Accumulation of technetium-99m glucarate: in vitro cell cultures and in vivo tumour models

Nuclear Medicine Communications

Volumn 24, Issue 5, 2003, Pages 597-606

  Ballinger, J R ^a   Hsue, V ^a   Rauth, A M ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Cell lines.; Glucarate; Hypoxia; Metabolic inhibitor; Technetium 99m; Tumour

Indexed keywords

AZIDE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FRUCTOSE; METRONIDAZOLE; MISONIDAZOLE; OXYGEN; POTASSIUM CYANIDE; RADIOPHARMACEUTICAL AGENT; SACCHARIC ACID; TECHNETIUM COMPLEX; TECHNETIUM TC 99M GLUCARATE;

ANIMAL; ANOXIA; ARTICLE; C3H MOUSE; CHO CELL; COMPARATIVE STUDY; CRICETULUS; EVALUATION; FIBROSARCOMA; HAMSTER; MALE; METABOLIC CLEARANCE RATE; METABOLISM; MOUSE; SCINTISCANNING; SQUAMOUS CELL CARCINOMA; TISSUE DISTRIBUTION;

ANIMALS; ANOXIA; AZIDES; CARCINOMA, SQUAMOUS CELL; CHO CELLS; CRICETINAE; CRICETULUS; FIBROSARCOMA; FRUCTOSE; GLUCARIC ACID; MALE; METABOLIC CLEARANCE RATE; METRONIDAZOLE; MICE; MICE, INBRED C3H; MISONIDAZOLE; ORGANOTECHNETIUM COMPOUNDS; OXYGEN; POTASSIUM CYANIDE; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 1542495692     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/00006231-200305000-00017     Document Type: Article

References (28)

1. Uehara T, Ahmad M, Khaw BA, et al. Tc-99m-glucarate: a marker of acute cerebral damage (abstract). J Nucl Med 1989; 30: 901.
2. Fornet B, Yasuda T, Wilkinson R, et al. Detection of acute cardiac injury with technetium-99m glucaric acid (abstract). J Nucl Med 1989; 30: 1743.
3. Pak KY, Nedelman MA, Daddona PE. Visualization of experimental tumor model: application of a new Tc-99m labeled compound (abstract). J Nucl Med 1989; 30: 906.
4. ten Cate CI, Fischman AJ, Wilkinson RA, et al. Tc-99m-glucarate: a glucose analog (abstract). Eur J Nucl Med 1990; 16: 451.
5. Yaoita H, Uehara T, Brownell AL, et al. Localization of technetium-99m-glucarate in zones of acute cerebral injury. J Nucl Med 1991; 32: 272-278.
6. Yaoita H, Fischman AJ, Wilkinson R, Khaw BA, Juweid M, Strauss HW. Distribution of deoxyglucose and technetium-99m-glucarate in the acutely ischemic myocardium. J Nucl Med 1993; 34: 1303-1308.
7. Orlandi C, Crane PD, Edwards BS, et al. Early scintigraphic detection of experimental myocardial infarction in dogs with technetium-99m-glucaric acid. J Nucl Med 1991; 32: 263-268.
8. Ohtani H, Callahan RJ, Khaw BA, Fischman AJ, Wilkinson RA, Strauss HW. Comparison of technetium-99m-glucarate and thallium-201 for the identification of acute myocardial infarction in rats. J Nucl Med 1992; 33: 1988-1993.
9. Ballinger JR, Proulx A, Ruddy TD. Stable kit formulation of technetium-99m glucarate. Appl Radiat Isot 1991; 42: 405-406.
10. Ballinger JR, Cowan DS, Boxen I, Zhang ZM, Rauth AM. Effect of hypoxia on the accumulation of technetium-99m-glucarate and technetium-99m-gluconate by Chinese hamster ovary cells in vitro. J Nucl Med 1993; 34: 242-245.
11. m-glucarate. Nucl Med Commun 1997; 18: 241-251.
12. 99mTc-glucaric acid in humans. J Nucl Biol Med 1994; 38: 279-280.
13. 99mTc-labeled D-glucaric acid imaging in patients with acute chest pain. J Nucl Med 1999; 40: 1832-1839.
14. Johnson LL, Schofield L, Mastrofrancesco P, Donahay T, Farb A, Khaw BA. Technetium-99m glucarate uptake in a swine model of limited flow plus increased demand. J Nucl Cardiol 2000; 7: 590-598.
15. Wiersema AM, Oyen WJG, Dirksen R, Verhofstad AAJ, Corstens FHM, van der Vliet JA. Early assessment of skeletal muscle damage after ischaemia-reperfusion injury using Tc-99m-glucarate. Cardiovasc Surg 2000; 8: 186-191.
16. 99mTc-glucarate for detection of isoproterenol-induced myocardial infarction in rats. Int J Pharm 2002; 233: 29-34.
17. Walaszek Z. Chemopreventive properties of D-glucaric acid derivatives. Cancer Bull 1993; 45: 453-457.
18. Whillans DW, Rauth AM. An experimental and analytical study of oxygen depletion in stirred cell suspensions. Radiat Res 1980; 84: 97-117.
19. Taylor YC, Rauth AM. Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and Chinese hamster ovary cells. Cancer Res 1978; 38: 2745-2752.
20. Melo T, Hua HA, Ballinger JR, Rauth AM. Modifying the in vitro accumulation of BMS181321, a technetium-99m-nitroimidazole, with unlabelled nitroaromatics. Biochem Pharmacol 1997; 54: 685-693.
21. 99mTc-gluconate to heart mitochondria. Eur J Nucl Med 1983; 8: 4-9.
22. Bristow RH, Hardy PA, Hill RP. Comparison between in vitro radiosensitivity and in vivo response of murine tumor cell lines. I. Parameters of in vitro radiosensitivity and endogenous cellular glutathione levels. Int J Radiat Oncol Biol Phys 1990; 18: 133-145.
23. Ballinger JR, Wan Min Kee J, Rauth AM. In vitro and in vivo evaluation of a technetium-99m-labeled 2-nitroimidazole (BMS181321) as a marker of tumor hypoxia. J Nucl Med 1996; 37: 1023-1031.
24. Leveille J, Pison C, Karakand Y, Lemieux R, Vallieres BJ. Technetium-99m glucoheptonate in brain-tumor detection: an important advance in radiotracer techniques. J Nucl Med 1977; 18: 957-961.
25. Vorne M, Sakki S, Jarvi K, Vahatalo S. Tc-99m glucoheptonate in detection of lung tumors. J Nucl Med 1982; 23: 250-254.
26. Rivera J, Rabito CA. Transport mechanism of Tc-99m glucoheptonate by renal and lung tumor cells (abstract). J Nucl Med 1989; 30: 912.
27. 99mTc-BnAO (HL-91): a non-nitroaromatic compound for hypoxic cell detection. Int J Radiat Oncol Biol Phys 1998; 42: 737-740.
28. Cowan DS, Melo T, Park L, Ballinger JR, Rauth AM. BMS181321 accumulation in rodent and human cells: the role of P-glycoprotein. Br J Cancer 1996; 74: S264-S266.