A brief evaluation of tumor imaging in mice with 99mTc-glucarate including a comparison with 18F-FDG

Current Radiopharmaceuticals

Volumn 4, Issue 1, 2011, Pages 5-9

  Cheng, Dengfeng ^a   Rusckowski, Mary ^a   Wang, Yuzhen ^a   Liu, Yuxia ^a   Liu, Guozheng ^a   Liu, Xinrong ^a   Hnatowich, Donald ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

18F FDG; 99mTc glucarate; Molecular imaging; Positron emission tomography (PET); Single photon emission computed tomography (SPECT); Tumor

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCARIC ACID TC 99M; GLUCOSE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CANCER CELL CULTURE; CANCER DIAGNOSIS; CONTROLLED STUDY; DRUG CLEARANCE; ISOTOPE LABELING; MOLECULAR IMAGING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR LOCALIZATION; XENOGRAFT;

ANIMALS; FEMALE; FLUORODEOXYGLUCOSE F18; GLUCARIC ACID; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS; ORGANOTECHNETIUM COMPOUNDS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 79955690390     PISSN: 18744710     EISSN: None     Source Type: Journal    
DOI: 10.2174/1874471011104010005     Document Type: Article

References (27)

1. 18F-FDG PET in oncology. J. Nucl. Med., 2008, 49, 480-508.
2. Kubota, R.; Yamada, S.; Kubota, K.; Ishiwata, K.; Tamahashi, N.; Ido, T. Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J. Nucl. Med., 1992, 33, 1972-1980.
3. Cook, G.J.; Fogelman, I.; Maisey, M.N. Normal physiological and benign pathological variants of 18-fluoro-2-deoxyglucose positron- emission tomography scanning: potential for error in interpretation. Semin. Nucl. Med., 1996, 26, 308-314.
4. Yamada, S.; Kubota, K.; Kubota, R.; Ido, T.; Tamahashi, N. High accumulation of fluorine-18-fluorodeoxyglucose in turpentine- induced inflammatory tissue. J. Nucl. Med., 1995, 36, 1301-1306.
5. 18F-FDG Imaging: Pitfalls and Artifacts. J. Nucl. Med. Technol., 2005, 33,145-155.
6. Chang, J.M.; Lee, H.J.; Goo, J.M.; Lee, H.Y.; Chung, J.K.; Im, J.G. False positive and false negative FDG-PET scans in various thoracic diseases. Korean. J. Radiol., 2006, 7, 57-69.
7. Yaoita, H.; Uehara, T.; Brownell, A.L.; Rabito, C.A.; Ahmad, M.; Khaw, B.A.; Fischman, A.J.; and Strauss, H.W. Localization of technetium-99m-glucarate in zones of acute cerebral injury. J. Nucl. Med., 1991, 32, 272-278.
8. Yaoita, H.; Fischman, A.J.; Wilkinson, R.; Khaw, B.A.; Juweid, M.; Strauss, H.W. Distribution of deoxyglucose and technetium- 99m-glucarate in the acutely ischemic myocardium. J. Nucl. Med., 1993,34, 1303-1308.
9. 99mTc-glucarate high- resolution imaging of drug sensitive and drug resistant human breast cancer xenografts in SCID mice. Nucl. Med. Commun., 2004,25, 711-720.
10. Ballinger, J.R.; Cowan, D.S.M.; Boxen, I.; Zhang, Z.M.; Rauth, A.M. Effect of hypoxia on the accumulation of technetium-99m- glucarate and technetium-99m-gluconate by chinese hamster ovary cells in vitro. J. Nucl. Med., 1993, 34, 242-245.
11. Ballinger, J.R.; Hsue, V.; and Rauth, A.M. Accumulation of technetium-99m glucarate: in vitro cell cultures and in vivo tumour models. Nucl. Med. Commun., 2003, 24, 597-606.
12. 99mTc-Glucarate uptake. Cancer. Biother. Radiopharm., 2005, 20, 391-400.
13. 99mTc-glucarate. Nucl. Med. Commun., 1997, 18, 241-251.
14. 99mTc-glucarate be used to evaluate tumor necrosis? In vitro and in vivo studies in leukaemic tumor cell line U937. Eur. J. Nucl. Med. Mol. Imaging, 2008, 35, 1290-1298.
15. 99mTc ECDG targeted at the multifunctional glucose transport system: feasibility study with rodents. Radiology, 2003, 226, 465-473.
16. Schibli, R.; Dumas, C.; Petrig, J.; Spadola, L.; Scapozza, L.; Garcia-Garayoa, E.; and Schubiger, P.A. Synthesis and in vitro characterization of organometallic rhenium and technetium glucose complexes against Glut 1 and hexokinase. Bioconjug. Chem., 2005, 16, 105-112.
17. Chen, X.; Li, L.; Liu, F.; and Liu, B. Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor. Bioorg. Med. Chem. Lett., 2006, 16, 5503-5506.
18. 99mTc-labeled glucarate. Circulation, 1997,95, 1577-1584.
19. 99mTc-glucarate. J. Nucl. Med., 2004, 45, 655-664.
20. 99mTc-labeled D-glucaric acid imaging in patients with acute chest pain. J. Nucl. Med., 1999, 40, 1832-1839.
21. Ohtani, H.; Callahan, R.J.; Khaw, B.A.; Fishman, A.J.; Wilkinson, R.A.; Strauss, H.W. Comparison of technetium-99m-glucarate and thallium-201 for the identification of acute myocardial infarction in rats. J. Nucl. Med., 1992, 33, 1988-1993.
22. 99mTc-glucarate. J. Nucl. Med. Technol., 2009, 37, 229-232.
23. 99mTc SPECT imaging in phantoms and in tumored mice. Bioconjug. Chem., 2010, 21, 1565-1570.
24. Ambrosini, V.; Quarta, C.; Nanni, C.; Pettinato, C.; Franchi, R.; Grassetto, G.; Al-Nahhas, A.; Fanti, S.; Rubello, D. Small animal PET in oncology: The Road from bench to bedside. Cancer Biother. Radiopharm., 2009, 24, 277-285.
25. Franc, B.L.; Acton, P.D.; Mari, C.; Hasegawa, B.H. Small-animal SPECT and SPECT/CT: important tools for preclinical investigation. J. Nucl. Med., 2008, 49, 1651-1663.
26. 18F-FDG PET/CT. J. Nucl. Med., 2003, 44, 1267-1270.
27. Lawrentschuk, N.; Davis, I.D.; Bolton, D.M.; Scott, A.M. Functional imaging of renal cell carcinoma. Nat. Rev. Urol., 2010, 7, 258-266.