Fornai F, Battaglia G et al: Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death. J Neurosci (2005) 25(10):2647-2657.
5. Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F: Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J Neurosci (2004) 24(26):6021-6027.
6. The Wnt homepage: Howard Hughes Medical Institute, Beckman Center, Stanford University Medical Center, Stanford, CA, USA. http://www.stanford.edu/~rnusse/wntwindow.html